Experts and Doctors on animals in Murcia, Spain

Summary

Locale: Murcia, Spain
Topic: animals

Top Publications

  1. Puelles L, Rubenstein J. Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci. 2003;26:469-76 pubmed
    ..By contrast, we continue to postulate that prosomeres p1-p3 (i.e. the pretectum, thalamus and prethalamus) are the caudal forebrain. ..
  2. Parrilla I, Vazquez J, Oliver Bonet M, Navarro J, Yelamos J, Roca J, et al. Fluorescence in situ hybridization in diluted and flow cytometrically sorted boar spermatozoa using specific DNA direct probes labelled by nick translation. Reproduction. 2003;126:317-25 pubmed
    ..Moreover, the ease of nick translation and the quality of the fluorescent signal obtained using this method makes this procedure the most appropriate method for labelling pig DNA probes to be used for direct FISH on pig spermatozoa. ..
  3. Navarro J, García de la Fuente J, Sanchez J, Martinez C, Buendia A, Gutiérrez Martín C, et al. Kinetics of infection and effects on the placenta of Chlamydophila abortus in experimentally infected pregnant ewes. Vet Pathol. 2004;41:498-505 pubmed
    ..abortus antigen in the degenerated caruncular tissues. ..
  4. Bayarri M, Iigo M, Muñoz Cueto J, Isorna E, Delgado M, Madrid J, et al. Binding characteristics and daily rhythms of melatonin receptors are distinct in the retina and the brain areas of the European sea bass retina (Dicentrarchus labrax). Brain Res. 2004;1029:241-50 pubmed
    ..This result suggests that retinal melatonin is a paracrine factor able to control receptor desensitization during photophase when ocular melatonin is higher in this species. ..
  5. Caro M, Buendia A, Del Rio L, Ortega N, Gallego M, Cuello F, et al. Chlamydophila abortus infection in the mouse: a useful model of the ovine disease. Vet Microbiol. 2009;135:103-11 pubmed publisher
    ..Future studies using these models will provide and reveal information about the precise mechanisms in the immune response against C. abortus and will increase the knowledge about poorly understood issues such as chlamydial persistence. ..
  6. Alarcón Martínez L, Avilés Trigueros M, Galindo Romero C, Valiente Soriano J, Agudo Barriuso M, Villa P, et al. ERG changes in albino and pigmented mice after optic nerve transection. Vision Res. 2010;50:2176-87 pubmed publisher
    ..These changes were maintained up to 12 weeks post-ONT, demonstrating that the ERG-STR is a useful parameter to monitor RGC functionality in adult mice...
  7. Perez Schindler J, Philp A, Baar K, Hernández Cascales J. Regulation of contractility and metabolic signaling by the ?2-adrenergic receptor in rat ventricular muscle. Life Sci. 2011;88:892-7 pubmed publisher
    ..Rather, ?(2)-AR could function to activate PKB and AMPK signaling, thereby modulating muscle mass and energetic metabolism of rat ventricular muscle. ..
  8. Blanco Vives B, Aliaga Guerrero M, Cañavate J, Muñoz Cueto J, Sanchez Vazquez F. Does lighting manipulation during incubation affect hatching rhythms and early development of sole?. Chronobiol Int. 2011;28:300-6 pubmed publisher
  9. González Barrio R, Truchado P, Garcia Villalba R, Hervás G, Frutos P, Espín J, et al. Metabolism of oak leaf ellagitannins and urolithin production in beef cattle. J Agric Food Chem. 2012;60:3068-77 pubmed publisher
    ..Further studies are needed to demonstrate if the efficiency in the metabolism of ellagitannins by the microbiota could explain the differences observed in susceptibility to intoxication by the different animals. ..

More Information

Publications273 found, 100 shown here

  1. Anchelin M, Alcaraz Pérez F, Martinez C, Bernabé García M, Mulero V, Cayuela M. Premature aging in telomerase-deficient zebrafish. Dis Model Mech. 2013;6:1101-12 pubmed publisher
  2. Tomé Carneiro J, Gonzálvez M, Larrosa M, Yáñez Gascón M, García Almagro F, Ruiz Ros J, et al. Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective. Ann N Y Acad Sci. 2013;1290:37-51 pubmed publisher
    ..However, statistically significant changes in CVD-risk markers do not necessarily equal clinical significance in the daily care of patients. ..
