Genomes and Genes
Experts and Doctors on amino acid sequence in Zurich, Switzerland
Locale: Zurich, Switzerland
Topic: amino acid sequence
Publications276 found, 100 shown here
- Kasper R, Shved N, Takahashi A, Reinecke M, Eppler E. A systematic immunohistochemical survey of the distribution patterns of GH, prolactin, somatolactin, beta-TSH, beta-FSH, beta-LH, ACTH, and alpha-MSH in the adenohypophysis of Oreochromis niloticus, the Nile tilapia. Cell Tissue Res. 2006;325:303-13 pubmed..This cross-reactivity was abolished by pre-absorption. We present a complete map of the distinct localisation sites for the classical pituitary hormones, thereby providing a solid basis for future research on teleost pituitary. ..
- Christen B, Wuthrich K, Hornemann S. Putative prion protein from Fugu (Takifugu rubripes). FEBS J. 2008;275:263-70 pubmed
- Butschi A, Titz A, Wälti M, Olieric V, Paschinger K, Nöbauer K, et al. Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. PLoS Pathog. 2010;6:e1000717 pubmed publisher..5 A resolution revealed the biophysical basis for this interaction. Our results suggest that fungal galectins play a role in the defense of fungi against predators by binding to specific glycoconjugates of these organisms. ..
- Mädler S, Seitz M, Robinson J, Zenobi R. Does chemical cross-linking with NHS esters reflect the chemical equilibrium of protein-protein noncovalent interactions in solution?. J Am Soc Mass Spectrom. 2010;21:1775-83 pubmed publisher..Consequently, based on the experimental approach used in this study, chemical cross-linking is not suitable for studying low-affinity complexes with K(D) > 25 ?M. ..
- Strycharska M, Arias Palomo E, Lyubimov A, Erzberger J, O Shea V, BUSTAMANTE C, et al. Nucleotide and partner-protein control of bacterial replicative helicase structure and function. Mol Cell. 2013;52:844-54 pubmed publisher..Our findings establish the DnaB collar as an autoregulatory hub that controls the ability of the helicase to transition between different functional states in response to both nucleotide and replication initiation/elongation factors. ..
- Magyar J, Ebensperger C, Schaeren Wiemers N, Suter U. Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family. Gene. 1997;189:269-75 pubmed..Expression analysis of the members of the MAL gene family indicates widespread expression in various tissues, suggesting a common role of these proteins in cell biology. ..
- Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, et al. Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli. Proc Natl Acad Sci U S A. 2014;111:E655-62 pubmed publisher..Our analysis also provides a structural rationale for the long-known effects of C-terminal palmitoylation reactions on G protein-coupled receptor signaling, receptor maturation, and desensitization. ..
- Boll W, Wagner P, Mantei N. Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase. Am J Hum Genet. 1991;48:889-902 pubmed..No allele was peculiar to the hypolactasic subject. We conclude that humans with high or low levels of lactase can code for identical LPH enzymes. ..
- Vorburger K, Lehner C, Kitten G, Eppenberger H, Nigg E. A second higher vertebrate B-type lamin. cDNA sequence determination and in vitro processing of chicken lamin B2. J Mol Biol. 1989;208:405-15 pubmed..Lamin precursors processing is discussed in relation to characteristic differences in the interactions of A and B-type lamins with the nuclear membrane. ..
- Reimmann C, Moore R, Little S, Savioz A, Willetts N, Haas D. Genetic structure, function and regulation of the transposable element IS21. Mol Gen Genet. 1989;215:416-24 pubmed..Analysis of the latter showed that IS21 had a low, but not totally random specificity of insertion and created target duplications of 4 bp (occasionally 5 bp).(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Hartmann C, Wagner C, Busch A, Markovich D, Biber J, Lang F, et al. Transport characteristics of a murine renal Na/Pi-cotransporter. Pflugers Arch. 1995;430:830-6 pubmed..The effect of Pi and Na concentration on the apparent Km values for Na or Pi, respectively, provides evidence for an ordered interaction of "cosubstrate" (Na first) and "substrate" (Pi or arsenate second). ..
