Experts and Doctors on apoptosis in Tainan, Taiwan


Locale: Tainan, Taiwan
Topic: apoptosis

Top Publications

  1. Kuo J, Jan M, Jeng J, Chiu H. Induction of apoptosis in macrophages by air oxidation of dioleoylphosphatidylglycerol. J Control Release. 2005;108:442-52 pubmed
    ..These results point to a need for precaution in formulating DOPG liposomes for drug delivery and therapeutic purposes. ..
  2. Kuo P, Chen C, Hsu Y. Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells. Cancer Res. 2007;67:7406-20 pubmed
    ..Moreover, blocking ASK1 by small interfering RNA inhibition completely suppressed IOA-induced apoptosis. Taken together, these results imply a critical role for ROS and ASK1 in IOA's anticancer activity. ..
  3. Lee K, Chen Y, Yeh S, Hsiao M, Lin J, Goan Y, et al. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene. 2009;28:3360-70 pubmed publisher
    ..Collectively, this is the first study to show that E2F1 is negatively regulated by miR-330 and also show that miR-330 induces apoptosis in prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. ..
  4. Liu W, Chen C, Foo N, Huang H, Wang J, Chen S, et al. Human umbilical cord blood cells protect against hypothalamic apoptosis and systemic inflammation response during heatstroke in rats. Pediatr neonatol. 2009;50:208-16 pubmed publisher
    ..These findings suggest that HUCBC transplantation may prevent the occurrence of heatstroke by reducing hypothalamic neuronal damage and the systemic inflammatory responses. ..
  5. Wu S, Ng L, Wang G, Huang Y, Chen J, Sun F. Chlorophyll a, an active anti-proliferative compound of Ludwigia octovalvis, activates the CD95 (APO-1/CD95) system and AMPK pathway in 3T3-L1 cells. Food Chem Toxicol. 2010;48:716-21 pubmed publisher
    ..These results conclude that CHL-a possesses potent anti-proliferative activity, and its apoptotic effects on 3T3-L1 adipocytes are mediated through the activation of CD95 (APO-1/CD95) system and the AMPK signaling pathway...
  6. Tsai C, Huang W, Chen C, Hsieh C, Lin Y, Chen S, et al. Glycogen synthase kinase-3 facilitates con a-induced IFN-?-- mediated immune hepatic injury. J Immunol. 2011;187:3867-77 pubmed publisher
    ..These results demonstrate the dual and indispensable role of GSK-3 in Con A hepatic injury by facilitating IFN-?-induced hepatopathy. ..
  7. Syu G, Chen H, Jen C. Severe exercise and exercise training exert opposite effects on human neutrophil apoptosis via altering the redox status. PLoS ONE. 2011;6:e24385 pubmed publisher
    ..In conclusion, while ASE induced an oxidative state and resulted in acceleration of human neutrophil apoptosis, CME delayed neutrophil apoptosis by maintaining a reduced state for long periods of time even after detraining. ..
  8. Huang S, Wang Y, Yu C, Su I, Wang J. Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement. Virology. 2012;422:132-43 pubmed publisher
    ..In sum, VP2(149M) and VP1(145E) mutations cooperatively promote viral binding and RNA accumulation of EV71, contributing to viral infectivity in vitro and mouse lethality in vivo...
  9. Lo Y, Liu Y, Tsai J. Overcoming multidrug resistance using liposomal epirubicin and antisense oligonucleotides targeting pump and nonpump resistances in vitro and in vivo. Biomed Pharmacother. 2013;67:261-7 pubmed publisher
    ..This approach provides a potential strategy to overcome MDR in cancer chemotherapy. ..

More Information

Publications155 found, 100 shown here

  1. Lin M, Yen J, Weng C, Wang L, Ha C, Wu M. Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways. Toxicology. 2014;315:24-37 pubmed publisher
    ..These results indicate that 4-HNE-induced transient p38 MAPK activation may serve as an upstream negative regulator of ER stress and confer adaptive cytoprotection against 4-HNE-mediated cell injury...
  2. Leung H, Lin C, Hour M, Yang W, Wang M, Lee H. Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem Toxicol. 2007;45:2005-13 pubmed
    ..The overexpression of antioxidant enzyme Mn SOD protein levels, which was promoted to a new type tumor suppressor gene in several human cancer cells recently, may be an important role in kaempferol-induced H460 cell apoptosis. ..
