Experts and Doctors on zebrafish in Uppsala, Sweden

Summary

Locale: Uppsala, Sweden
Topic: zebrafish

Top Publications

  1. Carlsson G, Patring J, Kreuger J, Norrgren L, Oskarsson A. Toxicity of 15 veterinary pharmaceuticals in zebrafish (Danio rerio) embryos. Aquat Toxicol. 2013;126:30-41 pubmed publisher
    ..It is suggested that the toxic effect of febantel in zebrafish embryos is due to metabolism into fenbendazole. ..
  2. Ulhaq M, Carlsson G, Orn S, Norrgren L. Comparison of developmental toxicity of seven perfluoroalkyl acids to zebrafish embryos. Environ Toxicol Pharmacol. 2013;36:423-6 pubmed publisher
    ..The EC50 values ranged from 1.5 to 2200mg/L. We observed a relationship between higher toxicity with longer carbon chain. In addition, we also observed a higher toxicity for sulfonic PFAAs than for carboxylic PFAAs. ..
  3. Fredriksson R, Höglund P, Gloriam D, Lagerström M, Schioth H. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 2003;554:381-8 pubmed
    ..Several ESTs for GPR141 were found in marrow and cancer cells, while the other receptors seem to have more restricted expression patterns. ..
  4. Filipek Gorniok B, Holmborn K, Haitina T, Habicher J, Oliveira M, Hellgren C, et al. Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development. Dev Dyn. 2013;242:964-75 pubmed publisher
    ..The overlap between intense CS/DS production and the expression of multiple CS/DS glycosyltransferases suggests that efficient CS/DS biosynthesis requires a combination of several glycosyltransferases. ..
  5. Noonin C, Watthanasurorot A, Winberg S, Söderhäll I. Circadian regulation of melanization and prokineticin homologues is conserved in the brain of freshwater crayfish and zebrafish. Dev Comp Immunol. 2013;40:218-26 pubmed publisher
    ..Therefore, this study shows that circadian oscillation of prokineticin homologues and enzymes involved in melanization are conserved. ..
  6. Sundström E, Komisarczuk A, Jiang L, Golovko A, Navratilova P, Rinkwitz S, et al. Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses. Pigment Cell Melanoma Res. 2012;25:28-36 pubmed publisher
    ..These results provide strong support for the causative nature of the duplication and constitute an explanation for the melanocyte-specific effects of the Grey allele. ..
  7. Reischauer S, Stone O, Villasenor A, Chi N, Jin S, Martin M, et al. Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 2016;535:294-8 pubmed publisher
  8. Starbäck P, Lundell I, Fredriksson R, Berglund M, Yan Y, Wraith A, et al. Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor. Brain Res Mol Brain Res. 1999;70:242-52 pubmed
    ..Thus, the sequence comparisons, pharmacological properties, and chromosomal localization suggest that the zYa receptor is a novel NPY receptor subtype which is likely to be present also in mammals. ..
  9. Svensson J, Mustafa A, Fick J, Schmitz M, Brunström B. Developmental exposure to progestins causes male bias and precocious puberty in zebrafish (Danio rerio). Aquat Toxicol. 2016;177:316-23 pubmed publisher
    ..Our results show that progestins can affect sexual development in fish and that the androgenic progestin levonorgestrel induces a male phenotype at concentrations similar to those detected in aquatic environments. ..

More Information

Publications20

  1. Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, et al. BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors. Stem Cell Reports. 2016;6:64-73 pubmed publisher
    ..Our study illustrates that BMP exerts its self-renewing effect through distinct functions of different Krüppel-like factors. ..
  2. Holmborn K, Habicher J, Kasza Z, Eriksson A, Filipek Gorniok B, Gopal S, et al. On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. J Biol Chem. 2012;287:33905-16 pubmed
  3. Carlsson G, Patring J, Ullerås E, Oskarsson A. Developmental toxicity of albendazole and its three main metabolites in zebrafish embryos. Reprod Toxicol. 2011;32:129-37 pubmed publisher
    ..Chemical analysis showed that at sublethal concentrations, most of ABZ was metabolized to ABZSO. The results demonstrate that in zebrafish embryos ABZ rather than ABZSO displays developmental toxicity...
  4. Sundstrom G, Larsson T, Larhammar D. Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. BMC Evol Biol. 2008;8:254 pubmed publisher
    ..The gene duplicates presumably provided raw material in early vertebrate evolution for neofunctionalization and subfunctionalization. ..
  5. Berlin S, Smith N. Testing for adaptive evolution of the female reproductive protein ZPC in mammals, birds and fishes reveals problems with the M7-M8 likelihood ratio test. BMC Evol Biol. 2005;5:65 pubmed publisher
  6. Fredriksson R, Sjödin P, Larson E, Conlon J, Larhammar D. Cloning and characterization of a zebrafish Y2 receptor. Regul Pept. 2006;133:32-40 pubmed
    ..Y2 from zebrafish binds very poorly to the Y2-specific antagonist BIIE0246. Our pharmacological characterization supports our previous conclusions regarding the binding pocket of BIIE0246 in the human Y2 receptor. ..
  7. Gloriam D, Bjarnadóttir T, Yan Y, Postlethwait J, Schioth H, Fredriksson R. The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish. Mol Phylogenet Evol. 2005;35:470-82 pubmed
    ..The evolutionary history of the TA-receptors is more complex than for most other GPCR families and here we suggest a mechanism by which they may have arisen...
  8. Park H, Marklund S, Jeon J, Mickelson J, Valberg S, Sandberg K, et al. Molecular characterization and mutational screening of the PRKAG3 gene in the horse. Cytogenet Genome Res. 2003;102:211-6 pubmed publisher
    ..The results will facilitate future studies of the possible functional significance of PRKAG3 polymorphisms in horses...
  9. Ringholm A, Fredriksson R, Poliakova N, Yan Y, Postlethwait J, Larhammar D, et al. One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. J Neurochem. 2002;82:6-18 pubmed
  10. Mattsson A, Ullerås E, Patring J, Oskarsson A. Albendazole causes stage-dependent developmental toxicity and is deactivated by a mammalian metabolization system in a modified zebrafish embryotoxicity test. Reprod Toxicol. 2012;34:31-42 pubmed publisher
    ..To conclude, the modified zebrafish embryotoxicity test with MAS can be expanded for assessment of metabolites at different developmental stages...
  11. Fredriksson R, Larson E, Yan Y, Postlethwait J, Larhammar D. Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications. J Mol Evol. 2004;58:106-14 pubmed
    ..The Y7 receptor supports the theory of early vertebrate genome duplications and suggests that the Y family of receptors is a result of these early genome duplications. ..