- Meile L, Fischer K, Leisinger T. Characterization of the superoxide dismutase gene and its upstream region from Methanobacterium thermoautotrophicum Marburg. FEMS Microbiol Lett. 1995;128:247-53 pubmed..The amino acid sequence for this presumptive product had a similarity coefficient of 55.5% to a subunit of the alkyl hydroperoxide reductase (encoded by the ahpC gene) from Salmonella typhimurium. ..
- Brunisholz R, Suter F, Zuber H. Structural and spectral characterisation of the antenna complexes of Rhodocyclus gelatinosus. Indications of a hairpin-like-arranged antenna apoprotein with an unusually high alanine content. Eur J Biochem. 1994;222:667-75 pubmed..gelatinosus revealed some remarkable structural similarities within presumed cofactor-binding sites of Fe-S-type-reaction-centre apoproteins, indicating possible basic structural motifs for complexing bacteriochlorophyll molecules...
- Torres Schumann S, Ringli C, Heierli D, Amrhein N, Keller B. In vitro binding of the tomato bZIP transcriptional activator VSF-1 to a regulatory element that controls xylem-specific gene expression. Plant J. 1996;9:283-96 pubmed
- Pellegrini A. Antimicrobial peptides from food proteins. Curr Pharm Des. 2003;9:1225-38 pubmed..This raises the question, whether multifunctionality is an intrinsic property of many proteins or limited to a few. ..
- Raschke M, Bürkle L, Müller N, Nunes Nesi A, Fernie A, Arigoni D, et al. Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC. Proc Natl Acad Sci U S A. 2007;104:19637-42 pubmed..The results suggest that vitamin B1 biosynthesis in plants is in fact more similar to prokaryotic counterparts and that the THIC protein is likely to be the key regulatory protein in the pathway. ..
- Krattinger S, Lagudah E, Spielmeyer W, Singh R, Huerta Espino J, McFadden H, et al. A putative ABC transporter confers durable resistance to multiple fungal pathogens in wheat. Science. 2009;323:1360-3 pubmed publisher..Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges. ..
- Semmler A, Bao X, Cao G, Kohler W, Weller M, Aubourg P, et al. Genetic variants of methionine metabolism and X-ALD phenotype generation: results of a new study sample. J Neurol. 2009;256:1277-80 pubmed publisher..Whereas the influence of other polymorphisms of methionine metabolism was not confirmed, the present study supports the previously made observation that the Tc2 genotype contributes to X-ALD phenotype generation. ..
- Hoelzle K, Peter S, Sidler M, Kramer M, Wittenbrink M, Felder K, et al. Inorganic pyrophosphatase in uncultivable hemotrophic mycoplasmas: identification and properties of the enzyme from Mycoplasma suis. BMC Microbiol. 2010;10:194 pubmed publisher..As an antigenic and conserved protein the M. suis sPPase could in future be further analyzed as a diagnostic antigen. ..
- Atanesyan L, Günther V, Celniker S, Georgiev O, Schaffner W. Characterization of MtnE, the fifth metallothionein member in Drosophila. J Biol Inorg Chem. 2011;16:1047-56 pubmed publisher..MtnE expression is induced in response to heavy metals, notably copper, mercury, and silver, and is upregulated in a genetic background where the other four MTs are missing. ..
- Müller M, Allison J, Hongdilokkul N, Gaillon L, Kast P, van Gunsteren W, et al. Directed evolution of a model primordial enzyme provides insights into the development of the genetic code. PLoS Genet. 2013;9:e1003187 pubmed publisher..The increase in fitness they confer indicates that building blocks with very similar side chain structures are highly beneficial for fine-tuning protein structure and function. ..
- Schein C, Boix E, Haugg M, Holliger K, Hemmi S, Frank G, et al. Secretion of mammalian ribonucleases from Escherichia coli using the signal sequence of murine spleen ribonuclease. Biochem J. 1992;283 ( Pt 1):137-44 pubmed..Thus this eukaryotic signal sequence is both recognized by the E. coli transport and processing apparatus and gives efficient secretion, as well as export, of active, mature mammalian RNAases. ..
