Experts and Doctors on cornea in Madrid, Spain


Locale: Madrid, Spain
Topic: cornea

Top Publications

  1. Ortega Usobiaga J, Martin Reyes C, Llovet Osuna F, Beltrán Sanz J, Caro M, Baviera Sabater J. Myopic LASIK and LASEK in patients with preoperative mean central keratometry ?47.50 D. J Refract Surg. 2011;27:591-6 pubmed publisher
    ..However, when this preoperative finding is accompanied by other topographic abnormalities, treatment options should be carefully evaluated. ..
  2. Llorente L, Barbero S, Cano D, Dorronsoro C, Marcos S. Myopic versus hyperopic eyes: axial length, corneal shape and optical aberrations. J Vis. 2004;4:288-98 pubmed
    ..Our results may be indicative of presbyopic changes occurring earlier in hyperopes than in myopes. ..
  3. Santodomingo Rubido J, Villa Collar C, Gilmartin B, Gutiérrez Ortega R, Suzaki A. The effects of entrance pupil centration and coma aberrations on myopic progression following orthokeratology. Clin Exp Optom. 2015;98:534-40 pubmed publisher
    ..Greater magnitude coma aberrations found at the entrance pupil centre in comparison to the CSCLR might be attributed to centration of orthokeratological treatments at the CSCLR. ..
  4. Sanchez M, Arriola Villalobos P, Torralbo Jimenez P, Giron N, de la Heras B, Herrero Vanrell R, et al. The effect of preservative-free HP-Guar on dry eye after phacoemulsification: a flow cytometric study. Eye (Lond). 2010;24:1331-7 pubmed publisher
    ..6, P=0.0002), CD3 (2.5+/-1.4 vs 1.1+/-1.1, P=0.011), and HLA-DR (6.8+/-4.5 vs 1.8+/-1.7, P=0.0002). The addition of HP-Guar to regular treatment after cataract surgery reduces ocular surface inflammation and dry eye signs and symptoms. ..
  5. Puell M, Carballo Álvarez J. Forward light scatter and visual acuity before and after intrastromal corneal ring segment implantation at different stages of keratoconus. Acta Ophthalmol. 2016;94:e738-e743 pubmed publisher
    ..In eyes with stage II and III keratoconus, stray light increased 6 months after ICRS placement. Higher postoperative stray light was correlated with a worse visual acuity outcome. ..
  6. Benitez del Castillo J, Acosta M, Wassfi M, Diaz Valle D, Gegúndez J, Fernandez C, et al. Relation between corneal innervation with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye. Invest Ophthalmol Vis Sci. 2007;48:173-81 pubmed
    ..001). The use of confocal microscopy and noncontact esthesiometry allow the detection of the presence of corneal neuropathy in patients with dry eye. ..
  7. Marcos S, Rosales P, Llorente L, Jiménez Alfaro I. Change in corneal aberrations after cataract surgery with 2 types of aspherical intraocular lenses. J Cataract Refract Surg. 2007;33:217-26 pubmed
    ..These results can be used to improve predictions of optical performance with new IOL designs using computer eye models and identify the potentially different impact of incision strategies on cataract surgery. ..
  8. Nieto Bona A, Lorente Velázquez A, Montes Mico R. Relationship between anterior corneal asphericity and refractive variables. Graefes Arch Clin Exp Ophthalmol. 2009;247:815-20 pubmed publisher
    ..However, the relationship between refractive state and corneal asphericity was found to be determined more by the geometric properties of the eye (corneal power and axial length) than by manifest refraction. ..
  9. de Benito Llopis L, Teus M, Sánchez Pina J, Fuentes I. Stability of laser epithelial keratomileusis with and without mitomycin C performed to correct myopia in thin corneas: a 15-month follow-up. Am J Ophthalmol. 2008;145:807-12 pubmed publisher
    ..Topography showed no signs of ectasia in any case. Myopic LASEK performed on thin corneas, regardless of the use of intraoperative MMC, seems to obtain stable refractive results, with no sign of ectasia during a 15-month follow-up. ..

