Experts and Doctors on aged in Madrid, Spain


Locale: Madrid, Spain
Topic: aged

Top Publications

  1. Lozano D, Feito M, Portal Nuñez S, Lozano R, Matesanz M, Serrano M, et al. Osteostatin improves the osteogenic activity of fibroblast growth factor-2 immobilized in Si-doped hydroxyapatite in osteoblastic cells. Acta Biomater. 2012;8:2770-7 pubmed publisher
    ..These findings provide an attractive strategy for bone tissue engineering. ..
  2. Jimenez Garcia R, Hernandez Barrera V, Rodríguez Rieiro C, Lopez de Andres A, de Miguel Diez J, Jimenez Trujillo I, et al. Hospitalizations from pandemic Influenza [A(H1N1)pdm09] infections among type 1 and 2 diabetes patients in Spain. Influenza Other Respir Viruses. 2013;7:439-47 pubmed publisher
    ..The results of multivariate analysis suggest that possibly concomitant conditions such as obesity increase the risk of dying from the infection, but not diabetes itself. ..
  3. Polo R, Del Mar Medina M, Arístegui M, Lassaletta L, Gutiérrez A, Aránguez G, et al. Subtotal Petrosectomy for Cochlear Implantation: Lessons Learned After 110 Cases. Ann Otol Rhinol Laryngol. 2016;125:485-94 pubmed publisher
    ..Subtotal petrosectomy is a safe technique, with a low rate of complications. ..
  4. Olaya B, Moneta M, Koyanagi A, Lara E, Miret M, Ayuso Mateos J, et al. The joint association of depression and cognitive function with severe disability among community-dwelling older adults in Finland, Poland and Spain. Exp Gerontol. 2016;76:39-45 pubmed publisher
    ..However, in Finland, those with better cognitive function may benefit from more aggressive depression treatment. Future research is warranted to assess whether our results may be replicated. ..
  5. Garcia Lopez A, Perez Ubeda M, Marco F, Molina M, Lopez Duran L. A modified technique of four-bone fusion for advanced carpal collapse (SLAC/SNAC wrist). J Hand Surg Br. 2001;26:352-4 pubmed
    ..In conclusion, this technique provides immediate stable fixation and early mobilization and assures bone fusion. ..
  6. Arroyo Espliguero R, Oteo Domínguez J, Castedo Mejuto E, Antorrena Miranda I, Ortigosa Aso J, Cañas Cañas A, et al. Late displacement of a ventricular pacing lead after respiratory therapy. Pacing Clin Electrophysiol. 2001;24:1693-5 pubmed
    ..The incident provoked the loss of the ventricular pacing and left pectoral stimulation. The different techniques for achieving airway patency that can be used in respiratory therapy of patients with permanent pacemakers are discussed. ..
  7. Pitarch A, Jimenez A, Nombela C, Gil C. Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analyses. Mol Cell Proteomics. 2006;5:79-96 pubmed
    ..Furthermore serum anti-wall enolase antibodies are a new prognostic indicator for SC and confer protection against it. Bgl2p and wall-associated enolase could be valuable candidates for future vaccine development. ..
  8. Garcia de la Pena Lefebvre P, Rodríguez Rubio S, Valero Expósito M, Carmona L, Gamir Gamir M, Beltrán Gutiérrez J, et al. Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients. Rheumatology (Oxford). 2008;47:464-6 pubmed publisher
    ..Toxicity related to bosentan included mild transitory events and one toxic hepatitis. Bosentan may be a safe long-term alternative for treating the recurrence of skin ulcers and healed ulcers in SSc patients. ..
  9. Perez M, Santa Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero J, et al. Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem. 2009;109:1756-66 pubmed publisher
    ..In addition, we found that an excess of tau protein, as a HDAC6 inhibitor, prevents induction of autophagy by inhibiting proteasome function. ..

More Information

Publications521 found, 100 shown here

  1. Laclaustra M, Stranges S, Navas Acien A, Ordovas J, Guallar E. Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Atherosclerosis. 2010;210:643-8 pubmed publisher
    ..Given increasing trends in dietary selenium intake and supplementation, the causal mechanisms underlying these associations need to be fully characterized. ..
  2. Garcia Rodriguez L, Cea Soriano L, Hill C, Johansson S. Increased risk of stroke after discontinuation of acetylsalicylic acid: a UK primary care study. Neurology. 2011;76:740-6 pubmed publisher
    ..This study provides Class III evidence that discontinuation of low-dose ASA is associated with a 40% increased risk of stroke within 31-180 days of discontinuation. ..
  3. Caballero M, Umpierrez A, Moneo I, Rodriguez Perez R. Ani s 10, a new Anisakis simplex allergen: cloning and heterologous expression. Parasitol Int. 2011;60:209-12 pubmed publisher
    ..A total of 30 of 77 Anisakis allergic patients (39%) were positive both to rAni s 10 and natural Ani s 10 by immunoblotting. The new allergen could be useful in a component-resolved diagnosis system for Anisakis allergy...