  3. Cheng Y, Lee C, Lin Y, Huang J, Su C, Chang W, et al. Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through the ERK pathway. Int J Cancer. 2008;123:1278-85 pubmed publisher
    ..In summary, caspase-3 induces ERK activation through a ceramide-dependant, protease activity-independent mechanism, which represents a novel role of caspase-3 in tumor metastasis. ..
  4. Wang C, Lin K, Lin B, Chio C, Kuo J. Resuscitation from experimental traumatic brain injury by magnolol therapy. J Surg Res. 2013;184:1045-52 pubmed publisher
  5. Lin Y, Lin Y, Wang Y, Yu I, Lin Y, Wang Y, et al. The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009;174:1857-68 pubmed publisher
    ..Electron microscopic examination of spermatozoa showed misshapen nuclei, disorganized mitochondria, and broken acrosomes. Our data indicate that Septin12 expression levels are critical for mammalian spermiogenesis. ..
  6. Chen C, Chen Z, Lin M, Hsu C. Activated protein C improves heatstroke outcomes through restoration of normal hypothalamic and thermoregulatory function. Am J Med Sci. 2009;338:382-7 pubmed publisher
    ..Our results show that human recombinant APC improves heatstroke through restoration of normal hypothalamic and thermoregulatory function. ..
  7. Fang S, Hsu C, Lin H, Yen G. Anticancer effects of flavonoid derivatives isolated from Millettia reticulata Benth in SK-Hep-1 human hepatocellular carcinoma cells. J Agric Food Chem. 2010;58:814-20 pubmed publisher
    ..These results demonstrate that genistein (6) induces apoptosis in SK-Hep-1 cells via both Fas- and mitochondria-mediated pathways...
  8. Chiu C, Wu J, Her G, Chou Y, Hong J. Aquatic birnavirus capsid protein, VP3, induces apoptosis via the Bad-mediated mitochondria pathway in fish and mouse cells. Apoptosis. 2010;15:653-68 pubmed publisher
  9. Huang C, Chang C, Lin C, Wang S, Wu M, Li E, et al. Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine. Cancer Immunol Immunother. 2010;59:1259-72 pubmed publisher
    ..Overall, these results clearly demonstrate that AC represents a promising immunomodulatory adjuvant that could enhance the therapeutic potency of HER-2/neu DNA vaccines in cancer therapy. ..
  10. Feng Y, Velazquez Torres G, Gully C, Chen J, Lee M, Yeung S. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med. 2011;15:825-36 pubmed publisher
    ..This study provides experimental evidence to support further investigation of metformin and rosiglitazone as first-line therapies for type 2 diabetes in cancer patients. ..
  11. Liu Z, Tseng J, Hong D, Huang H. Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. Biochem J. 2011;438:349-58 pubmed publisher
    ..Blockage of the PI3K/Akt pathway or TGIF expression combined with ATO treatment may be a promising strategy for HCC therapy. ..
  12. Huang H, Lin T, Huang Y, Huang R. Induction of apoptosis and differentiation by atractylenolide-1 isolated from Atractylodes macrocephala in human leukemia cells. Bioorg Med Chem Lett. 2016;26:1905-9 pubmed publisher
    ..Our study thus suggests the potential of developing new leukemia therapies by using ATL-I for leukemia treatment in the future. ..
  13. Kuo P, Hsu Y, Lin T, Lin L, Chang J, Lin C. Casuarinin from the bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells. Planta Med. 2005;71:237-43 pubmed
    ..Our study reports here for the first time that the induction of p21/WAF1 and the activity of Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of casuarinin in MCF-7 cells...
  14. Kuo J, Lin Y, Tseng J. Interactions between U-937 human macrophages and tyloxapol. Colloids Surf B Biointerfaces. 2008;64:208-15 pubmed publisher
    ..Our findings contribute to a better understanding of the molecular action of tyloxapol in macrophages and how it protects macrophages against endotoxin. ..
  15. Tu Y, Lu P, Huang C, Ho C, Chou Y. Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain. Stroke. 2012;43:491-8 pubmed publisher
    ..Moderate DR, but not extreme DR, reduces p53-mediated neurovascular damage after HI and confers long-term protection in neonatal brain. ..
  16. Chang C, Chio C, Cheong C, Chao C, Cheng B, Lin M. Hypoxic preconditioning enhances the therapeutic potential of the secretome from cultured human mesenchymal stem cells in experimental traumatic brain injury. Clin Sci (Lond). 2013;124:165-76 pubmed publisher
    ..Hypoxic preconditioning enhances the secretion of these bioactive factors from the MSCs and the therapeutic potential of the cultured MSC secretome in experimental TBI. ..
