Genomes and Genes
Experts and Doctors on molecular sequence data in Zurich, Switzerland
Locale: Zurich, Switzerland
Topic: molecular sequence data
Publications232 found, 100 shown here
- Stefl R, Xu M, Skrisovska L, Emeson R, Allain F. Structure and specific RNA binding of ADAR2 double-stranded RNA binding motifs. Structure. 2006;14:345-55 pubmed..In vitro mutagenesis studies with both the protein and the RNA further support our structural findings. ..
- Schaffitzel C, Oswald M, Berger I, Ishikawa T, Abrahams J, Koerten H, et al. Structure of the E. coli signal recognition particle bound to a translating ribosome. Nature. 2006;444:503-6 pubmed
- Haenni S, Hassa P, Altmeyer M, Fey M, Imhof R, Hottiger M. Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation. Int J Biochem Cell Biol. 2008;40:2274-83 pubmed publisher..Together, our results provide evidence that acetylation of PARP-2 is a key post-translational modification that may regulate DNA binding and consequently also the enzymatic activity of PARP-2. ..
- Geuking M, Weber J, Dewannieux M, Gorelik E, Heidmann T, Hengartner H, et al. Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration. Science. 2009;323:393-6 pubmed publisher..Thus, RNA viruses should be closely scrutinized for any capacity to interact with endogenous retroviral elements before their approval for therapeutic use in humans...
- Carapito C, Klemm C, Aebersold R, Domon B. Systematic LC-MS analysis of labile post-translational modifications in complex mixtures. J Proteome Res. 2009;8:2608-14 pubmed publisher..The technique was applied to the analysis of O-GlcNAc peptides, a very complex mixture of N-linked glycopeptides, and a phosphotyrosine peptide. ..
- Kilcher S, Loessner M, Klumpp J. Brochothrix thermosphacta bacteriophages feature heterogeneous and highly mosaic genomes and utilize unique prophage insertion sites. J Bacteriol. 2010;192:5441-53 pubmed publisher..Interestingly, both genes are reconstituted by phage sequence. ..
- Meyer J, Frapolli M, Keel C, Maurhofer M. Pyrroloquinoline quinone biosynthesis gene pqqC, a novel molecular marker for studying the phylogeny and diversity of phosphate-solubilizing pseudomonads. Appl Environ Microbiol. 2011;77:7345-54 pubmed publisher..In summary, we demonstrate that the gene pqqC is a novel molecular marker that can be used complementary to housekeeping genes for studying the diversity and evolution of plant-beneficial pseudomonads...
- Ma L, Jüttner M, Kullak Ublick G, Eloranta J. Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2. Am J Physiol Gastrointest Liver Physiol. 2012;302:G123-33 pubmed publisher..Our finding provides a possible explanation for the reported observation that ASBT is aberrantly expressed in esophageal metaplasia that also expresses CDX transcription factors. ..
- Maurer F, Keller P, Beuret C, Joha C, Achermann Y, Gubler J, et al. Close geographic association of human neoehrlichiosis and tick populations carrying "Candidatus Neoehrlichia mikurensis" in eastern Switzerland. J Clin Microbiol. 2013;51:169-76 pubmed publisher..Neoehrlichia mikurensis" was between 3.5 to 8% in pools of either nymphs, males, or females, showing a strong geographic association between the three patients and the assumed vector...
- Fehr A, Walther E, Schmidt Posthaus H, Nufer L, Wilson A, Svercel M, et al. Candidatus Syngnamydia venezia, a novel member of the phylum Chlamydiae from the broad nosed pipefish, Syngnathus typhle. PLoS ONE. 2013;8:e70853 pubmed publisher..We describe here a new bacterial species, Candidatus Syngnamydia venezia; epitheliocystis agent of S. typhle and close relative to other chlamydial pathogens which are known to infect diverse hosts ranging from invertebrates to humans. ..
- Brunisholz R, Zuber H. Structure, function and organization of antenna polypeptides and antenna complexes from the three families of Rhodospirillaneae. J Photochem Photobiol B. 1992;15:113-40 pubmed..Equally important for the formation of the antenna complexes or the entire antenna are polypeptide-polypeptide, pigment-pigment and pigment-polypeptide interactions...