  3. Espín S, Martinez Lopez E, León Ortega M, Martínez J, García Fernández A. Oxidative stress biomarkers in Eurasian eagle owls (Bubo bubo) in three different scenarios of heavy metal exposure. Environ Res. 2014;131:134-44 pubmed publisher
    ..In addition, we provide new data on Hg and Cd concentrations related to effects in the antioxidant system. ..
  4. García Gómez B, Fernández Gómez F, Muñoz Delgado E, Buée L, Blum D, Vidal C. MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance. J Mol Neurosci. 2016;58:411-5 pubmed publisher
  5. Baenas N, Piegholdt S, Schloesser A, Moreno D, García Viguera C, Rimbach G, et al. Metabolic Activity of Radish Sprouts Derived Isothiocyanates in Drosophila melanogaster. Int J Mol Sci. 2016;17:251 pubmed publisher
    ..These processes are often affected in chronic diseases associated with aging, including type II diabetes mellitus. ..
  6. Cordero H, Ceballos Francisco D, Cuesta A, Esteban M. Dorso-ventral skin characterization of the farmed fish gilthead seabream (Sparus aurata). PLoS ONE. 2017;12:e0180438 pubmed publisher
    ..Taking into account all together, this study represents a step forward in our knowledge of the skin structure and skin regeneration of an important farmed teleost, gilthead seabream, one of the most commonly farmed fish worldwide. ..
  7. Tatay Dualde J, Prats van der Ham M, de la Fe C, Paterna A, Sanchez A, Corrales J, et al. Resistance mechanisms against quinolones in Mycoplasma capricolum subsp. capricolum. Vet J. 2017;223:1-4 pubmed publisher
    ..Alterations in parC predicted amino acid sequences were most frequently associated with quinolone resistance in Mcc. ..
  8. Cuesta A, Esteban M, Meseguer J. Molecular characterization of the nonspecific cytotoxic cell receptor (NCCRP-1) demonstrates gilthead seabream NCC heterogeneity. Dev Comp Immunol. 2005;29:637-50 pubmed
    ..Immunofluorescence microscopic observations confirm the previous results. The implications of this receptor on seabream NCC activity are discussed. ..
  9. González Candela M, Martín Atance P, Seva J, Pallares F, León Vizcaíno L. Granulomatous hepatitis caused by Salmonella Typhimurium in a spur-thighed tortoise (Testudo graeca). Vet Rec. 2005;157:236-7 pubmed
  10. Larque E, Sabater Molina M, Zamora S. Biological significance of dietary polyamines. Nutrition. 2007;23:87-95 pubmed
    ..They are components of breast milk and might be important in neonatal gut maturation, for which reason the possible supplementation of infant formulas with these compounds is under study...
  11. Sepulcre M, Sarropoulou E, Kotoulas G, Meseguer J, Mulero V. Vibrio anguillarum evades the immune response of the bony fish sea bass (Dicentrarchus labrax L.) through the inhibition of leukocyte respiratory burst and down-regulation of apoptotic caspases. Mol Immunol. 2007;44:3751-7 pubmed
    ..These results suggest that the virulence mechanisms of V. anguillarum in sea bass involve the inhibition of leukocyte respiratory burst and apoptosis, and thereby providing a safe haven for growth. ..
  12. Parrilla Reverter G, Agudo M, Nadal Nicolás F, Alarcón Martínez L, Jiménez López M, Salinas Navarro M, et al. Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study. Vision Res. 2009;49:2808-25 pubmed publisher
    ..Importantly, this aberrant pNFH-expression pattern starts earlier and is more dramatic after IONT than after IONC, highlighting the importance that the type of injury has on the time-course of RGC degeneration. ..
  13. Sanchez J, Sanchez Vazquez F. Feeding entrainment of daily rhythms of locomotor activity and clock gene expression in zebrafish brain. Chronobiol Int. 2009;26:1120-35 pubmed publisher
  14. Amores J, Sanchez A, Martín A, Corrales J, Contreras A, de la Fe C. Viability of Mycoplasma agalactiae and Mycoplasma mycoides subsp. capri in goat milk samples stored under different conditions. Vet Microbiol. 2010;145:347-50 pubmed publisher
    ..Given the different sensitivity of the two mycoplasma species to BR, refrigerated milk samples treated with AZ could be used to detect infections caused by both species through culture-based methods...
