Experts and Doctors on cultured tumor cells in Madrid, Spain

Summary

Locale: Madrid, Spain
Topic: cultured tumor cells

Top Publications

  1. Arroyo A, Garcia Pardo A, Sanchez Madrid F. A high affinity conformational state on VLA integrin heterodimers induced by an anti-beta 1 chain monoclonal antibody. J Biol Chem. 1993;268:9863-8 pubmed
    ..Altogether, these results indicate that the interaction of VLA beta 1 heterodimers with their ligands can be regulated by switching between differently active conformations inherent to the alpha beta 1 receptors. ..
  2. Regales L, Giraldo P, García Díaz A, Lavado A, Montoliu L. Identification and functional validation of a 5' upstream regulatory sequence in the human tyrosinase gene homologous to the locus control region of the mouse tyrosinase gene. Pigment Cell Res. 2003;16:685-92 pubmed
  3. Alvarez Tejado M, Alfranca A, Aragones J, Vara A, Landazuri M, del Peso L. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem. 2002;277:13508-17 pubmed
    ..Furthermore, the activity of the PI3K/Akt is not sufficient for the activation of HIF nor is it essential for its induction by hypoxia. ..
  4. Campos D, Jiménez Díaz L, Carrión A. Ca(2+)-dependent prodynorphin transcriptional derepression in neuroblastoma cells is exerted through DREAM protein activity in a kinase-independent manner. Mol Cell Neurosci. 2003;22:135-45 pubmed
    ..Moreover, we demonstrate that in NB69 cells, the Ca(2+) signaling pathway uses DREAM as an effector to evoke prodynorphin transcription derepression in a kinase-independent manner. ..
  5. Barasoain I, García Carril A, Matesanz R, Maccari G, Trigili C, Mori M, et al. Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses. Chem Biol. 2010;17:243-53 pubmed publisher
    ..Association of the 4-4-20 antifluorescein monoclonal antibody-Hexaflutax complex to microtubules remains biphasic, thus indicating that the two phases observed arise from two different poses of the taxane moiety. ..
  6. Hernandez Losa J, Parada Cobo C, Guinea Viniegra J, Sánchez Arévalo Lobo V, Ramon Y Cajal S, Sanchez Prieto R. Role of the p38 MAPK pathway in cisplatin-based therapy. Oncogene. 2003;22:3998-4006 pubmed
    ..Therefore, we conclude that the p38 MAPK pathway is a specific target for cisplatin-based therapy with clinical implications. ..
  7. Rodriguez Gonzalez A, Ramirez de Molina A, Bañez Coronel M, Megias D, Lacal J. Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism. Int J Oncol. 2005;26:999-1008 pubmed
    ..Our results are consistent with a non-intrinsic process as the mechanism underlying the induction of apoptosis by ChoK inhibition in tumoral cells. ..
  8. Vanegas N, Castaneda V, Santamaria D, Hernandez P, Schvartzman J, Krimer D. Cloning, sequencing and expression in MEL cells of a cDNA encoding the mouse ribosomal protein S5. Biochim Biophys Acta. 1997;1357:1-4 pubmed
    ..Northern series analysis showed that S5 mRNA expression is reduced 5-fold throughout the differentiation process. The mouse S5 mRNA is 760 bp long and encodes for a 204 amino acid protein with 94% homology with the human and rat S5. ..
  9. Menendez J, Ropero S, del Barbacid M, Montero S, Solanas M, Escrich E, et al. Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. Breast Cancer Res Treat. 2002;72:203-19 pubmed
    ..In conclusion, our results give experimental support to the hypothesis that some UFAs can be used as modulators of tumor cell chemosensitivity and provide the rationale for in vivo preclinical investigation. ..

More Information

Publications86

  1. Sanchez C, de Ceballos M, Gomez del Pulgar T, Rueda D, Corbacho C, Velasco G, et al. Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res. 2001;61:5784-9 pubmed
    ..These results support a therapeutic approach for the treatment of malignant gliomas devoid of psychotropic side effects. ..
  2. Garcia Silva S, Perez Juste G, Aranda A. Cell cycle control by the thyroid hormone in neuroblastoma cells. Toxicology. 2002;181-182:179-82 pubmed
    ..As a consequence of these changes, retinoblastoma proteins are hypophosphorylated in T3-treated N2a-beta cells, and progression through the restriction point in the cell cycle is blocked. ..
