Experts and Doctors on animals in Valencia, Spain


Locale: Valencia, Spain
Topic: animals

Top Publications

  1. Such L, Rodriguez A, Alberola A, Lopez L, Ruiz R, Artal L, et al. Intrinsic changes on automatism, conduction, and refractoriness by exercise in isolated rabbit heart. J Appl Physiol (1985). 2002;92:225-9 pubmed
    ..Thus training depresses sinus chronotropism, A-V nodal conduction, and increases ventricular refractoriness by intrinsic mechanisms, which do not involve changes in myocardial mass and/or coronary flow...
  2. Ortega A, Ferrer P, Carretero J, Obrador E, Asensi M, Pellicer J, et al. Down-regulation of glutathione and Bcl-2 synthesis in mouse B16 melanoma cells avoids their survival during interaction with the vascular endothelium. J Biol Chem. 2003;278:39591-9 pubmed
    ..Our results indicate that survival of B16M cells with high metastatic potential can be challenged by inhibiting their GSH and Bcl-2 synthesis. ..
  3. Sanz González S, Melero Fernández de Mera R, Malek N, Andres V. Atheroma development in apolipoprotein E-null mice is not regulated by phosphorylation of p27(Kip1) on threonine 187. J Cell Biochem. 2006;97:735-43 pubmed
  4. Pérez Del Olmo A, Raga J, Kostadinova A, Fernandez M. Parasite communities in Boops boops (L.) (Sparidae) after the Prestige oil-spill: detectable alterations. Mar Pollut Bull. 2007;54:266-76 pubmed
    ..Endoparasite communities in B. boops reflected a notable change in the composition and abundance of the benthic fauna in the localities studied post-spill probably due to organic enrichment after the POS. ..
  5. Cauli O, Mlili N, Llansola M, Felipo V. Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats. Eur J Neurosci. 2007;25:2112-22 pubmed
    ..The identification of the mechanisms responsible for altered motor function and coordination in liver disease would allow designing treatments to improve motor function in patients with hepatic encephalopathy. ..
  6. Pastor Navarro N, Morais S, Maquieira A, Puchades R. Synthesis of haptens and development of a sensitive immunoassay for tetracycline residues. Application to honey samples. Anal Chim Acta. 2007;594:211-8 pubmed
    ..The obtained results confirmed the suitability of the assay as screening method for either food monitoring or laboratory quantification of tetracycline residues. ..
  7. Calvete J, Juárez P, Sanz L. Snake venomics. Strategy and applications. J Mass Spectrom. 2007;42:1405-14 pubmed
    ..The combined strategy allows us to assign unambiguously all the isolated venom toxins representing over 0.05% of the total venom proteins to known protein families. Protocols and applications of snake venomics are reviewed and discussed...
  8. Revert F, Merino R, Monteagudo C, Macias J, Peydró A, Alcácer J, et al. Increased Goodpasture antigen-binding protein expression induces type IV collagen disorganization and deposit of immunoglobulin A in glomerular basement membrane. Am J Pathol. 2007;171:1419-30 pubmed
    ..Finally, we describe a previously unrecognized pathogenic mechanism that may be relevant in human primary immune complex-mediated glomerulonephritis. ..
  9. Solaz Fuster M, Gimeno Alcañiz J, Ros S, Fernandez Sanchez M, Garcia Fojeda B, Criado Garcia O, et al. Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway. Hum Mol Genet. 2008;17:667-78 pubmed
    ..These data advance our understanding of the functional role of laforin and malin, which hopefully will facilitate the development of appropriate LD therapies. ..

More Information

Publications238 found, 100 shown here

  1. Gomez Munoz M, Navarro C, Garijo Toledo M, Dea Ayuela M, Fernandez Barredo S, Pérez Gracia M, et al. Occurrence and genotypes of Giardia isolated from lambs in Spain. Parasitol Int. 2009;58:297-9 pubmed publisher
    ..In each farm, one to six different beta-giardin subtypes were found, showing the high variability of the target. Also, one flock had the zoonotic Assemblage A. This is the first report of Giardia subgenotype A-1 in sheep in Spain. ..
