Experts and Doctors on colorectal neoplasms in Tainan, Taiwan


Locale: Tainan, Taiwan
Topic: colorectal neoplasms

Top Publications

  1. Feng H, Lin J, Hsu S, Lan W, Kuo C, Tian Y, et al. Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers. Int J Cancer. 2017;141:2537-2550 pubmed publisher
    ..The study highlights CSC targets specific to LFMS-predisposed invasive CRC in optimizing folate co-chemotherapy to minimize tumour metastasis potential of CRC patients. ..
  2. Lin L, Lee H, Hwang W, Li C, Huang C, Que J, et al. p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. Surg Oncol. 2006;15:211-6 pubmed
    ..Second, either the p53 (-) or p27 (+) status was a good predictor for FR in the pre-radiation biopsy specimens. Third, patients with p27 (+) markers in the surgical specimens lived longer at 3 years. ..
  3. Shi M, Lin H, Lee Y, Chao J, Lin R, Chen J. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. Chem Biol Interact. 2008;174:201-10 pubmed publisher
  4. Chien C, Lin S, Lai Y, Lin B, Lin S, Lee J, et al. Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clin Cancer Res. 2008;14:8043-51 pubmed publisher
    ..Regulation of CD151 by oxygen tension may play an important role in cancer metastasis by regulating the detachment from the primary site and homing in the secondary site. ..
  5. Hsu L, Schultz L, Hong Q, Van Moer K, Heath J, Li M, et al. Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem. 2009;284:16049-59 pubmed publisher
    ..Together, TGF-beta1 invokes a novel signaling by engaging cell surface Hyal-2 and recruiting WOX1 for regulating the activation of Smad-driven promoter, thereby controlling cell growth and death. ..
  6. Lai C, Tseng J, Lee Y, Chen Y, Lee J, Lin B, et al. Translational up-regulation of Aurora-A in EGFR-overexpressed cancer. J Cell Mol Med. 2010;14:1520-31 pubmed publisher
    ..Furthermore, the specific expression of exon 2 containing splicing variants in cancer tissues may serve as a potential target for cancer therapy in the future. ..
  7. Lin K, Tai C, Hsu J, Li C, Fang C, Lai H, et al. Overexpression of nuclear protein kinase CK2 ? catalytic subunit (CK2?) as a poor prognosticator in human colorectal cancer. PLoS ONE. 2011;6:e17193 pubmed publisher
    ..The data indicated that CK2?-specific siRNA treatment resulted in growth inhibition. Taken together, overexpression of nuclear CK2? can be a useful marker for predicting the outcome of patients with CRC. ..
  8. Chien C, Ko C, Shen S, Yang L, Chen Y. The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. J Cell Physiol. 2012;227:3128-37 pubmed publisher
  9. Chen M, Cheng Y, Lai P, Wu J, Hsu Y. In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention. Int J Colorectal Dis. 2012;27:869-78 pubmed publisher

More Information


  1. Hsiao K, Lin Y, Gupta S, Chang N, Yen L, Sun H, et al. Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. Cancer Res. 2017;77:2339-2350 pubmed publisher
    ..Taken together, these findings highlight a novel oncogenic function of circRNA in cancer progression and metastasis. Cancer Res; 77(9); 2339-50. ©2017 AACR. ..
  2. Hou P, Li Y, Lin S, Lin S, Lee J, Lin B, et al. Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. Cancer Res. 2017;77:4305-4316 pubmed publisher
    ..Our findings illuminate mechanisms of cancer stemness and suggest new cancer therapy regimens. Cancer Res; 77(16); 4305-16. ©2017 AACR. ..
  3. Lin G, Ting H, Tseng T, Juang V, Lo Y. Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PLoS ONE. 2017;12:e0185625 pubmed publisher
    ..Our study thus provides a powerful regimen for circumventing MDR in colon cancer cells...