  3. Longo N, Yanez Mo M, Mittelbrunn M, de la Rosa G, Munoz M, Sanchez Madrid F, et al. Regulatory role of tetraspanin CD9 in tumor-endothelial cell interaction during transendothelial invasion of melanoma cells. Blood. 2001;98:3717-26 pubmed
  4. de la Fuente M, Casanova B, Moyano J, Garcia Gila M, Sanz L, García Marco J, et al. Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine. J Leukoc Biol. 2002;71:495-502 pubmed
    ..These results indicate that Bcl-xL is involved in the survival signals induced by alpha4beta1 ligation and may contribute to the progressive drug resistance observed in B-CLL. ..
  5. Rodriguez Antona C, Leskela S, Zajac M, Cuadros M, Alves J, Moneo M, et al. Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas. Blood. 2007;110:3345-51 pubmed
    ..In conclusion, a high CYP3A4 tumoral expression could be useful to predict poor response to the standard PTCL chemotherapy; in these cases alternative chemotherapy combinations or doses should be explored. ..
  6. Arenzana N, Rodriguez De Cordoba S. Promoter region of the human gene coding for beta-chain of C4b binding protein. Hepatocyte nuclear factor-3 and nuclear factor-I/CTF transcription factors are required for efficient expression of C4BPB in HepG2 cells. J Immunol. 1996;156:168-75 pubmed
    ..Comparison of the structures of the C4BPA and C4BPB promoters reveals significant differences that could explain the differential transcription of the C4BP alpha and C4BP beta polypeptides during the acute phase response. ..
  7. Sanchez Elsner T, Botella L, Velasco B, Corbi A, Attisano L, Bernabeu C. Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem. 2001;276:38527-35 pubmed
    ..These results demonstrate that both TGF-beta and hypoxia signaling pathways can synergize in the regulation of VEGF gene expression at the transcriptional level. ..
  8. Pelaez B, Campillo J, Lopez Asenjo J, Subiza J. Cyclophosphamide induces the development of early myeloid cells suppressing tumor cell growth by a nitric oxide-dependent mechanism. J Immunol. 2001;166:6608-15 pubmed
    ..Both the recruitment and the activation of these myeloid cells at the site of tumor challenge appear to be dependent on the presence of tumor-specific lymphocytes. ..
  9. Fernández Nestosa M, Hernandez P, Schvartzman J, Krimer D. PU.1 is dispensable to block erythroid differentiation in Friend erythroleukemia cells. Leuk Res. 2008;32:121-30 pubmed
    ..Exposure to 5-Aza-2'-deoxycytidine activates PU.1 expression suggesting that the PU.1 coding gene is highly methylated in the resistant cells. Altogether these results suggest that PU.1 is dispensable to block erythroid differentiation. ..
  10. Gómez Ramos A, Diaz Hernandez M, Rubio A, Díaz Hernández J, Miras Portugal M, Avila J. Characteristics and consequences of muscarinic receptor activation by tau protein. Eur Neuropsychopharmacol. 2009;19:708-17 pubmed publisher
    ..These studies provide valuable information to help understand tau toxicity on neural cells bearing M1 or M3 muscarinic receptors and its contribution to neurodegenerative progression in tauopathies. ..
  11. Lemaire M, Ducommun B, Nebreda A. UV-induced downregulation of the CDC25B protein in human cells. FEBS Lett. 2010;584:1199-204 pubmed publisher
    ..We also show that translational repression mediated by eIF2alpha phosphorylation regulates CDC25B expression levels. Taken together, our results illustrate a new mechanism of CDC25B regulation in response to stress. ..
  12. Santa Maria I, Hernandez F, Smith M, Perry G, Avila J, Moreno F. Neurotoxic dopamine quinone facilitates the assembly of tau into fibrillar polymers. Mol Cell Biochem. 2005;278:203-12 pubmed
    ..In non-dopaminergic neurons, quinone oxidation products may be involved in tau polymerization. These results support a link between oxidative damage and the onset of tauopathies. ..
  13. Sanz Rodriguez F, Hidalgo A, Teixido J. Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. Blood. 2001;97:346-51 pubmed
    ..Modulation of VLA-4-dependent myeloma cell adhesion by SDF-1alpha could contribute to the trafficking and localization of these cells in the BM microenvironment. ..