  17. Wang Y, Yu C, Chen L, Chen C, Lin J, Liang Y, et al. Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. J Cell Biochem. 2002;87:147-59 pubmed
    ..Our results provide the molecular basis of TF-KT interaction and this information should allow more rational forecasting of the risk for TF therapy during co-administration of KT. ..
  18. Kuo P, Hsu Y, Cho C, Ng L, Kuo Y, Lin C. Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells. Food Chem Toxicol. 2006;44:1316-26 pubmed
  19. Lin W, Chang Y, Lee H, Huang C. CREB activation in the rapid, intermediate, and delayed ischemic preconditioning against hypoxic-ischemia in neonatal rat. J Neurochem. 2009;108:847-59 pubmed publisher
    ..In conclusion, IP, rapid, intermediate, or delayed, in neonatal rat brain activates CREB, up-regulates Bcl-2, induces extensive brakes on caspase-dependent and -independent apoptosis after HI, and provides long-term neuroprotection. ..
  20. Cheng A, Tsai M, Liu C, Lee M, Nagabhushanam K, Ho C, et al. Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food Funct. 2010;1:301-7 pubmed publisher
    ..Our data suggest a promising therapeutic application of garcinol in p53-independent apoptosis in cancers. ..
  21. Chiu W, Luo S, Chen C, Cheng J, Hsieh C, Wang C, et al. Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Biochem Pharmacol. 2012;83:1159-71 pubmed publisher
    ..These results demonstrate an essential role of ROS in vinca alkaloid-induced aberrant JNK-mediated Mcl-1 downregulation and DNA damage followed by mitochondrial dysfunction-related apoptosis but not mitotic arrest. ..
  22. Cheng H, Liu Y, Shan Y, Huang C, Lin F, Lin L, et al. Loss of RUNX3 increases osteopontin expression and promotes cell migration in gastric cancer. Carcinogenesis. 2013;34:2452-9 pubmed publisher
    ..Together, our data demonstrated that RUNX3 is a transcriptional repressor of OPN and that loss of RUNX3 upregulates OPN, which promotes migration in gastric cancer cells. ..
  23. Lai F, Cheng C, Chen S, Wu C, Hsu L, Lee J, et al. WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo. Clin Cancer Res. 2005;11:5769-77 pubmed
    ..During UVB-induced cutaneous SCC, epidermal cells have apparently prevented the apoptotic pressure from overexpressed WOX1 by shutting down the translation machinery for WWOX mRNA. ..
  24. Hsing C, Chiu C, Chang L, Hsu C, Chang M. IL-19 is involved in the pathogenesis of endotoxic shock. Shock. 2008;29:7-15 pubmed
    ..These results suggest that up-regulated IL-19 may be involved in lung and liver tissue injury in murine endotoxic shock. ..
  25. Chen C, Lin C, Chang W, Huang W, Teng C, Lin Y. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood. 2008;111:4365-74 pubmed publisher
  26. Yeh H, Giri R, Chang T, Chou C, Su W, Liu H. Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell. DNA Cell Biol. 2009;28:131-9 pubmed publisher
    ..The effect of Ha-ras on Stat3 phosphorylation at serine-727 was also detected in human bladder (T24) and lung (H460) cancer cells. Stat3 phosphorylation at serine-727 is important in Ras-related tumorigenesis. ..
  27. Pan Y, Li C, Ko C, Pan M, Chen P, Tseng J, et al. CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells. Clin Cancer Res. 2010;16:5770-80 pubmed publisher
    ..These results clearly demonstrate that HMDB kills cancer cells through activation of CEBPD pathways and suggest that HMDB can serve as a superior chemotherapeutic agent with limited potential for adverse side effects. ..
  28. Yeh C, Cho W, So E, Chu C, Lin M, Wang J, et al. Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression. Br J Anaesth. 2011;106:590-9 pubmed publisher
    ..Propofol reduces apoptosis in LPS-stimulated lung epithelial cells by decreasing HIF-1?, BNIP3, and cytokine production. Using propofol to inhibit HIF-1? expression may protect against the acute lung injury caused by LPS-induced sepsis. ..
  29. Cheng Y, Huang W, Chen C, Tsai C, Wang C, Chiu W, et al. Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli. Biochem Biophys Res Commun. 2011;412:334-40 pubmed publisher
    ..We found that GSK-3? upregulated galectin-3 and stabilized anti-apoptotic Bcl-2 family proteins, which is important for the escape of leukemia cells from apoptotic stimuli. ..