  2. Tárrega C, Pulido R. A one-step method to identify MAP kinase residues involved in inactivation by tyrosine- and dual-specificity protein phosphatases. Anal Biochem. 2009;394:81-6 pubmed publisher
  3. Fernandez Lizarbe S, Pascual M, Guerri C. Critical role of TLR4 response in the activation of microglia induced by ethanol. J Immunol. 2009;183:4733-44 pubmed publisher
  4. Martin R, Alvaro M, Herance J, Garcia H. Fenton-treated functionalized diamond nanoparticles as gene delivery system. ACS Nano. 2010;4:65-74 pubmed publisher
  5. Alcaraz M, Megías J, García Arnandis I, Clérigues V, Guillén M. New molecular targets for the treatment of osteoarthritis. Biochem Pharmacol. 2010;80:13-21 pubmed publisher
    ..Further insights into the molecular mechanisms involved in OA initiation and progression may lead to the development of new therapies able to control joint destruction and repair. ..
  6. Muñoz Soriano V, Belacortu Y, Durupt F, Muñoz Descalzo S, Paricio N. Mtl interacts with members of Egfr signaling and cell adhesion genes in the Drosophila eye. Fly (Austin). 2011;5:88-101 pubmed
    ..Since Egfr signaling is linked to cytoskeletal and cell junctional elements, it is likely that Mtl may be regulating cytoskeleton dynamics and thus cell adhesion during ommatidial rotation in the context of that pathway. ..
  7. Valbuena D, Póo M, Aguilar Gallardo C, Martínez S, Cobo A, Pellicer A, et al. Comparison of Cryotip vs. Cryotop for mouse and human blastomere vitrification. Fertil Steril. 2012;97:209-17 pubmed publisher
    ..6% and 47.16%, respectively, in Cryotop and Cryotip. The closed system is more efficient in preserving mouse and human blastomeres in terms of acceptable survival and division rates, and it also complies with European Union directives. ..
  8. Pereda J, Pérez S, Escobar J, Arduini A, Asensi M, Serviddio G, et al. Obese rats exhibit high levels of fat necrosis and isoprostanes in taurocholate-induced acute pancreatitis. PLoS ONE. 2012;7:e44383 pubmed publisher
    ..Future studies are needed to confirm the translational relevance of the present findings obtained in a rat model of taurocholate-induced pancreatic damage and necrosis. ..
  9. Murguía J, Serrano R. New functions of protein kinase Gcn2 in yeast and mammals. IUBMB Life. 2012;64:971-4 pubmed publisher
    ..These findings anticipate many expanding roles of Gcn2 in the future, with relevance for stress responses and human disease. ..
  10. Gonçalves Machado L, Pla D, Sanz L, Jorge R, Leitão De Araújo M, Alves M, et al. Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest. J Proteomics. 2016;135:73-89 pubmed publisher
    ..This article is part of a Special Issue entitled: Omics Evolutionary Ecolog. ..
  11. Sanz M, Burnett A, Lo Coco F, Lowenberg B. FLT3 inhibition as a targeted therapy for acute myeloid leukemia. Curr Opin Oncol. 2009;21:594-600 pubmed publisher
    ..These agents are also being tested in combination with conventional chemotherapy. Oral FLT3 inhibitors offer a hope of improved treatment outcomes for patients with relapsed and newly diagnosed AML. ..
  12. Donnez J, Dolmans M, Díaz C, Pellicer A. Ovarian cortex transplantation: time to move on from experimental studies to open clinical application. Fertil Steril. 2015;104:1097-8 pubmed publisher
  13. Bello R, Moreno L, Primo Yüfera E, Esplugues J. Globularia alypum L. extracts reduced histamine and serotonin contraction in vitro. Phytother Res. 2002;16:389-92 pubmed
    ..At the same doses, neither methanol nor dichloromethane extract reduced the contractile effects of acetylcholine on rat duodenum or noradrenaline on rat vas deferens. ..
  14. Blanco A, Valles S, Pascual M, Guerri C. Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. J Immunol. 2005;175:6893-9 pubmed
    ..In summary, these findings indicate that both TLR4 and IL-1RI activation occur upon ethanol treatment, and suggest that signaling through these receptors mediates ethanol-induced inflammatory events in astrocytes and brain. ..
  15. Gomez O, Romero A, Terrado J, Mesonero J. Differential expression of glucose transporter GLUT8 during mouse spermatogenesis. Reproduction. 2006;131:63-70 pubmed
    ..The specific GLUT8 location suggests that this transporter plays a pivotal role in the fuel supply of spermatozoa, and in the traffic of sugars during the capacitation and fertilization processes. ..