- Borer R, Lehner C, Eppenberger H, Nigg E. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell. 1989;56:379-90 pubmed..Moreover, they suggest that transient exposure of shuttling proteins to the cytoplasm may provide a mechanism for cytoplasmic regulation of nuclear activities. ..
- Szyperski T, Scheek S, Johansson J, Assmann G, Seedorf U, Wuthrich K. NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2. FEBS Lett. 1993;335:18-26 pubmed
- Roos M, Schachner M, Bernhardt R. Zebrafish semaphorin Z1b inhibits growing motor axons in vivo. Mech Dev. 1999;87:103-17 pubmed..Sema Z1b might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite. ..
- Marty C, Scheidegger P, Ballmer Hofer K, Klemenz R, Schwendener R. Production of functionalized single-chain Fv antibody fragments binding to the ED-B domain of the B-isoform of fibronectin in Pichia pastoris. Protein Expr Purif. 2001;21:156-64 pubmed..Our results indicate that the P. pastoris expression system is useful for the large-scale production of cysteine-functionalized alpha-ED-B scFv antibody fragments. ..
- El Andaloussi N, Valovka T, Toueille M, Hassa P, Gehrig P, Covic M, et al. Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen. FASEB J. 2007;21:26-34 pubmed..Together, our results provide evidence that PRMT1 methylation of pol beta might play a regulatory role in BER by preventing the involvement of pol beta in PCNA-dependent DNA metabolic events. ..
- Schulz N, Dave M, Stehberger P, Chau T, Wagner C. Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron. Cell Physiol Biochem. 2007;20:109-20 pubmed
- Erilova A, Brownfield L, Exner V, Rosa M, Twell D, Mittelsten Scheid O, et al. Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis. PLoS Genet. 2009;5:e1000663 pubmed publisher..We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues. ..
- Dominguez C, Fisette J, Chabot B, Allain F. Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. Nat Struct Mol Biol. 2010;17:853-61 pubmed publisher..We also show that isolated qRRMs of hnRNP F are sufficient to regulate the alternative splicing of the Bcl-x pre-mRNA, suggesting that hnRNP F would act by remodeling RNA secondary and tertiary structures. ..
- Wörsdörfer B, Woycechowsky K, Hilvert D. Directed evolution of a protein container. Science. 2011;331:589-92 pubmed publisher..Such structures could be used for diverse biotechnological applications in living cells. ..
- Kim H, Okamoto H, Felber A, Polomska A, Morone N, Heuser J, et al. Polymer-coated pH-responsive high-density lipoproteins. J Control Release. 2016;228:132-140 pubmed publisher..These data suggest that catHDL/PA may have a potential benefit to improve the cellular delivery and endosomal escape of therapeutics under mildly acidic conditions such as in tumor tissues. ..
- Meile L, Stettler R, Banholzer R, Kotik M, Leisinger T. Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg: molecular cloning and nucleotide sequence of a putative trpEGCFBAD operon. J Bacteriol. 1991;173:5017-23 pubmed..With the exception of TrpB, the beta subunit of tryptophan synthase, tryptophan was absent from all Trp polypeptides. ..
- Weidenhaupt M, Schmid Appert M, Thony B, Hennecke H, Fischer H. A new Bradyrhizobium japonicum gene required for free-living growth and bacteroid development is conserved in other bacteria and in plants. Mol Plant Microbe Interact. 1995;8:454-64 pubmed..The conservation of this DNA region in gram-negative and gram-positive bacteria suggests that the gene is essential for a fundamental cellular process which is required in B. japonicum for both free-living and symbiotic growth. ..
- Glaser A, Kirsch A, Zeller S, Menz G, Rhyner C, Crameri R. Molecular and immunological characterization of Asp f 34, a novel major cell wall allergen of Aspergillus fumigatus. Allergy. 2009;64:1144-51 pubmed publisher..fumigatus was identified as a major allergen. Asp f 34 belongs to the Aspergillus-specific proteins of the phiA family and has relevant potential for a specific diagnosis of Aspergillus sensitization. ..