  15. Soler L, Gutierrez A, Martinez Subiela S, Ceron J. Development and validation of a novel competitive ELISA for the detection of serum amyloid A in pigs. Vet J. 2011;190:e7-11 pubmed publisher
    ..This novel assay precisely and sensitively measures SAA levels in pigs and will facilitate the more accurate assessment and study of the acute phase response in this species. ..
  16. Pelegrin P, García Castillo J, Mulero V, Meseguer J. Interleukin-1beta isolated from a marine fish reveals up-regulated expression in macrophages following activation with lipopolysaccharide and lymphokines. Cytokine. 2001;16:67-72 pubmed
    ..More importantly, IL-1beta was highly expressed by purified macrophage monolayers and was up-regulated by lipopolysaccharide and lymphocyte-derived macrophage-activating factor stimulation. ..
  17. González Cuello A, Milanes M, Castells M, Laorden M. Activation of c-fos expression in the heart after morphine but not U-50,488H withdrawal. Br J Pharmacol. 2003;138:626-33 pubmed
  18. González Candela M, León Vizcaino L, Cubero Pablo M. Population effects of sarcoptic mange in Barbary sheep (Ammotragus lervia) from Sierra Espuña Regional Park, Spain. J Wildl Dis. 2004;40:456-65 pubmed
  19. Roca F, Cayuela M, Secombes C, Meseguer J, Mulero V. Post-transcriptional regulation of cytokine genes in fish: A role for conserved AU-rich elements located in the 3'-untranslated region of their mRNAs. Mol Immunol. 2007;44:472-8 pubmed
    ..Both cytokine mRNAs were unstable with an estimated half-life of about 45 min in control and activated cells. ..
  20. Hernandez Espinosa D, Minano A, Martinez C, Ordonez A, Perez Ceballos E, de Arriba F, et al. Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin. Lab Invest. 2008;88:306-17 pubmed publisher
  21. de Heredia F, Larque E, Portillo M, Canteras M, Zamora S, Garaulet M. Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin. Nutrition. 2008;24:1013-22 pubmed publisher
    ..In rats fed a high-fat diet, aging resulted in a lower saturation degree, with increased values in the cardiometabolic risk factor omega-6/omega-3 ratio in serum and adipose tissue. ..
  22. Saez F, Reverte V, Salazar F, Castells M, Llinas M, Salazar F. Hypertension and sex differences in the age-related renal changes when cyclooxygenase-2 activity is reduced during nephrogenesis. Hypertension. 2009;53:331-7 pubmed publisher
    ..However, the consequent age-dependent deterioration of the renal structure and renal function is only significantly enhanced in male rats. ..
  23. López Muñoz A, Roca F, Meseguer J, Mulero V. New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. J Immunol. 2009;182:3440-9 pubmed publisher
    ..Collectively, our results suggest nonredundant, complementary roles of type I zfIFNs in viral infections and provide evidence for a pivotal role of the recently identified group II IFN of fish in the early stages of viral infections. ..
  24. García Ayuso D, Salinas Navarro M, Agudo M, Cuenca N, Pinilla I, Vidal Sanz M, et al. Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina. Exp Eye Res. 2010;91:800-10 pubmed publisher
  25. Coy P, Jimenez Movilla M, García Vázquez F, Mondéjar I, Grullon L, Romar R. Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa. Hum Reprod. 2012;27:1985-93 pubmed publisher
    ..Since components of the PLG-PLA system are already available as drugs for heart attacks or cancer therapies, basic research on this novel function would be rapidly transferable for clinical application. ..
  26. Villamizar N, Ribas L, Piferrer F, Vera L, Sanchez Vazquez F. Impact of daily thermocycles on hatching rhythms, larval performance and sex differentiation of zebrafish. PLoS ONE. 2012;7:e52153 pubmed publisher
    ..3 fold increase). Taken together, these findings highlight the key role of environmental cycles during early development, which shaped the daily rhythms in fish embryo and larvae, and ultimately influenced sex differentiation. ..
  27. Egea Jiménez A, Pérez Lara A, Corbalan Garcia S, Gomez Fernandez J. Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C ? to reach maximum activity. PLoS ONE. 2013;8:e69041 pubmed publisher
  28. McGowan D, Herschke F, Pauwels F, Stoops B, Smyej I, Last S, et al. Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B. J Med Chem. 2017;60:6137-6151 pubmed publisher
    ..We aimed for a high first pass effect, limiting cytokine induction systemically, and demonstrated the potential for the immunotherapy of viral hepatitis. ..