  4. Gómez V, Galeano C, Diez V, Bueno C, Díaz F, Burgos F. Economic impact of the introduction of machine perfusion preservation in a kidney transplantation program in the expanded donor era: cost-effectiveness assessment. Transplant Proc. 2012;44:2521-4 pubmed publisher
    ..However, the incremental cost-effectiveness ratio was $3,369 for each DGF- or PNF- saved case. The introduction of the MP preservation technology in a KT program form ECD is cost-effective in terms of savings for DGF and PNF cases. ..
  5. Álvaro Afonso F, Lázaro Martínez J, Aragón Sánchez J, García Morales E, García Álvarez Y, Molines Barroso R. What Is the Clinical Utility of the Ankle-Brachial Index in Patients With Diabetic Foot Ulcers and Radiographic Arterial Calcification?. Int J Low Extrem Wounds. 2015;14:372-6 pubmed publisher
    ..4 but without RAC (n = 21; r = .686, P = .001). ABI values between 0.9 and 1.4 would be falsely considered as normal and could underestimate the prevalence of PAD, especially in patients with neuropathy, diabetic foot ulcers, or RAC. ..
  6. Perteguer M, Chivato T, Montoro A, Cuellar C, Mateos J, Laguna R. Specific and total IgE in patients with recurrent, acute urticaria caused by Anisakis simplex. Ann Trop Med Parasitol. 2000;94:259-68 pubmed
    ..Most (16) of the patients no longer had any urticaria and the others reported significant reductions in the intensity and frequency of their symptoms...
  7. de las Cuevas N, Muñoz U, Hermida O, Martin Requero A. Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients. Neurobiol Aging. 2005;26:615-24 pubmed
  8. Varona J, Guerra J, Grande C, Villena V, González Lois C, Martinez M. Primary pulmonary lymphoma: diagnosis and follow-up of 6 cases and review of an uncommon entity. Tumori. 2005;91:24-9 pubmed
    ..Primary pulmonary lymphoma is an uncommon disease with a poorly defined management. We reviewed and followed the cases of primary pulmonary lymphoma in our institution to gather an estimation of this entity in our population...
  9. Martinez Delgado B, Cuadros M, Honrado E, Ruiz de la Parte A, Roncador G, Alves J, et al. Differential expression of NF-kappaB pathway genes among peripheral T-cell lymphomas. Leukemia. 2005;19:2254-63 pubmed
    ..The expression profile associated to reduced expression of NF-kappaB genes was significantly associated with shorter survival of patients and seems to be an independent prognostic factor in a multivariate analysis. ..
  10. Ruiz Tovar J, Reguero Callejas M, Arano Bermejo J, Capote Armas L, González Palacios Martínez F, Cabañas Navarro L. Malignant mixed Mullerian tumors. Clin Transl Oncol. 2006;8:129-32 pubmed
    ..Because of the high incidence of recurrence and poor prognosis of these tumours, they should be studied and managed by a multidisciplinary team composed by surgeons, oncologists, radiotherapists and pathologists...
  11. Iglesias D, Fernández Peralta A, Nejda N, Daimiel L, Azcoita M, Oliart S, et al. RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis. Cancer Genet Cytogenet. 2006;167:138-44 pubmed
    ..3% of MSI-L) survived >25 months after surgery (log rank P < 0.001). All these results indicate, according to the Bethesda criteria, that RIS1 is a target gene in the mutator pathway. ..
  12. Martin M, Rodriguez Lescure A, Ruiz A, Alba E, Calvo L, Ruiz Borrego M, et al. Randomized phase 3 trial of fluorouracil, epirubicin, and cyclophosphamide alone or followed by Paclitaxel for early breast cancer. J Natl Cancer Inst. 2008;100:805-14 pubmed publisher
    ..Among patients with operable breast cancer, FEC-P treatment statistically significantly reduced the risk of relapse compared with FEC as adjuvant therapy. ..
  13. Rodríguez Aranda A, Daskalaki M, Villar J, Sanz F, Otero J, Chaves F. Nosocomial spread of linezolid-resistant Staphylococcus haemolyticus infections in an intensive care unit. Diagn Microbiol Infect Dis. 2009;63:398-402 pubmed publisher
    ..All linezolid-resistant isolates had the same G2576T mutation in at least 1 copy of the 23S rRNA gene...
  14. Fogeda M, Avellon A, Cilla C, Echevarria J. Imported and autochthonous hepatitis E virus strains in Spain. J Med Virol. 2009;81:1743-9 pubmed publisher
    ..Studies involving a significant number of human, swine, and environmental viral strains collected prospectively are, however, required in order to confirm a swine origin for autochthonous HEV genotype 3 human infections. ..
  15. Arriola Villalobos P, Diaz Valle D, Güell J, Iradier Urrutia M, Jiménez Alfaro I, Cuiña Sardiña R, et al. Intrastromal corneal ring segment implantation for high astigmatism after penetrating keratoplasty. J Cataract Refract Surg. 2009;35:1878-84 pubmed publisher
    ..To evaluate the safety and efficacy of intracorneal ring segments (ICRS) for high astigmatism after penetrating keratoplasty (PKP)...