  16. Tamames J, Gil R, Latorre A, Peretó J, Silva F, Moya A. The frontier between cell and organelle: genome analysis of Candidatus Carsonella ruddii. BMC Evol Biol. 2007;7:181 pubmed
    ..Furthermore, since most genes for the biosynthesis of essential amino acids have also been lost, it is likely that the host depends on another yet unidentified symbiont to complement its deficient diet. ..
  17. Carazo P, Font E, Forteza Behrendt E, Desfilis E. Quantity discrimination in Tenebrio molitor: evidence of numerosity discrimination in an invertebrate?. Anim Cogn. 2009;12:463-70 pubmed publisher
  18. Busso C, Garcia Velasco J, Gomez R, Alvarez C, Simon C, Pellicer A. Symposium: Update on prediction and management of OHSS. Prevention of OHSS--dopamine agonists. Reprod Biomed Online. 2009;19:43-51 pubmed
    ..As far as is known, this is the first pathophysiological approach for treatment and prevention of OHSS. ..
  19. Cambra López M, Aarnink A, Zhao Y, Calvet S, Torres A. Airborne particulate matter from livestock production systems: a review of an air pollution problem. Environ Pollut. 2010;158:1-17 pubmed publisher
    ..This paper reviews the state-of-the-art of PM in and from livestock production systems. Future research to characterize and control PM in livestock houses is discussed. ..
  20. Marco Jimenez F, Vicente J, Lavara R, Balasch S, Viudes De Castro M. Poor prediction value of sperm head morphometry for fertility and litter size in rabbit. Reprod Domest Anim. 2010;45:e118-23 pubmed publisher
  21. Navarro Llopis V, Domínguez Ruiz J, Zarzo M, Alfaro C, Primo J. Mediterranean fruit fly suppression using chemosterilants for area-wide integrated pest management. Pest Manag Sci. 2010;66:511-9 pubmed publisher
    ..In addition, the efficacy of chemosterilant treatment is increasing year after year. The possibility of using this technique combined with other control methods is discussed. ..
  22. Petras D, Sanz L, Segura A, Herrera M, Villalta M, Solano D, et al. Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches. J Proteome Res. 2011;10:1266-80 pubmed publisher
    ..The impaired activity of EchiTAb-Plus-ICP against N. katiensis may not represent a major concern. This species is sympatric with N. nigricollis in many regions of Africa, although very few bites have been attributed to it...
  23. Naturil Alfonso C, Saenz de Juano M, Peñaranda D, Vicente J, Marco Jimenez F. Parthenogenic blastocysts cultured under in vivo conditions exhibit proliferation and differentiation expression genes similar to those of normal embryos. Anim Reprod Sci. 2011;127:222-8 pubmed publisher
    ..Our study highlights the importance of culture conditions in subsequent uses of parthenotes, such as the production of stem cell lines. ..
  24. Navarro Campos C, Martínez Ferrer M, Campos J, Fibla J, Alcaide J, Bargues L, et al. The influence of host fruit and temperature on the body size of adult Ceratitis capitata (Diptera: Tephritidae) under laboratory and field conditions. Environ Entomol. 2011;40:931-8 pubmed publisher
    ..The implications of this adult size pattern on the biology of C. capitata and on the application of the sterile insect technique are discussed...
  25. Braza Boïls A, Ferrándiz M, Terencio M, Alcaraz M. Analysis of early biochemical markers and regulation by tin protoporphyrin IX in a model of spontaneous osteoarthritis. Exp Gerontol. 2012;47:406-9 pubmed publisher
    ..p.) for 4 weeks significantly reduced the progression of OA. Our data suggest that MMP-3 is a sensitive biomarker to detect early OA alterations and that SnPP could be a protective agent in OA. ..
  26. Carrió E, Güemes J. The role of a mixed mating system in the reproduction of a Mediterranean subshrub (Fumana hispidula, Cistaceae). J Plant Res. 2013;126:33-40 pubmed publisher
    ..These results support the idea that F. hispidula has a mixed mating strategy, which represents a successful reproduction mode in their patchy habitats...
  27. Pérez Ortín J, Alepuz P, Chávez S, Choder M. Eukaryotic mRNA decay: methodologies, pathways, and links to other stages of gene expression. J Mol Biol. 2013;425:3750-75 pubmed publisher
    ..Some of these factors can regulate both transcription and decay rates, thereby maintaining proper mRNA homeostasis during eukaryotic cell life. ..
