Experts and Doctors on mitochondria in Uppsala, Sweden


Locale: Uppsala, Sweden
Topic: mitochondria

Top Publications

  1. Sun R, Eriksson S, Wang L. Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity. Nucleosides Nucleotides Nucleic Acids. 2010;29:382-5 pubmed publisher
    ..However, mitochondrial phosphorylation of both dThd and dCyd was inhibited by AZT and FLT. Here a preliminary identification and characterization of mitochondrial factors is reported. ..
  2. Leino M, Teixeira R, Landgren M, Glimelius K. Brassica napus lines with rearranged Arabidopsis mitochondria display CMS and a range of developmental aberrations. Theor Appl Genet. 2003;106:1156-63 pubmed
    ..The existence of numerous CMS lines with different mitochondrial patterns involving a species with a sequenced genome offers new opportunities to investigate the genetic regulation of CMS and its associated developmental perturbations. ..
  3. Hammargren J, Rosenquist S, Jansson C, Knorpp C. A novel connection between nucleotide and carbohydrate metabolism in mitochondria: sugar regulation of the Arabidopsis nucleoside diphosphate kinase 3a gene. Plant Cell Rep. 2008;27:529-34 pubmed
    ..In this study we used two mutants containing T-DNA insertions in WRKY-genes, AtWrky4 and AtWrky34, to investigate the possible involvement of WRKY transcription factors in the sugar induction of NDPK3a. ..
  4. Jullig M, Eriksson S. Mitochondrial and submitochondrial localization of human deoxyguanosine kinase. Eur J Biochem. 2000;267:5466-72 pubmed
  5. Hoglund J, Morrison D, Mattsson J, Engstrom A. Population genetics of the bovine/cattle lungworm (Dictyocaulus viviparus) based on mtDNA and AFLP marker techniques. Parasitology. 2006;133:89-99 pubmed
    ..Second, the 2 smaller genetic groups occurred on farms where the predominant group also occurred, suggesting that these farms have had multiple introductions of D. viviparus...
  6. Metzendorf C, Lind M. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. BMC Dev Biol. 2010;10:68 pubmed publisher
    ..Furthermore, due to the similar expression patterns of some mitochondrial iron metabolism genes in Drosophila and mammals, it is likely that our results are applicable for mammals as well. ..
  7. Andersson S. Bioenergetics of the obligate intracellular parasite Rickettsia prowazekii. Biochim Biophys Acta. 1998;1365:105-11 pubmed
    ..prowazekii and to discuss the results of phylogenetic reconstructions based on a variety of bioenergetic molecules which shed light on the origin and evolution of the mitochondrial genomes...
  8. Rao S, Sigl V, Wimmer R, Novatchkova M, Jais A, Wagner G, et al. RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes Dev. 2017;31:2099-2112 pubmed publisher
    ..Inhibition of RANK using the approved drug denosumab may be a therapeutic drug candidate for primary lung cancer. ..
  9. Friederich Persson M, Thörn E, Hansell P, Nangaku M, Levin M, Palm F. Kidney hypoxia, attributable to increased oxygen consumption, induces nephropathy independently of hyperglycemia and oxidative stress. Hypertension. 2013;62:914-9 pubmed publisher

More Information


  1. Maklakov A, Lummaa V. Evolution of sex differences in lifespan and aging: causes and constraints. Bioessays. 2013;35:717-24 pubmed publisher
  2. Friederich Persson M, Aslam S, Nordquist L, Welch W, Wilcox C, Palm F. Acute knockdown of uncoupling protein-2 increases uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys. PLoS ONE. 2012;7:e39635 pubmed publisher
    ..However, blockade of the diabetes-induced upregulation of UCP- 2 results in excessive uncoupling and reduced oxidative stress in the kidney via activation of ANT. ..
  3. Persson M, Franzen S, Catrina S, Dallner G, Hansell P, Brismar K, et al. Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes. Diabetologia. 2012;55:1535-43 pubmed publisher
  4. Friederich M, Fasching A, Hansell P, Nordquist L, Palm F. Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells. Biochim Biophys Acta. 2008;1777:935-40 pubmed publisher
    ..This mechanism may be protective against diabetes-induced oxidative stress, but will increase O(2) usage. The subsequently reduced O(2) availability may contribute to diabetes-induced progressive kidney damage. ..
  5. Wang L, Hellman U, Eriksson S. Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA. FEBS Lett. 1996;390:39-43 pubmed
    ..The coding sequence of dGK showed 46% identity to the coding sequence of cytosolic deoxycytidine kinase, and conserved sequence motifs among the known deoxynucleoside kinase were identified. ..
  6. Wang L, Eriksson S. Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion. Nucleosides Nucleotides Nucleic Acids. 2010;29:400-3 pubmed publisher
    ..In most tissues TK2 is the only salvage enzyme present except liver and spleen. These results may help to explain the mechanisms of mitochondrial toxicity of antiviral nucleoside analogues and mtDNA depletion caused by TK2 deficiency. ..
  7. Carlsson J, Leino M, Sohlberg J, Sundstrom J, Glimelius K. Mitochondrial regulation of flower development. Mitochondrion. 2008;8:74-86 pubmed
    ..Here, we review the mitochondrial influence on flower development and give examples from CMS-systems developed in Brassica, Daucus carota, Nicotiana tabacum and Triticum aestivum. ..
  8. Troell K, Engström A, Morrison D, Mattsson J, Hoglund J. Global patterns reveal strong population structure in Haemonchus contortus, a nematode parasite of domesticated ruminants. Int J Parasitol. 2006;36:1305-16 pubmed
    ..contortus, the calculation of population structure gave high values (Nst=0.59). The strong structure was present also for the four Swedish isolates (Nst=0.16) representing a small geographical area...
  9. Atkinson G, Baldauf S. Evolution of elongation factor G and the origins of mitochondrial and chloroplast forms. Mol Biol Evol. 2011;28:1281-92 pubmed publisher
    ..Thus, the potential for fine tuning afforded by subfunctionalization may explain the maintenance of EF-G paralogs...
  10. Nabholz B, Ellegren H, Wolf J. High levels of gene expression explain the strong evolutionary constraint of mitochondrial protein-coding genes. Mol Biol Evol. 2013;30:272-84 pubmed publisher
    ..Our results not only reaffirm the link between gene expression and protein evolution but also open new questions about the functional role of expression level variation between mitochondrial genes. ..
  11. Amiri H, Karlberg O, Andersson S. Deep origin of plastid/parasite ATP/ADP translocases. J Mol Evol. 2003;56:137-50 pubmed
    ..A possible function of the two types of ATP/ADP translocases was to allow switches between glycolysis and aerobic respiration in the early eukaryotic cell and its endosymbiont...
  12. Wiemerslage L, Lee D. Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters. J Neurosci Methods. 2016;262:56-65 pubmed publisher
    ..We suggest at least four variables should be considered when using mitochondrial structure as an experimental endpoint. ..
  13. Harish A, Kurland C. Akaryotes and Eukaryotes are independent descendants of a universal common ancestor. Biochimie. 2017;138:168-183 pubmed publisher
    ..Finally, innovation of novel superfamilies has played a surprisingly small role in the evolution of Akaryotes and only a marginal role in the evolution of Eukaryotes. ..