  16. Montejo J, Minambres E, Bordejé L, Mesejo A, Acosta J, Heras A, et al. Gastric residual volume during enteral nutrition in ICU patients: the REGANE study. Intensive Care Med. 2010;36:1386-93 pubmed publisher
    ..A limit of 500 ml is not associated with adverse effects in gastrointestinal complications or in outcome variables. A value of 500 ml can be equally recommended as a normal limit for GRV. ..
  17. Lopez de Andres A, Martínez Huedo M, Carrasco Garrido P, Hernandez Barrera V, Gil de Miguel A, Jimenez Garcia R. Trends in lower-extremity amputations in people with and without diabetes in Spain, 2001-2008. Diabetes Care. 2011;34:1570-6 pubmed publisher
    ..To examine trends in nontraumatic lower-extremity amputations (LEAs) over an 8-year period in patients with and without diabetes in Spain...
  18. Galan L, Gomez Pinedo U, Vela Souto A, Guerrero Sola A, Barcia J, Gutierrez A, et al. Subventricular zone in motor neuron disease with frontotemporal dementia. Neurosci Lett. 2011;499:9-13 pubmed publisher
    ..This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS. ..
  19. Revelles J, Diaz J, Angulo J, Santonja C, Kutzner H, Requena L. Giant benign lymphangioendothelioma. J Cutan Pathol. 2012;39:950-6 pubmed publisher
    ..In our case, the positivity for WT1 supports the neoplastic nature of this lesion...
  20. Ruiz Garbajosa P, Curiao T, Tato M, Gijón D, Pintado V, Valverde A, et al. Multiclonal dispersal of KPC genes following the emergence of non-ST258 KPC-producing Klebsiella pneumoniae clones in Madrid, Spain. J Antimicrob Chemother. 2013;68:2487-92 pubmed publisher
    ..Non-ST258 K. pneumoniae isolates were mostly responsible for the dissemination of KPC enzymes, producing a complex epidemiological picture. ..
  21. Miguel J, Weisel K, Moreau P, Lacy M, Song K, Delforge M, et al. Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial. Lancet Oncol. 2013;14:1055-1066 pubmed publisher
    ..Pomalidomide plus low-dose dexamethasone, an oral regimen, could be considered a new treatment option in patients with refractory or relapsed and refractory multiple myeloma. Celgene Corporation. ..
  22. Núñez Gil I, Andrés M, Almendro Delia M, Sionis A, Martín A, Bastante T, et al. Characterization of Tako-tsubo Cardiomyopathy in Spain: Results from the RETAKO National Registry. Rev Esp Cardiol (Engl Ed). 2015;68:505-12 pubmed publisher
    ..It is characterized by anginal pain, shows no seasonal distribution, and has a good prognosis, although it is not without morbidity and mortality. ..
  23. Bastos Oreiro M, Anguita J, Martínez Laperche C, Fernández L, Buces E, Navarro A, et al. Inhibitory killer cell immunoglobulin-like receptor (iKIR) mismatches improve survival after T-cell-repleted haploidentical transplantation. Eur J Haematol. 2016;96:483-91 pubmed publisher
    ..004). Our data suggest that in the setting of T-cell-repleted haploidentical SCT with PT-Cy, iKIR mismatch is associated with improved survival, with particularly good results for both iKIR and KIR ligand mismatches in patients with HL. ..
  24. Marcelli D, Brand K, Ponce P, Milkowski A, Marelli C, Ok E, et al. Longitudinal Changes in Body Composition in Patients After Initiation of Hemodialysis Therapy: Results From an International Cohort. J Ren Nutr. 2016;26:72-80 pubmed publisher
    ..These were mainly associated with gender, older age, presence of diabetes, low baseline FTI, and high baseline LTI. BMI increases did not fully represent the changes in BC. ..
  25. Hernández V, Llorente C, de la Peña E, Pérez Fernández E, Guijarro A, Sola I. Long-term oncological outcomes of an active surveillance program in recurrent low grade Ta bladder cancer. Urol Oncol. 2016;34:165.e19-23 pubmed publisher
    ..Patients with previous history of T1 should not be included in AS protocols even when very small recurrences are diagnosed. ..
  26. Cohen S, Genovese M, Choy E, Perez Ruiz F, Matsumoto A, Pavelka K, et al. Efficacy and safety of the biosimilar ABP 501 compared with adalimumab in patients with moderate to severe rheumatoid arthritis: a randomised, double-blind, phase III equivalence study. Ann Rheum Dis. 2017;76:1679-1687 pubmed publisher
    ..Results from this study demonstrate that ABP 501 is similar to adalimumab in clinical efficacy, safety and immunogenicity in patients with moderate to severe RA. NCT01970475; Results. ..
  27. Muñoz Fernández S, de Miguel E, Cobo Ibáñez T, Madero R, Ferreira A, Hidalgo M, et al. Enthesis inflammation in recurrent acute anterior uveitis without spondylarthritis. Arthritis Rheum. 2009;60:1985-90 pubmed publisher
    ..To investigate whether patients with idiopathic recurrent acute anterior uveitis (AAU) have enthesis alterations comparable with those in patients with spondylarthritis (SpA)...