  30. Wang L, Tu Y, Huang C, Ho C. JNK signaling is the shared pathway linking neuroinflammation, blood-brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain. J Neuroinflammation. 2012;9:175 pubmed publisher
    ..LPS-sensitized HI causes white matter injury through JNK activation-mediated upregulation of neuroinflammation, BBB leakage and oligodendrocyte progenitor apoptosis in the immature brain. ..
  31. Lee S, Wu Y, Chien L, Chen S, Tzeng Y, Wu T. Proteomic exploration of the impacts of pomegranate fruit juice on the global gene expression of prostate cancer cell. Proteomics. 2012;12:3251-62 pubmed publisher
  32. Sze C, Lin Y, Lin Y, Hsieh T, Kuo Y, Lin C. The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups. Mediators Inflamm. 2013;2013:628094 pubmed publisher
    ..Early administration of Dex results in apoptosis of neural progenitor cells in the hippocampus and this is mediated through GCRs. ..
  33. Tsai C, Lai F, Sheu H, Lin Y, Chang T, Jan M, et al. WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. Cell Death Dis. 2013;4:e792 pubmed publisher
    ..Thus, WWOX renders SCC cells susceptible to MTX-induced apoptosis by dampening autophagy, and the failure in inducing WWOX expression leads to chemotherapeutic drug resistance. ..
  34. Chiu H, Yeh Y, Wang Y, Huang W, Chen Y, Chiou Y, et al. Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo. PLoS ONE. 2013;8:e76340 pubmed publisher
    ..SAHA not only enhances radiosensitivity but also suppresses lung metastasis in breast cancer. These novel findings suggest that SAHA alone or combined with IR could serve as a potential therapeutic strategy for breast cancer. ..
  35. Tsai Y, Wang C, Leung P, Lin K, Chio C, Hu C, et al. Extracellular signal-regulated kinase 1/2 is involved in a tamoxifen neuroprotective effect in a lateral fluid percussion injury rat model. J Surg Res. 2014;189:106-16 pubmed publisher
    ..TMX may be a promising TBI treatment strategy. ..
  36. Chen T, Yu M, Chien C, Wu M, Lee Y, Chen Y. Nilotinib reduced the viability of human ovarian cancer cells via mitochondria-dependent apoptosis, independent of JNK activation. Toxicol In Vitro. 2016;31:1-11 pubmed publisher
    ..The evidence supporting AMN effectively reducing the viability of human ovarian cancer cells via mitochondrion-dependent apoptosis is provided. ..
  37. Huang W, Lin Y, Chen C, Wang C, Chiu W, Lin C. Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia. J Pharmacol Exp Ther. 2009;329:524-31 pubmed publisher
    ..Taken together, we show that GSK-3beta exhibits a mechanism of ER stress-induced lysosomal apoptosis in leukemia involving caspase-2-induced LMP and cathepsin B relocation, which result in caspase-8 and -3 activation. ..
  38. Chen C, Wang S, Wei E, Chu T, Hsieh P. Hyaluronan enhances bone marrow cell therapy for myocardial repair after infarction. Mol Ther. 2013;21:670-9 pubmed publisher
    ..Together, our results indicate that combining the biocompatible material HA with bone marrow stem cells exerts a therapeutic effect on heart repair and may further provide potential treatment for ischemic diseases. ..
  39. Lien S, Chang S, Lee P, Wei S, Chang M, Chang J, et al. Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK. Biochim Biophys Acta. 2013;1833:3124-3133 pubmed publisher
    ..Our findings provide insights into the molecular mechanisms by which shear stress induces apoptosis and autophagy in tumor cells. ..
  40. Kuo P, Hsu Y, Lin T, Chang J, Lin C. Induction of cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells by casuarinin from the bark of Terminalia arjuna Linn. Anticancer Drugs. 2005;16:409-15 pubmed
    ..Our study reports here for the first time that the induction of p53 and the activity of the Fas/FasL apoptotic system may participate in the antiproliferative activity of casuarinin in A549 cells...
  41. Chang Y, Wu C, Tseng S, Kuo P, Tseng S. In vitro benzyl alcohol cytotoxicity: implications for intravitreal use of triamcinolone acetonide. Exp Eye Res. 2008;86:942-50 pubmed publisher
    ..Commercial development of a preservative-free TA suspension for intraocular use is urged...
  42. Chen R, Ho Y, Guo H, Wang Y. Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells. Toxicol Sci. 2010;115:118-30 pubmed publisher
    ..Stat3 could be the major target for increasing chemosensitivity in patients who develop chemoresistance during chemotherapy, and avoidance of cigarette smoking or nicotine-based treatments may increase the efficacy of chemotherapy. ..
