Experts and Doctors on cell adhesion molecules in Madrid, Spain


Locale: Madrid, Spain
Topic: cell adhesion molecules

Top Publications

  1. Serrano Gomez D, Sierra Filardi E, Martinez Nunez R, Caparros E, Delgado R, Muñoz Fernández M, et al. Structural requirements for multimerization of the pathogen receptor dendritic cell-specific ICAM3-grabbing non-integrin (CD209) on the cell surface. J Biol Chem. 2008;283:3889-903 pubmed
  2. Sacedon R, Vicente A, Varas A, Jimenez E, Munoz J, Zapata A. Glucocorticoid-mediated regulation of thymic dendritic cell function. Int Immunol. 1999;11:1217-24 pubmed
    ..Taken together, these results support certain GC-mediated regulation of the activity of thymic DC which could be relevant for the biology of the thymus gland. ..
  3. Serrano Gomez D, Dominguez Soto A, Ancochea J, Jimenez Heffernan J, Leal J, Corbi A. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages. J Immunol. 2004;173:5635-43 pubmed
    ..Our results suggest the involvement of DC-SIGN in the initial stages of pulmonary infection as well as in fungal spreading during invasive aspergillosis. ..
  4. Rodríguez Fernandez J, Gomez M, Luque A, Hogg N, Sanchez Madrid F, Cabanas C. The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes. Mol Biol Cell. 1999;10:1891-907 pubmed
  5. Cioffi M, Dorado J, Baeuerle P, Heeschen C. EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012;18:465-74 pubmed publisher
    ..Cytotoxic T cells can be effectively redirected against primary human pancreatic cancer cells by T-cell-engaging BiTE antibody MT110 including a subpopulation of highly tumorigenic CSCs. ..
  6. Sarrio D, Perez Mies B, Hardisson D, Moreno Bueno G, Suárez A, Cano A, et al. Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene. 2004;23:3272-83 pubmed
    ..Consequently, p120 may be an important mediator of the oncogenic effects derived from E-CD inactivation, including enhanced motility and invasion, in lobular breast cancer. ..
  7. Puig Kröger A, Serrano Gomez D, Caparros E, Dominguez Soto A, Relloso M, Colmenares M, et al. Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages. J Biol Chem. 2004;279:25680-8 pubmed
  8. del Pozo M, Vicente Manzanares M, Tejedor R, Serrador J, Sanchez Madrid F. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur J Immunol. 1999;29:3609-20 pubmed
    ..Together, these data demonstrate that Rho GTPases regulate lymphocyte polarization and chemokine-induced migration, and underscore the key role of Cdc42 in lymphocyte directional migration. ..
  9. Valderas Martínez P, Chiva Blanch G, Casas R, Arranz S, Martínez Huelamo M, Urpi Sarda M, et al. Tomato Sauce Enriched with Olive Oil Exerts Greater Effects on Cardiovascular Disease Risk Factors than Raw Tomato and Tomato Sauce: A Randomized Trial. Nutrients. 2016;8:170 pubmed publisher
    ..We concluded that tomato intake has beneficial effects on cardiovascular risk factors, especially cooked and enriched with oil. ..

More Information


  1. Berzal S, Alique M, Ruiz Ortega M, Egido J, Ortiz A, Ramos A. GSK3, snail, and adhesion molecule regulation by cyclosporine A in renal tubular cells. Toxicol Sci. 2012;127:425-37 pubmed publisher
    ..We conclude that calcineurin inhibitors may directly decrease the expression of epithelial adhesion molecules by repressing GSK3 and stabilizing Snail. This offers potential pharmacological targets for prevention of nephrotoxicity. ..
  2. Barreiro O, Vicente Manzanares M, Urzainqui A, Yanez Mo M, Sanchez Madrid F. Interactive protrusive structures during leukocyte adhesion and transendothelial migration. Front Biosci. 2004;9:1849-63 pubmed
    ..The adhesion receptor redistribution, cytoskeletal remodelling and intracellular signaling events that participate in this phenomenon are also discussed. ..