- Bott M, Bolliger M, Hennecke H. Genetic analysis of the cytochrome c-aa3 branch of the Bradyrhizobium japonicum respiratory chain. Mol Microbiol. 1990;4:2147-57 pubmed..The data suggest that a symbiosis-specific respiratory chain exists in B. japonicum in which the electrons branch off at the bc1 complex...
- Armstrong G, Runge S, Frick G, Sperling U, Apel K. Identification of NADPH:protochlorophyllide oxidoreductases A and B: a branched pathway for light-dependent chlorophyll biosynthesis in Arabidopsis thaliana. Plant Physiol. 1995;108:1505-17 pubmed
- Rognan D, Scapozza L, Folkers G, Daser A. Rational design of nonnatural peptides as high-affinity ligands for the HLA-B*2705 human leukocyte antigen. Proc Natl Acad Sci U S A. 1995;92:753-7 pubmed..This study constitutes an initial step toward the rational design of nonpeptide class I MHC ligands for use in the selective immunotherapy of autoimmune diseases associated with particular HLA alleles. ..
- Hilfiker H, Guerini D, Carafoli E. Cloning and expression of isoform 2 of the human plasma membrane Ca2+ ATPase. Functional properties of the enzyme and its splicing products. J Biol Chem. 1994;269:26178-83 pubmed..The response of the two pump types to activating acidic phospholipids was the same. ..
- Grob P, Michel P, Hennecke H, G ttfert M. A novel response-regulator is able to suppress the nodulation defect of a Bradyrhizobium japonicum nodW mutant. Mol Gen Genet. 1993;241:531-41 pubmed..japonicum. This low level of expression is obviously not sufficient to compensate for a nodW- defect, whereas strong overexpression of nwsB is a condition that leads to suppression of the nodW- mutation...
- Neuenschwander S, Rettenberger G, Meijerink E, Jörg H, Stranzinger G. Partial characterization of porcine obesity gene (OBS) and its localization to chromosome 18 by somatic cell hybrids. Anim Genet. 1996;27:275-8 pubmed..We conclude the border of conserved synteny to be in the 7q31-7q32 region of the human chromosome. ..
- Masabanda J, Wigger G, Eggen A, Stranzinger G, Fries R. The bovine glutamine synthase gene (GLUL) maps to 10q33 and a pseudogene (GLULP) to 16q21. Mamm Genome. 1997;8:794-5 pubmed
- Kutay U, Hartmann E, Treichel N, Calado A, Carmo Fonseca M, Prehn S, et al. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. J Biol Chem. 2000;275:40163-8 pubmed..Like the other members of the transport receptor superfamily, RanBP16 interacts with the nuclear pore complex and is able to enter the nucleus independent of energy and additional nuclear transport receptors. ..
- Marty C, Scheidegger P, Ballmer Hofer K, Klemenz R, Schwendener R. Production of functionalized single-chain Fv antibody fragments binding to the ED-B domain of the B-isoform of fibronectin in Pichia pastoris. Protein Expr Purif. 2001;21:156-64 pubmed..Our results indicate that the P. pastoris expression system is useful for the large-scale production of cysteine-functionalized alpha-ED-B scFv antibody fragments. ..
- Heller M, von der Ohe M, Kleene R, Mohajeri M, Schachner M. The immunoglobulin-superfamily molecule basigin is a binding protein for oligomannosidic carbohydrates: an anti-idiotypic approach. J Neurochem. 2003;84:557-65 pubmed..To our knowledge this is the first report that anti-idiotypic antibodies can be used to identify binding partners for carbohydrates. ..
- Landrier J, Eloranta J, Vavricka S, Kullak Ublick G. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol. 2006;290:G476-85 pubmed..By coordinated control of OSTalpha/OSTbeta expression, bile acids may adjust the rate of their own efflux from enterocytes in response to changes in intracellular bile acid levels. ..