  43. Hsu Y, Chang S, Wang M, Chen Y, Huang T. Growth inhibition and apoptosis of neuroblastoma cells through ROS-independent MEK/ERK activation by sulforaphane. Cell Biochem Biophys. 2013;66:765-74 pubmed publisher
    ..Results were confirmed by MTT assay, which demonstrated the cytotoxic activity of SFN against SH-SY5Y cells (IC50 values of 20 ?M). ..
  44. Sze C, Kuo Y, Hsu L, Fu T, Chiang M, Chang J, et al. A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency. Cell Death Dis. 2015;6:e1881 pubmed publisher
  45. Kuo P, Hsu Y, Sung S, Ni W, Lin T, Lin C. Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by pterocarnin A from the bark of Pterocarya stenoptera via the Fas-mediated pathway. Anticancer Drugs. 2007;18:555-62 pubmed
    ..Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of pterocarnin A in MCF-7 cells...
  46. Huang H, Liu Z, Hong D. Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes. Toxicol Appl Pharmacol. 2010;244:234-41 pubmed publisher
    ..Thus, the domains of TGIF that carried out its inhibitory effects on p21 were identified. Finally, treatment with JNK inhibitor SP600125 could enhance ATO-induced apoptosis of HaCaT keratinocytes by using flow cytometry. ..
  47. Chio C, Lin J, Cheng H, Chiu W, Wang Y, Wang J, et al. MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells. Arch Toxicol. 2013;87:459-68 pubmed publisher
    ..Taken together, this study shows that OGD can induce miR-210 expression through activating HIF-1?. And miR-210 can mediate hypoxia-induced neural apoptosis by targeting Bcl-2. ..
  48. Wang C, Chen Y, Lin B, Chio C, Hu C, Kuo J. The neuronal protective effects of local brain cooling at the craniectomy site after lateral fluid percussion injury in a rat model. J Surg Res. 2013;185:753-62 pubmed publisher
    ..We propose that the use of local cooling at the craniectomy site after FPI might have clinical benefits in the future. ..
  49. Lin C, Lei H, Shiau A, Liu H, Yeh T, Chen S, et al. Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. J Immunol. 2002;169:657-64 pubmed
    ..Endothelial cell damage may cause vascular leakage that contributes to the pathogenesis of dengue disease...
  50. Cheng A, Lee M, Tsai M, Lai C, Lee J, Ho C, et al. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Food Chem Toxicol. 2011;49:485-93 pubmed publisher
    ..These results demonstrate that the rosmanol-induced apoptosis in COLO 205 cells is involvement of caspase activation and involving complicated regulation of both the mitochondrial apoptotic pathway and death receptor pathway. ..
  51. Hsing C, Chen Y, Chen C, Huang W, Lin M, Tseng P, et al. Anesthetic propofol causes glycogen synthase kinase-3?-regulated lysosomal/mitochondrial apoptosis in macrophages. Anesthesiology. 2012;116:868-81 pubmed publisher
    ..Decreased Akt was important for GSK-3? activation caused by propofol. These results suggest an essential role of GSK-3? in propofol-induced lysosomal/mitochondrial apoptosis. ..
  52. Huang S, Chang S, Mu S, Jiang H, Wang S, Kao J, et al. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. J Dermatol Sci. 2016;81:182-91 pubmed publisher
    ..IMQ induced ROS production to stimulate ATM/ATR pathways and contributed to p53-dependent apoptosis in a skin basal cell carcinoma cell line BCC/KMC1. ..
  53. Chiu W, Tang M, Jao H, Shen M. Soft substrate up-regulates the interaction of STIM1 with store-operated Ca2+ channels that lead to normal epithelial cell apoptosis. Mol Biol Cell. 2008;19:2220-30 pubmed publisher
    ..Thus, soft substrate up-regulates the interaction of STIM1 with SOC channels, which results in the activation of mu-calpain and subsequently induces normal epithelial cell apoptosis. ..
  54. Huang H, Chen Y, Huang Y, Yang K, Pan H, Shih S, et al. Lapatinib induces autophagy, apoptosis and megakaryocytic differentiation in chronic myelogenous leukemia K562 cells. PLoS ONE. 2011;6:e29014 pubmed publisher
    ..This distinct activity of lapatinib against CML cells suggests potential for lapatinib as a therapeutic agent for treatment of CML. Further validation of lapatinib activity in vivo is warranted...
  55. Chiu W, Wang Y, Tang M, Shen M. Soft substrate induces apoptosis by the disturbance of Ca2+ homeostasis in renal epithelial LLC-PK1 cells. J Cell Physiol. 2007;212:401-10 pubmed
    ..Thus, soft substrate induces apoptosis in LLC-PK1 cells by the disturbance of Ca(2+) homeostasis. ..
