Experts and Doctors on signal transducing adaptor proteins in Geneva, Switzerland
Locale: Geneva, Switzerland
Topic: signal transducing adaptor proteins
Iynedjian P. Molecular physiology of mammalian glucokinase. Cell Mol Life Sci. 2009;66:27-42 pubmed publisher
..These advances are summarized here, with the aim of offering an integrated view of the role of GCK in the molecular physiology and medicine of glucose homeostasis. ..
Favre B, Fontao L, Koster J, Shafaatian R, Jaunin F, Saurat J, et al
. The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. J Biol Chem. 2001;276:32427-36 pubmed
Buchet Poyau K, Mehenni H, Radhakrishna U, Antonarakis S. Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2. Cytogenet Genome Res. 2002;97:171-8 pubmed
..Finally, we also excluded the recently identified STK11-interacting protein gene (STK11IP, alias LIP1) mapped in 2q36 as candidate for PJS in the PJS07 family, although this could be a good candidate in other non-STK11/LKB1 families...
Daubeuf B, Mathison J, Spiller S, Hugues S, Herren S, Ferlin W, et al
. TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. J Immunol. 2007;179:6107-14 pubmed
..These results demonstrate that neutralizing TLR4/MD-2 is highly efficacious in protecting against bacterial infection-induced toxemia and offers TLR4/MD-2 mAb treatment as a potential therapy for numerous clinical indications. ..
Tauzin S, Ding H, Khatib K, Ahmad I, Burdevet D, van Echten Deckert G, et al
. Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. Blood. 2008;111:2310-20 pubmed
..The Lyn-Cbp/PAG signalosome appears to control proliferation and survival in most B-NHLs and constitutes a therapeutic target in B-NHL cells that exhibit oncogenic "addiction" to the Lyn kinase. ..
Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, et al
. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev. 2009;23:1929-43 pubmed publisher
..This demonstrates that Sch9 is a master regulator of protein synthesis. ..
Yamazaki T, Walchli S, Fujita T, Ryser S, Hoshijima M, Schlegel W, et al
. Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy. Cardiovasc Res. 2010;86:374-82 pubmed publisher
..Antagonistic splice variants of ENH may play a central role in the adaptive changes of the link between mechanical stress-sensing and signalling occurring during embryonic development and/or heart hypertrophy. ..