Experts and Doctors on adenylate kinase in Stockholm, Sweden
Locale: Stockholm, Sweden
Topic: adenylate kinase
Van Rompay A, Johansson M, Karlsson A. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. Eur J Biochem. 1999;261:509-17 pubmed
..Based on the substrate specificity and the sequence similarity with the previously identified human adenylate kinases, we have named this novel enzyme adenylate kinase 5. ..
Kohler C, Gahm A, Noma T, Nakazawa A, Orrenius S, Zhivotovsky B. Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett. 1999;447:10-2 pubmed
..Thus, our data suggest that only intermembrane proteins are released from mitochondria during the early phase of the apoptotic process. ..
Zhang S, Sandström M, Aydin J, Westerblad H, Wieringa B, Katz A. Activation of glucose transport and AMP-activated protein kinase during muscle contraction in adenylate kinase-1 knockout mice. Acta Physiol (Oxf). 2008;192:413-20 pubmed
..In conclusion, AK(-/-) mice have a normal capacity for contraction-mediated glucose uptake. This appears to occur via increases in AMP and reactive oxygen species that result in the activation of AMPK. ..
Norrbom J, Sallstedt E, Fischer H, Sundberg C, Rundqvist H, Gustafsson T. Alternative splice variant PGC-1?-b is strongly induced by exercise in human skeletal muscle. Am J Physiol Endocrinol Metab. 2011;301:E1092-8 pubmed publisher
Apró W, Wang L, Pontén M, Blomstrand E, Sahlin K. Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle. Am J Physiol Endocrinol Metab. 2013;305:E22-32 pubmed publisher
..It is also suggested that prior activation of mTORC1 signaling may repress subsequent phosphorylation of AMPK. ..
Jiang L, de Castro Barbosa T, Massart J, Deshmukh A, LÃ¶fgren L, Duque Guimarães D, et al
. Diacylglycerol kinase-Î´ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics. Am J Physiol Endocrinol Metab. 2016;310:E51-60 pubmed publisher
..DGKÎ´ deficiency also influences skeletal muscle energetics, which may lead to low physical activity levels in type 2 diabetes. ..
Ruby M, Riedl I, Massart J, Åhlin M, Zierath J. Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2017;313:E483-E491 pubmed publisher
..Identification of PKN2 as a novel regulator of insulin and AMPK signaling may provide an avenue for manipulation of skeletal muscle metabolism. ..