Experts and Doctors on animals in Lausanne, Vaud, Switzerland


Locale: Lausanne, Vaud, Switzerland
Topic: animals

Top Publications

  1. Badaut J, Hirt L, Granziera C, Bogousslavsky J, Magistretti P, Regli L. Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2001;21:477-82 pubmed
  2. Fonck E, Prod hom G, Roy S, Augsburger L, Rufenacht D, Stergiopulos N. Effect of elastin degradation on carotid wall mechanics as assessed by a constituent-based biomechanical model. Am J Physiol Heart Circ Physiol. 2007;292:H2754-63 pubmed
  3. Maillard M, Tedjani A, Perregaux C, Burnier M. Calcium-sensing receptors modulate renin release in vivo and in vitro in the rat. J Hypertens. 2009;27:1980-7 pubmed publisher
    ..This suggests that CaSRs play a role as a regulatory pathway of renin release. ..
  4. Harris N, Gause W. To B or not to B: B cells and the Th2-type immune response to helminths. Trends Immunol. 2011;32:80-8 pubmed publisher
    ..In this review, we examine the role of B cells during Th2-type immune response to these multicellular parasites...
  5. Narayan S, Pazár B, Pazar B, Ea H, Kolly L, Bagnoud N, et al. Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice. Arthritis Rheum. 2011;63:422-33 pubmed publisher
    ..To determine the mechanisms involved in inflammatory responses to octacalcium phosphate (OCP) crystals in vivo...
  6. Yamashita T. Ca2+-dependent regulation of synaptic vesicle endocytosis. Neurosci Res. 2012;73:1-7 pubmed publisher
  7. Xiao L, Han Y, Runne H, Murray H, Kochubey O, Luthi Carter R, et al. Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons. Mol Cell Neurosci. 2010;44:374-85 pubmed publisher
    ..Our study sheds light on the molecular properties of putative calyx of Held-generating neurons and shows the developmental regulation of the Syt-isoform expression profile in a single neuron type. ..
  8. Blanchard M, Kellenberger S. Effect of a temperature increase in the non-noxious range on proton-evoked ASIC and TRPV1 activity. Pflugers Arch. 2011;461:123-39 pubmed publisher
    ..The contribution of TRPV1 relative to ASICs to H(+)-gated currents in DRG neurons increases with higher temperature and acidity. Still, ASICs remain the principal pH sensors of DRG neurons at 35°C in the pH range ?6. ..
  9. Frasnelli M, Tarussio D, Chobaz Péclat V, Busso N, So A. TLR2 modulates inflammation in zymosan-induced arthritis in mice. Arthritis Res Ther. 2005;7:R370-9 pubmed
    ..These results show that ZIA is more prolonged than was originally described and involves both the innate and acquired immune pathways. C3 does not seem to have a major role in this model of joint inflammation. ..

More Information

Publications774 found, 100 shown here

  1. Barbey F, Brakch N, Linhart A, Rosenblatt Velin N, Jeanrenaud X, Qanadli S, et al. Cardiac and vascular hypertrophy in Fabry disease: evidence for a new mechanism independent of blood pressure and glycosphingolipid deposition. Arterioscler Thromb Vasc Biol. 2006;26:839-44 pubmed
    ..19; P=0.028), respectively. LVH and CCA IMT occur concomitantly in Fabry suggesting common pathogenesis. The underlying cause may be a circulating growth-promoting factor whose presence has been confirmed in vitro. ..
  2. Lamy C, Chatton J. Optical probing of sodium dynamics in neurons and astrocytes. Neuroimage. 2011;58:572-8 pubmed publisher
    ..Synchronous electrophysiological and fluorometric recordings showed that ANG produced accurate Na(+) measurement in situ. This new Na(+) indicator opens innovative ways of probing neuronal circuits. ..
  3. Berdajs D, Mosbahi S, Forró Z, Gerber C, Ferrari E, Charbonnier D, et al. Numerical analysis of the 3-dimensional aortic root morphology during the cardiac cycle. Eur J Cardiothorac Surg. 2016;49:1213-21 pubmed publisher
    ..Findings can be used for comparative analysis of native and synthetic structures with individual compliance. ..