- Graf R, Mehmann B, Braus G. Analysis of feedback-resistant anthranilate synthases from Saccharomyces cerevisiae. J Bacteriol. 1993;175:1061-8 pubmed..From analysis of these variants, we propose an extended sequence, LLESX10S, as the regulatory element in tryptophan-responsive anthranilate synthases from prokaryotic and eukaryotic organisms. ..
- Stöckli J, Honing S, Rohrer J. The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding. J Biol Chem. 2004;279:23542-9 pubmed..4-fold higher than that of AP-1. This could regulate the binding of the two proteins to the partly overlapping sorting signals, allowing AP-1 binding to the CD-MPR only when GGA1 is released upon autoinhibition by phosphorylation. ..
- Minder A, Narberhaus F, Babst M, Hennecke H, Fischer H. The dnaKJ operon belongs to the sigma32-dependent class of heat shock genes in Bradyrhizobium japonicum. Mol Gen Genet. 1997;254:195-206 pubmed..The growth rate of dnaJ mutants was reduced but the final cell density reached in rich medium and their symbiotic properties were indistinguishable from the wild type...
- Thony Meyer L. Biogenesis of respiratory cytochromes in bacteria. Microbiol Mol Biol Rev. 1997;61:337-76 pubmed..Formation of the multisubunit cytochrome bc, complex and several terminal oxidases of the bo3, bd, aa3, and cbb3 types is discussed in detail, and models for linear maturation pathways are proposed wherever possible. ..
- Bellaoui M, Keddie J, Gruissem W. DCL is a plant-specific protein required for plastid ribosomal RNA processing and embryo development. Plant Mol Biol. 2003;53:531-43 pubmed..These results suggest that DCL is required for chloroplast rRNA processing, and emphasize the importance of plastid function during embryogenesis. ..
- Rinderknecht M, Villa A, Ballmer Hofer K, Neri D, Detmar M. Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3. PLoS ONE. 2010;5:e11941 pubmed publisher..6 kDa. Anti-VEGF-C V(H)-based immunoproteins hold promise to block the lymphangiogenic activity of VEGF-C, which would present a significant advance in inhibiting lymphatic-based metastatic spread of certain cancer types. ..
- Ringli C. The hydroxyproline-rich glycoprotein domain of the Arabidopsis LRX1 requires Tyr for function but not for insolubilization in the cell wall. Plant J. 2010;63:662-9 pubmed publisher..Finally, modified LRX1 proteins lacking Tyr in the extensin domain are still insolubilized in the cell wall, indicating strong interactions of extensins within the cell wall in addition to the well-described Tyr cross-links. ..
- Hua H, Günther V, Georgiev O, Schaffner W. Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila. Biometals. 2011;24:445-53 pubmed publisher..In addition, compared to controls, Drosophila Atox1 mutants are relatively insensitive to the anticancer drug cisplatin, a compound which is also imported via Ctr1 copper transporters and was recently found to bind mammalian Atox1. ..
- Bantle S, Keller S, Haussmann I, Auerbach D, Perriard E, Muhlebach S, et al. Tissue-specific isoforms of chicken myomesin are generated by alternative splicing. J Biol Chem. 1996;271:19042-52 pubmed..We postulate that myomesin, M-protein, and skelemin belong to the same subfamily of high molecular weight M-band-associated proteins of the immunoglobulin superfamily and that they probably have the same ancestor in evolution. ..
- Epple P, Apel K, Bohlmann H. ESTs reveal a multigene family for plant defensins in Arabidopsis thaliana. FEBS Lett. 1997;400:168-72 pubmed..In seedlings, it is inducible by methyl jasmonate, silver nitrate, and different phytopathogenic fungi, notably Fusarium oxysporum f. sp. matthiolae. The regulation of Pdf1.2 resembles that of the pathogen-inducible thionin gene Thi2.1. ..