  3. Miranda Carús M, Balsa A, Benito Miguel M, Pérez de Ayala C, Martin Mola E. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol. 2004;173:1463-76 pubmed
    ..In turn, these cytokines stimulate the expression of IL-15, IL-8, and IL-6 in RASFibs, thereby creating a feedback loop that favors persistent synovial inflammation. Methotrexate seems to disrupt this loop by decreasing cell adhesion. ..
  4. Alio J, Sales Sanz M, Vaz M, Barrancos C, Reguero M, Diamantopoulus J, et al. Primary extraosseous Ewing sarcoma of the orbit. Ophthalmic Plast Reconstr Surg. 2013;29:e91-3 pubmed publisher
    ..The patient received neoadjuvant chemotherapy and an orbital exenteration with preservation of eyelids and conjunctiva. He also received adjuvant chemotherapy and local radiotherapy, and he has remained disease-free for almost 3 years...
  5. Speicher S, Garcia Alonso L, Carmena A, Martin Bermudo M, De La Escalera S, Jimenez F. Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila. Neuron. 1998;20:221-33 pubmed
    ..This result provides evidence for functional cooperativity in vivo between the adhesion and signaling pathways controlled by neurotactin and the other three genes. ..
  6. Relloso M, Puig Kröger A, Pello O, Rodríguez Fernández J, de la Rosa G, Longo N, et al. DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents. J Immunol. 2002;168:2634-43 pubmed
    ..This feature might help in the development of strategies to modulate the DC-SIGN-dependent cell surface attachment of HIV for therapeutic purposes. ..
  7. Estecha A, Aguilera Montilla N, Sánchez Mateos P, Puig Kröger A. RUNX3 regulates intercellular adhesion molecule 3 (ICAM-3) expression during macrophage differentiation and monocyte extravasation. PLoS ONE. 2012;7:e33313 pubmed publisher
  8. Jean Mairet R, López Menéndez C, Sánchez Ruiloba L, Sacristán S, Rodríguez Martínez M, Riol Blanco L, et al. The neuronal protein Kidins220/ARMS associates with ICAM-3 and other uropod components and regulates T-cell motility. Eur J Immunol. 2011;41:1035-46 pubmed publisher
    ..Altogether, our findings show that Kidins220/ARMS is a novel component of the uropod involved in the regulation of T-cell motility, an essential process for the immune response. ..
  9. Molina Ortiz I, Bartolomé R, Hernández Varas P, Colo G, Teixido J. Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA. J Biol Chem. 2009;284:15147-57 pubmed publisher
  10. Dominguez Soto A, Puig Kröger A, Vega M, Corbi A. PU.1 regulates the tissue-specific expression of dendritic cell-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin. J Biol Chem. 2005;280:33123-31 pubmed
    ..1 has on the acquisition of the antigen uptake molecular repertoire by dendritic cells and macrophages. ..
  11. Díaz López A, Rivas C, Iniesta P, Moran A, García Aranda C, Megias D, et al. Characterization of MDGA1, a novel human glycosylphosphatidylinositol-anchored protein localized in lipid rafts. Exp Cell Res. 2005;307:91-9 pubmed
    ..Finally, as other proteins of the secretory pathway, hMDGA1 undergoes other post-translational modification consisting of N-glycosylation. ..
  12. Jimenez D, Roda Navarro P, Springer T, Casasnovas J. Contribution of N-linked glycans to the conformation and function of intercellular adhesion molecules (ICAMs). J Biol Chem. 2005;280:5854-61 pubmed
    ..N-Linked glycosylation regulate both conformation and immune related functions of ICAM receptors. ..