More Information


  1. Kling S, Remon L, Pérez Escudero A, Merayo Lloves J, Marcos S. Corneal biomechanical changes after collagen cross-linking from porcine eye inflation experiments. Invest Ophthalmol Vis Sci. 2010;51:3961-8 pubmed publisher
    ..The apparent biomechanical anisotropy of pig corneas must be confirmed in humans. ..
  2. Ortiz S, Siedlecki D, Grulkowski I, Remon L, Pascual D, Wojtkowski M, et al. Optical distortion correction in optical coherence tomography for quantitative ocular anterior segment by three-dimensional imaging. Opt Express. 2010;18:2782-96 pubmed publisher
    ..Optical distortion correction in 3-D is critical for quantitative analysis of OCT anterior segment imaging, and allows accurate topography of the internal surfaces of the eye. ..
  3. de Benito Llopis L, Alio J, Ortiz D, Teus M, Artola A. Ten-year follow-up of excimer laser surface ablation for myopia in thin corneas. Am J Ophthalmol. 2009;147:768-73, 773.e1-2 pubmed publisher
    ..Thirty eyes (40%) needed enhancement. Surface ablation seems to be safe and effective to correct myopia in corneas thinner than 500 microm, with stable visual and refractive outcomes in a 10-year follow-up. ..
  4. Marcos S, Rosales P, Llorente L, Barbero S, Jiménez Alfaro I. Balance of corneal horizontal coma by internal optics in eyes with intraocular artificial lenses: evidence of a passive mechanism. Vision Res. 2008;48:70-9 pubmed
    ..Our results cannot exclude a fine-tuning for the orientation of the crystalline lens, since cataract surgery seems to preserve the position of the capsule. ..
  5. Fernández Vigo J, Garcia Feijoo J, Martínez de la Casa J, Garcia Bella J, Arriola Villalobos P, Fernandez Perez C, et al. Fourier domain optical coherence tomography to assess the iridocorneal angle and correlation study in a large Caucasian population. BMC Ophthalmol. 2016;16:42 pubmed publisher
    ..705; p?<?0.001). In this Caucasian population, strong correlation was detected between FD-OCT anterior angle measurements and ACV, ACD, spherical refractive error and sex, emerging the ACV as the main determinant of TIA. ..
  6. Llorente L, Barbero S, Merayo J, Marcos S. Total and corneal optical aberrations induced by laser in situ keratomileusis for hyperopia. J Refract Surg. 2004;20:203-16 pubmed
    ..Hyperopic LASIK induced significant amounts of aberrations. The largest increase occurred in spherical aberration, which showed a shift (toward negative values) of opposite sign; increase was greater than for myopic LASIK. ..
  7. Crooke A, Mediero A, Guzm n Ar nguez A, Pintor J. Silencing of P2Y2 receptor delays Ap4A-corneal re-epithelialization process. Mol Vis. 2009;15:1169-78 pubmed
    ..The application of P2Y(2)-R siRNA has demonstrated the role of this receptor in the accelerating effect of diadenosine tetraphosphate (Ap(4)A) on the corneal wound healing process...
  8. Perucho González L, Martínez de la Casa J, Morales Fernandez L, Bañeros Rojas P, Saenz Frances F, Garcia Feijoo J. Intraocular pressure and biomechanical corneal properties measure by ocular response analyser in patients with primary congenital glaucoma. Acta Ophthalmol. 2016;94:e293-7 pubmed publisher
  9. Kling S, Marcos S. Effect of hydration state and storage media on corneal biomechanical response from in vitro inflation tests. J Refract Surg. 2013;29:490-7 pubmed publisher
    ..Dextran instillation decreased corneal thickness on average to 56.5% at 0 hours and 72.7% at 24 hours. Corneal hydration and tissue preservation changed corneal biomechanics, in particular its relaxation over a period of 24 hours. ..
  10. Guzman Aranguez A, Woodward A, Pintor J, ARGUESO P. Targeted disruption of core 1 ?1,3-galactosyltransferase (C1galt1) induces apical endocytic trafficking in human corneal keratinocytes. PLoS ONE. 2012;7:e36628 pubmed publisher
    ..Together, the data suggest that core 1 O-glycans contribute to maintenance of apical barrier function on exposed mucosal surfaces by preventing clathrin-mediated endocytosis. ..
  11. Gallego Muñoz P, Ibares Frías L, Lorenzo E, Marcos S, Peréz Merino P, Bekesi N, et al. Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study. Invest Ophthalmol Vis Sci. 2017;58:3471-3480 pubmed publisher
  12. Fernández Vigo J, Macarro Merino A, Fernández Vigo C, Fernández Vigo J, De Pablo Gómez de Liaño L, Fernandez Perez C, et al. Impacts of Implantable Collamer Lens V4c Placement on Angle Measurements Made by Optical Coherence Tomography: Two-Year Follow-up. Am J Ophthalmol. 2017;181:37-45 pubmed publisher