- Huber R, Gao B, Sidler Pfändler M, Zhang Fu W, Leuthold S, Hagenbuch B, et al. Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol. 2007;292:C795-806 pubmed
- Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolásek B, Ban N. Structure of fungal fatty acid synthase and implications for iterative substrate shuttling. Science. 2007;316:254-61 pubmed
- Erat M, Sigel R. Determination of the intrinsic affinities of multiple site-specific Mg(2+) ions coordinated to domain 6 of a group II intron ribozyme. Inorg Chem. 2007;46:11224-34 pubmed
- Polymenidou M, Trusheim H, Stallmach L, Moos R, Julius C, Miele G, et al. Canine MDCK cell lines are refractory to infection with human and mouse prions. Vaccine. 2008;26:2601-14 pubmed publisher..These factors may account for their resistance to infection. Alternatively, prion resistance may be related to the specific sequence of canine Prnp, as suggested by the lack of documented prion diseases in dogs. ..
- Klinge S, Voigts Hoffmann F, Leibundgut M, Arpagaus S, Ban N. Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6. Science. 2011;334:941-8 pubmed publisher..Furthermore, it elucidates the molecular basis of the interaction with eIF6 and provides a structural framework for further studies of ribosome-associated diseases and the role of the 60S subunit in the initiation of protein synthesis...
- Stecher B, Denzler R, Maier L, Bernet F, Sanders M, Pickard D, et al. Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae. Proc Natl Acad Sci U S A. 2012;109:1269-74 pubmed publisher..These blooms may favor reassortment of plasmid-encoded genes between pathogens and commensals fostering the spread of fitness-, virulence-, and antibiotic-resistance determinants. ..
- Aguzzi A, Falsig J. Prion propagation, toxicity and degradation. Nat Neurosci. 2012;15:936-9 pubmed publisher..Here we review these developments and summarize those open questions that we currently deem most interesting in prion biology: how do prions damage their hosts, and how do hosts attempt to neutralize invading prions? ..
- Masliah G, Barraud P, Allain F. RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence. Cell Mol Life Sci. 2013;70:1875-95 pubmed publisher..We especially focus on the molecular determinants of dsRNA recognition and describe how sequence discrimination can be achieved by this type of domain. ..
- Lange C, Ackermann M, Favrot C, Tobler K. Entire genomic sequence of novel canine papillomavirus type 13. J Virol. 2012;86:10226-7 pubmed publisher..The sequence of the novel virus canine papillomavirus type 13 (CPV13) shares the highest levels of similarity with the Tau papillomaviruses CPV2 and CPV7. ..
- Schmuki M, Erne D, Loessner M, Klumpp J. Bacteriophage P70: unique morphology and unrelatedness to other Listeria bacteriophages. J Virol. 2012;86:13099-102 pubmed publisher..The P70 genome contains 67,170 bp and 119 open reading frames (ORFs). Our analyses suggest that P70 represents an archetype of virus unrelated to other known Listeria bacteriophages. ..
- Warinner C, Rodrigues J, Vyas R, Trachsel C, Shved N, Grossmann J, et al. Pathogens and host immunity in the ancient human oral cavity. Nat Genet. 2014;46:336-44 pubmed publisher..Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past. ..
- Strehler E, Strehler Page M, Vogel G, Carafoli E. mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon. Proc Natl Acad Sci U S A. 1989;86:6908-12 pubmed..When expressed as protein, these mRNAs encode Ca2+ pump isoforms that differ in their C-terminal regulatory domains. ..
- Hennet T, Dinter A, Kuhnert P, Mattu T, Rudd P, Berger E. Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes. J Biol Chem. 1998;273:58-65 pubmed..The identification of beta3GalT genes emphasizes the structural diversity present in the galactosyltransferase gene family. ..
- Wenger R, Rolfs A, Spielmann P, Zimmermann D, Gassmann M. Mouse hypoxia-inducible factor-1alpha is encoded by two different mRNA isoforms: expression from a tissue-specific and a housekeeping-type promoter. Blood. 1998;91:3471-80 pubmed..5% O2 for up to 72 hours) also caused a decrease in liver HIF-1alpha mRNA, whereas aldolase mRNA levels increased. These findings might be related to the relatively low Epo levels in the adult liver. ..
- Haugstetter J, Maurer M, Blicher T, Pagac M, Wider G, Ellgaard L. Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain. J Biol Chem. 2007;282:33859-67 pubmed..Overall, the data indicate that in addition to their role as substrate and co-factor binding domains, redox-inactive thioredoxin-like domains also function in stabilizing neighboring redox-active domains. ..