  29. Martinez Menarguez J, Prekeris R, Oorschot V, Scheller R, Slot J, Geuze H, et al. Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with the cisternal progression model of intra-Golgi transport. J Cell Biol. 2001;155:1213-24 pubmed
    ..These data suggest a role of peri-Golgi vesicles in recycling of Golgi residents, rather than an important role in anterograde transport. ..
  30. Laorden M, Nunez C, Almela P, Milanes M. Morphine withdrawal-induced c-fos expression in the hypothalamic paraventricular nucleus is dependent on the activation of catecholaminergic neurones. J Neurochem. 2002;83:132-40 pubmed
  31. Barcia C, Sánchez Bahillo A, Fernández Villalba E, Bautista V, Poza Y Poza M, Fernández Barreiro A, et al. Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia. 2004;46:402-9 pubmed
    ..These data suggest that neurodegeneration was still active despite the absence of the agent triggering cell death and that the glial reaction is associated with long-term neurodegeneration. ..
  32. Nieto Cerón S, del Campo L, Muñoz Delgado E, Vidal C, Campoy F. Muscular dystrophy by merosin deficiency decreases acetylcholinesterase activity in thymus of Lama2dy mice. J Neurochem. 2005;95:1035-46 pubmed
  33. Crespo León F, Gutiérrez Díez F, Rodríguez Ferri F, León Vizcaíno L, Cuello Gijón F, Gimeno E, et al. The translation into Spanish of the OIE Manual of diagnostic tests and vaccines for terrestrial animals (mammals, birds and bees): problems, solutions and conclusions. Rev Sci Tech. 2005;24:1095-104 pubmed
  34. González Candela M, Verbisck Bucker G, Martín Atance P, Cubero Pablo M, León Vizcaíno L. Mycoplasmas isolated from Spanish ibex (Capra pyrenaica hispanica): frequency and risk factors. Vet Rec. 2007;161:167-8 pubmed
  35. Canovas S, Romar R, Grullon L, Aviles M, Coy P. Pre-fertilization zona pellucida hardening by different cross-linkers affects IVF in pigs and cattle and improves embryo production in pigs. Reproduction. 2009;137:803-12 pubmed publisher
  36. Navarro Zaragoza J, Nunez C, Laorden M, Milanes M. Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal. Mol Pharmacol. 2010;77:864-73 pubmed publisher
    ..However, CRF1R activation may not contribute to the functional interaction between NA and CRF systems in mediating morphine withdrawal-activation of brain stress neurocircuitry. ..
  37. Vergara Chen C, González Wangüemert M, Marcos C, Pérez Ruzafa A. Genetic diversity and connectivity remain high in Holothuria polii (Delle Chiaje 1823) across a coastal lagoon-open sea environmental gradient. Genetica. 2010;138:895-906 pubmed publisher
  38. Cabas I, Chaves Pozo E, Alcázar A, Meseguer J, Mulero V, García Ayala A. Dietary intake of 17?-ethinylestradiol promotes leukocytes infiltration in the gonad of the hermaphrodite gilthead seabream. Mol Immunol. 2011;48:2079-86 pubmed publisher
    ..Moreover, the dietary intake of EE(2) promoted a dose-dependent up-regulation of the expression of genes coding for cytokines, chemokines and adhesion molecules correlated with a leukocyte infiltration...
  39. Escribano D, Gutierrez A, Martinez Subiela S, Tecles F, Ceron J. Validation of three commercially available immunoassays for quantification of IgA, IgG, and IgM in porcine saliva samples. Res Vet Sci. 2012;93:682-7 pubmed publisher
    ..Therefore, these assays may be used in porcine saliva samples, in addition, the measurement of Igs in saliva could be a practical tool, simple and minimally invasive, to evaluate the humoral immune status of pigs. ..
  40. Tomás M, Marín M, Martínez Alonso E, Esteban Pretel G, Diaz Ruiz A, Vazquez Martinez R, et al. Alcohol induces Golgi fragmentation in differentiated PC12 cells by deregulating Rab1-dependent ER-to-Golgi transport. Histochem Cell Biol. 2012;138:489-501 pubmed publisher
    ..Taken together, our results support the view that alcohol and neurodegenerative diseases such as Parkinson have similar effects on intracellular trafficking and provide new clues on the neuropathology of alcoholism. ..
