Experts and Doctors on cell line in Lausanne, Vaud, Switzerland

Summary

Locale: Lausanne, Vaud, Switzerland
Topic: cell line

Top Publications

  1. Baisamy L, Jurisch N, Diviani D. Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc. J Biol Chem. 2005;280:15405-12 pubmed
    ..Altogether, these findings provide a novel mechanistic explanation of how oligomerization can regulate the activity of exchange factors of the Dbl family. ..
  2. Russell R, Gori I, Pellegrini C, Kumar R, Achtari C, Canny G. Lipoxin A4 is a novel estrogen receptor modulator. FASEB J. 2011;25:4326-37 pubmed publisher
    ..These findings reveal a previously unappreciated facet of LXA(4) bioactions, implicating this lipid mediator in novel immunoendocrine crosstalk mechanisms. ..
  3. Lathuilière A, Cosson S, Lutolf M, Schneider B, Aebischer P. A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells. Biomaterials. 2014;35:779-91 pubmed publisher
    ..Therefore, this encapsulation system is an effective platform for the implantation of genetically engineered cells in allogeneic conditions, which could be adapted to the chronic administration of recombinant proteins. ..
  4. Stanasila L, Perez J, Vogel H, Cotecchia S. Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization. J Biol Chem. 2003;278:40239-51 pubmed
    ..Oligomerization might therefore represent an additional mechanism regulating the physiological responses mediated by the alpha 1a- and alpha 1b-AR subtypes. ..
  5. Djojosubroto M, Bollotte F, Wirapati P, Radtke F, Stamenkovic I, Arsenijevic Y. Chromosomal number aberrations and transformation in adult mouse retinal stem cells in vitro. Invest Ophthalmol Vis Sci. 2009;50:5975-87 pubmed publisher
    ..The culture condition plays an important role in supporting the selection and growth of transformed cells. ..
  6. Marroquin Belaunzaran O, Cordero M, Setola V, Bianchi S, Galli C, Bouche N, et al. Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool. PLoS ONE. 2011;6:e18268 pubmed publisher
    ..This novel technique could potentially benefit other diseases presently treated by local and systemic antibody administration. ..
  7. Ramelet A, Hirt Burri N, Raffoul W, Scaletta C, Pioletti D, Offord E, et al. Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells. Exp Gerontol. 2009;44:208-18 pubmed publisher
    ..0% of genes over-expressed in fetal fibroblasts. It is perhaps these differences which contribute to efficient tissue repair seen in the clinic with fetal cell therapy. ..
  8. Redon S, Reichenbach P, Lingner J. The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res. 2010;38:5797-806 pubmed publisher
    ..Our data identify TERRA as a telomerase ligand and natural direct inhibitor of human telomerase. Telomerase regulation by the telomere substrate may be mediated via its transcription. ..
  9. Diviani D, Abuin L, Cotecchia S, Pansier L. Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. EMBO J. 2004;23:2811-20 pubmed
    ..Therefore, while it is known that AKAP-Lbc activity can be stimulated by Galpha12, in this study we demonstrated that it is inhibited by the anchoring of both PKA and 14-3-3. ..

More Information

Publications114 found, 100 shown here

  1. Gonzalez Rodriguez E, Gaeggeler H, Rossier B. IGF-1 vs insulin: respective roles in modulating sodium transport via the PI-3 kinase/Sgk1 pathway in a cortical collecting duct cell line. Kidney Int. 2007;71:116-25 pubmed
    ..IGF-1 could play an important physiological role in regulating basal sodium transport via the PI3-K/Sgk1 pathway in ASDN. ..
  2. Brakch N, Allemandou F, Keller I, Nussberger J. The renin prosequence enhances constitutive secretion of renin and optimizes renin activity. Curr Neurovasc Res. 2011;8:121-30 pubmed
    ..The renin prosequence [1-43] optimizes renin activity possibly through appropriate protein folding and it enhances the constitutive secretion of (pro)renin. The major part of generated renin may be targeted to lysosomes. ..