  14. Abad Rodriguez J, Bernabe M, Romero Ramirez L, Vallejo Cremades M, Fernandez Mayoralas A, Nieto Sampedro M. Purification and structure of neurostatin, an inhibitor of astrocyte division of mammalian brain. J Neurochem. 2000;74:2547-56 pubmed
    ..Mono- and bidimensional NMR spectra, together with biochemical studies, suggest that neurostatin may be the 9-O-monoacetyl ester of GD1b. ..
  15. Barderas R, Shochat S, Timmerman P, Hollestelle M, Martinez Torrecuadrada J, Höppener J, et al. Designing antibodies for the inhibition of gastrin activity in tumoral cell lines. Int J Cancer. 2008;122:2351-9 pubmed publisher
    ..These findings should contribute to a more rational design of antibody-based antigastrin therapies in cancer, including passive administration of human antibodies with blocking activity. ..
  16. Vicente Manzanares M, Rey M, Perez Martinez M, Yanez Mo M, Sancho D, Cabrero J, et al. The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes. J Immunol. 2003;171:1023-34 pubmed
    ..Together, our data demonstrate that RhoA is involved in the control of the filamentous actin/monomeric actin balance through mDia, and that this balance is critical for T cell responses. ..
  17. Fraga M, Ballestar E, Villar Garea A, Boix Chornet M, Espada J, Schotta G, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet. 2005;37:391-400 pubmed
    ..Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells. ..
  18. Bermejo R, Vilaboa N, Calés C. Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization. Mol Biol Cell. 2002;13:3989-4000 pubmed
    ..Our results show that both cdt1 and cdc6 are differentially regulated during megakaryocytic differentiation and suggest an active role of cdc6 in endomitosis. ..
  19. Alvarez C, Lasala F, Carrillo J, Muniz O, Corbi A, Delgado R. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J Virol. 2002;76:6841-4 pubmed
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection. ..
  20. Bellón T, Kitzig F, Sayos J, Lopez Botet M. Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. J Immunol. 2002;168:3351-9 pubmed
    ..By contrast, mutation of tyrosine 533 (NLYAAV) interfered with ILT2 tyrosine phosphorylation and the subsequent SHP-1 recruitment, thus supporting a regulatory role for this motif. ..
  21. Guijarro M, Leal J, Fominaya J, Blanco Aparicio C, Alonso S, Lleonart M, et al. MAP17 overexpression is a common characteristic of carcinomas. Carcinogenesis. 2007;28:1646-52 pubmed
    ..Taken together, our data show an independent activation of MAP17 promoter that can be driven by oncogenes and that might explain the common overexpression of MAP17 in human carcinomas. ..
  22. Caulin C, Lopez Barcons L, Gonzáles Garrigues M, Navarro P, Lozano E, Rodrigo I, et al. Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E-cadherin expression and correlated with reduced Ha-ras oncogene products. Mol Carcinog. 1996;15:104-14 pubmed
    ..These results suggest that suppression of the metastatic phenotype in E24 cells occurs independently of E-CD expression and correlates with decreased levels of the oncogenic ras p21 protein...
  23. Sánchez Martínez R, Castillo A, Steinmeyer A, Aranda A. The retinoid X receptor ligand restores defective signalling by the vitamin D receptor. EMBO Rep. 2006;7:1030-4 pubmed
    ..This study shows that, in VDR/RXR heterodimers, allosteric communication triggered by the RXR ligand has a previously unrecognized role in vitamin D signalling, with important physiological and therapeutic implications. ..
  24. Sanchez Elsner T, Botella L, Velasco B, Langa C, Bernabeu C. Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem. 2002;277:43799-808 pubmed
  25. Ventoso I, Navarro J, Muñoz M, Carrasco L. Involvement of HIV-1 protease in virus-induced cell killing. Antiviral Res. 2005;66:47-55 pubmed
    ..These findings may contribute towards a better understanding of HIV-1 pathogenesis, and emphasise the potential of the virus protease as a key therapeutic target in AIDS treatment. ..
  26. Navarro P, Lozano E, Cano A. Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin. J Cell Sci. 1993;105 ( Pt 4):923-34 pubmed
    ..The presence of plakoglobin could be required for the proper organization of E-cadherin in the transfectant cells in order to acquire an epithelioid phenotype. ..
  27. Casanova M, Blazquez C, Martínez Palacio J, Villanueva C, Fernández Aceñero M, Huffman J, et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest. 2003;111:43-50 pubmed
    ..Abrogation of EGF-R function was also observed in cannabinoid-treated tumors. These results support a new therapeutic approach for the treatment of skin tumors. ..