  28. Esteras N, Muñoz U, Alquezar C, Bartolomé F, Bermejo Pareja F, Martin Requero A. Altered calmodulin degradation and signaling in non-neuronal cells from Alzheimer's disease patients. Curr Alzheimer Res. 2012;9:267-77 pubmed
    ..The systemic failure of CaM degradation, and thus of Ca(2+)/CaM-dependent signaling pathways, may be important in the etiopathogenesis of AD. ..
  29. Zeuzem S, Hézode C, Bronowicki J, Loustaud Ratti V, Gea F, Buti M, et al. Daclatasvir plus simeprevir with or without ribavirin for the treatment of chronic hepatitis C virus genotype 1 infection. J Hepatol. 2016;64:292-300 pubmed publisher
    ..Daclatasvir plus simeprevir, with or without ribavirin, was effective with a 12- or 24-week duration in genotype 1b-infected patients and was well tolerated. identifier: NCT01628692. ..
  30. Cosio B, Villena V, Echave Sustaeta J, de Miguel E, Alfaro J, Hernandez L, et al. Endobronchial hamartoma. Chest. 2002;122:202-5 pubmed
    ..EH frequently produces respiratory complaints and radiographic abnormalities. Patients with endobronchial obstructions had satisfactory responses to endoscopic therapy. ..
  31. Esteban A, Frutos Vivar F, Ferguson N, Arabi Y, Apezteguia C, Gonzalez M, et al. Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med. 2004;350:2452-60 pubmed
    ..2 hours 30 minutes, P=0.02). Noninvasive positive-pressure ventilation does not prevent the need for reintubation or reduce mortality in unselected patients who have respiratory failure after extubation. ..
  32. Yáñez I, Munoz A, Contreras J, Gonzalez J, Rodríguez Veiga E, DeFelipe J. Double bouquet cell in the human cerebral cortex and a comparison with other mammals. J Comp Neurol. 2005;486:344-60 pubmed
    ..We conclude that, although these interneurons may be an important element in the organization of cortical microcolumns in primates, this is not the case in other mammalian species. ..
  33. Manzano M, Vilacosta I, San Roman J, Aragoncillo P, Sarria C, Lopez D, et al. [Acute coronary syndrome in infective endocarditis]. Rev Esp Cardiol. 2007;60:24-31 pubmed
    ..The most frequent cause of myocardial ischemia was coronary artery compression secondary to periannular complications. ..
  34. Puente P, Anadón A, Rodero M, Romaris F, Ubeira F, Cuellar C. Anisakis simplex: the high prevalence in Madrid (Spain) and its relation with fish consumption. Exp Parasitol. 2008;118:271-4 pubmed
    ..These results are discussed in relation to the much lower prevalence observed in Galicia (N.W. Spain)...
  35. Ruiz Llorente S, Montero Conde C, Milne R, Moya C, Cebrian A, Leton R, et al. Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma. Cancer Res. 2007;67:9561-7 pubmed
    ..These results highlight the utility of association studies using homogeneous series of cases for better understanding complex diseases. ..
  36. Padial A, Antunez C, Blanca Lopez N, Fernandez T, Cornejo Garcia J, Mayorga C, et al. Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test. Clin Exp Allergy. 2008;38:822-8 pubmed publisher
    ..The time between drug intake and the reaction appearance is generally 24-48 h. Because the mechanisms involved are not completely understood, diagnostic tests for these reactions have still to be fully validated...
  37. Torres Narbona M, Guinea J, Martínez Alarcón J, Munoz P, Pelaez T, Bouza E. Workload and clinical significance of the isolation of zygomycetes in a tertiary general hospital. Med Mycol. 2008;46:225-30 pubmed publisher
    ..Data from specific institutions cannot be generalized. ..
  38. Naredo E, Moller I, Cruz A, Carmona L, Garrido J. Power Doppler ultrasonographic monitoring of response to anti-tumor necrosis factor therapy in patients with rheumatoid arthritis. Arthritis Rheum. 2008;58:2248-56 pubmed publisher
    ..PDUS findings may have predictive value in relation to radiologic outcome. ..
  39. Garcia Saenz J, Martin M, Calles A, Bueno C, Rodriguez L, Bobokova J, et al. Bevacizumab in combination with metronomic chemotherapy in patients with anthracycline- and taxane-refractory breast cancer. J Chemother. 2008;20:632-9 pubmed
    ..0% in Ki-67 > or =20% tumors, P = 0.015). Adverse effects were mild. The combination of bevacizumab and a metronomic-based chemotherapy was effective, well tolerated and provided clinical benefit in heavilytreated MBC patients. ..
  40. Cuadrado M, Valle B, Fernandez de Las Penas C, Barriga F, Pareja J. Bifocal nummular headache: the first three cases. Cephalalgia. 2009;29:583-6 pubmed publisher
    ..This finding seems to be consistent with bifocal NH and further enlarges the clinical diversity of this headache disorder. The pathogenic mechanisms of NH may be active in multiple cranial areas in some particular patients. ..
  41. Ortiz Muñoz G, Lopez Parra V, Lopez Franco O, Fernandez Vizarra P, Mallavia B, Flores C, et al. Suppressors of cytokine signaling abrogate diabetic nephropathy. J Am Soc Nephrol. 2010;21:763-72 pubmed publisher
    ..Suppression of the JAK/STAT pathway by increasing intracellular SOCS proteins may have therapeutic potential in diabetic nephropathy. ..
