Genomes and Genes
Experts and Doctors on brain injuries in Stockholm, Sweden
Locale: Stockholm, Sweden
Topic: brain injuries
- Nekludov M, Bellander B, Blomback M, Wallen H. Platelet dysfunction in patients with severe traumatic brain injury. J Neurotrauma. 2007;24:1699-706 pubmed..The observed platelet dysfunction appears to involve the cyclooxygenase pathway. TEG-PM analysis can be used to identify patients with a high risk of bleeding complications. ..
- Froelich M, Ni Q, Wess C, Ougorets I, Hartl R. Continuous hypertonic saline therapy and the occurrence of complications in neurocritically ill patients. Crit Care Med. 2009;37:1433-41 pubmed publisher..However, there was a significant risk of developing hypernatremia. We conclude that CHS administration in patients with severe injuries is safe as long as sodium levels are carefully monitored. ..
- Ho J, Kleiven S. Can sulci protect the brain from traumatic injury?. J Biomech. 2009;42:2074-80 pubmed publisher..The results suggested that the inclusion of sulci should be considered for future FE head models as it alters the strain and strain distribution in an FE model. ..
- Lundberg J, Sodersten E, Sundström E, Le Blanc K, Andersson T, Hermanson O, et al. Targeted intra-arterial transplantation of stem cells to the injured CNS is more effective than intravenous administration: engraftment is dependent on cell type and adhesion molecule expression. Cell Transplant. 2012;21:333-43 pubmed publisher..In addition, we conclude that careful analysis of cells intended for local, intra-arterial transplantation with respect to integrin expression is important. ..
- Nelson D, Nyström H, MacCallum R, Thornquist B, Lilja A, Bellander B, et al. Extended analysis of early computed tomography scans of traumatic brain injured patients and relations to outcome. J Neurotrauma. 2010;27:51-64 pubmed publisher..Finally we present a practical clinical "rule of thumb" to help predict the probability of unfavorable outcome using clinical and CT variables. ..
- Nygren De Boussard C, Holm L, Cancelliere C, Godbolt A, Boyle E, Stålnacke B, et al. Nonsurgical interventions after mild traumatic brain injury: a systematic review. Results of the International Collaboration on Mild Traumatic Brain Injury Prognosis. Arch Phys Med Rehabil. 2014;95:S257-64 pubmed publisher..Well-designed intervention studies are required to develop effective treatments and improve outcomes for adults and children at risk for persistent symptoms after MTBI. ..
- von Holst H, Li X, Kleiven S. Increased strain levels and water content in brain tissue after decompressive craniotomy. Acta Neurochir (Wien). 2012;154:1583-93 pubmed publisher..Hence, this new numerical method provides more insight of the consequences following DC and may be used to better define the most optimal size and area of the craniotomy in reducing the strain level development. ..
- Rostami E, Davidsson J, Gyorgy A, Agoston D, Risling M, Bellander B. The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury. J Neurotrauma. 2013;30:1954-65 pubmed publisher..The role of complement activation in TAI is unclear, but might indicate an alternative function following rot-TBI, such as opsonizing the synapses for elimination. ..
- Rostami E, Krueger F, Zoubak S, Dal Monte O, Raymont V, Pardini M, et al. BDNF polymorphism predicts general intelligence after penetrating traumatic brain injury. PLoS ONE. 2011;6:e27389 pubmed publisher..Identifying the underlying mechanism of this brain-derived neurotrophic factor effect could provide insight into an important aspect of post-traumatic cognitive recovery. ..
- Witman N, Behm M, Ohman M, Morrison J. ADAR-related activation of adenosine-to-inosine RNA editing during regeneration. Stem Cells Dev. 2013;22:2254-67 pubmed publisher..The link between RNA editing and regeneration provides further insights into how lower organisms, such as the newt, can activate essential molecular pathways via the discrete alteration of RNA sequences...
- von Holst H, Li X. Numerical impact simulation of gradually increased kinetic energy transfer has the potential to break up folded protein structures resulting in cytotoxic brain tissue edema. J Neurotrauma. 2013;30:1192-9 pubmed publisher..The definition of mild, moderate, and severe TBI should thus be looked upon as the same condition and separated only by a gradual severity of impact. ..
- Thelin E, Johannesson L, Nelson D, Bellander B. S100B is an important outcome predictor in traumatic brain injury. J Neurotrauma. 2013;30:519-28 pubmed publisher..Early samples of S100B, within 12?h after trauma, appear to have little prognostic value, and S100B should likely be sampled 12-36?h following trauma to best enhance TBI outcome prediction. ..
- Plantman S. Osteopontin is upregulated after mechanical brain injury and stimulates neurite growth from hippocampal neurons through ?1 integrin and CD44. Neuroreport. 2012;23:647-52 pubmed publisher..Finally, growth on OPN was mediated through ?1 intregrins and CD44. These findings indicate that injury-induced OPN may support neurite sprouting, suggesting a role for this molecule in recovery from central nervous system trauma. ..
- Kenne E, Erlandsson A, Lindbom L, Hillered L, Clausen F. Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice. J Neuroinflammation. 2012;9:17 pubmed publisher..Our results suggest that neutrophils are involved in the edema formation, but not the extravasation of large proteins, as well as contributing to cell death and tissue loss following TBI in mice. ..
- Nakahara M, Ericson K, Bellander B. Diffusion-weighted MR and apparent diffusion coefficient in the evaluation of severe brain injury. Acta Radiol. 2001;42:365-9 pubmed..To study apparent diffusion coefficient (ADC) maps in severely brain-injured patients...
- Nelson D, Thornquist B, MacCallum R, Nyström H, Holst A, Rudehill A, et al. Analyses of cerebral microdialysis in patients with traumatic brain injury: relations to intracranial pressure, cerebral perfusion pressure and catheter placement. BMC Med. 2011;9:21 pubmed publisher..This suggests that disturbances other than pressure and/or flow have a dominant influence on MD levels in patients with TBI. ..
- Sköld M, von Gertten C, Sandberg Nordqvist A, Mathiesen T, Holmin S. VEGF and VEGF receptor expression after experimental brain contusion in rat. J Neurotrauma. 2005;22:353-67 pubmed..The data provide a foundation for future pharmacological intervention studies focusing on posttraumatic angiogenesis and possible injury repair effects of the VEGF system in TBI. ..
- Al Nimer F, Ström M, Lindblom R, Aeinehband S, Bellander B, Nyengaard J, et al. Naturally occurring variation in the Glutathione-S-Transferase 4 gene determines neurodegeneration after traumatic brain injury. Antioxid Redox Signal. 2013;18:784-94 pubmed publisher..A naturally occurring variation in Gsta4 expression in rats affects neurodegeneration after TBI. Further studies are needed to explore if genetic variability in Gsta4 can be associated to outcome also in human TBI. ..
- Lu M, Zhang X, Mix E, Quezada H, Jin T, Zhu J, et al. TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice. J Neurosci Res. 2008;86:1608-14 pubmed publisher..These data suggest that TNF-alpha may play a protective role through TNFR1 signaling. ..
- Gahm C, Holmin S, Rudehill S, Mathiesen T. Neuronal degeneration and iNOS expression in experimental brain contusion following treatment with colchicine, dexamethasone, tirilazad mesylate and nimodipine. Acta Neurochir (Wien). 2005;147:1071-84; discussion 1084 pubmed..Early neuroprotection may to some extent target iNOS via different pathways since all tested drugs affected both iNOS expression and neuronal degeneration. ..