  3. Di Gioia S, Letteboer S, Kostic C, Bandah Rozenfeld D, Hetterschijt L, Sharon D, et al. FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies. Hum Mol Genet. 2012;21:5174-84 pubmed publisher
    ..Taken together, these data indicate that FAM161A-associated RP can be considered as a novel retinal ciliopathy and that its molecular pathogenesis may be related to other ciliopathies...
  4. Gadhari N, Charnley M, Marelli M, Brugger J, Chiquet M. Cell shape-dependent early responses of fibroblasts to cyclic strain. Biochim Biophys Acta. 2013;1833:3415-3425 pubmed publisher
    ..We conclude that integrin-mediated responses to external mechanical strain are differentially modulated in cells that have the same spreading area but different geometries, and do not only depend on mere cell size. ..
  5. Spertini C, Baïsse B, Spertini O. Ezrin-radixin-moesin-binding sequence of PSGL-1 glycoprotein regulates leukocyte rolling on selectins and activation of extracellular signal-regulated kinases. J Biol Chem. 2012;287:10693-702 pubmed publisher
  6. Gheldof N, Witwicki R, Migliavacca E, Leleu M, Didelot G, Harewood L, et al. Structural variation-associated expression changes are paralleled by chromatin architecture modifications. PLoS ONE. 2013;8:e79973 pubmed publisher
    ..We conclude that large genomic rearrangements can lead to chromatin conformation changes that extend far away from the structural variant, thereby possibly modulating expression globally and modifying the phenotype. GSE33784, GSE33867. ..
  7. Menozzi Smarrito C, Riera C, Munari C, le Coutre J, Robert F. Synthesis and evaluation of new alkylamides derived from alpha-hydroxysanshool, the pungent molecule in szechuan pepper. J Agric Food Chem. 2009;57:1982-9 pubmed publisher
    ..The data provide knowledge of the main sanshool chemical functionalities required for TRP channel activation, but they also evidence new selective and potent TRPA1 agonists based on alpha-hydroxysanshool. ..
  8. Mansuy V, Geller S, Rey J, Campagne C, Boccard J, Poulain P, et al. Phenotypic and molecular characterization of proliferating and differentiated GnRH-expressing GnV-3 cells. Mol Cell Endocrinol. 2011;332:97-105 pubmed publisher
    ..Moreover, the genes differentially regulated between these two different states are providing novel pathways potentially important for a better understanding of the physiology of mature GnRH neurons. ..
  9. Jalabert A, Vial G, Guay C, Wiklander O, Nordin J, Aswad H, et al. Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice. Diabetologia. 2016;59:1049-58 pubmed publisher
    ..Our data suggest that muscle ELVs might have an endocrine effect and could participate in adaptations in beta cell mass during insulin resistance. ..
  10. Agrawal N, Delanoue R, Mauri A, Basco D, Pasco M, Thorens B, et al. The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response. Cell Metab. 2016;23:675-84 pubmed publisher
    ..Therefore, we have identified a humoral connexion between the fat body and the brain insulin-producing cells relying on TNF-? that mediates adaptive response to nutrient deprivation. ..
  11. Roger T, Ding X, Chanson A, Renner P, Calandra T. Regulation of constitutive and microbial pathogen-induced human macrophage migration inhibitory factor (MIF) gene expression. Eur J Immunol. 2007;37:3509-21 pubmed
  12. Casson N, Médico N, Bille J, Greub G. Parachlamydia acanthamoebae enters and multiplies within pneumocytes and lung fibroblasts. Microbes Infect. 2006;8:1294-300 pubmed
    ..This indirectly supports the role of Parachlamydia as an agent of pneumonia...
  13. Towne C, Pertin M, Beggah A, Aebischer P, Decosterd I. Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery. Mol Pain. 2009;5:52 pubmed publisher
    ..Furthermore, the characterization of the transduction profile may facilitate gene transfer studies to dissect mechanisms behind neuropathic pain. ..
  14. Kolly L, Busso N, Palmer G, Talabot Ayer D, Chobaz V, So A. Expression and function of the NALP3 inflammasome in rheumatoid synovium. Immunology. 2010;129:178-85 pubmed publisher
    ..The NALP3 inflammasome activity does not account for the difference in level of inflammation between RA and osteoarthritis. ..
