Experts and Doctors on parathyroid hormone related protein in Madrid, Spain


Locale: Madrid, Spain
Topic: parathyroid hormone related protein

Top Publications

  1. Martinez P, Esbrit P, Rodrigo A, Alvarez Arroyo M, Martinez M. Age-related changes in parathyroid hormone-related protein and vascular endothelial growth factor in human osteoblastic cells. Osteoporos Int. 2002;13:874-81 pubmed
    ..These data might provide a rationale to explain the impaired angiogenesis associated with trabecular bone loss in aging. ..
  2. Gómez García L, Esbrit P, Carreno L, Sabando P, Garcia Flores M, Martinez M. Alendronate interacts with the inhibitory effect of 1,25(OH)2D3 on parathyroid hormone-related protein expression in human osteoblastic cells. J Bone Miner Res. 2003;18:78-87 pubmed
    ..Our findings indicate that an increase in calcium influx appears to be involved in the mechanism mediating this effect of alendronate. ..
  3. Perez Martinez F, Alonso V, Sarasa J, Nam Cha S, Vela Navarrete R, Manzarbeitia F, et al. Immunohistochemical analysis of low-grade and high-grade prostate carcinoma: relative changes of parathyroid hormone-related protein and its parathyroid hormone 1 receptor, osteoprotegerin and receptor activator of nuclear factor-kB ligand. J Clin Pathol. 2007;60:290-4 pubmed
    ..Our findings indicate that, in most patients with PCa (with Ki67 values between 1% and 9%), sequential determination of C-terminal PTHrP and RANKL immunoreactivities is a useful approach to discriminate low-grade and high-grade tumours. ..
  4. Lozano D, Manzano M, Doadrio J, Salinas A, Vallet Regi M, Gomez Barrena E, et al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010;6:797-803 pubmed publisher
    ..These findings support the notion that osteostatin coating confers osteogenic features to silica-based ordered mesoporous materials, which make them suitable biomaterials for bone repair. ..
  5. Alonso V, Pérez Martínez F, Calahorra F, Esbrit P. Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in human prostate cancer cells. Life Sci. 2009;85:421-30 pubmed publisher
    ..Our findings indicate that high doses of genistein and daidzein cause PCa cell death. On the other hand, low doses of these phytoestrogens induce some osteomimetic features in PCa cells with putative impact on PCa development. ..
  6. Martin Ventura J, Ortego M, Esbrit P, Hernandez Presa M, Ortega L, Egido J. Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis. Stroke. 2003;34:1783-9 pubmed
    ..Our data provide a new rationale to understand the mechanisms involved in the beneficial effects of statins in atherosclerosis. ..
  7. Ortega A, Rámila D, Izquierdo A, Gonzalez L, Barat A, Gazapo R, et al. Role of the renin-angiotensin system on the parathyroid hormone-related protein overexpression induced by nephrotoxic acute renal failure in the rat. J Am Soc Nephrol. 2005;16:939-49 pubmed
    ..In this setting, intracellular Ang II/AT1 receptor recycling seems to be related to PTHrP induction through ERK and CREB activation in tubuloepithelial cells. ..
  8. de Castro L, Lozano D, Dapia S, Portal Nuñez S, Caeiro J, Gomez Barrena E, et al. Role of the N- and C-terminal fragments of parathyroid-hormone-related protein as putative therapies to improve bone regeneration under high glucocorticoid treatment. Tissue Eng Part A. 2010;16:1157-68 pubmed publisher
    ..These effects were reversed at least in part by either PTHrP peptide. The present novel findings support the use of both PTHrP peptides tested as putative bone regenerative therapies in GC-related bone diseases. ..
  9. Ortega A, Pérez de Prada M, Mateos Cáceres P, Ramos Mozo P, González Armengol J, González Del Castillo J, et al. Effect of parathyroid-hormone-related protein on human platelet activation. Clin Sci (Lond). 2007;113:319-27 pubmed
    ..In conclusion, human platelets express the PTH1R. PTHrP can interact with this receptor to enhance human platelet activation induced by several agonists through a MAPK-dependent mechanism. ..

More Information


  1. Rámila D, Ardura J, Esteban V, Ortega A, Ruiz Ortega M, Bosch R, et al. Parathyroid hormone-related protein promotes inflammation in the kidney with an obstructed ureter. Kidney Int. 2008;73:835-47 pubmed publisher
  2. Martin Ventura J, Blanco Colio L, Aparicio C, Ortega L, Esbrit P, Egido J. LDL induces parathyroid hormone-related protein expression in vascular smooth muscle cells: Modulation by simvastatin. Atherosclerosis. 2008;198:264-71 pubmed publisher
    ..LDL might be responsible for PTHrP overexpression in atherosclerotic plaques of hyperlipidemic rabbits. The inhibition of this effect by simvastatin provides further insights into the mechanisms of action of statins. ..
  3. Portal Núñez S, Lozano D, de Castro L, de Gortázar A, Nogues X, Esbrit P. Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice. FEBS Lett. 2010;584:3095-100 pubmed publisher
    ..Our data show that both N- and C-terminal parathyroid hormone-related peptide fragments might exert osteogenic effects in this setting by targeting several genes of this pathway and increasing beta-catenin in osteoblastic cells. ..
  4. Martinez M, Garcia Ocana A, Sanchez M, Medina S, del Campo T, Valin A, et al. C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells. J Bone Miner Res. 1997;12:778-85 pubmed
    ..These findings suggest that PTHrP may act as a local regulator of bone formation. ..
  5. Ardura J, Rayego Mateos S, Rámila D, Ruiz Ortega M, Esbrit P. Parathyroid hormone-related protein promotes epithelial-mesenchymal transition. J Am Soc Nephrol. 2010;21:237-48 pubmed publisher
    ..Taken together, these data suggest that PTHrP, TGF-beta, EGF, and VEGF might cooperate through activation of ERK1/2 to induce EMT in renal tubuloepithelial cells. ..
  6. Alonso V, de Gortázar A, Ardura J, Andrade Zapata I, Alvarez Arroyo M, Esbrit P. Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2. J Cell Physiol. 2008;217:717-27 pubmed publisher
    ..Our findings demonstrate that PTHrP (107-139) interacts with VEGFR-2 to promote human osteoblastic cell survival by a mechanism involving Runx2 activation. ..
  7. Ardura J, Berruguete R, Rámila D, Alvarez Arroyo M, Esbrit P. Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney. Am J Physiol Renal Physiol. 2008;295:F415-25 pubmed publisher
    ..Collectively, these findings strongly suggest that VEGF acts as an important mediator of PTHrP to promote fibrogenesis in the obstructed kidney. ..
  8. Romero Prado M, Blazquez C, Rodríguez Navas C, Muñoz J, Guerrero I, Delgado Baeza E, et al. Functional characterization of human mesenchymal stem cells that maintain osteochondral fates. J Cell Biochem. 2006;98:1457-70 pubmed
    ..These specific cellular conditions match those observed during endochondral bone formation. ..
  9. Duran A, Serrano M, Leitges M, Flores J, Picard S, Brown J, et al. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell. 2004;6:303-9 pubmed
    ..These observations demonstrate that p62 is an important mediator during osteoclastogenesis and induced bone remodeling. ..
  10. Guillen C, Martinez P, de Gortázar A, Martínez M, Esbrit P. Both N- and C-terminal domains of parathyroid hormone-related protein increase interleukin-6 by nuclear factor-kappa B activation in osteoblastic cells. J Biol Chem. 2002;277:28109-17 pubmed
    ..These studies also provide further insights into the putative role of PTHrP as a modulator of bone remodeling. ..