  41. Stetson I, Izquierdo Rico M, Moros C, Chevret P, Lorenzo P, Ballesta J, et al. Rabbit zona pellucida composition: a molecular, proteomic and phylogenetic approach. J Proteomics. 2012;75:5920-35 pubmed publisher
    ..The data presented in this manuscript provide evidence, for the first time, that the rabbit ZP is composed of four glycoproteins...
  42. Martínez Mora C, Mrowiec A, García Vizcaíno E, Alcaraz A, Cenis J, Nicolás F. Fibroin and sericin from Bombyx mori silk stimulate cell migration through upregulation and phosphorylation of c-Jun. PLoS ONE. 2012;7:e42271 pubmed publisher
    ..Altogether, our results showed that fibroin and sericin initiate cell migration by activating the MEK, JNK and PI3K signalling pathways ending in c-Jun activation. ..
  43. Salazar F, Vazquez M, Masferrer J, Mbalaviele G, Llinas M, Saez F, et al. Renal effects induced by prolonged mPGES1 inhibition. Am J Physiol Renal Physiol. 2014;306:F68-74 pubmed publisher
  44. de Oliveira S, López Muñoz A, Candel S, Pelegrin P, Calado A, Mulero V. ATP modulates acute inflammation in vivo through dual oxidase 1-derived H2O2 production and NF-?B activation. J Immunol. 2014;192:5710-9 pubmed publisher
  45. Martínez B, Rubio B, Viera C, Linares M, Egea M, Panella Riera N, et al. Evaluation of different strategies to mask boar taint in cooked sausage. Meat Sci. 2016;116:26-33 pubmed publisher
    ..Only the combined use of spices and smoking was able to eliminate the perception of androstenone. The application of this strategy in frankfurters could be an alternative in the commercialization of entire pigs. ..
  46. Munoz P, Meseguer J, Esteban M. Phenoloxidase activity in three commercial bivalve species. Changes due to natural infestation with Perkinsus atlanticus. Fish Shellfish Immunol. 2006;20:12-9 pubmed
    ..The present work constitutes the first report on the influence of this parasite on PO activity in haemolymph and haemocytes from T. decussatus. ..
  47. González Cuello A, Sanchez L, Hernandez J, Teresa Castells M, Victoria Milanés M, Laorden M. Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart. Eur J Pharmacol. 2007;570:1-9 pubmed
  48. Salinas I, Abelli L, Bertoni F, Picchietti S, Roque A, Furones D, et al. Monospecies and multispecies probiotic formulations produce different systemic and local immunostimulatory effects in the gilthead seabream (Sparus aurata L.). Fish Shellfish Immunol. 2008;25:114-23 pubmed publisher
    ..The advantages provided by administration of killed probiotic bacteria as well as multispecies versus monospecies formulations are discussed in light of the results obtained and for their possible application in aquacultural practices. ..
  49. Garcia Vazquez F, García Roselló E, Gutierrez Adan A, Gadea J. Effect of sperm treatment on efficiency of EGFP-expressing porcine embryos produced by ICSI-SMGT. Theriogenology. 2009;72:506-18 pubmed publisher
    ..However, severe sperm treatments such as QF and TX-100 may damage the sperm nucleus, induce DNA fragmentation, and/or lead to chromosomal breakage with a detrimental effect on further embryonic development. ..
  50. Gil M, Cuello C, Parrilla I, Vazquez J, Roca J, Martinez E. Advances in swine in vitro embryo production technologies. Reprod Domest Anim. 2010;45 Suppl 2:40-8 pubmed publisher
    ..This study summarizes recent advancements in IVM-IVF-IVC porcine systems. Recent methods to select monospermic embryos are also discussed. Finally, achievements in vitrification and in somatic cell nuclear transfer are discussed. ..
  51. Azorín Ortuño M, Yáñez Gascón M, Gonzalez Sarrias A, Larrosa M, Vallejo F, Pallares F, et al. Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: a transcriptomic approach to disease prevention. J Nutr Biochem. 2012;23:829-37 pubmed publisher
  52. Mondéjar I, Grullón L, García Vázquez F, Romar R, Coy P. Fertilization outcome could be regulated by binding of oviductal plasminogen to oocytes and by releasing of plasminogen activators during interplay between gametes. Fertil Steril. 2012;97:453-61 pubmed publisher
    ..The plasminogen/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte. ..