  56. Cheung C, Lin W, Hsu J, Hour T, Yeh T, Ko S, et al. BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells. PLoS ONE. 2011;6:e23485 pubmed publisher
    ..Therefore, BPR1K653 is a promising anti-cancer compound that has potential for the management of various malignancies, particularly for patients with MDR1-related drug resistance after prolonged chemotherapeutic treatments. ..
  57. Lin C, Hsu C, Lin M, Chen S. Flutamide, an androgen receptor antagonist, improves heatstroke outcomes in mice. Eur J Pharmacol. 2012;688:62-7 pubmed publisher
    ..myeloperoxidase activity), and (vii) allowed three times the fractional survival compared with vehicle. Thus, flutamide appears to be a novel agent for the treatment of mice with heatstroke or patients in the early stage of heatstroke...
  58. Chen S, Chuang J, Cheng C, Hsu L, Chang N. Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domain-containing oxidoreductase in vivo. Neuroscience. 2005;130:397-407 pubmed
    ..In conclusion, activated WOX1 is likely to exert apoptosis of neuronal cells in the outer retina during the light-induced injury and in mice with an inherited retinal defect. ..
  59. Lee C, Wu C, Shiau A. Salmonella choleraesuis as an anticancer agent in a syngeneic model of orthotopic hepatocellular carcinoma. Int J Cancer. 2008;122:930-5 pubmed
    ..In conclusion, these results suggest that tumor-targeted therapy using S. choleraesuis, which exerts tumoricidal and antiangiogenic activities, represents a potential strategy for the treatment of HCC. ..
  60. Chien C, Ko C, Shen S, Yang L, Chen Y. The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. J Cell Physiol. 2012;227:3128-37 pubmed publisher
  61. Huang W, Tsai C, Chen C, Chen T, Chen Y, Lin Y, et al. Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J. 2011;25:3661-73 pubmed publisher
    ..This study suggests a feasible novel anti-CML strategy by accumulating endogenous ceramide to reactivate GSK-3 and abrogate drug resistance. ..
  62. Peng C, You B, Lee C, Wu Y, Lin W, Lu T, et al. The Roles of 4?-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells. Am J Chin Med. 2016;44:617-36 pubmed publisher
    ..Furthermore, 4[Formula: see text]-hydroxywithanolide E was demonstrated to significantly reduce the sizes of the tumor nodules in the human breast cancer MDA-MB231 xenograft tumor model. ..
  63. Yen J, Wu P, Chen S, Wu M. Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..In conclusion, this result shows that fisetin activates Nrf2, MAPK and SIRT1, which may elicit adaptive cellular stress response pathways so as to protect cells from Tm-induced cytotoxicity. ..
  64. Chuang T, Lin K, Chio C, Wang C, Chang C, Kuo J. Effects of secretome obtained from normoxia-preconditioned human mesenchymal stem cells in traumatic brain injury rats. J Trauma Acute Care Surg. 2012;73:1161-7 pubmed publisher
    ..We also recommend that secretome from normoxia-preconditioned human mesenchymal stem cells could be a promising treatment strategy for traumatic brain injury. ..
  65. Tian Y, Chen T, Lin C, Chen L, Lin L, Hsing C, et al. SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential. Tumour Biol. 2013;34:1107-17 pubmed publisher
    ..In the presence of chemotherapy with or without radiotherapy, the promoted sensitivity of colorectal cancer cells to Bortezomib with an SKP2-repressing effect indicated that it is a potential therapeutic target. ..
  66. Tzeng C, Tzeng W, Lin L, Lee C, Yen F, Lin C. Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system. Phytomedicine. 2016;23:528-40 pubmed publisher
    ..The research provided a basis of ArtN could be explored as a low-dose alternative of artocarpin in anticancer treatment and research applications. ..
  67. Jiang Shieh Y, Yeh K, Wei I, Chang C, Chien H, Tsai R, et al. Responses of microglia in vitro to the gram-positive bacterial component, lipoteichoic acid. J Neurosci Res. 2005;82:515-24 pubmed
    ..In conclusion, staphylococcal LTA can exert an immunomodulatory effect on microglial morphology, cell cycle, and immunomolecules, including its receptors. ..
  68. Leung H, Yang W, Lai M, Lin C, Lee H. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Food Chem Toxicol. 2007;45:403-11 pubmed
    ..These data suggest that baicalein, a 12-LOX inhibitor, inhibits the proliferation of H460 cells via S-phase arrest and induces apoptosis in association with the regulation of molecules in the cell cycle and apoptosis-related proteins. ..