    ..159). In response to ICL V4c implant, considerable angle narrowing was detected at 1 month but this narrowing remained stable at 2 years. In the 8 cases of TIC, no progression of contact was observed beyond 3 months postimplant. ..
  13. Jimenez B, Volpert O, Reiher F, Chang L, Munoz A, Karin M, et al. c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1. Oncogene. 2001;20:3443-8 pubmed
    ..TSP-1 inhibition of corneal neovascularization induced by bFGF was severely impaired in mice null for JNK-1, pointing to a critical role for this stress-activated kinase in the inhibition of neovascularization by TSP-1. ..
  14. Fernandez Velazquez F. Kerasoft IC compared to Rose-K in the management of corneal ectasias. Cont Lens Anterior Eye. 2012;35:175-9 pubmed publisher
    ..19) as well as in mild and moderate keratoconus (p = 0.45). KIC is a good alternative for the optical management of irregular corneal astigmatism in non surgical corneal ectasias such as keratoconus and pellucid marginal degeneration. ..
  15. Lopez Caballero C, Puerto Hernandez B, Munoz Negrete F, Rebolleda G, Contreras I, Cabarga C, et al. Quantitative evaluation of anterior chamber changes after iridotomy using Pentacam anterior segment analyzer. Eur J Ophthalmol. 2010;20:327-32 pubmed
  16. Arriola Villalobos P, Diaz Valle D, Güell J, Iradier Urrutia M, Jiménez Alfaro I, Cuiña Sardiña R, et al. Intrastromal corneal ring segment implantation for high astigmatism after penetrating keratoplasty. J Cataract Refract Surg. 2009;35:1878-84 pubmed publisher
    ..To evaluate the safety and efficacy of intracorneal ring segments (ICRS) for high astigmatism after penetrating keratoplasty (PKP)...
  17. Bravo Osuna I, Noiray M, Briand E, Woodward A, Argueso P, Molina Martínez I, et al. Interfacial interaction between transmembrane ocular mucins and adhesive polymers and dendrimers analyzed by surface plasmon resonance. Pharm Res. 2012;29:2329-40 pubmed publisher
    ..Results reinforce the usefulness of chitosan and dendrimers as polymers able to increase the retention time of drugs on the ocular surface and hence their bioavailability. ..
  18. Kling S, Marcos S. Contributing factors to corneal deformation in air puff measurements. Invest Ophthalmol Vis Sci. 2013;54:5078-85 pubmed publisher
    ..65), indicating a change in the viscoelastic properties with treatment. Corneal deformation following an air puff allows the measurement of dynamic properties, which are essential for the characterization of corneal biomechanics. ..
  19. Pardo Muñoz A, Muriel Herrero A, Abraira V, Muriel A, Munoz Negrete F, Murube J. Phacoemulsification in previously vitrectomized patients: an analysis of the surgical results in 100 eyes as well as the factors contributing to the cataract formation. Eur J Ophthalmol. 2006;16:52-9 pubmed
  20. García Pérez J, Gros Otero J, Sánchez Ramos C, Blázquez V, Contreras I. Short term visual outcomes of a new trifocal intraocular lens. BMC Ophthalmol. 2017;17:72 pubmed publisher
    ..ISRCTN60143265 , retrospectively registered on the 24th of April 2017. ..
  21. Pintor J, Bautista A, Carracedo G, Peral A. UTP and diadenosine tetraphosphate accelerate wound healing in the rabbit cornea. Ophthalmic Physiol Opt. 2004;24:186-93 pubmed
    ..Mitogen-activated protein kinase (MAPK) cascade inhibitors also abolished the effects of UTP, suggesting that P2Y receptors are coupled to the MAPK cascade, and that this is involved in controlling the rate of epithelial cell migration. ..
  22. Lorente Velázquez A, Nieto Bona A, Collar C, Mesa A. Straylight and contrast sensitivity after corneal refractive therapy. Optom Vis Sci. 2011;88:1245-51 pubmed publisher
    ..Mesopic contrast sensitivity was more affected by the treatment intervention than photopic contrast sensitivity. ..
  23. Manrique R, Noval S, Aguilar Amat M, Arpa J, Rosa I, Contreras I. Ophthalmic features of spinocerebellar ataxia type 7. J Neuroophthalmol. 2009;29:174-9 pubmed publisher
    ..Patients with spinocerebellar ataxia 7 (SCA7) are known to develop ocular abnormalities. The purpose of this study was to characterize these abnormalities in greater detail and with the aid of newer quantitative technologies...
  24. Alvarez M, Figueroa M, Teus M. Toxic keratolysis from combined use of nonsteroid anti-inflammatory drugs and topical steroids following vitreoretinal surgery. Eur J Ophthalmol. 2006;16:582-7 pubmed
    ..To evaluate the corneal complications associated with the combined use of non-steroid anti-inflammatory drugs (NSAIDs) and topical steroids following vitreoretinal surgery...
  25. Murube J, Rivas L. Impression cytology on conjunctiva and cornea in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity. Eur J Ophthalmol. 2003;13:115-27 pubmed