  42. Cisneros C, Garcia Rio F, Romera D, Villasante C, Girón R, Ancochea J. Bronchial reactivity indices are determinants of health-related quality of life in patients with stable asthma. Thorax. 2010;65:795-800 pubmed publisher
    ..However, this relationship still has not been sufficiently explored for bronchial reactivity indices...
  43. Alegre A, Aguado B, Giraldo P, Rios E, Cánovas A, Ibanez A, et al. Lenalidomide is effective as salvage therapy in refractory or relapsed multiple myeloma: analysis of the Spanish Compassionate Use Registry in advanced patients. Int J Hematol. 2011;93:351-360 pubmed publisher
    ..Lenalidomide as salvage compassionate therapy in refractory/relapsed MM showed, in this series of heavily pre-treated patients, similar efficacy to that reported in pivotal clinical trials with acceptable tolerance. ..
  44. Gonzalez Lama Y, Bermejo F, Lopez Sanroman A, Garcia Sanchez V, Esteve M, Cabriada J, et al. Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients. Aliment Pharmacol Ther. 2011;34:544-54 pubmed publisher
    ..Our results do not support determination of TPMT activity or 6TGN concentrations to predict treatment outcome, and no useful serum metabolites threshold value to adjust the drug's dose was identified. ..
  45. González Parra E, Avila P, Mahillo Fernandez I, Lentisco C, Gracia C, Egido J, et al. High prevalence of winter 25-hydroxyvitamin D deficiency despite supplementation according to guidelines for hemodialysis patients. Clin Exp Nephrol. 2012;16:945-51 pubmed publisher
    ..More intensive monitoring or pre-emptive winter dose increases should be evaluated to achieve guideline targets. ..
  46. López Menéndez C, Gamir Morralla A, Jurado Arjona J, Higuero A, Campanero M, Ferrer I, et al. Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance. Hum Mol Genet. 2013;22:466-82 pubmed publisher
    ..The striking differences in Kidins220 stability resulting from chronic versus acute brain damage may also have important implications for the therapeutic intervention of neurodegenerative disorders. ..
  47. Martínez Flores J, Serrano M, Morales P, Paz Artal E, Morales J, Serrano A. Comparison of several functional methods to evaluate the immune response on stable kidney transplant patients. J Immunol Methods. 2014;403:62-5 pubmed publisher
    ..45 vs. 2.37±0.41; 2.84±0.76 vs. 2.37±0.32; 2.32±0.34 vs. 1.89±0.38 respectively). In summary, our results show that the measurement of ATP in CD4+ lymphocytes gives more accurate information in comparison to the classical methods. ..
  48. Perea S, Ramos M, Garau M, Gonzalez A, Noriega A, Del Palacio A. Prevalence and risk factors of tinea unguium and tinea pedis in the general population in Spain. J Clin Microbiol. 2000;38:3226-30 pubmed
    ..65) was predictive for the occurrence of tinea pedis. In both analyses, the presence of one of the two conditions was associated with a higher risk for the appearance of the other disease (RR, >25)...
  49. Rodriguez Perez R, Fernandez Rivas M, Gonzalez Mancebo E, Sanchez Monge R, Diaz Perales A, Salcedo G. Peach profilin: cloning, heterologous expression and cross-reactivity with Bet v 2. Allergy. 2003;58:635-40 pubmed
    ..01. Peach profilin Pru p 4 is very closed to other allergenic profilins from plant foods and pollens. A complete correlation between reactivity to rPru p 4 and rBet v 2 has been found in sera from peach allergic patients. ..
  50. Oton Nieto E, Cano Ruiz A, Martín Scapa M, Navas Elorza E, Camarasa Lillo N, Palmeiro Uriach A. [Controversies about the clinical management of Whipple's disease]. An Med Interna. 2004;21:488-90 pubmed
    ..There are a lot of controversies related to the diagnostic and therapeutic management of Whipple s disease...
  51. Rebolleda G, Munoz Negrete F, Benatar J, Corcostegui J, Alonso N. Comparison of lidocaine 2% gel versus retrobulbar anaesthesia for implantation of Ahmed glaucoma drainage. Acta Ophthalmol Scand. 2005;83:201-5 pubmed
    ..It provides a reasonably safe and comfortable surgical environment and is well tolerated by patients. ..
  52. Martin P, Santon A, Garcia Cosio M, Bellas C. hMLH1 and MGMT inactivation as a mechanism of tumorigenesis in monoclonal gammopathies. Mod Pathol. 2006;19:914-21 pubmed
    ..This study indicates that repair pathway defects play a role in the pathogenesis and evolution of monoclonal gammopathies, and suggests that inactivation of hMLH1 could be implicated in multiple myeloma tumorigenesis. ..
  53. Linares C, Diaz J. Impact of high temperatures on hospital admissions: comparative analysis with previous studies about mortality (Madrid). Eur J Public Health. 2008;18:317-22 pubmed
  54. Gonzalez Sanchez J, Martinez Larrad M, Zabena C, Pérez Barba M, Serrano Rios M. Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population. Diabetologia. 2008;51:1993-7 pubmed publisher
    ..The association with increased proinsulin:insulin ratio after an OGTT suggests that TCF7L2 might be involved in insulin synthesis and processing. ..