- Pellecchia M, Guntert P, Glockshuber R, Wuthrich K. NMR solution structure of the periplasmic chaperone FimC. Nat Struct Biol. 1998;5:885-90 pubmed..The availability of the NMR structure of FimC provides a new basis for rational design of drugs against infections by uropathogenic bacteria. ..
- Hvorup R, Goetz B, Niederer M, Hollenstein K, Perozo E, Locher K. Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF. Science. 2007;317:1387-90 pubmed..A comparison with BtuCD and the homologous HI1470/71 protein suggests that the structure of BtuCD-F may reflect a posttranslocation intermediate...
- Soranno A, Koenig I, Borgia M, Hofmann H, Zosel F, Nettels D, et al. Single-molecule spectroscopy reveals polymer effects of disordered proteins in crowded environments. Proc Natl Acad Sci U S A. 2014;111:4874-9 pubmed publisher..Our results suggest that excluded volume interactions between overlapping biopolymers and the resulting criticality of the system can be essential contributions to the physics governing the crowded cellular milieu. ..
- Ochsner U, Fiechter A, Reiser J. Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis. J Biol Chem. 1994;269:19787-95 pubmed..The controlled expression of the rhlAB genes in Escherichia coli led to the formation of active rhamnosyltransferase. This provides direct evidence for the fact that the rhamnosyltransferase encoding genes have been identified. ..
- Keller P, Semenza G, Shaltiel S. Phosphorylation of the N-terminal intracellular tail of sucrase-isomaltase by cAMP-dependent protein kinase. Eur J Biochem. 1995;233:963-8 pubmed
- Vasak M, Meloni G. Chemistry and biology of mammalian metallothioneins. J Biol Inorg Chem. 2011;16:1067-78 pubmed publisher..In this review, after a brief summary of the historical milestones of the MT-1/MT-2 research, the recent advances in the structure, chemistry, and biological function of MT-3 and MT-4 are discussed. ..
- Jacquemin E, Hagenbuch B, Stieger B, Wolkoff A, Meier P. Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc Natl Acad Sci U S A. 1994;91:133-7 pubmed
- Stieger B, Meier Y, Meier P. The bile salt export pump. Pflugers Arch. 2007;453:611-20 pubmed..Furthermore, many genetic variants of Bsep are known, some of which potentially render individuals susceptible to acquired forms of liver disease...
- Baumgartner M, Weiss A, Fritzius T, Heinrich J, Moelling K. The PDZ protein MPP2 interacts with c-Src in epithelial cells. Exp Cell Res. 2009;315:2888-98 pubmed publisher..In conclusion we demonstrate here that MPP2 interacts with c-Src in cells to control c-Src activity and morphological function. ..
- Xia T, Bushweller J, Sodano P, Billeter M, Bjornberg O, Holmgren A, et al. NMR structure of oxidized Escherichia coli glutaredoxin: comparison with reduced E. coli glutaredoxin and functionally related proteins. Protein Sci. 1992;1:310-21 pubmed..coli glutaredoxin showed a general trend to increase upon reduction. Only the sulfhydryl group of Cys 11 is exposed to the solvent, whereas that of Cys 14 is buried and solvent inaccessible. ..
- Beck J, Maerki S, Posch M, Metzger T, Persaud A, Scheel H, et al. Ubiquitylation-dependent localization of PLK1 in mitosis. Nat Cell Biol. 2013;15:430-9 pubmed publisher..Our data suggest that CUL3-KLHL22-mediated ubiquitylation signals degradation-independent removal of PLK1 from kinetochores and SAC satisfaction, which are required for faithful mitosis. ..
- Polymenidou M, Trusheim H, Stallmach L, Moos R, Julius C, Miele G, et al. Canine MDCK cell lines are refractory to infection with human and mouse prions. Vaccine. 2008;26:2601-14 pubmed publisher..These factors may account for their resistance to infection. Alternatively, prion resistance may be related to the specific sequence of canine Prnp, as suggested by the lack of documented prion diseases in dogs. ..