  15. Feige J, Gerber A, Casals Casas C, Yang Q, Winkler C, Bedu E, et al. The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. Environ Health Perspect. 2010;118:234-41 pubmed publisher
  16. Yalcin B, Adams D, Flint J, Keane T. Next-generation sequencing of experimental mouse strains. Mamm Genome. 2012;23:490-8 pubmed publisher
  17. Abrami L, Brandi L, Moayeri M, Brown M, Krantz B, Leppla S, et al. Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin. Cell Rep. 2013;5:986-96 pubmed publisher
    ..These can deliver LF to the cytosol of naive cells in a manner that is independent of the typical anthrax toxin receptor-mediated trafficking pathway, while being sheltered from neutralizing extracellular factors of the immune system. ..
  18. Di Poï N, Tan N, Michalik L, Wahli W, Desvergne B. Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell. 2002;10:721-33 pubmed
    ..Together, these results provide a molecular mechanism by which PPARbeta protects keratinocytes against apoptosis and may contribute to the process of skin wound closure. ..
  19. Bach D, Peddi S, Mangeat B, Lakkaraju A, Strub K, Trono D. Characterization of APOBEC3G binding to 7SL RNA. Retrovirology. 2008;5:54 pubmed publisher
    ..We thus conclude that 7SL RNA is not an essential mediator of the virion packaging of these antiviral cytidine deaminases. ..
  20. de Barsy M, Greub G. Waddlia chondrophila: from biology to pathogenicity. Microbes Infect. 2013;15:1033-41 pubmed publisher
    ..Moreover, new cell biology approaches and the use of novel inhibitors have allowed detailed investigations of its interaction with host cells. ..
  21. Jurvansuu J, Raj K, Stasiak A, Beard P. Viral transport of DNA damage that mimics a stalled replication fork. J Virol. 2005;79:569-80 pubmed
    ..By using the AAV2 system, we show that in human cells activation of phosphorylation of Chk1 depends on TopBP1 and that it is a prerequisite for the appearance of DNA damage foci. ..
  22. Klinger S, Poussin C, Debril M, Dolci W, Halban P, Thorens B. Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. Diabetes. 2008;57:584-93 pubmed
  23. Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B. cFLIP protein prevents tumor necrosis factor-alpha-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells. Diabetes. 2002;51:1805-14 pubmed
  24. Blanchard M, Kellenberger S. Effect of a temperature increase in the non-noxious range on proton-evoked ASIC and TRPV1 activity. Pflugers Arch. 2011;461:123-39 pubmed publisher
    ..The contribution of TRPV1 relative to ASICs to H(+)-gated currents in DRG neurons increases with higher temperature and acidity. Still, ASICs remain the principal pH sensors of DRG neurons at 35°C in the pH range ?6. ..
  25. Backliwal G, Hildinger M, Chenuet S, Wulhfard S, De Jesus M, Wurm F. Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions. Nucleic Acids Res. 2008;36:e96 pubmed publisher
  26. Favre D. Reverse transcriptase activity of hepatitis B virus polymerase in eukaryotic cell extracts in vitro. ALTEX. 2008;25:197-211 pubmed
  27. Schütz C, Juillerat Jeanneret L, Käuper P, Wandrey C. Cell response to the exposure to chitosan-TPP//alginate nanogels. Biomacromolecules. 2011;12:4153-61 pubmed publisher
    ..The results identify fungal chitosan as an alternative to animal chitosan in particular if biomedical/pharmaceutical applications are intended. ..
  28. Rappaz B, Breton B, Shaffer E, Turcatti G. Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening. Comb Chem High Throughput Screen. 2014;17:80-8 pubmed
    ..The DHM technology is suitable for the development of robust and unbiased image-based assays. ..
  29. Hotter D, Krabbe T, Reith E, Gawanbacht A, Rahm N, Ayouba A, et al. Primate lentiviruses use at least three alternative strategies to suppress NF-?B-mediated immune activation. PLoS Pathog. 2017;13:e1006598 pubmed publisher
    ..Our findings highlight the key role of NF-?B in antiviral immunity and demonstrate that primate lentiviruses follow distinct evolutionary paths to modulate NF-?B-dependent expression of viral and antiviral genes. ..