  69. Liang C, Shiu L, Chang L, Sheu H, Kuo K. Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Mol Nutr Food Res. 2007;51:999-1005 pubmed
    ..These findings provide the synergistic therapeutic interaction between SM and epirubicin, suggesting that such combinations may be effectively exploited in future human cancer clinical trials. ..
  70. Wu S, Ng L. Tocotrienols inhibited growth and induced apoptosis in human HeLa cells through the cell cycle signaling pathway. Integr Cancer Ther. 2010;9:66-72 pubmed publisher
  71. Huang J, Chuang J. Fibroblast growth factor 9 upregulates heme oxygenase-1 and gamma-glutamylcysteine synthetase expression to protect neurons from 1-methyl-4-phenylpyridinium toxicity. Free Radic Biol Med. 2010;49:1099-108 pubmed publisher
    ..These results indicate that FGF9 upregulates gamma-GCS and HO-1 expression to protect cortical and dopaminergic neurons from MPP(+)-induced oxidative insult. ..
  72. Chen S, Yeh C, Lin M, Kang C, Chu C, Chang F, et al. Premarin improves outcomes of spinal cord injury in male rats through stimulating both angiogenesis and neurogenesis. Crit Care Med. 2010;38:2043-51 pubmed publisher
    ..Our results indicate that Premarin therapy may protect against spinal cord apoptosis after spinal cord injury through mechanisms stimulating both angiogenesis and neurogenesis in male rats. ..
  73. Yeng C, Chen P, Chang H, Lo W, Wu C, Chang C, et al. Attenuating spinal cord injury by conditioned medium from human umbilical cord blood-derived CD34⁺ cells in rats. Taiwan J Obstet Gynecol. 2016;55:85-93 pubmed publisher
    ..The neuroprotective effects of CM from cultured human CD34(+) cells are similar to those of human CD34(+) cells and the CM was found to enhance the neuroprotective effects of E2 in rat SCI. ..
  74. Shen K, Chang J, Hsu Y, Kuo P. Chalcone arrests cell cycle progression and induces apoptosis through induction of mitochondrial pathway and inhibition of nuclear factor kappa B signalling in human bladder cancer cells. Basic Clin Pharmacol Toxicol. 2007;101:254-61 pubmed
    ..Our study suggests that the induction of mitochondrial pathway and inhibition of the nuclear factor kappa B survival system may play important roles in the antiproliferative activity of chalcone in T24 and HT-1376 cells. ..
  75. Leung H, Hour M, Chang W, Wu Y, Lai M, Wang M, et al. P38-associated pathway involvement in apoptosis induced by photodynamic therapy with Lonicera japonica in human lung squamous carcinoma CH27 cells. Food Chem Toxicol. 2008;46:3389-400 pubmed publisher
    ..We also have demonstrated that PDT with Lonicera japonica extracts-induced CH27 cells apoptosis was probably related to its ability to change the protein expression and distribution of heat shock protein 27...
  76. Chuang J, Wu C, Lai M, Chang W, Hung J. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. Int J Cancer. 2009;125:2066-76 pubmed publisher
    ..In conclusion, p53 was an essential factor for Sp1 overexpression-induced apoptotic cell death in transforming cells. ..
  77. Cheng J, Shu S, Kuo C, Chou C, Tsai W, Fang Y, et al. Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells. Arch Toxicol. 2011;85:1257-66 pubmed publisher
    ..Diindolylmethane induced cell death that may involve apoptosis. ..
  78. Chen C, Chen T, Chen H. Extracellular signal-regulated kinase plays a proapoptotic role in podocytes after reactive oxygen species treatment and inhibition of integrin-extracellular matrix interaction. Exp Biol Med (Maywood). 2012;237:777-83 pubmed publisher
    ..Our study demonstrated that ROS and blocking integrin-ECM interaction induce podocyte apoptosis, which is mediated by ERK activation. ..
  79. Chen Y, Lin H, Chen J, Tsai M, Hsieh H, Chang J, et al. CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors. Int J Cancer. 2014;135:751-62 pubmed publisher
    ..Our study suggests CDKN1A could be a potential biomarker in determining the drug responsiveness of Aurora kinase inhibitors in ALL, particularly in MLL-AF4-positive patients. ..