  28. Griffeth R, Carretero J, Burks D. Insulin receptor substrate 2 is required for testicular development. PLoS ONE. 2013;8:e62103 pubmed publisher
    ..Collectively, our results demonstrate that IRS2 plays a critical role in testicular development, potentially by mediating IGF1 signalling during embryonic and early postnatal development. ..
  29. Vina J, Borras C, Abdelaziz K, Garcia Valles R, Gomez Cabrera M. The free radical theory of aging revisited: the cell signaling disruption theory of aging. Antioxid Redox Signal. 2013;19:779-87 pubmed publisher
    ..The hurdles are, no doubt, very high, but the intellectual and practical promise of these studies is of such magnitude that we feel that all efforts will be generously rewarding. ..
  30. Savietto D, Cervera C, Blas E, Baselga M, Larsen T, Friggens N, et al. Environmental sensitivity differs between rabbit lines selected for reproductive intensity and longevity. Animal. 2013;7:1969-77 pubmed publisher
    ..The results for LP does indicate a direct use of DE ingested for reproduction with little PFT change, whereas V does actively use the PFT reserves for reproduction. ..
  31. Tzanoulinou S, García Mompó C, Riccio O, Grosse J, Zanoletti O, Dedousis P, et al. Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress. Neuropsychopharmacology. 2016;41:751-61 pubmed publisher
    ..Furthermore, NLGN-2 is underscored as a promising target to treat stress-induced cognitive alterations, and in particular attentional deficits as manifested by augmented omissions in a continuous performance task. ..
  32. Herráiz F, Villano D, Plazas M, Vilanova S, Ferreres F, Prohens J, et al. Phenolic Profile and Biological Activities of the Pepino (Solanum muricatum) Fruit and Its Wild Relative S. caripense. Int J Mol Sci. 2016;17:394 pubmed publisher
    ..caripense E-7 (high for antioxidant activity) to select and breed pepino varieties with enhanced properties. ..
  33. Arias Mutis O, Marrachelli V, Ruiz Sauri A, Alberola A, Morales J, Such Miquel L, et al. Development and characterization of an experimental model of diet-induced metabolic syndrome in rabbit. PLoS ONE. 2017;12:e0178315 pubmed publisher
    ..This experimental model should provide a valuable tool for studies into the mechanisms of cardiovascular problems related to MetS, with special relevance in the study of cardiovascular remodeling, arrhythmias and SCD. ..
  34. Penades J, Bernal D, Revert F, Johansson C, Fresquet V, Cervera J, et al. Characterization and expression of multiple alternatively spliced transcripts of the Goodpasture antigen gene region. Goodpasture antibodies recognize recombinant proteins representing the autoantigen and one of its alternative forms. Eur J Biochem. 1995;229:754-60 pubmed
  35. Diez Juan A, Andres V. The growth suppressor p27(Kip1) protects against diet-induced atherosclerosis. FASEB J. 2001;15:1989-95 pubmed
    ..Thus, our study establishes a molecular link between decreased p27 protein expression and atherogenesis in hypercholesterolemic animals. ..
  36. Castro C, Diez Juan A, Cortés M, Andres V. Distinct regulation of mitogen-activated protein kinases and p27Kip1 in smooth muscle cells from different vascular beds. A potential role in establishing regional phenotypic variance. J Biol Chem. 2003;278:4482-90 pubmed
  37. Llansola M, Hernandez Viadel M, Erceg S, Montoliu C, Felipo V. Increasing the function of the glutamate-nitric oxide-cyclic guanosine monophosphate pathway increases the ability to learn a Y-maze task. J Neurosci Res. 2009;87:2351-5 pubmed publisher
  38. Marrachelli V, Miranda F, Centeno J, Salom J, Torregrosa G, Jover Mengual T, et al. Role of NO-synthases and cyclooxygenases in the hyperreactivity of male rabbit carotid artery to testosterone under experimental diabetes. Pharmacol Res. 2010;61:62-70 pubmed publisher
    ..The hypotestosteronemia observed in diabetic rabbits could be a consequence of the increased expression of iNOS and could contribute to the hyperreactivity of the rabbit carotid artery to testosterone. ..