  30. Diviani D, Lattion A, Larbi N, Kunapuli P, Pronin A, Benovic J, et al. Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor. J Biol Chem. 1996;271:5049-58 pubmed
    ..They also identify the alpha1BAR as a potential phosphorylation substrate of GRK5 and GRK6. However, the physiological implications of GRK5- and GRK6-mediated phosphorylation of the alpha1BAR remain to be elucidated. ..
  31. Waeber G, Thompson N, Nicod P, Bonny C. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol. 1996;10:1327-34 pubmed
    ..These data demonstrate that the murine GLUT2 promoter is controlled by the PDX-1 homeobox factor through the identified GLUT2TAAT motif. ..
  32. Diviani D, Lattion A, Abuin L, Staub O, Cotecchia S. The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis. J Biol Chem. 2003;278:19331-40 pubmed
    ..The direct association of the adaptor complex 2 with a G protein-coupled receptor has not been reported so far and might represent a common mechanism underlying clathrin-mediated receptor endocytosis. ..
  33. Reina J, Azzouz T, Hernandez N. Maf1, a new player in the regulation of human RNA polymerase III transcription. PLoS ONE. 2006;1:e134 pubmed
    ..These data suggest that Maf1 is a major regulator of pol III transcription in human cells. ..
  34. Buchon N, Poidevin M, Kwon H, Guillou A, Sottas V, Lee B, et al. A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proc Natl Acad Sci U S A. 2009;106:12442-7 pubmed publisher
    ..It also reveals the conserved role of modular serine proteases in the activation of insect immune reactions. ..
  35. Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, et al. Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4). Fertil Steril. 2013;99:1965-73.e2 pubmed publisher
    ..We report for the first time that MRP4 is expressed in human endometrium, elevated in peritoneal endometriosis, and modulated by LXA(4) in endometriotic epithelial cells. ..
  36. Godinot N, Yasumatsu K, Barcos M, Pineau N, Ledda M, Viton F, et al. Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. Neuroscience. 2013;250:20-30 pubmed publisher
    ..Together these data indicate that GPR40 mediated taste perception is not sufficient to generate preference. ..
  37. Benathan M, Labidi F. Cysteine-dependent 5-S-cysteinyldopa formation and its regulation by glutathione in normal epidermal melanocytes. Arch Dermatol Res. 1996;288:697-702 pubmed
    ..It is proposed that the synthesis of 5-S-CD is a mechanism regulating dopaquinone levels during pigment formation and/or a defence mechanism against oxidative stress...
  38. Lattion A, Abuin L, Nenniger Tosato M, Cotecchia S. Constitutively active mutants of the beta1-adrenergic receptor. FEBS Lett. 1999;457:302-6 pubmed
    ..The results of this study might have interesting implications for future studies aiming at elucidating the activation process of the beta(1)-AR as well as the mechanism of action of beta-blockers...
  39. Plantard L, Huber M, Macari F, Meda P, Hohl D. Molecular interaction of connexin 30.3 and connexin 31 suggests a dominant-negative mechanism associated with erythrokeratodermia variabilis. Hum Mol Genet. 2003;12:3287-94 pubmed
    ..These results not only provide new insights into epidermal connexin synthesis and polymerization, but also allow a novel molecular explanation for the similarity of EKV phenotypes. ..
  40. Rosso L, Marques A, Weier M, Lambert N, Lambot M, Vanderhaeghen P, et al. Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein. PLoS Biol. 2008;6:e140 pubmed publisher
    ..CDC14Bretro evolution represents a paradigm example of rapid, selectively driven subcellular relocalization, thus revealing a novel mode for the emergence of new gene function. ..
  41. Seredenina T, Gokce O, Luthi Carter R. Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation. PLoS ONE. 2011;6:e22231 pubmed publisher
    ..Our findings both identify RGS2 downregulation as a novel compensatory response in HD neurons and suggest that RGS2 inhibition might be considered as an innovative target for neuroprotective drug development. ..
  42. Winnik S, Gaul D, Siciliani G, Lohmann C, Pasterk L, Calatayud N, et al. Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-?-dependent feedback regulation of SOD2. Basic Res Cardiol. 2016;111:33 pubmed publisher
    ..In cultured endothelial cells, a novel C/EBP-?-dependent rescue mechanism maintains net SOD2 activity upon transient knockdown of Sirt3. ..