  4. Gasparini J, Piault R, Bize P, Roulin A. Synergistic and antagonistic interaction between different branches of the immune system is related to melanin-based coloration in nestling tawny owls. J Evol Biol. 2009;22:2348-53 pubmed publisher
  5. Yalcin Ozuysal O, Fiche M, Guitierrez M, Wagner K, Raffoul W, Brisken C. Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ. 2010;17:1600-12 pubmed publisher
    ..Thus, the balance between basal and luminal cell compartments of the breast is regulated by antagonistic functions of ?Np63 and Notch. ..
  6. Laurenti E, Barde I, Verp S, Offner S, Wilson A, Quenneville S, et al. Inducible gene and shRNA expression in resident hematopoietic stem cells in vivo. Stem Cells. 2010;28:1390-8 pubmed publisher
    ..In summary, this easy to implement conditional system provides inducible and reversible overexpression or knock down of genes in resident HSCs in vivo using a drug devoid of toxic or activating effects. ..
  7. Guay C, Roggli E, Nesca V, Jacovetti C, Regazzi R. Diabetes mellitus, a microRNA-related disease?. Transl Res. 2011;157:253-64 pubmed publisher
    ..Finally, we discuss the possible use of miRNAs as blood biomarkers to prevent diabetes development and as tools for gene-based therapy to treat both type 1 and type 2 diabetes mellitus. ..
  8. Lima F, Milne C, Amarasinghe D, Rittmann Frank M, van der Veen R, Reinhard M, et al. A high-repetition rate scheme for synchrotron-based picosecond laser pump/x-ray probe experiments on chemical and biological systems in solution. Rev Sci Instrum. 2011;82:063111 pubmed publisher
    ..The simplicity and compactness of the scheme allows for straightforward implementation at any synchrotron beamline and for a wide range of x-ray probe techniques, such as time-resolved diffraction or x-ray emission studies. ..
  9. Abrami L, Brandi L, Moayeri M, Brown M, Krantz B, Leppla S, et al. Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin. Cell Rep. 2013;5:986-96 pubmed publisher
    ..These can deliver LF to the cytosol of naive cells in a manner that is independent of the typical anthrax toxin receptor-mediated trafficking pathway, while being sheltered from neutralizing extracellular factors of the immune system. ..
  10. Jalabert A, Vial G, Guay C, Wiklander O, Nordin J, Aswad H, et al. Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice. Diabetologia. 2016;59:1049-58 pubmed publisher
    ..Our data suggest that muscle ELVs might have an endocrine effect and could participate in adaptations in beta cell mass during insulin resistance. ..
  11. Matthieu J, Amiguet P. Myelin/oligodendrocyte glycoprotein expression during development in normal and myelin-deficient mice. Dev Neurosci. 1990;12:293-302 pubmed
    ..These results suggest that MOG could play a role in the maintenance or completion of the myelin sheath. Its expression level may be modulated by the presence of compact myelin and/or MBP in the myelin sheath. ..
  12. Grunder S, Firsov D, Chang S, Jaeger N, Gautschi I, Schild L, et al. A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. EMBO J. 1997;16:899-907 pubmed
    ..We propose that this mutation favors a gating mode characterized by short-open and long-closed times. We suggest that determination of the gating mode of ENaC is a key regulator of channel activity...
  13. Brunet J, Grollimund L, Chatton J, Lengacher S, Magistretti P, Villemure J, et al. Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes. Glia. 2004;46:8-17 pubmed
    ..Altogether, our results show that acquisition of some specific metabolic features by astrocytes occurs early in their differentiation process and that LIF represents a candidate signal to induce their expression. ..
  14. Rignault S, Haefliger J, Gasser D, Markert M, Nicod P, Liaudet L, et al. Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium. Crit Care Med. 2005;33:1302-10 pubmed
    ..In this experimental model, recovery from an early transient dysfunction of the aortic endothelium is associated with an enhanced expression of aortic endothelial Cx40. ..
  15. Martin D, Allagnat F, Chaffard G, Caille D, Fukuda M, Regazzi R, et al. Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells. Diabetologia. 2008;51:1429-39 pubmed publisher
    ..Specifically, we provide evidence that the downregulation of these genes is detrimental for the exocytosis of large dense core vesicles, thus contributing to beta cell dysfunction and impaired glucose homeostasis. ..
