Experts and Doctors on neutralization tests in Taiwan


Locale: Taiwan
Topic: neutralization tests

Top Publications

  1. Wu H, Yeh C, Huang Y, Tarn L, Lung C. Characterization of neutralizing antibodies and identification of neutralizing epitope mimics on the Clostridium botulinum neurotoxin type A. Appl Environ Microbiol. 2001;67:3201-7 pubmed
    ..In the future, the identification of the neutralizing epitopes of BTx-A may provide important information for the identification of the BTx-A receptor and the design of a BTx-A vaccine. ..
  2. Leng C, Liu S, Tsai J, Li Y, Chen M, Liu H, et al. A novel dengue vaccine candidate that induces cross-neutralizing antibodies and memory immunity. Microbes Infect. 2009;11:288-95 pubmed publisher
    ..These results demonstrate the possibility of developing a single tetravalent vaccine against dengue viral infections. ..
  3. Lee F, Jong M, Yang D. Presence of antibodies to non-structural proteins of foot-and-mouth disease virus in repeatedly vaccinated cattle. Vet Microbiol. 2006;115:14-20 pubmed
    ..A low percentage of field sera sampled from beef cattle in Kinmen also tested positive, but the key factor resulting in the positive reactions could not be positively identified based on our data. ..
  4. Wu C, Wang H, Wang K, Weng S, Chang W, Shih D, et al. Neutralization of five subgenotypes of Enterovirus 71 by Taiwanese human plasma and Taiwanese plasma derived intravenous immunoglobulin. Biologicals. 2013;41:154-7 pubmed publisher
    ..IVIG derived from Taiwanese plasma may be desirable for treatment of patients infected with EV71 of specific subgenotypes. ..
  5. Huang H, Leu J, Huang P, Chen L. A putative cell surface receptor for white spot syndrome virus is a member of a transporter superfamily. PLoS ONE. 2012;7:e33216 pubmed publisher
    ..These findings have important implications for our understanding of WSSV entry. ..
  6. Wang K, Lin S, Wang H, Chen P, Lin J, Chiang J, et al. Establishment of an animal challenge model as a potency assay for an inactivated Enterovirus Type 71 vaccine. Biologicals. 2016;44:183-190 pubmed publisher
    ..Our results could facilitate candidate EV71 vaccine immunogenicity and efficacy evaluations, and may help establish reference EV71 antisera in the future. ..
  7. Huang M, Chiang P, Luo S, Liou G, Lee M. Development of a high-throughput assay for measuring serum neutralizing antibody against enterovirus 71. J Virol Methods. 2010;165:42-5 pubmed publisher
    ..In the quantitative comparison, the correlation coefficient between Nt-EIA and Nt-CPE was 0.91 after log transformation. Overall, the Nt-EIA is a suitable alternative assay for the quantitation of EV71 neutralizing antibody to EV71. ..
  8. Shao H, Yu S, Sia C, Chen Y, Chitra E, Chen I, et al. Immunogenic properties of RSV-B1 fusion (F) protein gene-encoding recombinant adenoviruses. Vaccine. 2009;27:5460-71 pubmed publisher
    ..Results from these studies suggest that rAd-F0DeltaTM or rAd-F0 possess immunogenic properties that meet the requirements expected from potential RSV vaccine candidates. ..
  9. Chen H, Liu S, Liu H, Kwok Y, Lin C, Lin L, et al. A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design. Vaccine. 2009;27:1400-9 pubmed publisher
    ..These results have successfully demonstrated the merit of lipo-immunogens for novel vaccine development. ..