  43. Yang J, Michod D, Walicki J, Murphy B, Kasibhatla S, Martin S, et al. Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Mol Cell Biol. 2004;24:10425-36 pubmed
    ..Executioner caspases therefore control the extent of their own activation by a feedback regulatory mechanism initiated by the partial cleavage of RasGAP that is crucial for cell survival under adverse conditions. ..
  44. Vallet V, Chraibi A, Gaeggeler H, Horisberger J, Rossier B. An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature. 1997;389:607-10 pubmed
    ..This previously undiscovered mechanism for autocrine regulation may apply to other ion channels, in particular to members of the ENaC family that are present in neurons and epithelial cells. ..
  45. Henrichsen C, Csárdi G, Zabot M, Fusco C, Bergmann S, Merla G, et al. Using transcription modules to identify expression clusters perturbed in Williams-Beuren syndrome. PLoS Comput Biol. 2011;7:e1001054 pubmed publisher
    ..This modular approach increases the power to identify pathways dysregulated in WBS patients, thus providing a testable set of additional candidates for genes and their interactions that modulate the WBS phenotypes. ..
  46. Cacquevel M, Aeschbach L, Houacine J, Fraering P. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified ?-secretase complexes. PLoS ONE. 2012;7:e35133 pubmed publisher
    ..Our data support the view that PS1 mutations lead to a strong ?-secretase loss-of-function phenotype and an increased A?1-42/A?1-40 ratio, two mechanisms that are potentially involved in the pathogenesis of Alzheimer's disease. ..
  47. Ljubicic S, Bezzi P, Brajkovic S, Nesca V, Guay C, Ohbayashi N, et al. The GTPase Rab37 Participates in the Control of Insulin Exocytosis. PLoS ONE. 2013;8:e68255 pubmed publisher
  48. Abderrahmani A, Niederhauser G, Favre D, Abdelli S, Ferdaoussi M, Yang J, et al. Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells. Diabetologia. 2007;50:1304-14 pubmed
    ..These data provide strong evidence that oxidised LDL particles exert deleterious effects in the progression of beta cell failure in diabetes and that these effects can be countered by HDL particles. ..
  49. Appert Collin A, Cotecchia S, Nenniger Tosato M, Pedrazzini T, Diviani D. The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2007;104:10140-5 pubmed
    ..These findings identify AKAP-Lbc as the first Rho-guanine nucleotide exchange factor (GEF) involved in the signaling pathways leading to cardiomyocytes hypertrophy. ..
  50. Flahaut M, Meier R, Coulon A, Nardou K, Niggli F, Martinet D, et al. The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway. Oncogene. 2009;28:2245-56 pubmed publisher
    ..Our data represent the first implication of the Wnt/beta-catenin pathway in NB chemoresistance and identify potential new targets to treat aggressive and resistant NB. ..
  51. Lajczak N, Saint Criq V, O Dwyer A, Perino A, Adorini L, Schoonjans K, et al. Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β-defensin-1 and -2 secretion by colonic epithelial cells. FASEB J. 2017;31:3848-3857 pubmed publisher
    ..K., Saint-Criq, V., O'Dwyer, A. M., Perino, A., Adorini, L., Schoonjans, K., Keely, S. J. Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β-defensin-1 and -2 secretion by colonic epithelial cells. ..
  52. Stasiak A, Larquet E, Stasiak A, Muller S, Engel A, Van Dyck E, et al. The human Rad52 protein exists as a heptameric ring. Curr Biol. 2000;10:337-40 pubmed
    ..Thus, the structures formed by the hexameric helicases may be a more general property of other proteins involved in DNA metabolism, including those, such as Rad52, that do not bind and hydrolyze ATP. ..
  53. Schlesinger T, Bonvin C, Jarpe M, Fanger G, Cardinaux J, Johnson G, et al. Apoptosis stimulated by the 91-kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments. J Biol Chem. 2002;277:10283-91 pubmed
  54. Hajjaj H, Mace C, Roberts M, Niederberger P, Fay L. Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors. Appl Environ Microbiol. 2005;71:3653-8 pubmed
    ..lucidum. These 26-oxygenosterols could lead to novel therapeutic agents that lower blood cholesterol...
