Experts and Doctors on caenorhabditis elegans proteins in Zurich, Switzerland


Locale: Zurich, Switzerland
Topic: caenorhabditis elegans proteins

Top Publications

  1. Kouyos R, Abel Zur Wiesch P, Bonhoeffer S. On being the right size: the impact of population size and stochastic effects on the evolution of drug resistance in hospitals and the community. PLoS Pathog. 2011;7:e1001334 pubmed publisher
    ..Overall, our study shows that the distribution of hospital sizes is a crucial factor for the spread of drug resistance. ..
  2. Butschi A, Titz A, Wälti M, Olieric V, Paschinger K, Nöbauer K, et al. Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. PLoS Pathog. 2010;6:e1000717 pubmed publisher
    ..5 A resolution revealed the biophysical basis for this interaction. Our results suggest that fungal galectins play a role in the defense of fungi against predators by binding to specific glycoconjugates of these organisms. ..
  3. Claassen M, Reiter L, Hengartner M, Buhmann J, Aebersold R. Generic comparison of protein inference engines. Mol Cell Proteomics. 2012;11:O110.007088 pubmed publisher
  4. Singh K, Zheng X, Milstein S, Keller M, Roschitzki B, Grossmann J, et al. Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans. PLoS ONE. 2017;12:e0182270 pubmed publisher
    ..This observation is consistent with the distinct phenotypes observed in the various CPEB family mutants. ..
  5. Eberhard R, Stergiou L, Hofmann E, Hofmann J, Haenni S, Teo Y, et al. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003943 pubmed publisher
    ..Ribosome synthesis and growth-factor signalling are perturbed in many cancer cells; such an interplay between basic cellular processes and signalling might be critical for how tumours evolve or respond to treatment. ..
  6. Pintard L, Kurz T, Glaser S, Willis J, Peter M, Bowerman B. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Curr Biol. 2003;13:911-21 pubmed
    ..We conclude that both neddylation and deneddylation of CUL-3 is required for MEI-1 degradation and propose that cycles of CUL-3 neddylation and deneddylation are necessary for its ligase activity in vivo. ..
  7. Pintard L, Willis J, Willems A, Johnson J, Srayko M, Kurz T, et al. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature. 2003;425:311-6 pubmed
    ..Our results suggest that BTB-containing proteins may generally function as substrate-specific adaptors in Cul3-based E3-ubiquitin ligases. ..
  8. Couwenbergs C, Spilker A, Gotta M. Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8. Curr Biol. 2004;14:1871-6 pubmed
    ..We suggest that RIC-8 directly modulates Galpha activity and that Galpha-GTP is the signaling molecule regulating spindle positioning in the early embryo. ..
  9. Neukomm L, Frei A, Cabello J, Kinchen J, Zaidel Bar R, Ma Z, et al. Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Nat Cell Biol. 2011;13:79-86 pubmed publisher
    ..We propose that C. elegans uses the engulfment machinery as part of a primitive, but evolutionarily conserved, survey mechanism that identifies and removes unfit cells within a tissue. ..