- Stephan R, Van Trappen S, Cleenwerck I, Iversen C, Joosten H, De Vos P, et al. Enterobacter pulveris sp. nov., isolated from fruit powder, infant formula and an infant formula production environment. Int J Syst Evol Microbiol. 2008;58:237-41 pubmed publisher..nov. The type strain is 601/05(T) (=LMG 24057(T)=DSM 19144(T)). ..
- Frapolli M, Moënne Loccoz Y, Meyer J, Défago G. A new DGGE protocol targeting 2,4-diacetylphloroglucinol biosynthetic gene phlD from phylogenetically contrasted biocontrol pseudomonads for assessment of disease-suppressive soils. FEMS Microbiol Ecol. 2008;64:468-81 pubmed publisher..In conclusion, this DGGE protocol was useful for monitoring indigenous rhizosphere consortia of phlD+ pseudomonads. ..
- Exner V, Aichinger E, Shu H, Wildhaber T, Alfarano P, Caflisch A, et al. The chromodomain of LIKE HETEROCHROMATIN PROTEIN 1 is essential for H3K27me3 binding and function during Arabidopsis development. PLoS ONE. 2009;4:e5335 pubmed publisher..Therefore, binding to H3K27me3 is essential for LHP1 protein function. ..
- Wilson M, Mori T, Ruckert C, Uria A, Helf M, Takada K, et al. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature. 2014;506:58-62 pubmed publisher..The pronounced bioactivities and chemical uniqueness of 'Entotheonella' compounds provide significant opportunities for ecological studies and drug discovery. ..
- Campagne S, Marsh M, Capitani G, Vorholt J, Allain F. Structural basis for -10 promoter element melting by environmentally induced sigma factors. Nat Struct Mol Biol. 2014;21:269-76 pubmed publisher..This mechanism of promoter melting explains the increased promoter-selection stringency of environmentally induced sigma factors. ..
- Furter Graves E, Hall B, Furter R. Role of a small RNA pol II subunit in TATA to transcription start site spacing. Nucleic Acids Res. 1994;22:4932-6 pubmed..Deletion of the non-essential SHI gene also results in usage of upstream initiation sites and causes conditional growth defects. ..
- Taylor V, Suter U. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. Gene. 1996;175:115-20 pubmed
- Schmalfeldt M, Dours Zimmermann M, Winterhalter K, Zimmermann D. Versican V2 is a major extracellular matrix component of the mature bovine brain. J Biol Chem. 1998;273:15758-64 pubmed..g. hyaluronectin or glial hyaluronate-binding protein. Having biochemical quantities of versican V2 available will allow us to test its putative modulatory role in neuronal cell adhesion and axonal growth. ..
- Ratnatilleke A, Vrijbloed J, Robinson J. Cloning and sequencing of the coenzyme B(12)-binding domain of isobutyryl-CoA mutase from Streptomyces cinnamonensis, reconstitution of mutase activity, and characterization of the recombinant enzyme produced in Escherichia coli. J Biol Chem. 1999;274:31679-85 pubmed..A V(max) of 38 +/- 3 units/mg IcmA and a k(cat) of 39 +/- 3 s(-1) were determined under saturating molar ratios of IcmB to IcmA...
- Wiget P, Shimada Y, Butty A, Bi E, Peter M. Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating. EMBO J. 2004;23:1063-74 pubmed..Our results imply that Gbetagamma not only targets Far1p to the correct site but may also trigger a conformational change in Far1p that is required for its ability to activate Cdc24p in vivo. ..
- Duc L, Noll M, Meier B, Bürgmann H, Zeyer J. High diversity of diazotrophs in the forefield of a receding alpine glacier. Microb Ecol. 2009;57:179-90 pubmed publisher..Moreover, the four libraries displayed low similarity values. This indicated that both soil age and the presence of pioneer plants influence diversification and population structure of free-living diazotrophs. ..
- van der Ploeg J. Characterization of Streptococcus gordonii prophage PH15: complete genome sequence and functional analysis of phage-encoded integrase and endolysin. Microbiology. 2008;154:2970-8 pubmed publisher..gordonii strains tested and several different streptococcal species, including the pathogens Streptococcus mutans, S. pyogenes and Streptococcus agalactiae...