  55. Yang J, Walicki J, Abderrahmani A, Cornu M, Waeber G, Thorens B, et al. Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion. J Biol Chem. 2005;280:32835-42 pubmed
    ..These data indicate that fragment N protects beta cells without affecting their function. The pathways regulated by fragment N are therefore promising targets for antidiabetogenic therapy. ..
  56. Kitagawa D, Vakonakis I, Olieric N, Hilbert M, Keller D, Olieric V, et al. Structural basis of the 9-fold symmetry of centrioles. Cell. 2011;144:364-75 pubmed publisher
    ..Overall, our findings establish a structural basis for the universal 9-fold symmetry of centrioles. ..
  57. Quenneville S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, et al. In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell. 2011;44:361-72 pubmed publisher
    ..These results significantly advance our understanding of imprinting and suggest a general mechanism for the protection of specific loci against the wave of DNA demethylation that affects the mammalian genome during early embryogenesis. ..
  58. Chen J, Zhang M, Rybniker J, Basterra L, Dhar N, Tischler A, et al. Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence. J Bacteriol. 2013;195:5421-30 pubmed publisher
    ..However, our data also indicate for the first time that blockage of M. tuberculosis ESAT-6 and CFP-10 secretion in vitro and attenuation are mutually exclusive...
  59. Odermatt N, Sala C, Benjak A, Kolly G, Vocat A, Lupien A, et al. Rv3852 (H-NS) of Mycobacterium tuberculosis Is Not Involved in Nucleoid Compaction and Virulence Regulation. J Bacteriol. 2017;199: pubmed publisher
    ..Our findings reduce the repertoire of identified nucleoid-associated proteins in M. tuberculosis to four transcription regulators and underline the importance of genetic studies to assign a function to bacterial genes. ..
  60. Roger T, Chanson A, Knaup Reymond M, Calandra T. Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1. Eur J Immunol. 2005;35:3405-13 pubmed
    ..Taken together, these data identify MKP-1 as a molecular target of MIF-glucocorticoid crosstalk and provide a molecular basis for the control of macrophage responses by a pair of physiological regulators of innate immunity. ..
  61. Stanasila L, Abuin L, Diviani D, Cotecchia S. Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling. J Biol Chem. 2006;281:4354-63 pubmed
    ..These findings identify ezrin as a new protein directly interacting with a G protein-coupled receptor and demonstrate the direct implication of ezrin in GPCR trafficking via an actin-dependent mechanism. ..
  62. Buetler T, Latado H, Leclerc E, Weigle B, Baumeyer A, Heizmann C, et al. Glycolaldehyde-modified ?-lactoglobulin AGEs are unable to stimulate inflammatory signaling pathways in RAGE-expressing human cell lines. Mol Nutr Food Res. 2011;55:291-9 pubmed publisher
    ..The observed cell-activating activity can be ascribed to an endotoxin-like lipophilic contamination present in AGE preparations and affinity column purification was insufficient to remove this contamination. ..
  63. Rolli J, Rosenblatt Velin N, Li J, Loukili N, Levrand S, Pacher P, et al. Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. PLoS ONE. 2010;5:e12687 pubmed publisher
    ..These results are the first to indicate that flagellin has the ability to trigger cardiac innate immune responses and to acutely depress myocardial contractility. ..
  64. Pasquato A, Rochat C, Burri D, Pasqual G, de la Torre J, Kunz S. Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242. Virology. 2012;423:14-22 pubmed publisher
    ..Notably, PF-429242 was able to efficiently and rapidly clear persistent infection by arenaviruses. Interruption of drug treatment did not result in re-emergence of infection, indicating that PF-429242 treatment leads to virus extinction...
  65. Redon S, Zemp I, Lingner J. A three-state model for the regulation of telomerase by TERRA and hnRNPA1. Nucleic Acids Res. 2013;41:9117-28 pubmed publisher
    ..Telomere extension by telomerase may require balanced levels of TERRA and hnRNPA1 at telomeres. Thus, TERRA and hnRNPA1 can function as a bimolecular regulator to turn telomerase and the telomere on and off. ..