  28. Grau R, Iñiguez M, Fresno M. Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated recep. Cancer Res. 2004;64:5162-71 pubmed
    ..Together, these findings provide new insight into the antitumoral properties of 15d-PGJ(2) through the inhibition of the induction of AP-1-dependent genes involved in tumor progression, such as COX-2 and VEGF. ..
  29. Fernandez M, Quiroga J, Carreno V. Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins. J Gen Virol. 2003;84:2073-82 pubmed
    ..These results demonstrate a mechanism that HBV probably uses to downregulate an element of the IFN-induced host antiviral responses, which accounts for the impairment observed in HBV-infected patients. ..
  30. Cuesta Mateos C, López Giral S, Alfonso Pérez M, de Soria V, Loscertales J, Guasch Vidal S, et al. Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia. Exp Hematol. 2010;38:756-64, 764.e1-4 pubmed publisher
    ..The role of PI3K, Rho guanosine triphosphatases, and MAPKs in CCR7-mediated CLL cells migration and survival suggests that these signal transduction pathways could represent promising targets for CLL therapy. ..
  31. López Barahona M, Iglesias T, Garcia Higuera I, Mayor F, Zaballos A, Bernal J, et al. Post-transcriptional induction of beta 1-adrenergic receptor by retinoic acid, but not triiodothyronine, in C6 glioma cells expressing thyroid hormone receptors. Eur J Endocrinol. 1996;135:709-15 pubmed
    ..We conclude that lack of responsiveness of the beta 1-AR gene in C6 cells to T3 is not due to high expression of c-erbA alpha 2 but to undefined cell-specific factors. ..
  32. Moneo V, Serelde B, Fominaya J, Leal J, Blanco Aparicio C, Romero L, et al. Extreme sensitivity to Yondelis (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53. J Cell Biochem. 2007;100:339-48 pubmed
    ..01). In a pair of isogenic cell lines differing only in the presence or absence of wild-type p53, the absence of p53 rendered cells threefold more sensitive to Trabectedin. ..
  33. Carrión A, Mellstrom B, Naranjo J. Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element. Mol Cell Biol. 1998;18:6921-9 pubmed
    ..Upon PKA stimulation, binding to the DRE is reduced and transcription increases. We propose a model for human prodynorphin activation through PKA-dependent derepression at the DRE site. ..
  34. Mellstrom B, Ceña V, Lamas M, Perales C, Gonzalez C, Naranjo J. Gas1 is induced during and participates in excitotoxic neuronal death. Mol Cell Neurosci. 2002;19:417-29 pubmed
    ..These results indicate that Gas1 is induced by activation of glutamate receptors and is part of the gene expression program directing neuronal death after mild excitotoxic insults. ..
  35. Castillo A, Jimenez Lara A, Tolon R, Aranda A. Synergistic activation of the prolactin promoter by vitamin D receptor and GHF-1: role of the coactivators, CREB-binding protein and steroid hormone receptor coactivator-1 (SRC-1). Mol Endocrinol. 1999;13:1141-54 pubmed
    ..Furthermore, CBP also increases the activation of the PRL promoter by GHF-1 and the ligand-independent activation by both wild-type and mutant VDR. ..
  36. de Felipe P, Izquierdo M, Wandosell F, Lim F. Integrating retroviral cassette extends gene delivery of HSV-1 expression vectors to dividing cells. Biotechniques. 2001;31:394-402, 404-5 pubmed
    ..These vectors have wide applications for the genetic modification of many cell types. ..
  37. Ayerbes M, Díaz Prado S, Ayude D, Campelo R, Iglesias P, Haz M, et al. In silico and in vitro analysis of small breast epithelial mucin as a marker for bone marrow micrometastasis in breast cancer. Adv Exp Med Biol. 2008;617:331-9 pubmed publisher
    ..379). A model system based on RT-PCR for SBEM mRNA was highly sensitive and specific in order to detect isolated tumor cells. Our results demonstrate that SBEM mRNA may be an imp ortant marker for targeting BC micrometastasis. ..
  38. Bosque A, Aguilo J, Alava M, Paz Artal E, Naval J, Allende L, et al. The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling. Blood. 2007;109:1627-35 pubmed
    ..The present results connect the 2 main pathways described until the moment for the control of T-cell responses: death receptor-mediated activation-induced cell death and apoptosis by cytokine deprivation. ..