- Stefanic S, Spycher C, Morf L, Fabrias G, Casas J, Schraner E, et al. Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia. J Lipid Res. 2010;51:2527-45 pubmed publisher..In addition, we identified ceramide as a potent bioactive molecule, underscoring the universal conservation of ceramide signaling in eukaryotes. ..
- Klemenz R, Fröhli E, Aoyama A, Hoffmann S, Simpson R, Moritz R, et al. Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts. Mol Cell Biol. 1991;11:803-12 pubmed..In addition, we identified a second minor initiation site 49 nucleotides further upstream. Serum growth factors did not stimulate alpha B crystallin expression in growth-arrested cells. ..
- Barraud P, Emmerth S, Shimada Y, Hotz H, Allain F, B hler M. An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer. EMBO J. 2011;30:4223-35 pubmed publisher..The C-terminal domain of Dcr1 constitutes a novel regulatory module that might represent a potential target for therapeutic intervention with fungal diseases...
- Qian Y, Otting G, Furukubo Tokunaga K, Affolter M, Gehring W, Wuthrich K. NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein. Proc Natl Acad Sci U S A. 1992;89:10738-42 pubmed
- Rhyner J, Ottiger M, Wicki R, Greenwood T, Strehler E. Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2. Eur J Biochem. 1994;225:71-82 pubmed..The entire family consists of three bona fide CALM genes, at least one expressed calmodulin-like CALML gene as well as at least five pseudogenes. ..
- Preisig O, Zufferey R, Hennecke H. The Bradyrhizobium japonicum fixGHIS genes are required for the formation of the high-affinity cbb3-type cytochrome oxidase. Arch Microbiol. 1996;165:297-305 pubmed
- Meijerink E, Fries R, Vögeli P, Masabanda J, Wigger G, Stricker C, et al. Two alpha(1,2) fucosyltransferase genes on porcine chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. Mamm Genome. 1997;8:736-41 pubmed..coli F18 adhesion-resistant animals in this breed. Whether the FUT1 or possibly the FUT2 gene products are involved in the synthesis of carbohydrate structures responsible for bacterial adhesion remains to be determined. ..
- Bodmer S, Podlisny M, Selkoe D, Heid I, Fontana A. Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease. Biochem Biophys Res Commun. 1990;171:890-7 pubmed..The complex formation between TGF beta and beta APP may have important implications in regulation of biological activity of the two proteins and in delivery or clearance of TGF beta and beta APP in the brain and other compartments. ..
- Taylor V, Welcher A, Program A, Suter U. Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family. J Biol Chem. 1995;270:28824-33 pubmed..The proteins of this family are likely to serve similar functions possibly related to cell proliferation and differentiation in a variety of cell types. ..
- Birringer M, Claus M, Folkers G, Kloer D, Schulz G, Scapozza L. Structure of a type II thymidine kinase with bound dTTP. FEBS Lett. 2005;579:1376-82 pubmed..This results in a specificity difference exploited for antiviral therapy. The presented structure will foster the development of new drugs and prodrugs for numerous therapeutic applications. ..
- Kirioukhova O, Johnston A, Kleen D, Kägi C, Baskar R, Moore J, et al. Female gametophytic cell specification and seed development require the function of the putative Arabidopsis INCENP ortholog WYRD. Development. 2011;138:3409-20 pubmed publisher..Our data reveal a novel developmental function of the conserved cell cycle-associated INCENP protein in plant reproduction, in particular in the regulation of egg and central cell fate and differentiation. ..
- Daubner G, Cléry A, Jayne S, Stevenin J, Allain F. A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well. EMBO J. 2012;31:162-74 pubmed publisher..In conclusion, in addition to describe for the first time the RNA recognition mode of SRSF2, we provide the precise consensus sequence to identify new putative binding sites for this splicing factor. ..
- Reiland S, Messerli G, Baerenfaller K, Gerrits B, Endler A, Grossmann J, et al. Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks. Plant Physiol. 2009;150:889-903 pubmed publisher..We propose that ATP synthase is regulated in cooperation with 14-3-3 proteins by CKII-mediated phosphorylation of ATP synthase beta-subunit in the dark. ..