  53. Soler L, Molenaar A, Merola N, Eckersall P, Gutierrez A, Ceron J, et al. Why working with porcine circulating serum amyloid A is a pig of a job. J Theor Biol. 2013;317:119-25 pubmed publisher
    ..It is concluded that pig systemic SAA is unique compared to other species, which raises questions about the proposed importance of acute phase SAA in HDL metabolism during inflammation in this species. ..
  54. Soler L, Gutierrez A, Escribano D, Fuentes M, Ceron J. Response of salivary haptoglobin and serum amyloid A to social isolation and short road transport stress in pigs. Res Vet Sci. 2013;95:298-302 pubmed publisher
    ..0001). These results indicate that salivary serum amyloid A (and not haptoglobin) determination is a potential biomarker for the assessment of complex stress in pigs, and that it has a more prolonged response than cortisol. ..
  55. Herráiz F, Villano D, Plazas M, Vilanova S, Ferreres F, Prohens J, et al. Phenolic Profile and Biological Activities of the Pepino (Solanum muricatum) Fruit and Its Wild Relative S. caripense. Int J Mol Sci. 2016;17:394 pubmed publisher
    ..caripense E-7 (high for antioxidant activity) to select and breed pepino varieties with enhanced properties. ..
  56. Gómez Ramírez P, Bustnes J, Eulaers I, Herzke D, Johnsen T, Lepoint G, et al. Per- and polyfluoroalkyl substances in plasma and feathers of nestling birds of prey from northern Norway. Environ Res. 2017;158:277-285 pubmed publisher
    ..However, further studies on larger sample sizes are needed to confirm this hypothesis since toxic thresholds for nestling birds of prey are not established. ..
  57. Jiménez Atiénzar M, Cabanes J, Gandia Herrero F, Garcia Carmona F. Kinetic analysis of catechin oxidation by polyphenol oxidase at neutral pH. Biochem Biophys Res Commun. 2004;319:902-10 pubmed
    ..The results obtained by simulation of the model produced the same qualitative dependences as obtained experimentally. ..
  58. García Estañ J, Ortiz M, O Valle F, Alcaraz A, Navarro E, Vargas F, et al. Effects of angiotensin-converting-enzyme inhibitors in combination with diuretics on blood pressure and renal injury in nitric oxide-deficiency-induced hypertension in rats. Clin Sci (Lond). 2006;110:227-33 pubmed
    ..The protective effect is related to an activation of endothelial NO synthase expression and to a normalization of the oxidative stress parameters due to the inhibition of angiotensin II. ..
  59. Nunez C, Martín F, Földes A, Luisa Laorden M, Kovacs K, Victoria Milanés M. Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. J Neurochem. 2010;114:475-87 pubmed publisher
  60. Moral Naranjo M, Cabezas Herrera J, Vidal C, Campoy F. Muscular dystrophy with laminin deficiency decreases the content of butyrylcholinesterase tetramers in sciatic nerves of Lama2dy mice. Neurosci Lett. 2002;331:155-8 pubmed
    ..The anomalous synthesis of BuChE forms in dystrophic nerve may be related with peripheral neuropathy of MCMD. ..
  61. Martínez M, Milanes M, Laorden M. Implication of the signal transduction pathways in the enhancement of noradrenaline turnover induced by morphine withdrawal in the heart. Eur J Pharmacol. 2003;471:113-9 pubmed
    ..The present finding suggests that protein kinase A and Ca(2+) influx through L-type Ca(2+) channels might contribute to the activation of noradrenergic system in the heart observed during morphine withdrawal...
  62. González Cuello A, Milanes M, Laorden M. Increase of tyrosine hydroxylase levels and activity during morphine withdrawal in the heart. Eur J Pharmacol. 2004;506:119-28 pubmed
    ..Our results suggest that an increase in tyrosine hydroxylase protein levels and tyrosine hydroxylase enzyme activity might contribute to the enhanced noradrenergic activity in the heart in response to morphine withdrawal. ..