  16. Rezakhaniha R, Stergiopulos N. A structural model of the venous wall considering elastin anisotropy. J Biomech Eng. 2008;130:031017 pubmed publisher
    ..We conclude that anisotropic description of elastin is required for a full 3D characterization of the biomechanics of the venous wall. ..
  17. Bergomi M, Cugnoni J, Botsis J, Belser U, Anselm Wiskott H. The role of the fluid phase in the viscous response of bovine periodontal ligament. J Biomech. 2010;43:1146-52 pubmed publisher
    ..Removing the liquid from the PDL largely eliminates its damping effect in compression. ..
  18. Bessero A, Chiodini F, Rungger Brandle E, Bonny C, Clarke P. Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition. J Neurochem. 2010;113:1307-18 pubmed publisher
    ..Thus, the JNK pathway is involved in NMDA-mediated retinal excitotoxicity and JNK inhibition by D-JNKI-1 provides strong neuroprotection as shown morphologically, biochemically and physiologically. ..
  19. Bonfanti P, Claudinot S, Amici A, Farley A, Blackburn C, Barrandon Y. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells. Nature. 2010;466:978-82 pubmed publisher
    ..Hence, microenvironmental cues are sufficient here to re-direct epithelial cell fate, allowing crossing of primitive germ layer boundaries and an increase in potency...
  20. Plasari G, Edelmann S, Högger F, Dusserre Y, Mermod N, Calabrese A. Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling. J Biol Chem. 2010;285:34115-25 pubmed publisher
    ..Taken together with prior observations, these findings also designate NFI-C as a regulator of adult progenitor cell proliferation and of postnatal tissue growth or regeneration...
  21. Vale Silva L, Ischer F, LeibundGut Landmann S, Sanglard D. Gain-of-function mutations in PDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells. Infect Immun. 2013;81:1709-20 pubmed publisher
    ..glabrata through increased adherence to epithelial cell layers. These data reveal that GOF mutations in CgPDR1 modulate the interaction with host cells in ways that may contribute to increased virulence. ..
  22. Rappaz B, Breton B, Shaffer E, Turcatti G. Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening. Comb Chem High Throughput Screen. 2014;17:80-8 pubmed
    ..The DHM technology is suitable for the development of robust and unbiased image-based assays. ..
  23. Gaulard P, de Leval L. Pathology of peripheral T-cell lymphomas: where do we stand?. Semin Hematol. 2014;51:5-16 pubmed publisher
    ..While most clonal NK/T-cell proliferations are in general highly malignant, some more indolent forms of NK or T-cell lympho-proliferations are being identified. ..
  24. Bulat N, Jaccard E, Peltzer N, Khalil H, Yang J, Dubuis G, et al. RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes. PLoS ONE. 2011;6:e22609 pubmed publisher
    ..Fragment N exerts therefore a protective effect on beta cells within the pro-diabetogenic NOD background and this prevents a fast progression from mild to overt diabetes. ..
  25. Podhajska A, Musso A, Trancikova A, Stafa K, Moser R, Sonnay S, et al. Common pathogenic effects of missense mutations in the P-type ATPase ATP13A2 (PARK9) associated with early-onset parkinsonism. PLoS ONE. 2012;7:e39942 pubmed publisher
    ..Collectively, our study provides support for common loss-of-function effects of homozygous and heterozygous missense mutations in ATP13A2 associated with early-onset forms of parkinsonism. ..
  26. Roulin A, Dauwe T, Blust R, Eens M, Beaud M. A link between eumelanism and calcium physiology in the barn owl. Naturwissenschaften. 2006;93:426-30 pubmed
    ..Our study supports the idea that eumelanin-based coloration is associated with a number of physiological processes requiring calcium. ..
  27. Ferrari S, Sanguinetti M, Torelli R, Posteraro B, Sanglard D. Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata. PLoS ONE. 2011;6:e17589 pubmed publisher
    ..These data therefore demonstrate that at least these two CgPDR1-dependent and -upregulated genes contribute to the enhanced virulence of C. glabrata that acquired azole resistance. ..
