Experts and Doctors on nad in Stockholm, Sweden
Locale: Stockholm, Sweden
Perez Zabaleta M, Sjöberg G, Guevara Martínez M, Jarmander J, Gustavsson M, Quillaguamán J, et al
. Increasing the production of (R)-3-hydroxybutyrate in recombinant Escherichia coli by improved cofactor supply. Microb Cell Fact. 2016;15:91 pubmed publisher
..Acetic acid production is still the dominating by-product and this needs attention in the future to increase the volumetric productivity further. ..
Pontén E, Stål P. Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis. J Neurol Sci. 2007;253:25-33 pubmed
Aslund F, Ehn B, Miranda Vizuete A, Pueyo C, Holmgren A. Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant. Proc Natl Acad Sci U S A. 1994;91:9813-7 pubmed
..The physiological functions of Grx2 and Grx3 remain to be determined. ..
Svensson S, Hoog J, Schneider G, Sandalova T. Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency. J Mol Biol. 2000;302:441-53 pubmed
..This is consistent with hydrogen transfer from an alcoholate intermediate where the Pro/His replacement focuses on the function of the enzyme. ..
Hedberg J, Griffiths W, Nilsson S, Höög J. Reduction of S-nitrosoglutathione by human alcohol dehydrogenase 3 is an irreversible reaction as analysed by electrospray mass spectrometry. Eur J Biochem. 2003;270:1249-56 pubmed
..We propose that alcohol dehydrogenase 3 catalysed S-nitrosoglutathione reduction is of physiological relevance in the metabolism of NO in humans. ..
Li Y, He X, Li Y, He J, Anderstam B, Andersson G, et al
. Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals. J Bone Miner Res. 2011;26:2656-64 pubmed publisher
..Furthermore, we suggest that side effects on bone should be considered when evaluating the long-term safety of NAD-interfering pharmaceuticals. ..
Mardinoglu A, Björnson E, Zhang C, Klevstig M, Soderlund S, Ståhlman M, et al
. Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. Mol Syst Biol. 2017;13:916 pubmed publisher
..In a proof-of-concept human study, we found improved liver function and decreased HS after supplementation with serine (a precursor to glycine) and hereby propose a strategy for NAFLD treatment. ..