  80. Chuang J, Chang T, Liu H. Glutathione depletion-induced apoptosis of Ha-ras-transformed NIH3T3 cells can be prevented by melatonin. Oncogene. 2003;22:1349-57 pubmed
    ..Cotreatment of ras-related cancer cells with melatonin and BSO stops cell growth as well as apoptosis. Whether these cancer cells will undergo further regression or become recurrent merits investigation. ..
  81. Chen S, Yang H, Her G, Lin H, Jeng M, Wu J, et al. Betanodavirus induces phosphatidylserine exposure and loss of mitochondrial membrane potential in secondary necrotic cells, both of which are blocked by bongkrekic acid. Virology. 2006;347:379-91 pubmed
    ..Our data suggest that RGNNV induces apoptotic death via opening the mitochondrial permeability transition pore thereby triggering secondary necrosis in the mid-apoptotic phase...
  82. Chen J, Tang Y, Li W, Chiou Y, Shieh J, Wang Y. A synthetic podophyllotoxin derivative exerts anti-cancer effects by inducing mitotic arrest and pro-apoptotic ER stress in lung cancer preclinical models. PLoS ONE. 2013;8:e62082 pubmed publisher
    ..We provided preclinical evidence that novel synthetic microtubule inhibitor Ching001, which can trigger DNA damage and apoptosis by inducing mitotic arrest and ER stress, is a potential anti-cancer compound for further drug development. ..
  83. Chen J, Chen Y, Yen C, Chen W, Huang W. HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3. Oncotarget. 2016;7:473-89 pubmed publisher
    ..Our data suggest that HBx shifts the oncogenic addiction of HCC cells to ErbB2/ErbB3 signaling pathway via inducing ErbB3 expression and thereby enhances their sensitivity to EGFR/ErbB2 inhibitors. ..
  84. Theron M, Huang K, Chen Y, Liu C, Lei H. A probable role for IFN-gamma in the development of a lung immunopathology in SARS. Cytokine. 2005;32:30-8 pubmed
    ..Based on the clinical data collected previously, the available literature and our in vitro experimentation, we propose that IFN-gamma may be responsible for acute lung injury in the late phase of the SARS pathology. ..
  85. Tsai P, Lin Y, Kuo C, Lei H, Wu J. Group A Streptococcus induces apoptosis in human epithelial cells. Infect Immun. 1999;67:4334-9 pubmed
    ..The caspase pathway is involved in GAS-induced apoptosis, and the expression of SPE B in the cells enhances apoptosis...
  86. Wu S, Ng L. MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. Food Chem Toxicol. 2007;45:2446-53 pubmed
    ..These results suggest that p53 induction and MAPK signaling pathways are required for Cin-mediated apoptosis in PLC/PRF/5 cells...
  87. Wei C, Li H, Hsu Y, Hsing C, Sung J, Chang M. Interleukin-20 targets renal cells and is associated with chronic kidney disease. Biochem Biophys Res Commun. 2008;374:448-53 pubmed publisher
    ..Therefore, IL-20 injured renal epithelial cells and induced fibroblasts to produce TGF-beta1 that hastened the progression of CKD. ..
  88. Liang C, Wang G, Liaw C, Lee M, Wang S, Cheng D, et al. Extracts from Cladiella australis, Clavularia viridis and Klyxum simplex (soft corals) are capable of inhibiting the growth of human oral squamous cell carcinoma cells. Mar Drugs. 2008;6:595-606 pubmed publisher
    ..Thereby, it is possible that extracts of C. australis, C. viridis and K. simplex cause apoptosis of SCCs and warrant further research investigating the possible anti-oral cancer compounds in these soft corals. ..
  89. Liu W, Huang C, Lu I, Gean P. Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death. Neuro Oncol. 2013;15:1127-41 pubmed publisher
    ..We have reported that minocycline (Mino) induced autophagic death in glioma cells. In the present study, we characterize the upstream regulators that control autophagy and switch cell death from autophagic to apoptotic...
  90. Liao Y, Liang W, Chen F, Hsu J, Yang J, Chang M. IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha. J Immunol. 2002;169:4288-97 pubmed
    ..Taken together, our results indicate that mouse IL-19 may play some important roles in inflammatory responses because it up-regulates IL-6 and TNF-alpha and induces apoptosis. ..
  91. Lin C, Chen C, Chang W, Jan M, Hsu L, Wu R, et al. Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis. J Biol Chem. 2004;279:40755-61 pubmed
    ..These data suggest sequential initiator caspase-2 and caspase-8 activation in the mitochondrial apoptotic pathway induced by ceramide or etoposide. ..
  92. Hong J, Lin G, Lin C, Wang W, Lee C, Lin T, et al. Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. Development. 2004;131:5417-27 pubmed