  13. Sarria B, Martínez López S, Sierra Cinos J, García Diz L, Mateos R, Bravo L. Regular consumption of a cocoa product improves the cardiometabolic profile in healthy and moderately hypercholesterolaemic adults. Br J Nutr. 2014;111:122-34 pubmed publisher
  14. Alvarez C, Lasala F, Carrillo J, Muniz O, Corbi A, Delgado R. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J Virol. 2002;76:6841-4 pubmed
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection. ..
  15. Carvalho Pinto C, Garcia M, Mellado M, Rodríguez Frade J, Martin Caballero J, Flores J, et al. Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol. 2002;169:1058-67 pubmed
  16. Dominguez Soto A, Sierra Filardi E, Puig Kröger A, Pérez Maceda B, Gomez Aguado F, Corcuera M, et al. Dendritic cell-specific ICAM-3-grabbing nonintegrin expression on M2-polarized and tumor-associated macrophages is macrophage-CSF dependent and enhanced by tumor-derived IL-6 and IL-10. J Immunol. 2011;186:2192-200 pubmed publisher
  17. Ortega P, Moran A, Fernandez Marcelo T, de Juan C, Frias C, Lopez Asenjo J, et al. MMP-7 and SGCE as distinctive molecular factors in sporadic colorectal cancers from the mutator phenotype pathway. Int J Oncol. 2010;36:1209-15 pubmed
  18. Silva Martin N, Schauer J, Park C, Hermoso J. Crystallization and preliminary X-ray diffraction studies of the carbohydrate-recognition domain of SIGN-R1, a receptor for microbial polysaccharides and sialylated antibody on splenic marginal zone macrophages. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:1264-6 pubmed publisher
    ..5. Single crystals, which belonged to the monoclinic space group C2 with unit-cell parameters a = 146.72, b = 92.77, c = 77.06 A, beta = 121.66 degrees , allowed the collection of a full X-ray data set to a maximum resolution of 1.87 A. ..
  19. Moreno Bueno G, Hardisson D, Sarrio D, Sanchez C, Cassia R, Prat J, et al. Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. J Pathol. 2003;199:471-8 pubmed
    ..Finally, upregulation of P-cadherin was observed in 28.6% of cases. This alteration was associated with the histology of the lesion, since it was found in 9.5% of AEHs, 27.7% of EECs, and 46.2% of NEECs (p = 0.021). ..
  20. Serrador J, Alonso Lebrero J, del Pozo M, Furthmayr H, Schwartz Albiez R, Calvo J, et al. Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization. J Cell Biol. 1997;138:1409-23 pubmed
  21. Caparros E, Munoz P, Sierra Filardi E, Serrano Gomez D, Puig Kröger A, Rodríguez Fernández J, et al. DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production. Blood. 2006;107:3950-8 pubmed
    ..Since pathogens stimulate Th2 responses via preferential activation of ERK1/2, these results provide a molecular explanation for the ability of DC-SIGN-interacting pathogens to preferentially evoke Th2-type immune responses. ..
  22. Escudero L, Wei S, Chiu W, Modolell J, Hsu J. Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Development. 2003;130:6305-16 pubmed
    ..Consistently, we find that Ed also antagonizes the bristle-promoting activity of the Egfr pathway, either by the enhancement of N signalling or, similar to the eye, by a more direct action on the Egfr pathway. ..
  23. Lasala F, Arce E, Otero J, Rojo J, Delgado R. Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans. Antimicrob Agents Chemother. 2003;47:3970-2 pubmed
    ..BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection...
  24. de la Rosa G, Yanez Mo M, Samaneigo R, Serrano Gomez D, Martínez Muñoz L, Fernández Ruiz E, et al. Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation. J Leukoc Biol. 2005;77:699-709 pubmed
    ..DC-SIGN was highly concentrated at points of cell-cell contact, suggesting a role for enhanced avidity during DC-SIGN-mediated intercellular adhesion. ..