  39. Calvo D, Vega M. Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. J Biol Chem. 1993;268:18929-35 pubmed
    ..Transient transfection experiments of a CD36-CLA-1 chimera, constructed by replacing the carboxyl cytoplasmic tail of CD36 for the carboxyl cytoplasmic tail of CLA-1, suggest that native CLA-1 protein is found on the plasma membrane. ..
  40. Sanchez Corral P, Criado Garcia O, Rodriguez De Cordoba S. Isoforms of human C4b-binding protein. I. Molecular basis for the C4BP isoform pattern and its variations in human plasma. J Immunol. 1995;155:4030-6 pubmed
    ..These observations provide a new way to explore the possible association between elevated levels of C4BP and an increased risk to thromboembolic disorders. ..
  41. Hidalgo A, Sanz Rodriguez F, Rodríguez Fernandez J, Albella B, Blaya C, Wright N, et al. Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells. Exp Hematol. 2001;29:345-55 pubmed
    ..Modulation of VLA-4-mediated CD34(hi) BM cell adhesion by SDF-1alpha could play a key role in their migration within and to the BM and therefore influence their proliferation and differentiation. ..
  42. Gimenez Cassina A, Lim F, Cerrato T, Palomo G, Diaz Nido J. Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3. J Biol Chem. 2009;284:3001-11 pubmed publisher
    ..Furthermore, the neuroprotective effect of HKII may be relevant to neurodegenerative diseases in which glucose hypometabolism and mitochondrial dysfunction are prominent features. ..
  43. Ballestar E, Paz M, Valle L, Wei S, Fraga M, Espada J, et al. Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. EMBO J. 2003;22:6335-45 pubmed
    ..Our results support an essential role for MBDs in gene silencing and, when combined with genomic strategies, their potential to 'catch' new hypermethylated genes in cancer. ..
  44. Cortes Canteli M, Pignatelli M, Santos A, Perez Castillo A. CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells. J Biol Chem. 2002;277:5460-7 pubmed
    ..Finally, cell death was also induced by C/EBPbeta through activation of the p53 protein and the cdk inhibitor p21. ..
  45. Belandia B, Powell S, García Pedrero J, Walker M, Bevan C, Parker M. Hey1, a mediator of notch signaling, is an androgen receptor corepressor. Mol Cell Biol. 2005;25:1425-36 pubmed
  46. Riesco Eizaguirre G, Rodríguez I, De La Vieja A, Costamagna E, Carrasco N, Nistal M, et al. The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer. Cancer Res. 2009;69:8317-25 pubmed publisher
    ..Our study describes a novel mechanism of NIS repression in thyroid cancer and provides evidence that TGFbeta may play a key role in promoting radioiodide resistance and tumor invasion during PTC progression. ..
  47. Wozniak M, Villuendas R, Bischoff J, Aparicio C, Martinez Leal J, de la Cueva P, et al. Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma. Haematologica. 2010;95:613-21 pubmed publisher
    ..Additionally, we showed that combination therapies involving histone deacetylase inhibitors and inhibitors of PI3K are potentially efficacious for the treatment of cutaneous T-cell lymphoma. ..
  48. de Marco M, Martin Belmonte F, Kremer L, Albar J, Correas I, Vaerman J, et al. MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells. J Cell Biol. 2002;159:37-44 pubmed
    ..Normal transcytosis persisted in cells that expressed exogenous MAL2 designed to resist the depletion treatment. MAL2 is therefore essential for transcytosis in HepG2 cells. ..
  49. Garcia Aragoncillo E, Carrillo J, Lalli E, Agra N, Gomez Lopez G, Pestana A, et al. DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells. Oncogene. 2008;27:6034-43 pubmed publisher
  50. Campillos M, Garcia M, Valdivieso F, Vazquez J. Transcriptional activation by AP-2alpha is modulated by the oncogene DEK. Nucleic Acids Res. 2003;31:1571-5 pubmed
    ..Finally, electrophoretic mobility shift assays suggested that DEK enhances the DNA-binding activity of AP-2alpha. Our data suggest a novel cellular function of DEK as a transcriptional co-activator. ..