  28. Scherer S, Pietramaggiori G, Matthews J, Gennaoui A, Demcheva M, Fischer T, et al. Poly-N-acetyl glucosamine fibers induce angiogenesis in ADP inhibitor-treated diabetic mice. J Trauma. 2011;71:S183-6 pubmed publisher
    ..sNAG treatment did not inhibit angiogenesis in CL-treated mice and induced faster wound closure; sNAG technology is a promising strategy to facilitate the healing of complex bleeding wounds in CL-treated diabetic patients. ..
  29. Rezzonico E, Mestdagh R, Delley M, Combremont S, Dumas M, Holmes E, et al. Bacterial adaptation to the gut environment favors successful colonization: microbial and metabonomic characterization of a simplified microbiota mouse model. Gut Microbes. 2011;2:307-18 pubmed publisher
    ..We conclude that adaptation of bacterial strains to the host's gut environment (mono-colonization) may predict a successful establishment of a more complex microbiota in rodents. ..
  30. Osman D, Buchon N, Chakrabarti S, Huang Y, Su W, Poidevin M, et al. Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division. J Cell Sci. 2012;125:5944-9 pubmed publisher
    ..Taken together, our results show that Upd ligands are required to maintain the midgut homeostasis under both normal and pathological states. ..
  31. Larsson H, Lee S, Roccio M, Velluto D, Lutolf M, Frey P, et al. Sorting live stem cells based on Sox2 mRNA expression. PLoS ONE. 2012;7:e49874 pubmed publisher
    ..These results demonstrate the utility of MBs for stem cell sorting in an mRNA-specific manner. ..
  32. Pérez López I, Cariolato L, Maric D, Gillet L, Abriel H, Diviani D. A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy. Mol Cell Biol. 2013;33:2903-17 pubmed publisher
    ..These results indicate that AKAP-Lbc enhances p38-mediated hypertrophic signaling in the heart in response to abrupt increases in the afterload. ..
  33. Trompette A, Gollwitzer E, Yadava K, Sichelstiel A, Sprenger N, Ngom Bru C, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014;20:159-66 pubmed publisher
    ..Our results show that dietary fermentable fiber and SCFAs can shape the immunological environment in the lung and influence the severity of allergic inflammation. ..
  34. Petrelli F, Bezzi P. Novel insights into gliotransmitters. Curr Opin Pharmacol. 2016;26:138-45 pubmed publisher
    ..This review critically evaluates the currently available findings concerning gliotransmitters with the aim of stimulating discussion in the field. ..
  35. Burri R, Antoniazza S, Gaigher A, Ducrest A, Simon C, Fumagalli L, et al. The genetic basis of color-related local adaptation in a ring-like colonization around the Mediterranean. Evolution. 2016;70:140-53 pubmed publisher
    ..These results from a system reminiscent of ring species provide a striking example of how local adaptation can evolve from derived genetic variation. ..
  36. LeKieffre C, Spangenberg J, Mabilleau G, Escrig S, Meibom A, Geslin E. Surviving anoxia in marine sediments: The metabolic response of ubiquitous benthic foraminifera (Ammonia tepida). PLoS ONE. 2017;12:e0177604 pubmed publisher
    ..Together, our results show that anoxia induced a greatly reduced rate of heterotrophic metabolism in Ammonia tepida on a time scale of less than 24 hours, these observations are consistent with a state of dormancy. ..
  37. Salvi R, Arsenijevic Y, Giacomini M, Rey J, Voirol M, Gaillard R, et al. The fetal hypothalamus has the potential to generate cells with a gonadotropin releasing hormone (GnRH) phenotype. PLoS ONE. 2009;4:e4392 pubmed publisher
    ..This in vitro model should be useful to study the molecular mechanisms involved in GnRH neuronal differentiation. ..
  38. Jan A, Hartley D, Lashuel H. Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research. Nat Protoc. 2010;5:1186-209 pubmed publisher
    ..The procedures described can be performed in as little as 1 day, or may take longer, depending on the exact toxicity assays used. ..