  25. Herreros L, Rodríguez Fernandez J, Brown M, Alonso Lebrero J, Cabanas C, Sanchez Madrid F, et al. Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. J Biol Chem. 2000;275:26436-40 pubmed
  26. Nunez C, Oliver J, Mendoza J, Gómez Garcia M, Taxonera C, Gomez L, et al. CD209 in inflammatory bowel disease: a case-control study in the Spanish population. BMC Med Genet. 2007;8:75 pubmed
    ..However, it could be involved in the etiology or pathology of Ulcerative Colitis in HLA-DR3-positive individuals but further studies are necessary. ..
  27. Baena Lopez L, Baonza A, García Bellido A. The orientation of cell divisions determines the shape of Drosophila organs. Curr Biol. 2005;15:1640-4 pubmed
    ..In addition, we find that a subset of planar cell polarity genes is required for the proper orientation of cell division during organ development. ..
  28. Serrano Gomez D, Leal J, Corbi A. DC-SIGN mediates the binding of Aspergillus fumigatus and keratinophylic fungi by human dendritic cells. Immunobiology. 2005;210:175-83 pubmed
  29. Colmenares M, Corbi A, Turco S, Rivas L. The dendritic cell receptor DC-SIGN discriminates among species and life cycle forms of Leishmania. J Immunol. 2004;172:1186-90 pubmed
    ..DC-SIGN in Leishmania-dendritic cell interactions, an essential link between innate and Leishmania-specific adaptive immune responses, and suggest that DC-SIGN might be a therapeutic target for both visceral and cutaneous leishmaniasis ..
  30. Montoya M, Sancho D, Bonello G, Collette Y, Langlet C, He H, et al. Role of ICAM-3 in the initial interaction of T lymphocytes and APCs. Nat Immunol. 2002;3:159-68 pubmed
    ..Our data indicate that ICAM-3 is important in the initial scanning of the APC surface by T cells and, therefore, in generating the immune response. ..
  31. Serrador J, Vicente Manzanares M, Calvo J, Barreiro O, Montoya M, Schwartz Albiez R, et al. A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. J Biol Chem. 2002;277:10400-9 pubmed
    ..Our results underscore the key role of specific serine residues within the cytoplasmic region of ICAM-3 for its ERM-directed positioning at the trailing edge of motile lymphocytes. ..
  32. de Juan C, Iniesta P, Gonzalez Quevedo R, Moran A, Sánchez Pernaute A, Torres A, et al. Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors. Oncogene. 2002;21:3089-94 pubmed
    ..Thus, GPIM is a novel gene codifying a protein with structural features characteristics of some CAMs, which might be involved in the tumor progression. ..
  33. Marazuela M, Postigo A, Acevedo A, Diaz Gonzalez F, Sanchez Madrid F, de Landazuri M. Adhesion molecules from the LFA-1/ICAM-1,3 and VLA-4/VCAM-1 pathways on T lymphocytes and vascular endothelium in Graves' and Hashimoto's thyroid glands. Eur J Immunol. 1994;24:2483-90 pubmed
    ..Our data suggest that both the LFA-1/ICAM-1, ICAM-3 and VLA-4/VCAM-1 pathways could play a relevant role in localizing and perpetuating the autoimmune response in the thyroid gland in autoimmune thyroid disorders. ..
  34. Nunez C, Rueda B, Martinez A, Maluenda C, Polanco I, Lopez Nevot M, et al. A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population. World J Gastroenterol. 2006;12:4397-400 pubmed
    ..026, OR = 3.71). The -336G CD209 allele seems to be involved in CD susceptibility in HLA-DQ2 (-) patients. Our results might suggest a possible role of pathogens in the onset of a minor group of CD patients. ..
  35. De La Escalera S, Bockamp E, Moya F, Piovant M, Jimenez F. Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases. EMBO J. 1990;9:3593-601 pubmed
    ..The extracellular domain also contains three copies of the tripeptide leucine-arginine-glutamate, a motif that forms the primary sequence of the adhesive site of vertebrate s-laminin. ..