More Information


  1. Chang C, Lin Y, Shih S, Lee C, Lee Y, Tai C, et al. Design, synthesis, and antipicornavirus activity of 1-[5-(4-arylphenoxy)alkyl]-3-pyridin-4-ylimidazolidin-2-one derivatives. J Med Chem. 2005;48:3522-35 pubmed
    ..Three of the more potent imidazolidinone compounds, 14a, 28b, and 32b, were subjected to a large group of picornaviruses to determine their spectrum of antiviral activity. ..
  2. Tsao K, Chen G, Huang C, Huang Y, Lin J, Mok C, et al. False positive antibody results against human T-cell lymphotropic virus in patients with severe acute respiratory syndrome. J Med Virol. 2005;77:331-6 pubmed
    ..Without such knowledge, blood products can be discarded mistakenly even though they contain anti-SARS-CoV antibodies that may be potentially valuable for SARS therapy...
  3. Liu C, Chou A, Lien S, Lin H, Liu S, Chang J, et al. Identification and characterization of a cross-neutralization epitope of Enterovirus 71. Vaccine. 2011;29:4362-72 pubmed publisher
    ..Thus, VP2-28 could be used as the surrogate biomarker in the potency testing of candidate EV71 vaccines...
  4. Chen G, Huang J, Lo Y, Tsao K, Chang S. Mosaic genome structure of echovirus type 30 that circulated in Taiwan in 2001. Arch Virol. 2007;152:1807-17 pubmed
    ..Recombination analysis of these two E30 genomes revealed that their genome structures are mosaic, which might have been formed gradually and frequently over time...
  5. Hu A, Weng T, Tseng Y, Chen Y, Wu C, Hsiao S, et al. Microcarrier-based MDCK cell culture system for the production of influenza H5N1 vaccines. Vaccine. 2008;26:5736-40 pubmed publisher
  6. Lin Y, Lee L, Shih W, Hu Y, Liu H. Baculovirus surface display of sigmaC and sigmaB proteins of avian reovirus and immunogenicity of the displayed proteins in a mouse model. Vaccine. 2008;26:6361-7 pubmed publisher
    ..This demonstrates that the recombinant baculoviruses BacSC-sigmaC and BacSC-sigmaB can be a potential vaccine against ARV infections...
  7. Chiu F, Venkatesan N, Wu C, Chou A, Chen H, Lian S, et al. Immunological study of HA1 domain of hemagglutinin of influenza H5N1 virus. Biochem Biophys Res Commun. 2009;383:27-31 pubmed publisher
  8. Luo S, Chiang P, Chao A, Liou G, Lin R, Lin T, et al. Enterovirus 71 maternal antibodies in infants, Taiwan. Emerg Infect Dis. 2009;15:581-4 pubmed publisher
    ..Approximately 50% of neonates had detectable EV71 neutralizing antibodies, which declined to almost undetectable levels by 6 months of age. ..
  9. Huang M, Huang C, Lin S, Chen J, Ku C, Chou A, et al. Enhancement of potent antibody and T-cell responses by a single-dose, novel nanoemulsion-formulated pandemic influenza vaccine. Microbes Infect. 2009;11:654-60 pubmed publisher
    ..These results indicate that PELC can be used for effective single-dose immunization and could thus play an important role in influenza pandemic preparedness. ..
  10. Chang L, King C, Hsu K, Ning H, Tsao K, Li C, et al. Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. Pediatrics. 2002;109:e88 pubmed
    ..We measured EV71 seroprevalence rates before and after the epidemic and investigated risk factors associated with EV71 infection and illness...
  11. Lu C, Lee C, Kao C, Shao W, Lee P, Twu S, et al. Incidence and case-fatality rates resulting from the 1998 enterovirus 71 outbreak in Taiwan. J Med Virol. 2002;67:217-23 pubmed
    ..The lack of a protective antibody in younger children may account for the high incidence and case-fatality rate in this age group...
  12. Liu H, Kuo L, Hu Y, Liao M, Lien Y. Development of an ELISA for detection of antibodies to avian reovirus in chickens. J Virol Methods. 2002;102:129-38 pubmed
    ..This combination antigen may thus be the best suited for preparing an ELISA for improving the determination of the immune status of chicken flocks or for detection of chicken infections with avian reovirus...
  13. Pan S, Kung H, Kao T, Wu H, Dong S, Hu M, et al. The Madin-Darby canine kidney cell culture derived influenza A/H5N1 vaccine: a phase I trial in Taiwan. J Microbiol Immunol Infect. 2013;46:448-55 pubmed publisher
    ..MDCK cell line-derived H5N1 vaccine was well tolerated. It is necessary to investigate further the immunogenicity of higher antigen doses and the role of aluminum adjuvant in augmenting the effect of the vaccine. ..
  14. Liao Y, Inaba Y, Li N, Chain C, Lee S, Liou P. Epidemiology of bovine ephemeral fever virus infection in Taiwan. Microbiol Res. 1998;153:289-95 pubmed
    ..We have tried to advise farmers that they must vaccinate their cattle annually to prevent BEF outbreak in the future...
  15. Lin K, Sheu M, Wang H, Huang W, Chen C, Yang C. Study on some biological and antigenic characteristics of CA24v isolates in Taiwan in 1985-1989. Gaoxiong Yi Xue Ke Xue Za Zhi. 1994;10:279-86 pubmed