Experts and Doctors on ribonucleotides in Stockholm, Sweden


Locale: Stockholm, Sweden
Topic: ribonucleotides

Top Publications

  1. Yamada T, Zhang S, Westerblad H, Katz A. {beta}-Hydroxybutyrate inhibits insulin-mediated glucose transport in mouse oxidative muscle. Am J Physiol Endocrinol Metab. 2010;299:E364-73 pubmed publisher
    ..These data demonstrate that BOH inhibits insulin-mediated glucose transport in oxidative muscle by inhibiting insulin signaling. Thus ketone bodies may be potent diabetogenic agents in vivo. ..
  2. Song X, Fiedler M, Galuska D, Ryder J, Fernstrom M, Chibalin A, et al. 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice. Diabetologia. 2002;45:56-65 pubmed
  3. Roos K, Siegbahn P. Oxygen cleavage with manganese and iron in ribonucleotide reductase from Chlamydia trachomatis. J Biol Inorg Chem. 2011;16:553-65 pubmed publisher
    ..A tentative energy profile of the thermodynamics of the radical transfer from R2 to subunit I is constructed to illustrate how the stability of the active states can be understood from a thermodynamical point of view. ..
  4. Koistinen H, Chibalin A, Zierath J. Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients. Diabetologia. 2003;46:1324-8 pubmed
    ..However, basal p38 MAPK phosphorylation is increased in skeletal muscle from Type 2 diabetic patients. Thus, aberrant p38 MAPK signalling might contribute to the pathogenesis of insulin resistance. ..
  5. Al Khalili L, Forsgren M, Kannisto K, Zierath J, Lonnqvist F, Krook A. Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1. Diabetologia. 2005;48:1173-9 pubmed
    ..These data show that chronic treatment of human myotubes with insulin, metformin or rosiglitazone has a direct positive effect on insulin action and mRNA expression. ..
  6. Norrbom J, Sallstedt E, Fischer H, Sundberg C, Rundqvist H, Gustafsson T. Alternative splice variant PGC-1?-b is strongly induced by exercise in human skeletal muscle. Am J Physiol Endocrinol Metab. 2011;301:E1092-8 pubmed publisher
  7. Szekeres F, Chadt A, Tom R, Deshmukh A, Chibalin A, Björnholm M, et al. The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. Am J Physiol Endocrinol Metab. 2012;303:E524-33 pubmed publisher
    ..In conclusion, TBC1D1 plays a role in regulation of glucose metabolism in skeletal muscle. Moreover, functional TBC1D1 is required for AICAR- or contraction-induced metabolic responses, implicating a role in energy-sensing signals. ..
  8. Al Khalili L, Chibalin A, Yu M, Sjödin B, Nylén C, Zierath J, et al. MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol. 2004;286:C1410-6 pubmed
    ..Thus activation of MEF2 in skeletal muscle is regulated via parallel intracellular signaling pathways in response to insulin, cellular stress, or activation of AMPK. ..
  9. Vieira E, Nilsson E, Nerstedt A, Ormestad M, Long Y, Garcia Roves P, et al. Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle. Am J Physiol Endocrinol Metab. 2008;295:E1032-7 pubmed publisher
    ..Our results indicate AMPK heterotrimeric complexes containing the AMPKgamma(3) subunit may play a specific role in linking circadian oscillators and energy metabolism in skeletal muscle. ..

More Information


  1. Glund S, Treebak J, Long Y, Barres R, Viollet B, Wojtaszewski J, et al. Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle. Endocrinology. 2009;150:600-6 pubmed publisher
    ..Furthermore, in addition to activating AMPK, AICAR suppresses IL-6 release by an unknown, AMPK-independent mechanism. ..