  51. Gurzov E, Bakiri L, Alfaro J, Wagner E, Izquierdo M. Targeting c-Jun and JunB proteins as potential anticancer cell therapy. Oncogene. 2008;27:641-52 pubmed
    ..These results indicate that in the absence of c-Jun, JunB can act as a tumor promoter and inactivation of both, c-Jun and JunB, could provide a valuable strategy for antitumor intervention. ..
  52. Ledo F, Carrión A, Link W, Mellstrom B, Naranjo J. DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. Mol Cell Biol. 2000;20:9120-6 pubmed
    ..Thus, our results propose a new mechanism for DREAM-mediated derepression that can operate independently of changes in nuclear Ca(2+). ..
  53. Galve Roperh I, Rueda D, Gómez del Pulgar T, Velasco G, Guzman M. Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Mol Pharmacol. 2002;62:1385-92 pubmed
    ..In conclusion, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision. ..
  54. Fernandez Mayoralas A, de la Figuera N, Zurita M, Vaquero J, Abraham G, San Roman J, et al. Central neural tumor destruction by controlled release of a synthetic glycoside dispersed in a biodegradable polymeric matrix. J Med Chem. 2003;46:1286-8 pubmed
    ..The glycoside inhibited the growth of a neuroectodermic tumor implanted in rats and, when loaded on a slow-delivery polymer disk, caused the destruction of cultured human astroblastoma obtained after surgical biopsy. ..
  55. del Fresno C, Otero K, Gómez García L, González León M, Soler Ranger L, Fuentes Prior P, et al. Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4. J Immunol. 2005;174:3032-40 pubmed
    ..Altogether, our findings indicate that deactivation of human monocytes in the presence of tumor cells involves IRAK-M up-regulation, and this effect appears to be mediated by hyaluronan through the engagement of CD44 and TLR4. ..
  56. Di Lisio L, Gomez Lopez G, Sanchez Beato M, Gomez Abad C, Rodriguez M, Villuendas R, et al. Mantle cell lymphoma: transcriptional regulation by microRNAs. Leukemia. 2010;24:1335-42 pubmed publisher
    ..In summary, using a novel bioinformatics approach, this study identified miRNA changes that contribute to MCL pathogenesis and markers of potential utility in MCL diagnosis and clinical prognostication. ..
  57. Locascio A, Vega S, de Frutos C, Manzanares M, Nieto M. Biological potential of a functional human SNAIL retrogene. J Biol Chem. 2002;277:38803-9 pubmed
    ..In light of this data, we have renamed it SNAIL-like, a new player that must be considered in both physiological and pathological studies of SNAIL function in humans. ..
  58. Cano A, Perez Moreno M, Rodrigo I, Locascio A, Blanco M, del Barrio M, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2000;2:76-83 pubmed
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs. ..
  59. Conejo R, de Alvaro C, Benito M, Cuadrado A, Lorenzo M. Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway. Oncogene. 2002;21:3739-53 pubmed
    ..A crosstalk between P70S6K and p38-MAPK was observed under rapamycin treatment in both insulin or active AKT induced myogenesis. Our results are delineating an AKT/P70S6K/p38-MAPK pathway involved in skeletal muscle differentiation. ..
  60. Lara Pezzi E, Gomez Gaviro M, Galvez B, Mira E, Iñiguez M, Fresno M, et al. The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. J Clin Invest. 2002;110:1831-8 pubmed
  61. Sanjuan M, Pradet Balade B, Jones D, Martinez A C, Stone J, Garcia Sanz J, et al. T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation. J Immunol. 2003;170:2877-83 pubmed
    ..This study is the first demonstration of in vivo regulation of DGK alpha, and provides new insight into the functional role of a member of this family of lipid kinases in the regulation of the immune response. ..
  62. Caffarel M, Moreno Bueno G, Cerutti C, Palacios J, Guzman M, Mechta Grigoriou F, et al. JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008;27:5033-44 pubmed publisher
  63. Paz M, Wei S, Cigudosa J, Rodriguez Perales S, Peinado M, Huang T, et al. Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. Hum Mol Genet. 2003;12:2209-19 pubmed
    ..Thus, our results demonstrate the role of DNMT1 and DNMT3b in CpG island methylation associated silencing and the usefulness of genetic disruption strategies in searching for new hypermethylated loci. ..
  64. Perez Juste G, Garcia Silva S, Aranda A. An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells. J Biol Chem. 2000;275:1307-14 pubmed
    ..These studies provide insight into mechanisms by which TR mediate transcriptional repression and contribute to the understanding of the important effects of thyroid hormones on growth and differentiation of neuronal cells. ..
