Experts and Doctors on pectobacterium carotovorum in Lausanne, Vaud, Switzerland
Locale: Lausanne, Vaud, Switzerland
Topic: pectobacterium carotovorum
Gendrin M, Welchman D, Poidevin M, Hervé M, Lemaitre B. Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila. PLoS Pathog. 2009;5:e1000694 pubmed publisher
..Genital infection is thus an intriguing new model for studying the systemic immune response to local epithelial infections and a potential route of entry for naturally occurring pathogens of Drosophila...
Osman D, Buchon N, Chakrabarti S, Huang Y, Su W, Poidevin M, et al
. Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division. J Cell Sci. 2012;125:5944-9 pubmed publisher
..Taken together, our results show that Upd ligands are required to maintain the midgut homeostasis under both normal and pathological states. ..
Gendrin M, Zaidman Rémy A, Broderick N, Paredes J, Poidevin M, Roussel A, et al
. Functional analysis of PGRP-LA in Drosophila immunity. PLoS ONE. 2013;8:e69742 pubmed publisher
..Together, our results suggest that PGRP-LA positively regulates the Imd pathway in barrier epithelia. ..
Buchon N, Broderick N, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe. 2009;5:200-11 pubmed publisher
..The Drosophila gut provides a powerful model to study the integration of stress and immunity with pathways associated with stem cell control, and this study should prove to be a useful resource for such further studies...
Buchon N, Broderick N, Kuraishi T, Lemaitre B. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 2010;8:152 pubmed publisher
..We show that one signaling pathway, the EGFR pathway, is central to all these stages, and its activation at multiple steps could synchronize the complex cellular events leading to gut repair and homeostasis. ..
Kuraishi T, Binggeli O, Opota O, Buchon N, Lemaitre B. Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011;108:15966-71 pubmed publisher
..Collectively, our analysis of the dcy immune phenotype indicates that the PM plays an important role in Drosophila host defense against enteric pathogens, preventing the damaging action of pore-forming toxins on intestinal cells. ..