  55. Baleriola J, Garcia Feijoo J, Martinez de la Casa J, Fernandez Cruz A, de la Rosa E, Fernández Durango R. Apoptosis in the trabecular meshwork of glaucomatous patients. Mol Vis. 2008;14:1513-6 pubmed
    ..The utility of this method to study apoptosis in the trabecular meshwork is discussed, as well as its application as a tool in biologic samples...
  56. Porta Etessam J, Cuadrado M, Rodríguez Gómez O, García Ptacek S, Valencia C. Are Cox-2 drugs the second line option in indomethacin responsive headaches?. J Headache Pain. 2010;11:405-7 pubmed publisher
    ..In our experience celecoxib is a good option treatment for patients suffering from hemicrania continua or chronic paroxysmal hemicranea that presents indomethacin adverse effects. ..
  57. Camacho D, Pielasinski U, Revelles J, Górgolas M, Manzarbeitia F, Kutzner H, et al. Lichen scrofulosorum mimicking lichen planus. Am J Dermatopathol. 2011;33:186-91 pubmed publisher
    ..The most striking features of the reported case were the onset of the eruption in an adult patient and the clinical appearance of the lesions, resembling lichen planus. ..
  58. Agüera Ortiz L, Frank Garcia A, Gil P, Moreno A. Clinical progression of moderate-to-severe Alzheimer's disease and caregiver burden: a 12-month multicenter prospective observational study. Int Psychogeriatr. 2010;22:1265-79 pubmed publisher
    ..Research into unexplored factors that might reduce caregiver burden, ultimately benefiting both patients and caregivers, is encouraged. ..
  59. Daudén E, Herrera E, Puig L, Sánchez Carazo J, Toribio J, Caloto M, et al. Validation of a new tool to assess health-related quality of life in psoriasis: the PSO-LIFE questionnaire. Health Qual Life Outcomes. 2012;10:56 pubmed
    ..01 (large effect size). The present results provide substantial support for the reliability, validity, and responsiveness of the PSO-LIFE questionnaire in the population for which it was designed. ..
  60. Leandro García L, Leskela S, Jara C, Green H, Avall Lundqvist E, Wheeler H, et al. Regulatory polymorphisms in ?-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy. Clin Cancer Res. 2012;18:4441-8 pubmed
    ..This is the first study showing that paclitaxel neuropathy risk is influenced by polymorphisms regulating the expression of a ?-tubulin gene. ..
  61. González de la Fuente M, Barana A, Gomez R, Amorós I, Dolz Gaiton P, Sacristán S, et al. Chronic atrial fibrillation up-regulates ?1-Adrenoceptors affecting repolarizing currents and action potential duration. Cardiovasc Res. 2013;97:379-88 pubmed publisher
    ..This, together with the ion channel derangements produced by CAF, could contribute to the long-term stabilization of the arrhythmia by shortening the AP duration. ..
  62. Rodriguez Rodriguez L, Jover Jover J, Fontsere O, Peña Blanco R, Leon L, Fernandez Gutierrez B, et al. Leflunomide discontinuation in rheumatoid arthritis and influence of associated disease-modifying anti-rheumatic drugs: a survival analysis. Scand J Rheumatol. 2013;42:433-6 pubmed publisher
    ..Therefore, when taking MTX or HC, patients receiving leflunomide should be closely monitored early to detect the occurrence of adverse reactions, and hence prevent their aggravation. ..
  63. Saez de la Fuente I, Sáez de la Fuente J, Quintana Estelles M, Garcia Gigorro R, Terceros Almanza L, Sánchez Izquierdo J, et al. Enteral Nutrition in Patients Receiving Mechanical Ventilation in a Prone Position. JPEN J Parenter Enteral Nutr. 2016;40:250-5 pubmed publisher
    ..Larger studies are needed to confirm these findings. ..
  64. Nicoll R, Wiklund U, Zhao Y, Diederichsen A, Mickley H, Ovrehus K, et al. The coronary calcium score is a more accurate predictor of significant coronary stenosis than conventional risk factors in symptomatic patients: Euro-CCAD study. Int J Cardiol. 2016;207:13-9 pubmed publisher
    ..85) than using a combination of the CAC score and risk factors with conventional angiography (AUC=0.81). In symptomatic patients, the CAC score is a more accurate predictor of significant coronary stenosis than conventional risk factors. ..
  65. Verdaguer J, Soler F, Fernandez Alba J, Concejo C, Acero J. Sliding osteotomies in mandibular reconstruction. Plast Reconstr Surg. 2001;107:1107-14 pubmed
    ..Good results were obtained in 10 patients, total failure occurred in two, and complications without failure of the reconstruction arose in the other two...
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    ..10; 95% confidence interval (95% CI), 1.25-3.52 (P=0.005)] and overall survival [HR, 1.91; 95% CI 1.01-3.34 (P=0.023)]. Aurora B may be a novel prognostic biomarker for LSCC and a potential therapeutic target in this type of tumour. ..