  39. Armiñán A, Gandia C, Garcia Verdugo J, Lledó E, Trigueros C, Ruiz Sauri A, et al. Mesenchymal stem cells provide better results than hematopoietic precursors for the treatment of myocardial infarction. J Am Coll Cardiol. 2010;55:2244-53 pubmed publisher
    ..Mesenchymal stem cells might be more effective than CD34(+) cells for the healing of the infarct. This study contributes to elucidate the mechanisms by which these cell types operate in the course of MI treatment. ..
  40. Castelló Ruiz M, Torregrosa G, Burguete M, Salom J, Gil J, Miranda F, et al. Soy-derived phytoestrogens as preventive and acute neuroprotectors in experimental ischemic stroke: influence of rat strain. Phytomedicine. 2011;18:513-5 pubmed publisher
  41. Fernández Alvarez A, Alvarez M, Gonzalez R, Cucarella C, Muntane J, Casado M. Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem. 2011;286:21466-77 pubmed publisher
    ..Collectively, our results identify PPAR? as a novel regulatory factor in SREBP1c regulation which plays a relevant role in the interplay between lipids and insulin metabolic regulation. ..
  42. Gelis S, De Groot P, Castillo L, Moragues M, Sentandreu R, Gómez M, et al. Pga13 in Candida albicans is localized in the cell wall and influences cell surface properties, morphogenesis and virulence. Fungal Genet Biol. 2012;49:322-31 pubmed publisher
    ..This is consistent with the observed reduced virulence of pga13? mutants in a mouse model of disseminated candidiasis. ..
  43. Marinho A, Morais I, Lima D, Jorge A, Jorge R, Menezes R, et al. Bothropoides pauloensis venom effects on isolated perfused kidney and cultured renal tubular epithelial cells. Toxicon. 2015;108:126-33 pubmed publisher
    ..These findings demonstrated that BpV cytotoxicity on renal epithelial cells might be responsible for the nephrotoxicity observed in isolated kidney. ..
  44. Agramunt Lerma M, Errando Mariscal J, Delgado Cordón F, Gómez Abril S, Montalvá Orón E, Martínez Pérez M. Small bowel obstruction caused by snail's shell: radiographic and CT findings. J Comput Assist Tomogr. 2002;26:529-31 pubmed
    ..This is an unusual case of small bowel obstruction due to a foreign body that was preoperatively diagnosed with imaging. ..
  45. Blanco A, Pascual M, Valles S, Guerri C. Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-kappa B. Neuroreport. 2004;15:681-5 pubmed
    ..These results suggest that ethanol is able to induce inflammatory mediators in astrocytes through the NF-kappa B activation. ..
  46. Perdiguero Alonso D, Montero F, Raga J, Balbuena J. Diclidophora merlangi (Monogenea: Diclidophoridae) on Atlantic cod, Gadus morhua. J Parasitol. 2006;92:697-702 pubmed
    ..By contrast, the aspect and smaller size of the oocytes suggested that D. merlangi on cod could not produce viable ova, although 1 specimen exhibited an egg with normal sized and shaped capsule. ..
  47. Comas I, Moya A, Gonzalez Candelas F. From phylogenetics to phylogenomics: the evolutionary relationships of insect endosymbiotic gamma-Proteobacteria as a test case. Syst Biol. 2007;56:1-16 pubmed
    ..Nevertheless, other phylogenomic methods such as supertree approaches were useful in revealing alternative phylogenetic signals and should be included in comprehensive phylogenomic studies. ..
  48. Romero A, Gomez O, Terrado J, Mesonero J. Expression of GLUT8 in mouse intestine: identification of alternative spliced variants. J Cell Biochem. 2009;106:1068-78 pubmed publisher
  49. Piqueras L, Sanz M, Perretti M, Morcillo E, Norling L, Mitchell J, et al. Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukoc Biol. 2009;86:115-22 pubmed publisher
    ..Taken together, our results show that PPARbeta/delta modulates acute inflammation in vivo and in vitro under flow by targeting the neutrophil-endothelial cell interaction. ..
  50. Gómez Lechón M, Castell J, Donato M. The use of hepatocytes to investigate drug toxicity. Methods Mol Biol. 2010;640:389-415 pubmed publisher
    ..In this regard, cytomic, proteomic, toxicogenomic and metabonomic approaches help to define patterns of hepatotoxicity for early identification of potential adverse effects of the drug to the liver. ..