- Butschi A, Titz A, Wälti M, Olieric V, Paschinger K, Nöbauer K, et al. Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. PLoS Pathog. 2010;6:e1000717 pubmed publisher..5 A resolution revealed the biophysical basis for this interaction. Our results suggest that fungal galectins play a role in the defense of fungi against predators by binding to specific glycoconjugates of these organisms. ..
- van der Ploeg J. Genome sequence of the temperate bacteriophage PH10 from Streptococcus oralis. Virus Genes. 2010;41:450-8 pubmed publisher..oralis, S. pneumoniae and Streptococcus mitis, but not with other streptococcal species...
- Monroe N, Sennhauser G, Seeger M, Briand C, Grutter M. Designed ankyrin repeat protein binders for the crystallization of AcrB: plasticity of the dominant interface. J Struct Biol. 2011;174:269-81 pubmed publisher..We observe that small variations in the interface can lead to differing behavior of the DARPins with regards to affinity, stoichiometry of the complexes and specificity for their target. ..
- Liu Y, Hüttenhain R, Surinova S, Gillet L, Mouritsen J, Brunner R, et al. Quantitative measurements of N-linked glycoproteins in human plasma by SWATH-MS. Proteomics. 2013;13:1247-56 pubmed publisher..We suggest that SWATH-MS analysis combined with N-glycoproteome enrichment in plasma samples is a promising integrative proteomic approach for biomarker discovery and verification. ..
- Scheller T, Kraev A, Skinner S, Carafoli E. Cloning of the multipartite promoter of the sodium-calcium exchanger gene NCX1 and characterization of its activity in vascular smooth muscle cells. J Biol Chem. 1998;273:7643-9 pubmed..In mammalian species transcripts from all three promoters undergo splicing via an intermediate, containing two noncoding exons, of which the downstream one is normally not present in the terminal splicing product. ..
- Hülsmeier A, Gehrig P, Geyer R, Sack R, Gottstein B, Deplazes P, et al. A major Echinococcus multilocularis antigen is a mucin-type glycoprotein. J Biol Chem. 2002;277:5742-8 pubmed..The data presented reveal that the Em2(G11) antigen is a mucin-type glycosylated protein. ..
- Ochsner U, Fiechter A, Reiser J. Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis. J Biol Chem. 1994;269:19787-95 pubmed..The controlled expression of the rhlAB genes in Escherichia coli led to the formation of active rhamnosyltransferase. This provides direct evidence for the fact that the rhamnosyltransferase encoding genes have been identified. ..
- Holm J, Hillenbrand R, Steuber V, Bartsch U, Moos M, Lubbert H, et al. Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. Eur J Neurosci. 1996;8:1613-29 pubmed..Our findings suggest a common ancestral L1-like molecule which evolved via gene duplication to generate a diversity of structurally and functionally distinct yet similar molecules. ..
- Thony B, Blau N. Mutations in the GTP cyclohydrolase I and 6-pyruvoyl-tetrahydropterin synthase genes. Hum Mutat. 1997;10:11-20 pubmed
- Mouillet J, Bousquet F, Sedano N, Alabouvette J, Nicolai M, Zelus D, et al. Cloning and characterization of new orphan nuclear receptors and their developmental profiles during Tenebrio metamorphosis. Eur J Biochem. 1999;265:972-81 pubmed
- Nyati S, Beck A, Honegger R. Fine structure and phylogeny of green algal photobionts in the microfilamentous genus Psoroglaena (Verrucariaceae, lichen-forming ascomycetes). Plant Biol (Stuttg). 2007;9:390-9 pubmed
- Aeschbacher R, Schrott M, Potrykus I, Saul M. Isolation and molecular characterization of PosF21, an Arabidopsis thaliana gene which shows characteristics of a b-Zip class transcription factor. Plant J. 1991;1:303-16 pubmed..Evidence for a regulatory function of PosF21 was obtained since co-expression of the full PosF21 protein or its DNA-binding region alone specifically stimulated GUS gene expression directed from the PosF21 promoter by 6-8-fold. ..