  66. Mace K, Bowman E, Vautravers P, Shields P, Harris C, Pfeifer A. Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. Eur J Cancer. 1998;34:914-20 pubmed
  67. Levrand S, Pesse B, Feihl F, Waeber B, Pacher P, Rolli J, et al. Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. J Biol Chem. 2005;280:34878-87 pubmed
    ..These findings offer new perspectives for the understanding of the relationships between redox stress and inflammation. ..
  68. Ferrand A, Imbert D, Chauvin A, Vandevyver C, Bünzli J. Non-cytotoxic, bifunctional EuIII and TbIII luminescent macrocyclic complexes for luminescence resonant energy-transfer experiments. Chemistry. 2007;13:8678-87 pubmed
    ..Cell viability after 24 h incubation at 37 degrees C with 500 microM TbL3 was >90% for all cell lines, except Jurkat (>70%). All of these properties make LnL3 complexes interesting potential probes for bioanalyses...
  69. Fragkos M, Jurvansuu J, Beard P. H2AX is required for cell cycle arrest via the p53/p21 pathway. Mol Cell Biol. 2009;29:2828-40 pubmed publisher
    ..The results establish a new role for H2AX in the p53/p21 pathway and indicate that H2AX is required for p21-induced cell cycle arrest after replication stalling. ..
  70. Barde I, Laurenti E, Verp S, Groner A, Towne C, Padrun V, et al. Regulation of episomal gene expression by KRAB/KAP1-mediated histone modifications. J Virol. 2009;83:5574-80 pubmed publisher
  71. Kohlmaier G, Loncarek J, Meng X, McEwen B, Mogensen M, Spektor A, et al. Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP. Curr Biol. 2009;19:1012-8 pubmed publisher
    ..This in turn leads to multipolar spindle assembly and cytokinesis defects. Overall, our findings suggest that centriole length must be carefully regulated to restrict procentriole number and thus ensure accurate cell division. ..
  72. Delaloye J, Roger T, Steiner Tardivel Q, Le Roy D, Knaup Reymond M, Akira S, et al. Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog. 2009;5:e1000480 pubmed publisher
    ..Delineation of the host response induced by MVA is critical for improving our understanding of poxvirus antiviral escape mechanisms and for designing new MVA vaccine vectors with improved immunogenicity. ..
  73. Morikawa K, Gouttenoire J, Hernandez C, Dao Thi V, Tran H, Lange C, et al. Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. Hepatology. 2014;59:423-33 pubmed publisher
    ..We provide proof-of-concept for the use of quantitative proteomics to identify cellular substrates of a viral protease and describe GPx8 as a novel proviral host factor targeted by the HCV NS3-4A protease. ..
  74. Lakkaraju A, van der Goot F. Calnexin controls the STAT3-mediated transcriptional response to EGF. Mol Cell. 2013;51:386-96 pubmed publisher
    ..Thus, cells integrate the health status of the ER to determine the amplitude of their response to EGF. ..
  75. Byrgazov K, Kastner R, Górna M, Hoermann G, Koenig M, Lucini C, et al. NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors. Leukemia. 2017;31:237-240 pubmed publisher
  76. Canessa C, Horisberger J, Louvard D, Rossier B. Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance. EMBO J. 1992;11:1681-7 pubmed
    ..Thus we propose that an amino acid residue of the first transmembrane segment located deep in the plasma membrane participates in the structure and the function of the ouabain binding site. ..
  77. Vuagniaux G, Vallet V, Jaeger N, Hummler E, Rossier B. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes. J Gen Physiol. 2002;120:191-201 pubmed
    ..The synergistic effect of the two activation pathways allows a large dynamic range for ENaC-mediated sodium regulation crucial for a tight control of sodium homeostasis. ..
  78. Yang J, Walicki J, Michod D, Dubuis G, Widmann C. Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157. Mol Biol Cell. 2005;16:3511-20 pubmed
    ..Therefore, the role of the second caspase-mediated cleavage of RasGAP is to allow the inactivation of the antiapoptotic function of fragment N so that caspases are no longer hampered in their ability to kill cells. ..