- Rüfenacht U, Gouya L, Schneider Yin X, Puy H, Schafer B, Aquaron R, et al. Systematic analysis of molecular defects in the ferrochelatase gene from patients with erythropoietic protoporphyria. Am J Hum Genet. 1998;62:1341-52 pubmed..Our systematic molecular study has resulted in a significant enlargement of the mutation repertoire in the FECH gene and has shed new light on the hereditary behavior of EPP. ..
- Cheneval D, Carafoli E. Identification and primary structure of the cardiolipin-binding domain of mitochondrial creatine kinase. Eur J Biochem. 1988;171:1-9 pubmed..Chemical modification of the basic amino acids Lys and Arg of the enzyme abolished its binding to cardiolipin. ..
- Caudron F, Denarier E, Thibout Quintana J, Brocard J, Andrieux A, Fourest Lieuvin A. Mutation of Ser172 in yeast ? tubulin induces defects in microtubule dynamics and cell division. PLoS ONE. 2010;5:e13553 pubmed publisher..In the absence of Mad2p-dependent spindle checkpoint, both mutations are deleterious. These findings show the importance of Ser172 for the correct function of both cytoplasmic and spindle MTs and for normal cell division. ..
- Huber S, Winterhalter K, Vaughan L. Isolation and sequence analysis of the glycosaminoglycan attachment site of type IX collagen. J Biol Chem. 1988;263:752-6 pubmed..That it is an adequate acceptor can be inferred from the observation that type IX collagen carries a glycosaminoglycan chain on over 70% of the molecules isolated. ..
- Mouillet J, Henrich V, Lezzi M, Vogtli M. Differential control of gene activity by isoforms A, B1 and B2 of the Drosophila ecdysone receptor. Eur J Biochem. 2001;268:1811-9 pubmed..Furthermore, they provide evidence for the existence of an autonomous ligand-independent activation function (AF1) in the A/B domains of EcRB1 and EcRB2 and of an inhibitory function (IF) in the A/B domain of EcRA. ..
- Zahn R, Güntert P, von Schroetter C, Wuthrich K. NMR structure of a variant human prion protein with two disulfide bridges. J Mol Biol. 2003;326:225-34 pubmed
- Oberstrass F, Auweter S, Erat M, Hargous Y, Henning A, Wenter P, et al. Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science. 2005;309:2054-7 pubmed..Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor. ..
- Schwinkendorf D, Gallant P. The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in vivo. Gene. 2009;436:90-100 pubmed publisher..Thus, although MB2 and MB3 are highly conserved in evolution, loss of either domain has comparatively mild consequences on Myc activity in vivo. ..
- Von Niederhäusern V, Kastenhuber E, Stäuble A, Gesemann M, Neuhauss S. Phylogeny and expression of canonical transient receptor potential (TRPC) genes in developing zebrafish. Dev Dyn. 2013;242:1427-41 pubmed publisher..Intriguingly, zebrafish paralogs show mainly nonoverlapping expression patterns, suggesting that duplicated genes have either split their functions or have adapted new ones. ..
- Gottfert M, Holzhäuser D, Bani D, Hennecke H. Structural and functional analysis of two different nodD genes in Bradyrhizobium japonicum USDA110. Mol Plant Microbe Interact. 1992;5:257-65 pubmed..We conclude from these data that nodD1 is the critical gene that contributes to maximal nodulation efficiency, whereas the nodD2 gene does not play any obvious role in nodulation of the host plants tested. ..
- Schläpfer B, Portmann W, Branlant C, Branlant G, Zuber H. Nucleotide sequence of the glyceraldehyde-3-phosphate dehydrogenase from Bacillus megaterium. Nucleic Acids Res. 1990;18:6422 pubmed
- Wulf P, Bernhardt R, Suter U. Characterization of peripheral myelin protein 22 in zebrafish (zPMP22) suggests an early role in the development of the peripheral nervous system. J Neurosci Res. 1999;57:467-78 pubmed