  39. Bize P, Diaz C, Lindström J. Experimental evidence that adult antipredator behaviour is heritable and not influenced by behavioural copying in a wild bird. Proc Biol Sci. 2012;279:1380-8 pubmed publisher
    ..Those findings provide strong evidence that antipredator behaviour of adult Alpine swifts is shaped by genetics and/or pre-hatching maternal effects taking place at conception but not by behavioural copying. ..
  40. Stöck M, Ustinova J, Betto Colliard C, Schartl M, Moritz C, Perrin N. Simultaneous Mendelian and clonal genome transmission in a sexually reproducing, all-triploid vertebrate. Proc Biol Sci. 2012;279:1293-9 pubmed publisher
    ..Elucidating the mechanisms that allow simultaneous transmission of two genomes, one of Mendelian, the other of clonal inheritance, might shed light on the general processes that regulate meiosis in vertebrates. ..
  41. Cordero M, Just N, Poirier G, Sandi C. Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum. Eur Neuropsychopharmacol. 2016;26:357-367 pubmed publisher
    ..These data support the view that early-life stress can affect the behavioral and neurodevelopmental trajectories of individuals and their offspring, which may involve different neurobiological mechanisms. ..
  42. Que Y, Francois P, Haefliger J, Entenza J, Vaudaux P, Moreillon P. Reassessing the role of Staphylococcus aureus clumping factor and fibronectin-binding protein by expression in Lactococcus lactis. Infect Immun. 2001;69:6296-302 pubmed
    ..Taken together, the present observations suggest that if antiadhesin therapy were to be developed, at least both of the clfA and fnbA products should be blocked for the therapy to be effective. ..
  43. Haefliger J, Tissieres P, Tawadros T, Formenton A, Beny J, Nicod P, et al. Connexins 43 and 26 are differentially increased after rat bladder outlet obstruction. Exp Cell Res. 2002;274:216-25 pubmed
    ..The data show that Cx43 and Cx26 are differentially regulated during bladder outlet obstruction and contribute to the response of the bladder wall to increased voiding pressure, possibly to control its elasticity. ..
  44. Krauskopf A, Lhote P, Mutter M, Dufour J, Ruegg U, Buetler T. Vasopressin type 1A receptor up-regulation by cyclosporin A in vascular smooth muscle cells is mediated by superoxide. J Biol Chem. 2003;278:41685-90 pubmed
  45. Gardier S, Pedretti S, Sarre A, Raddatz E. Transient anoxia and oxyradicals induce a region-specific activation of MAPKs in the embryonic heart. Mol Cell Biochem. 2010;340:239-47 pubmed publisher
    ..At a critical stage of early cardiogenesis, anoxia, reoxygenation, exogenous H(2)O(2) and opening of mitoK(ATP) channels can subtly modulate ERK, p38, and JNK pathways in a region-specific manner. ..
  46. Dreiss A, Antoniazza S, Burri R, Fumagalli L, Sonnay C, Frey C, et al. Local adaptation and matching habitat choice in female barn owls with respect to melanic coloration. J Evol Biol. 2012;25:103-14 pubmed publisher
    ..Although small in magnitude, matching habitat selection and local adaptation may help maintain variation in pheomelanin coloration in the barn owl. ..
  47. Gouttenoire E, Lupo V, Calpena E, Bartesaghi L, Schüpfer F, Medard J, et al. Sh3tc2 deficiency affects neuregulin-1/ErbB signaling. Glia. 2013;61:1041-51 pubmed publisher
    ..Altogether, our results indicate that the molecular mechanism for the axonal size sensing is disturbed in Sh3tc2-deficient myelinating Schwann cells, thus providing a novel insight into the pathophysiology of CMT4C neuropathy. ..
  48. Preitner F, Laverriere Loss A, Metref S, Da Costa A, Moret C, Rotman S, et al. Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice. Am J Physiol Renal Physiol. 2013;305:F786-95 pubmed publisher
    ..Furthermore, a sterile inflammation caused by the initial crystal-induced lesions developed despite the disappearance of urate and uric acid crystals. ..