More Information


  1. Morf M, Rimann I, Alexander M, Roy P, Hajnal A. The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulval development. Dev Biol. 2013;374:108-14 pubmed publisher
    ..Therefore, developmental cell invasion depends on a precise balance between pro- and anti-invasive factors. ..
  2. Nakdimon I, Walser M, Fröhli E, Hajnal A. PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development. PLoS Genet. 2012;8:e1002881 pubmed publisher
    ..Thus, mutations in the PTEN tumor suppressor gene may result in the simultaneous hyper-activation of two oncogenic signaling pathways. ..
  3. John C, Hite R, Weirich C, Fitzgerald D, Jawhari H, Faty M, et al. The Caenorhabditis elegans septin complex is nonpolar. EMBO J. 2007;26:3296-307 pubmed
    ..Together, our study establishes that the septin core complex is symmetric, and suggests that septins form nonpolar filaments. ..
  4. Neukomm L, Nicot A, Kinchen J, Almendinger J, Pinto S, Zeng S, et al. The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development. 2011;138:2003-14 pubmed publisher
    ..Finally, we show that the CED-12 PH domain can bind to PtdIns(3,5)P(2) (one target of MTM-1 phosphatase activity), suggesting that MTM-1 might regulate CED-12 recruitment to the plasma membrane. ..
  5. Spilker A, Rabilotta A, Zbinden C, Labbé J, Gotta M. MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo. Genetics. 2009;183:965-77 pubmed publisher
    ..Our data therefore indicates that MAP kinase signaling antagonizes PAR-1 signaling during early C. elegans embryonic polarization. ..
  6. Almendinger J, Doukoumetzidis K, Kinchen J, Kaech A, Ravichandran K, Hengartner M. A conserved role for SNX9-family members in the regulation of phagosome maturation during engulfment of apoptotic cells. PLoS ONE. 2011;6:e18325 pubmed publisher
    ..The functional conservation between LST-4 and SNX33 indicate that these early steps of apoptotic phagosome maturation are likely conserved through evolution. ..
  7. Luke Glaser S, Pintard L, Lu C, Mains P, Peter M. The BTB protein MEL-26 promotes cytokinesis in C. elegans by a CUL-3-independent mechanism. Curr Biol. 2005;15:1605-15 pubmed
    ..Our results suggest that MEL-26 not only acts as a substrate-specific adaptor within the MEL-26/CUL-3 complex, but also promotes cytokinesis by a CUL-3- and microtubule-independent mechanism. ..
  8. Baumer A, Wiedemann U, Hergersberg M, Schinzel A. A novel MSP/DHPLC method for the investigation of the methylation status of imprinted genes enables the molecular detection of low cell mosaicisms. Hum Mutat. 2001;17:423-30 pubmed
  9. Dittrich C, Kratz K, Sendoel A, Gruenbaum Y, Jiricny J, Hengartner M. LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans. PLoS ONE. 2012;7:e24555 pubmed publisher
    ..Our data suggest that BAF-1, together with the LEM domain proteins, plays an important role following DNA damage - possibly by promoting the reorganization of damaged chromatin. ..
  10. Zanin E, Pacquelet A, Scheckel C, Ciosk R, Gotta M. LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline. J Cell Sci. 2010;123:2717-24 pubmed publisher
    ..By contrast, levels of fem-3 mRNA are not affected in nos-3 mutants. Therefore, our data indicate that LARP-1 and NOS-3 promote oogenesis by regulating fem-3 expression through distinct mechanisms. ..
  11. Yang Q, Roiz D, Mereu L, Daube M, Hajnal A. The Invading Anchor Cell Induces Lateral Membrane Constriction during Vulval Lumen Morphogenesis in C. elegans. Dev Cell. 2017;42:271-285.e3 pubmed publisher
    ..Invasive cells may induce shape changes in adjacent cells to penetrate their target tissues. ..
  12. Stetak A, Hörndli F, Maricq A, van den Heuvel S, Hajnal A. Neuron-specific regulation of associative learning and memory by MAGI-1 in C. elegans. PLoS ONE. 2009;4:e6019 pubmed publisher
    ..elegans are likely carried out by distinct subsets of interneurons. The synaptic scaffolding protein MAGI-1 plays a critical role in these processes in part by regulating the clustering of iGluRs at synapses. ..
  13. Pacquelet A, Zanin E, Ashiono C, Gotta M. PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditiselegans. Dev Biol. 2008;319:267-72 pubmed publisher
    ..Our data strongly suggest that PAR-6 levels are regulated by the CBC(FEM-1) ubiquitin ligase thereby uncovering a novel role for the FEM proteins and cullin-dependent degradation in regulating PAR proteins and polarity processes. ..