- Kast P. pKSS--a second-generation general purpose cloning vector for efficient positive selection of recombinant clones. Gene. 1994;138:109-14 pubmed
- Kania T, Russenberger D, Peng S, Apel K, Melzer S. FPF1 promotes flowering in Arabidopsis. Plant Cell. 1997;9:1327-38 pubmed
- Wachtel M, Dettling M, Koscielniak E, Stegmaier S, Treuner J, Simon Klingenstein K, et al. Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. Cancer Res. 2004;64:5539-45 pubmed..These experiments demonstrate for the first time that gene expression profiling is capable of identifying novel chromosomal translocations. ..
- Blasius M, Buob R, Shevelev I, Hubscher U. Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radiodurans. BMC Mol Biol. 2007;8:69 pubmed..Characterization of another protein from the same operon revealed a 5'-polynucleotide kinase with a possible role in DNA strand-break repair. ..
- Cheneval D, Carafoli E. Identification and primary structure of the cardiolipin-binding domain of mitochondrial creatine kinase. Eur J Biochem. 1988;171:1-9 pubmed..Chemical modification of the basic amino acids Lys and Arg of the enzyme abolished its binding to cardiolipin. ..
- Qian Y, Otting G, Billeter M, Muller M, Gehring W, Wuthrich K. Nuclear magnetic resonance spectroscopy of a DNA complex with the uniformly 13C-labeled Antennapedia homeodomain and structure determination of the DNA-bound homeodomain. J Mol Biol. 1993;234:1070-83 pubmed..The structure of the DNA-bound protein was the starting point for the subsequent structure determination of the complete Antp(C39S) homeodomain-DNA complex in solution. ..
- Hu Q, Brunisholz R, Frank G, Zuber H. The antenna complexes of the purple non-sulfur photosynthetic bacterium Rhodocyclus tenuis. Structural and spectral characterization. Eur J Biochem. 1996;238:381-90 pubmed..The possible correlation between the intensity of the near-infrared circular dichroic signal and the specific structural features of the alpha and beta core antenna polypeptides is also discussed...
- Thony Meyer L. Biogenesis of respiratory cytochromes in bacteria. Microbiol Mol Biol Rev. 1997;61:337-76 pubmed..Formation of the multisubunit cytochrome bc, complex and several terminal oxidases of the bo3, bd, aa3, and cbb3 types is discussed in detail, and models for linear maturation pathways are proposed wherever possible. ..
- Wittwer F, van der Straten A, Keleman K, Dickson B, Hafen E. Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. Development. 2001;128:791-800 pubmed..These results suggest that Lilli acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. ..
- Lemberg M, Bland F, Weihofen A, Braud V, Martoglio B. Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes. J Immunol. 2001;167:6441-6 pubmed..This cut is essential for the release of the HLA-E epitope-containing fragment from the lipid bilayer and its subsequent transport into the lumen of the endoplasmic reticulum via the TAP...
- Boll W, Schmid Chanda T, Semenza G, Mantei N. Messenger RNAs expressed in intestine of adult but not baby rabbits. Isolation of cognate cDNAs and characterization of a novel brush border protein with esterase and phospholipase activity. J Biol Chem. 1993;268:12901-11 pubmed..Finally, the protein was found to have esterase and phospholipase A/lysophospholipase activity. ..
- Schweitzer B, Taylor V, Welcher A, McClelland M, Suter U. Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system. Mol Cell Neurosci. 1998;11:260-73 pubmed..We conclude that NMP35 and GBP are members of a gene family which is likely to play a role in the development and the maintenance of the nervous system. ..
- Canevascini S, Marti M, Fröhli E, Hajnal A. The Caenorhabditis elegans homologue of the proto-oncogene ect-2 positively regulates RAS signalling during vulval development. EMBO Rep. 2005;6:1169-75 pubmed..Our results raise the possibility that the transforming activity of the mammalian ect-2 oncogene could be due to hyperactivation of the RAS/MAPK pathway. ..
- Tweedie Cullen R, Brunner A, Grossmann J, Mohanna S, Sichau D, Nanni P, et al. Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain. PLoS ONE. 2012;7:e36980 pubmed publisher..Overall, the present data newly identify a specific histone code in the mouse brain and reveal its level of complexity, suggesting its potential relevance for higher-order brain functions. ..