  63. Aroca P, Puelles L. Postulated boundaries and differential fate in the developing rostral hindbrain. Brain Res Brain Res Rev. 2005;49:179-90 pubmed
  64. del Rio M, Penuelas Rivas G, Dominguez Perles R, Ramirez P, Parrilla P, Rodriguez Barbosa J. Antibody-mediated signaling through PD-1 costimulates T cells and enhances CD28-dependent proliferation. Eur J Immunol. 2005;35:3545-60 pubmed
  65. Almela P, Cerezo M, Milanes M, Laorden M. Role of PKC in regulation of Fos and TH expression after naloxone induced morphine withdrawal in the heart. Naunyn Schmiedebergs Arch Pharmacol. 2006;372:374-82 pubmed
  66. Salazar F, Reverte V, Saez F, Loria A, Llinas M, Salazar F. Age- and sodium-sensitive hypertension and sex-dependent renal changes in rats with a reduced nephron number. Hypertension. 2008;51:1184-9 pubmed publisher
    ..This study shows that the reduction of angiotensin II effects during the nephrogenic period modifies renal function and induces the development of an angiotensin II-dependent hypertension that becomes sodium sensitive during aging...
  67. Mulero I, Pilar Sepulcre M, Roca F, Meseguer J, García Ayala A, Mulero V. Characterization of macrophages from the bony fish gilthead seabream using an antibody against the macrophage colony-stimulating factor receptor. Dev Comp Immunol. 2008;32:1151-9 pubmed publisher
    ..Finally, as the epitope recognized by the anti-Mcsfr is well conserved, we illustrate the potential usefulness of this antibody in other teleost species, such as the European seabass. ..
  68. Galindo Tovar A, Vargas M, Kaumann A. Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium. Naunyn Schmiedebergs Arch Pharmacol. 2009;379:379-84 pubmed publisher
    ..In contrast to the (-)-CGP12177-evoked tachycardia, not controlled by PDE3 and PDE4, these isoenzymes jointly reduce (-)-CGP12177-evoked increases of left atrial contractility through beta(1L)AR. ..
  69. Belda E, Beldao E, Blissitt K, Duncan J, Laredo F, Escobar Gil de Montes M, et al. The bispectral index during recovery from halothane and sevoflurane anaesthesia in horses. Vet Anaesth Analg. 2010;37:25-34 pubmed publisher
    ..Bispectral indices appear to approximate levels of unconsciousness, suggesting that monitoring the BIS may assist equine anaesthesia. However, it does not predict intra-operative movement. ..
  70. Navarro J, Sanchez J, Peñafiel Verdú C, Buendia A, Altimira J, Vilafranca M. Histopathological lesions in 15 cats with leishmaniosis. J Comp Pathol. 2010;143:297-302 pubmed publisher
    ..The presence of amastigotes was confirmed by immunohistochemistry in each case. The results of the study confirm the value of histopathological and immunohistochemical techniques for the diagnosis of feline leishmaniosis. ..
  71. Larrosa M, Tomé Carneiro J, Yáñez Gascón M, Alcantara D, Selma M, Beltran D, et al. Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents. J Med Chem. 2010;53:7365-76 pubmed publisher
  72. Sánchez Vázquez F, Terry M, Felizardo V, Vera L. Daily rhythms of toxicity and effectiveness of anesthetics (MS222 and eugenol) in zebrafish (Danio rerio). Chronobiol Int. 2011;28:109-17 pubmed publisher
    ..In conclusion, these results revealed that the toxicity and effectiveness of both anesthetic substances is highest during daytime, the active phase of fish, thus suggesting a link between the daily rhythms of behavior and toxicity. ..
  73. Martin F, Mora L, Laorden M, Milanés M. Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal. Br J Pharmacol. 2011;163:857-75 pubmed publisher
  74. Tvarijonaviciute A, Ceron J, Caldin M. Serum butyrylcholinesterase activity in dogs with diabetes mellitus. Vet J. 2012;192:494-7 pubmed publisher
    ..12 ± 1.94 kUI/L; P<0.05), and with the dogs with other diseases (5.55 ± 2.06 kUI/L; P<0.01). Such increased activity could be the result of the altered glucose and lipid metabolism that occurs in DM. ..
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    ..PDE4, but not PDE3, controls the atrial inotropic and cAMP beta(1)-adrenoceptor-mediated responses to (-)-noradrenaline. Both PDE3 and PDE4 blunt left atrial inotropic and cAMP responses to (-)-adrenaline through beta(2)-adrenoceptors. ..
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