  14. Luke Glaser S, Roy M, Larsen B, Le Bihan T, Metalnikov P, Tyers M, et al. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Mol Cell Biol. 2007;27:4526-40 pubmed
    ..F and inactivation of cif-1 impairs translation in vivo. Taken together, our results indicate that CIF-1 is a shared subunit of the CSN and eIF3 complexes and may therefore link protein translation and degradation. ..
  15. Stergiou L, Doukoumetzidis K, Sendoel A, Hengartner M. The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans. Cell Death Differ. 2007;14:1129-38 pubmed
  16. Kritikou E, Milstein S, Vidalain P, Lettre G, Bogan E, Doukoumetzidis K, et al. C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival. Genes Dev. 2006;20:2279-92 pubmed
    ..elegans germline and functions as a negative regulator of the MAPK signaling pathway during vulval development and in muscle cells. ..
  17. Walser C, Battu G, Hoier E, Hajnal A. Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development. Development. 2006;133:3461-71 pubmed
    ..Thus, translational repressors regulate various aspects of vulval cell fate specification, and they may play a conserved role in modulating signal transduction during animal development. ..
  18. Labbé J, Pacquelet A, Marty T, Gotta M. A genomewide screen for suppressors of par-2 uncovers potential regulators of PAR protein-dependent cell polarity in Caenorhabditis elegans. Genetics. 2006;174:285-95 pubmed
    ..Taken together, our results identify conserved components that regulate PAR protein function and also suggest a role for NOS-3 in PAR protein-dependent cell polarity. ..
  19. Canevascini S, Marti M, Fröhli E, Hajnal A. The Caenorhabditis elegans homologue of the proto-oncogene ect-2 positively regulates RAS signalling during vulval development. EMBO Rep. 2005;6:1169-75 pubmed
    ..Our results raise the possibility that the transforming activity of the mammalian ect-2 oncogene could be due to hyperactivation of the RAS/MAPK pathway. ..
  20. Kurz T, Ozlu N, Rudolf F, O Rourke S, Luke B, Hofmann K, et al. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature. 2005;435:1257-61 pubmed
    ..Both in vivo and in vitro experiments indicate that Dcn1p does not inhibit deneddylation of Cdc53p by the COP9 signalosome, but greatly increases the kinetics of the neddylation reaction. ..
  21. Dutt A, Canevascini S, Froehli Hoier E, Hajnal A. EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid. PLoS Biol. 2004;2:e334 pubmed
    ..These results indicate that, in spite of their structural diversity, Rhomboid proteins play a conserved role in activating EGFR signaling in C. elegans, Drosophila, and possibly also in mammals. ..
  22. Hoerndli F, Walser M, Fröhli Hoier E, de Quervain D, Papassotiropoulos A, Hajnal A. A conserved function of C. elegans CASY-1 calsyntenin in associative learning. PLoS ONE. 2009;4:e4880 pubmed publisher
    ..Our experiments demonstrate a remarkable conservation of the molecular function of Calsyntenins between nematodes and humans and point at a role of C. elegans casy-1 in regulating a glutamate receptor signaling pathway. ..
  23. Couwenbergs C, Labbé J, Goulding M, Marty T, Bowerman B, Gotta M. Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans. J Cell Biol. 2007;179:15-22 pubmed
    ..These results indicate that dynein activity functions with regulators of G protein signaling to regulate common downstream effectors during spindle positioning in the early C. elegans embryo. ..
  24. Luke Glaser S, Pintard L, Tyers M, Peter M. The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line. J Cell Sci. 2007;120:3179-87 pubmed
    ..We conclude that degradation of FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis. ..
  25. Stetak A, Hoier E, Croce A, Cassata G, Di Fiore P, Hajnal A. Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development. EMBO J. 2006;25:2347-57 pubmed
    ..Extracellular signals thus regulate EGFR trafficking in a cell type-specific manner to control pattern formation during organogenesis. ..
  26. Nusser Stein S, Beyer A, Rimann I, Adamczyk M, Piterman N, Hajnal A, et al. Cell-cycle regulation of NOTCH signaling during C. elegans vulval development. Mol Syst Biol. 2012;8:618 pubmed publisher
    ..Our findings reveal a synchronization mechanism that coordinates NOTCH signaling with cell-cycle progression and thus permits the formation of a stable cell fate pattern. ..
  27. Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell. 2006;125:509-22 pubmed