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    ..This relation seems to be modulated by BMI. The relevance and the nature of the association of FT levels and frailty are sex-specific, suggesting that different biological mechanisms may be involved. ..
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    ..2% in the validation cohort. For normotensive patients who have acute PE, we derived and validated a multimarker model that predicts all-cause mortality, hemodynamic collapse, and/or recurrent PE within the following 30 days. ..
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    ..Treatment with oral acitretin was started and great improvement of the lesion was noted; the patient became asymptomatic. We review the literature on the effect of retinoids in cutaneous amyloidosis. ..
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    ..The frequency of the 7q deletion in this series was 3 of 7 (42%). 7q loss may play an alternative role in the inactivation of the p53 and p16INK4a pathway, thereby favoring tumoral progression...
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    ..LA activation is predominantly descending, but in Bachmann's bundle block it becomes ascending, and double potentials suggest a location of block in the LA roof. ..
  73. Santa Mara I, Santpere G, MacDonald M, Gomez de Barreda E, Hernandez F, Moreno F, et al. Coenzyme q induces tau aggregation, tau filaments, and Hirano bodies. J Neuropathol Exp Neurol. 2008;67:428-34 pubmed publisher
    ..Taken together, the in vitro models and findings in AD suggest that in the presence of ubiquinone, Hirano bodies may result from the interaction of actin and other proteins, including tau. ..
  74. Zapatero A, Minguez R, Nieto S, Martin de Vidales C, García Vicente F. Post-treatment prostate biopsies in the era of three-dimensional conformal radiotherapy: what can they teach us?. Eur Urol. 2009;55:902-9 pubmed publisher
    ..The results of the present study show a strong correlation between a post-treatment PB and the 5-yr probability of bDFS, confirming that PSA control can be an adequate surrogate for local control, as assessed by post-treatment biopsies. ..
  75. Esteban Vasallo M, Domínguez Berjón M, Astray Mochales J, Genova Maleras R, Pérez Sania A, Sánchez Perruca L, et al. Epidemiological usefulness of population-based electronic clinical records in primary care: estimation of the prevalence of chronic diseases. Fam Pract. 2009;26:445-54 pubmed publisher
    ..Both data sources provide complementary information about chronic disease prevalence. ECRPC have the advantage of generating an ongoing standardized register and entailing no additional effort for health professionals. ..
  76. Castrejón I, Ortiz A, Toledano E, Castañeda S, García Vadillo A, Patiño E, et al. Estimated cutoff points for the 28-joint disease activity score based on C-reactive protein in a longitudinal register of early arthritis. J Rheumatol. 2010;37:1439-43 pubmed publisher
    ..Our study confirms that the cutoff points for DAS28-CRP are lower than those described for DAS28-ESR, suggesting that DAS28-CRP may be more accurate to assess disease activity in our population. ..
  77. Arnalich F, Maldifassi M, Ciria E, Quesada A, Codoceo R, Herruzo R, et al. Association of cell-free plasma DNA with perioperative mortality in patients with suspected acute mesenteric ischemia. Clin Chim Acta. 2010;411:1269-74 pubmed publisher
    ..Diagnosing patients with acute mesenteric ischemia (AMI) in the emergency ward is challenging. This study assesses the usefulness of plasma DNA in patients with clinically suspected AMI...
  78. Cuevas O, Cercenado E, Gimeno M, Marin M, Coronel P, Bouza E. Comparative in vitro activity of cefditoren and other antimicrobials against Enterobacteriaceae causing community-acquired uncomplicated urinary tract infections in women: a Spanish nationwide multicenter study. Diagn Microbiol Infect Dis. 2010;67:251-60 pubmed publisher
    ..2%, 5.5%, 2.3%, 20.2%, 27.4%, and 4.8%. The activity of cefditoren against Enterobacteriaceae producing community-acquired uncomplicated UTI in women was superior to that of AMP, A/C, FUR, CIP, and SxT and similar to that of FOS...
  79. Vivas D, Bernardo E, Garcia Rubira J, Azcona L, Núñez Gil I, González Ferrer J, et al. Can resistance to aspirin be reversed after an additional dose?. J Thromb Thrombolysis. 2011;32:356-61 pubmed publisher
    ..Using the PFA-100 system, reassessment of platelet function following oral administration of daily aspirin dosage significantly reduces the number of stable coronary disease patients considered to be non-responders to such treatment. ..
  80. Alonso S, Ferrero E, Donat M, Martinez G, Vargas C, Hidalgo M, et al. The usefulness of high pre-operative levels of serum type I collagen bone markers for the prediction of changes in bone mineral density after parathyroidectomy. J Endocrinol Invest. 2012;35:640-4 pubmed publisher
    ..Serum ?CTX and P1NP levels were potently related to lumbar BMD changes over one year after PTX. The measurement of ?CTX and P1NP would be useful to predict long-term changes in lumbar BMD after PTX. ..