  79. Rio Frio T, Wade N, Ransijn A, Berson E, Beckmann J, Rivolta C. Premature termination codons in PRPF31 cause retinitis pigmentosa via haploinsufficiency due to nonsense-mediated mRNA decay. J Clin Invest. 2008;118:1519-31 pubmed publisher
    ..Furthermore, these data provide compelling evidence that the pathogenic effect of PRPF31 mutations is likely due to haploinsufficiency rather than to gain of function. ..
  80. Rosso L, Marques A, Reichert A, Kaessmann H. Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection. PLoS Genet. 2008;4:e1000150 pubmed publisher
    ..We suggest that rapid, selectively driven subcellular adaptation, as exemplified by GLUD2, represents a common route underlying the emergence of new gene functions...
  81. Renner P, Roger T, Bochud P, Sprong T, Sweep F, Bochud M, et al. A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease. FASEB J. 2012;26:907-16 pubmed publisher
    ..09 and P=0.09 for MIF production). Taken together, these data suggest that polymorphisms of the MIF gene affecting MIF expression are associated with the occurrence, severity, and outcome of meningococcal disease in children. ..
  82. Kitagawa D, Kohlmaier G, Keller D, Strnad P, Balestra F, Flückiger I, et al. Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL. J Cell Sci. 2011;124:3884-93 pubmed publisher
    ..Our findings are compatible with the notion that mutations in CPAP and STIL cause MCPH because of aberrant spindle positioning in progenitor cells during brain development...
  83. Brajkovic S, Ferdaoussi M, Pawlowski V, Ezanno H, Plaisance V, Zmuda E, et al. Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity. J Diabetes Res. 2016;2016:9158562 pubmed publisher
    ..These findings highlight the importance in preserving the IB1 content for protecting beta cell against lipotoxicity in diabetes. ..
  84. Brunati M, Perucca S, Han L, Cattaneo A, Consolato F, Andolfo A, et al. The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. elife. 2015;4:e08887 pubmed publisher
  85. Domercq M, Brambilla L, Pilati E, Marchaland J, Volterra A, Bezzi P. P2Y1 receptor-evoked glutamate exocytosis from astrocytes: control by tumor necrosis factor-alpha and prostaglandins. J Biol Chem. 2006;281:30684-96 pubmed
    ..The identified pathway may play physiological roles in glial-glial and glial-neuronal communication. ..
  86. Roggli E, Britan A, Gattesco S, Lin Marq N, Abderrahmani A, Meda P, et al. Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes. 2010;59:978-86 pubmed publisher
    ..Our data identify miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines, notably during the development of peri-insulitis that precedes overt diabetes in NOD mice. ..
  87. Ouertatani Sakouhi H, Liu M, El Turk F, Cuny G, Glicksman M, Lashuel H. Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. J Biomol Screen. 2010;15:347-58 pubmed publisher
    ..Using this assay, they screened 80,000 small molecules and identified and validated 13 novel inhibitors of MIF catalytic activity. These small molecules demonstrated inhibition constant (K(i,app)) values ranging from 0.5 to 13 microM. ..
  88. Pasqual G, Rojek J, Masin M, Chatton J, Kunz S. Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport. PLoS Pathog. 2011;7:e1002232 pubmed publisher
    ..Our data further suggest that the virus-receptor complexes undergo sorting into ILV of the MVB mediated by the ESCRT, possibly using a pathway that may be linked to the cellular trafficking and degradation of the cellular receptor. ..
  89. Renaud M, Praz V, Vieu E, Florens L, Washburn M, l Hôte P, et al. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Genome Res. 2014;24:37-51 pubmed publisher
  90. Puoti A, May A, Canessa C, Horisberger J, Schild L, Rossier B. The highly selective low-conductance epithelial Na channel of Xenopus laevis A6 kidney cells. Am J Physiol. 1995;269:C188-97 pubmed
    ..Our data suggest that the triplication of the ENaC subunits occurred before the divergence between mammalian and amphibian lineages...
  91. Pick H, Preuss A, Mayer M, Wohland T, Hovius R, Vogel H. Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells. Biochemistry. 2003;42:877-84 pubmed
  92. Tan N, Michalik L, Di Poï N, Ng C, Mermod N, Roberts A, et al. Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. EMBO J. 2004;23:4211-21 pubmed