  49. Santo Domingo J, Chareyron I, Broenimann C, Lassueur S, Wiederkehr A. Antibiotics induce mitonuclear protein imbalance but fail to inhibit respiration and nutrient activation in pancreatic ?-cells. Exp Cell Res. 2017;357:170-180 pubmed publisher
  50. Corthesy B, Boris S, Isler P, Grangette C, Mercenier A. Oral immunization of mice with lactic acid bacteria producing Helicobacter pylori urease B subunit partially protects against challenge with Helicobacter felis. J Infect Dis. 2005;192:1441-9 pubmed
    ..This is the first report of successful induction of partial protection against H. felis with a mucosal prime-boost regimen in which recombinant Lactobacillus strains were used as antigen-delivery vehicles. ..
  51. García Ródenas C, Bergonzelli G, Nutten S, Schumann A, Cherbut C, Turini M, et al. Nutritional approach to restore impaired intestinal barrier function and growth after neonatal stress in rats. J Pediatr Gastroenterol Nutr. 2006;43:16-24 pubmed
    ..Our results suggest that an adapted diet containing specific long-chain polyunsaturated fatty acids, prebiotics and probiotics can revert the negative imprinting of neonatal stress on both intestinal barrier function and growth. ..
  52. Pierre K, Parent A, Jayet P, Halestrap A, Scherrer U, Pellerin L. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. J Physiol. 2007;583:469-86 pubmed
    ..This observation could be relevant in the context of obesity development and its consequences for brain function. ..
  53. Lei H, Berthet C, Hirt L, Gruetter R. Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain. J Cereb Blood Flow Metab. 2009;29:811-9 pubmed publisher
    ..Such investigations should lead to a better understanding and insight into the sequential early changes in the brain parenchyma after ischemia, which could be used for identifying new targets for neuroprotection. ..
  54. Gambazzi L, Gokce O, Seredenina T, Katsyuba E, Runne H, Markram H, et al. Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments. J Pharmacol Exp Ther. 2010;335:13-22 pubmed publisher
    ..Moreover, the novel model paradigm established here is well suited to further mechanistic and drug screening research applications. ..
  55. Milano G, Bianciardi P, Rochemont V, Vassalli G, Segesser L, Corno A, et al. Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium. PLoS ONE. 2011;6:e27910 pubmed publisher
  56. Thompson N, Gesina E, Scheinert P, Bucher P, Grapin Botton A. RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Mol Cell Biol. 2012;32:1189-99 pubmed publisher
    ..In addition, we identify Bmp7, Nr5a2, RhoV, and P2rx1 as new targets of PTF1a in pancreas progenitors. ..
  57. Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, et al. PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice. J Clin Invest. 2012;122:4105-17 pubmed publisher
    ..Taken together, these results provide evidence for a repressive role for PPARβ/δ in β cell mass and insulin exocytosis, and shed a new light on PPARβ/δ metabolic action. ..
  58. Ninomiya T, Vuillemin M, Walter Barakat I, Winking H, Pexieder T, Droz B. Mouse fetal trisomy 13 and hypotrophy of the spinal cord: effect on calbindin-D28k and calretinin expressed by neurons of the spinal cord and dorsal root ganglia. Neuroscience. 1993;57:1109-20 pubmed
    ..The defect of calbindin or calretinin expression by subsets of dorsal root ganglion or spinal cord neurons may result from deficient cell-to-cell interactions with targets which are hypoplastic. ..
  59. Jeninga E, Schoonjans K, Auwerx J. Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility. Oncogene. 2010;29:4617-24 pubmed publisher
    ..We review here how these metabolic signaling pathways, affecting GCN5 and Sirt1 activity, allow the reversible acetylation-deacetylation of PGC-1alpha and the adaptation of mitochondrial energy homeostasis to energy levels. ..
  60. Feuerhahn S, Iglesias N, Panza A, Porro A, Lingner J. TERRA biogenesis, turnover and implications for function. FEBS Lett. 2010;584:3812-8 pubmed publisher
    ..Here, we review the current knowledge of TERRA structure, biogenesis and turnover. In addition, we discuss presumed roles of this RNA during replication of telomeric DNA, heterochromatin formation and the regulation of telomerase. ..