  81. Bleda S, De Haro J, Varela C, Esparza L, Ferruelo A, Acin F. Vascular endothelial growth factor polymorphisms are involved in the late vascular complications in Type II diabetic patients. Diab Vasc Dis Res. 2012;9:68-74 pubmed publisher
    ..002). The VEGF +405 genotype was not associated with diabetic vascular complications. This study provides preliminary evidence that VEGF polymorphisms are associated with a differential presentation of diabetic vascular complications. ..
  82. Herranz B, Marquez S, Guijarro B, Aracil E, Aicart Ramos C, Rodríguez Crespo I, et al. Integrin-linked kinase regulates vasomotor function by preventing endothelial nitric oxide synthase uncoupling: role in atherosclerosis. Circ Res. 2012;110:439-49 pubmed publisher
    ..Our results identify ILK as a regulatory partner of eNOS in vivo that prevents eNOS uncoupling, and suggest ILK as a therapeutic target for prevention of endothelial dysfunction related to shear stress-induced vascular diseases. ..
  83. García Redondo A, Dols Icardo O, Rojas Garcia R, Esteban Pérez J, Cordero Vázquez P, Munoz Blanco J, et al. Analysis of the C9orf72 gene in patients with amyotrophic lateral sclerosis in Spain and different populations worldwide. Hum Mutat. 2013;34:79-82 pubmed publisher
    ..This haplotype was found in 5.6% Yoruba Africans, 8.9% CEU, 3.9% Japanese, and 1.6% Han Chinese chromosomes. ..
  84. Scagliotti G, Hirsh V, Siena S, Henry D, Woll P, Manegold C, et al. Overall survival improvement in patients with lung cancer and bone metastases treated with denosumab versus zoledronic acid: subgroup analysis from a randomized phase 3 study. J Thorac Oncol. 2012;7:1823-1829 pubmed publisher
    ..7% denosumab versus 0.8% ZA). Hypocalcemia rates were 8.6% with denosumab and 3.8% with ZA. In this exploratory analysis, denosumab was associated with improved overall survival compared with ZA, in patients with metastatic lung cancer. ..
  85. Datino T, Arenal A, Ruiz Hernández P, Pelliza M, Hernandez Hernandez J, Gonzalez Torrecilla E, et al. Arrhythmia ablation using the Amigo Robotic Remote Catheter System versus manual ablation: One year follow-up results. Int J Cardiol. 2016;202:877-8 pubmed publisher
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    ..Importantly, age (only in the oldest-old adults) altered perceptual visual asymmetries. These results suggest that some neural plasticity is still present even in oldest-old adults, but a lack of specificity occurs in advanced age. ..
  87. Quijano Y, Vicente E, Ielpo B, Duran H, Diaz E, Fabra I, et al. Robotic Liver Surgery: Early Experience From a Single Surgical Center. Surg Laparosc Endosc Percutan Tech. 2016;26:66-71 pubmed publisher
    ..7% and 19%, respectively. The mean length of hospital stay was 13.4 days (range, 4 to 64 d). From our early experience, robotic liver surgery is a safe and feasible procedure, especially for major hepatectomies. ..
  88. García Esquinas E, Andrade E, Martinez Gomez D, Caballero F, Lopez Garcia E, Rodriguez Artalejo F. Television viewing time as a risk factor for frailty and functional limitations in older adults: results from 2 European prospective cohorts. Int J Behav Nutr Phys Act. 2017;14:54 pubmed publisher
    ..Among older adults, longer television viewing time is prospectively associated with limitations in physical function independently of physical activity. ..
  89. Carobene A, Marino I, Coskun A, Serteser M, Unsal I, Guerra E, et al. The EuBIVAS Project: Within- and Between-Subject Biological Variation Data for Serum Creatinine Using Enzymatic and Alkaline Picrate Methods and Implications for Monitoring. Clin Chem. 2017;63:1527-1536 pubmed publisher
    ..The alkaline picrate method failed to meet this CVAPS, raising questions regarding its future use. ..
  90. Arranz Marquez E, Teus M, Saornil M, Mendez M, Gil R. Analysis of irises with a latanoprost-induced change in iris color. Am J Ophthalmol. 2004;138:625-30 pubmed
    ..001, P = .01, P = .004, P = .01, respectively, by the chi(2) test). Chronic therapy with latanoprost appears to induce more changes in the iris than a simple increase in the melanin content of the melanocytes. ..
  91. San Andrés Rebollo F, Rubio Garcia R, Castilla Catalán J, Pulido Ortega F, Palao G, de Pedro Andrés I, et al. [Mortality and survival in a cohort of 1,115 HIV-infected patients (1989-97)]. An Med Interna. 2004;21:523-32 pubmed
    ..55-0.95 respectively). In recent years PCP-prophylaxis and antiretroviral treatment (especially combined therapy) have contributed to a decrease in AIDS-related mortality. Adherence to treatments relates to risk of death and survival. ..
  92. Moreno Antón F, Sastre Valera J, Loboff de León B, López Tarruella S, Ortega Medina L, Diaz Rubio E. Epididymal metastases as the first sign of a colon cancer recurrence. Clin Transl Oncol. 2005;7:321-3 pubmed
    ..Although metastatic cancer presenting as an intra-scrotal mass is extremely rare, it should be considered as a possibility in patients who present with a mass involving the testicle or epididymis...