- Kast P, Wehrli C, Hennecke H. Impaired affinity for phenylalanine in Escherichia coli phenylalanyl-tRNA synthetase mutant caused by Gly-to-Asp exchange in motif 2 of class II tRNA synthetases. FEBS Lett. 1991;293:160-3 pubmed..This alteration is located within motif 2, one of 3 conserved sequence motifs characteristic for class II aminoacyl-tRNA synthetases. Motif 2 may thus participate in the formation of the phenylalanine binding site in PheRS. ..
- Heinrich J, Schultz J, Bosse M, Ziegelin G, Lanka E, Moelling K. Linear closed mini DNA generated by the prokaryotic cleaving-joining enzyme TelN is functional in mammalian cells. J Mol Med (Berl). 2002;80:648-54 pubmed..Therefore, the TelN/ telRL system is well suited to generate linear closed mini DNA with high stability and a minimum of foreign nucleotide sequences. ..
- Stephan R, Van Trappen S, Cleenwerck I, Vancanneyt M, De Vos P, Lehner A. Enterobacter turicensis sp. nov. and Enterobacter helveticus sp. nov., isolated from fruit powder. Int J Syst Evol Microbiol. 2007;57:820-6 pubmed..nov. (type strain 508/05(T)=LMG 23730(T)=DSM 18397(T)) and Enterobacter helveticus sp. nov. (type strain 513/05(T)=LMG 23732(T)=DSM 18396(T)). ..
- Trueb J, Trueb B. Type XIV collagen is a variant of undulin. Eur J Biochem. 1992;207:549-57 pubmed
- Schuppli D, Miranda G, Tsui H, Winkler M, Sogo J, Weber H. Altered 3'-terminal RNA structure in phage Qbeta adapted to host factor-less Escherichia coli. Proc Natl Acad Sci U S A. 1997;94:10239-42 pubmed..One mutation disrupts the base pairing of the 3'-terminal CCCOH sequence, suggesting that the host factor stimulates activity of the wild-type RNA template by melting out its 3'-end...
- Wulf P, Bernhardt R, Suter U. Characterization of peripheral myelin protein 22 in zebrafish (zPMP22) suggests an early role in the development of the peripheral nervous system. J Neurosci Res. 1999;57:467-78 pubmed
- Desirò A, Salvioli A, Ngonkeu E, Mondo S, Epis S, Faccio A, et al. Detection of a novel intracellular microbiome hosted in arbuscular mycorrhizal fungi. ISME J. 2014;8:257-70 pubmed publisher..These findings show for the first time that fungi support an intracellular bacterial microbiome, in which distinct types of endobacteria coexist in a single cell. ..
- Suriyanarayanan S, Auranen M, Toppila J, Paetau A, Shcherbii M, Palin E, et al. The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy. Neuromolecular Med. 2016;18:81-90 pubmed publisher..Sequencing of SPTLC2 should be considered in all patients presenting with mild late-onset sensory-predominant small or large fiber neuropathy. ..
- Koller E, Trueb B. Characterization of the chicken alpha 1(VI) collagen promoter. Eur J Biochem. 1992;208:769-74 pubmed..Other DNA fragments that are either shorter or longer than the 621-bp fragment show markedly reduced promoter activity. Thus, the basic promoter element of the alpha 1(VI) collagen gene must reside within this 621-bp fragment. ..
- Kullik I, Fritsche S, Knobel H, Sanjuan J, Hennecke H, Fischer H. Bradyrhizobium japonicum has two differentially regulated, functional homologs of the sigma 54 gene (rpoN). J Bacteriol. 1991;173:1125-38 pubmed..Expression of rpoN2 was observed under all conditions tested and was increased fivefold in an rpoN2 mutant. The data suggested that the rpoN1 gene was regulated in response to oxygen, whereas the rpoN2 gene was negatively autoregulated...
- Weber P, Montag D, Schachner M, Bernhardt R. Zebrafish tenascin-W, a new member of the tenascin family. J Neurobiol. 1998;35:1-16 pubmed..Similar and possibly overlapping functions could also be performed by tn-c, which appears to have additional functions during the development of the CNS. ..