  61. Santoni de Sio F, Barde I, Offner S, Kapopoulou A, Corsinotti A, Bojkowska K, et al. KAP1 regulates gene networks controlling T-cell development and responsiveness. FASEB J. 2012;26:4561-75 pubmed publisher
    ..These results reveal the so far unsuspected yet important role of KAP1-mediated epigenetic regulation in T-lymphocyte differentiation and activation. ..
  62. Li P, Spann N, Kaikkonen M, Lu M, Oh D, Fox J, et al. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013;155:200-214 pubmed publisher
    ..Therapeutic methods to harness this mechanism could lead to a new approach to insulin-sensitizing therapies. ..
  63. Friebe S, van der Goot F, Bürgi J. The Ins and Outs of Anthrax Toxin. Toxins (Basel). 2016;8: pubmed publisher
    ..Here we will review the literature on anthrax disease with a focus on the structure of the toxin, how it enters cells and its immunological effects. ..
  64. Roulin A, Almasi B, Meichtry Stier K, Jenni L. Eumelanin- and pheomelanin-based colour advertise resistance to oxidative stress in opposite ways. J Evol Biol. 2011;24:2241-7 pubmed publisher
    ..Our results reveal that eumelanin- and pheomelanin-based colourations can be redundant signals of resistance to oxidative stress. ..
  65. Reber A, Chapuisat M. No evidence for immune priming in ants exposed to a fungal pathogen. PLoS ONE. 2012;7:e35372 pubmed publisher
    ..These results show that immune priming is not ubiquitous across pathogens, hosts and conditions, possibly because of immune evasion by the pathogen or efficient social defences by the host. ..
  66. Reina J, Hernandez N. On a roll for new TRF targets. Genes Dev. 2007;21:2855-60 pubmed
  67. Scholz S, Williamson G. Interactions affecting the bioavailability of dietary polyphenols in vivo. Int J Vitam Nutr Res. 2007;77:224-35 pubmed
    ..Information derived from such experiments could be useful for the optimal design of future bioefficacy studies. ..
  68. Rutkowski J, Markhus C, Gyenge C, Alitalo K, Wiig H, Swartz M. Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. Am J Pathol. 2010;176:1122-9 pubmed publisher
    ..These opposing tissue responses to primary lymphedema imply that tissue remodeling--predominantly collagen and fat deposition--may dictate tissue swelling and govern interstitial transport in lymphedema. ..
  69. Ricard G, Molina J, Chrast J, Gu W, Gheldof N, Pradervand S, et al. Phenotypic consequences of copy number variation: insights from Smith-Magenis and Potocki-Lupski syndrome mouse models. PLoS Biol. 2010;8:e1000543 pubmed publisher
    ..Thus, the presence of a genomic structural change, as well as gene dosage imbalance, contributes to the ultimate phenotype. ..
  70. Groner A, Tschopp P, Challet L, Dietrich J, Verp S, Offner S, et al. The Krüppel-associated box repressor domain can induce reversible heterochromatization of a mouse locus in vivo. J Biol Chem. 2012;287:25361-9 pubmed publisher
    ..This finding not only sheds light on KRAB-mediated transcriptional processes, but also suggests approaches for the externally controllable and reversible modulation of chromatin and transcription in vivo. ..
  71. Massouras A, Waszak S, Albarca Aguilera M, Hens K, Holcombe W, Ayroles J, et al. Genomic variation and its impact on gene expression in Drosophila melanogaster. PLoS Genet. 2012;8:e1003055 pubmed publisher
    ..Finally, we performed RNA-seq-based allelic expression imbalance analyses in the offspring of crosses between sequenced lines, which revealed that the majority of strong cis-eQTLs can be validated in heterozygous individuals. ..
  72. Munch M, Kawasaki A. Intrinsically photosensitive retinal ganglion cells: classification, function and clinical implications. Curr Opin Neurol. 2013;26:45-51 pubmed publisher
    ..Clinical implications of the melanopsin system are widespread, particularly as related to chronobiology. ..
  73. Kohl C, Riccio O, Grosse J, Zanoletti O, Fournier C, Schmidt M, et al. Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats. PLoS ONE. 2013;8:e56871 pubmed publisher
    ..Our data suggest nlgn2 in the hippocampus to be strongly implicated in maintaining the E/I balance in the brain and thereby modulating social and emotional behavior. ..
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