  51. Gozalbes R, Pineda Lucena A. Small molecule databases and chemical descriptors useful in chemoinformatics: an overview. Comb Chem High Throughput Screen. 2011;14:548-458 pubmed
  52. Maicas N, Ibáñez L, Alcaraz M, Ubeda A, Ferrándiz M. Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. Arthritis Rheum. 2012;64:130-40 pubmed publisher
    ..Our findings indicate that PGD2 is produced in articular tissue during the development of CIA and plays an antiinflammatory role, acting through the DP1 receptor. ..
  53. Moya M, Benet M, Guzmán C, Tolosa L, García Monzón C, Pareja E, et al. Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver. PLoS ONE. 2012;7:e30014 pubmed publisher
    ..However, Foxa1 is down-regulated in human and rat NAFL and, therefore, increasing Foxa1 levels could protect from steatosis. Altogether, we suggest that Foxa1 could be a novel therapeutic target for NAFL disease and insulin resistance. ..
  54. Rodríguez Jimnez F, Alastrue Agudo A, Erceg S, Stojkovic M, Moreno Manzano V. FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction. Stem Cells. 2012;30:2221-33 pubmed publisher
    ..Overall, FM19G11 exerts an important influence on the self-renewal of ependymal stem progenitor cells with a plausible neuroprotective role, providing functional benefits for spinal cord injury treatment. ..
  55. Ferrian S, Guerrero I, Blas E, García Diego F, Viana D, Pascual J, et al. How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions. Vet Immunol Immunopathol. 2012;150:53-60 pubmed publisher
  56. Santos Garcia D, Farnier P, Beitia F, Zchori Fein E, Vavre F, Mouton L, et al. Complete genome sequence of "Candidatus Portiera aleyrodidarum" BT-QVLC, an obligate symbiont that supplies amino acids and carotenoids to Bemisia tabaci. J Bacteriol. 2012;194:6654-5 pubmed publisher
    ..It presents a reduced genome (357 kb) encoding the capability to synthetize, or participate in the synthesis of, several amino acids and carotenoids, being the first insect endosymbiont capable of supplying carotenoids...
  57. Monleón S, Duque A, Vinader Caerols C. Effects of several degrees of chronic social defeat stress on emotional and spatial memory in CD1 mice. Behav Processes. 2016;124:23-31 pubmed publisher
    ..In conclusion, CSDS has a greater impact on emotional memory than on spatial memory. These negative effects of CSDS on memory do not seem to be secondary to the motor or emotional effects of stress. ..
  58. Vidal Gómez X, Novella S, Pérez Monzó I, Garabito M, Dantas A, Segarra G, et al. Decreased bioavailability of nitric oxide in aorta from ovariectomized senescent mice. Role of cyclooxygenase. Exp Gerontol. 2016;76:1-8 pubmed publisher
    ..These effects were reversed by estrogen administration. ..
  59. Martinez Jimenez C, Gomez Lechon M, Castell J, Jover R. Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein). Mol Pharmacol. 2005;67:2088-101 pubmed
    ..Together, our results uncover a new distal enhancer site in the CYP3A4 gene where C/EBPbeta-LAP binds and activates transcription, whereas the truncated form, C/EBPbeta-LIP, antagonizes LAP activity and causes gene repression. ..
  60. Espana F, Navarro S, Medina P, Zorio E, Estelles A. The role of protein C inhibitor in human reproduction. Semin Thromb Hemost. 2007;33:41-5 pubmed
    ..05 microM of PCI, fertilization rates might be significantly reduced. All of these data suggest that PCI is involved in human reproduction at several steps, including the fertilization process. ..
  61. Apostolova N, Blas García A, Esplugues J. Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-? inhibition. Trends Pharmacol Sci. 2011;32:715-25 pubmed publisher
    ..This review aims to provide a comprehensive overview of the mechanisms and factors which influence the mitochondrial involvement in the toxicity of all three major classes of anti-HIV drugs. ..
  62. Andrés Pons A, Gil A, Oliver M, Sotelo N, Pulido R. Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus. Cell Signal. 2012;24:577-87 pubmed publisher
  63. Vayá I, Andreu I, Monje V, Jiménez M, Miranda M. Mechanistic Studies on the Photoallergy Mediated by Fenofibric Acid: Photoreactivity with Serum Albumins. Chem Res Toxicol. 2016;29:40-6 pubmed publisher
    ..This results in the formation of caged radical pairs followed by C-C coupling to give covalent photoaducts. ..