  65. Efeyan A, Murga M, Martinez Pastor B, Ortega Molina A, Soria R, Collado M, et al. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS ONE. 2009;4:e5475 pubmed publisher
    ..Regarding murine Atm, our data suggest that it plays a minor role in oncogene-induced senescence or in p53-dependent tumor suppression, being its tumor suppressive activity probably limited to the maintenance of genomic stability. ..
  66. Martinez Torrecuadrada J, Cheung L, López Serra P, Barderas R, Canamero M, Ferreiro S, et al. Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. Mol Cancer Ther. 2008;7:862-73 pubmed publisher
    ..These results show that FGFR3-driven immunotoxins may be an effective therapeutic agent against human bladder and other tumor types overexpressing FGFR3. ..
  67. Ibanez de Caceres I, Cortes Sempere M, Moratilla C, Machado Pinilla R, Rodriguez Fanjul V, Manguan Garcia C, et al. IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer. Oncogene. 2010;29:1681-90 pubmed publisher
  68. Canesin G, Gonzalez Peramato P, Palou J, Urrutia M, Cordon Cardo C, Sanchez Carbayo M. Galectin-3 expression is associated with bladder cancer progression and clinical outcome. Tumour Biol. 2010;31:277-85 pubmed publisher
    ..Urinary protein levels served to identify bladder cancer patients. These observations suggest a role for galectin-3 as a biomarker for bladder cancer diagnostics, staging, and outcome prognosis. ..
  69. Paneda C, Gorospe I, Herrera B, Nakamura T, Fabregat I, Varela Nieto I. Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation. Hepatology. 2002;35:1381-91 pubmed
    ..In conclusion, our results show that MAT2A expression not only correlates with liver cell proliferation but is required for this process. ..
  70. Leon F, Cespon C, Franco A, Lombardia M, Roldan E, Escribano L, et al. SHP-1 expression in peripheral T cells from patients with Sezary syndrome and in the T cell line HUT-78: implications in JAK3-mediated signaling. Leukemia. 2002;16:1470-7 pubmed
    ..These results suggest that SHP-1 might be involved in maintaining the IL-2R/JAK3 signaling pathway under control and point towards a role of SHP-1 in the pathogenesis of the disease. ..
  71. Grau R, Punzon C, Fresno M, Iñiguez M. Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. Biochem J. 2006;395:81-8 pubmed
  72. Ramirez de Molina A, Rodriguez Gonzalez A, Gutierrez R, Martinez Pineiro L, Sanchez J, Bonilla F, et al. Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. Biochem Biophys Res Commun. 2002;296:580-3 pubmed
    ..These findings strongly support the role of ChoK alterations in the carcinogenic process in human tumors, suggesting that ChoK could be used as a tumor marker. ..
  73. Blánquez M, Regadera J, Marino J, Newman R, Notario V. Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia. Mol Carcinog. 2002;35:186-95 pubmed
    ..In addition, detection of altered PCPH polypeptides by Western analysis potentially can be applied to the early identification of laryngeal squamous cell carcinoma. ..
  74. Campillos M, Lamas J, Garcia M, Bullido M, Valdivieso F, Vazquez J. Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity. Nucleic Acids Res. 2003;31:3063-70 pubmed
    ..These results indicate that A1 transactivates APOE promoter activity by direct and specific interaction with the -219T site. ..
  75. de Juan C, Iniesta P, Gonzalez Quevedo R, Moran A, Sánchez Pernaute A, Torres A, et al. Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors. Oncogene. 2002;21:3089-94 pubmed
    ..Thus, GPIM is a novel gene codifying a protein with structural features characteristics of some CAMs, which might be involved in the tumor progression. ..
  76. Wright N, de Lera T, Garcia Moruja C, Lillo R, García Sánchez F, Caruz A, et al. Transforming growth factor-beta1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion. Blood. 2003;102:1978-84 pubmed
    ..These data indicate that TGF-beta1-controlled reduction in SDF-1 expression influences BM cell migration and adhesion, which could affect the motility of cells trafficking the bone marrow. ..
  77. Lim F, Hernandez F, Lucas J, Gomez Ramos P, Moran M, Avila J. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Mol Cell Neurosci. 2001;18:702-14 pubmed
    ..Our results show that Tau modifications can provoke lysosomal aberrations and suggest that this may be a cause of neurodegeneration in tauopathies. ..