  64. López Coronado J, Bellés J, Lesage F, Serrano R, Rodriguez P. A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase. J Biol Chem. 1999;274:16034-9 pubmed
    ..Finally, an unexpected connection between PAP and inositol-1,4-bisphosphate metabolism emerges from this work. ..
  65. Torregrosa G, Burguete M, Pérez Asensio F, Salom J, Gil J, Alborch E. Pharmacological profile of phytoestrogens in cerebral vessels: in vitro study with rabbit basilar artery. Eur J Pharmacol. 2003;482:227-34 pubmed
    ..Phytoestrogens act as cerebrovascular relaxants by a mechanism which involves Ca(2+) entry blockade in the vascular smooth muscle rather than stimulation of vasorelaxant endothelium-related mechanisms such as NO/cGMP or prostaglandins. ..
  66. Ortiz C, Ito T, Hashimoto Y, Nagayama S, Iwai A, Tsunoda S, et al. Effects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines. Diagn Pathol. 2010;5:41 pubmed publisher
    ..This indicates that targeting fascin pathway could be a novel therapeutic strategy for the human ESCC. ..
  67. Cosin Roger J, Vernia S, Alvarez M, Cucarella C, Bosca L, Martín Sanz P, et al. Identification of a novel Pfkfb1 mRNA variant in rat fetal liver. Biochem Biophys Res Commun. 2013;431:36-40 pubmed publisher
    ..The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism. ..
  68. Pascual Lucas M, Fernandez Lizarbe S, Montesinos J, Guerri C. LPS or ethanol triggers clathrin- and rafts/caveolae-dependent endocytosis of TLR4 in cortical astrocytes. J Neurochem. 2014;129:448-62 pubmed publisher
    ..The results provide new insights into the effects of ethanol on TLR4 signalling in astrocytes, events that may underlie neuroinflammation. ..
  69. Gomez Lechon M, Jover R, Donato T, Ponsoda X, Rodriguez C, Stenzel K, et al. Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix. J Cell Physiol. 1998;177:553-62 pubmed
  70. Arnal Pastor M, Comín Cebrián S, Martínez Ramos C, Monleón Pradas M, Vallés Lluch A. Hydrophilic surface modification of acrylate-based biomaterials. J Biomater Appl. 2016;30:1429-41 pubmed publisher
    ..This surface modification of 3D porous hydrophobic scaffolds makes easier the wetting with culture medium and aqueous solutions in general, and thus represents an advantage in the manageability of the scaffolds. ..
  71. Waqas S, Hoang A, Lin Y, Ampem G, Azegrouz H, Balogh L, et al. Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest. 2017;127:2842-2854 pubmed publisher
    ..NPFF thus plays an important role in supporting healthy adipose tissue via the maintenance of metabolically beneficial ATMs. ..
  72. Sánchez Sánchez A, Camp E, Leal Tassias A, Mullor J. Wnt signaling has different temporal roles during retinal development. Dev Dyn. 2010;239:297-310 pubmed publisher
    ..Instead, Wnt regulated Vsx1 expression, but not the expression of other retinal cell markers tested. Thus, the response of NRP cells to Wnt signaling is stage-dependent. ..
  73. Marin M, Esteban Pretel G, Ponsoda X, Romero A, Ballestín R, Lopez C, et al. Endocytosis in cultured neurons is altered by chronic alcohol exposure. Toxicol Sci. 2010;115:202-13 pubmed publisher
    ..Our results in neurons also stress the notion that one of the main targets of ethanol is intracellular transport. ..
  74. Ferrer P, Asensi M, Priego S, Benlloch M, Mena S, Ortega A, et al. Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma. J Biol Chem. 2007;282:2880-90 pubmed
    ..Direct NO-induced cytotoxicity and ceramide-induced mitochondrial permeability transition and apoptosis activation can explain the increased endothelium-induced death of Bcl-2-depleted B16M-F10 cells. ..
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    ..Although stochastic gene loss plays a role in the genome reduction process, it is also clear that metabolism, as a functional constraint, is also a powerful evolutionary force in insect endosymbionts...
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    ..The developed 100MHz QCM immunosensor strongly improves sensitivity in biosensing, and therefore can be considered as a very promising new analytical tool for in liquid applications where highly sensitive detection is required. ..
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