Experts and Doctors on signal transduction in Barcelona, Catalonia, Spain


Locale: Barcelona, Catalonia, Spain
Topic: signal transduction

Top Publications

  1. Ninov N, Menezes Cabral S, Prat Rojo C, Manjón C, Weiss A, Pyrowolakis G, et al. Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. Curr Biol. 2010;20:513-20 pubmed publisher
  2. Grillo M, Furriols M, Casanova J, Luschnig S. Control of germline torso expression by the BTB/POZ domain protein pipsqueak is required for embryonic terminal patterning in Drosophila. Genetics. 2011;187:513-21 pubmed publisher
  3. Wibowo I, Pinto Teixeira F, Satou C, Higashijima S, Lopez Schier H. Compartmentalized Notch signaling sustains epithelial mirror symmetry. Development. 2011;138:1143-52 pubmed publisher
    ..We conclude that a strongly anisotropic regeneration process that relies on the dynamic stabilization of progenitor identity in permissive polar compartments sustains bilateral symmetry in the lateral line. ..
  4. Pena E, Padro T, Molins B, Vilahur G, Badimon L. Proteomic signature of thrombin-activated platelets after in vivo nitric oxide-donor treatment: coordinated inhibition of signaling (phosphatidylinositol 3-kinase-?, 14-3-3?, and growth factor receptor-bound protein 2) and cytoskeleton protein transl. Arterioscler Thromb Vasc Biol. 2011;31:2560-9 pubmed publisher
    ..Our results show that exogenous NO donor treatment renders platelets less sensitive to thrombin activation and inhibits thrombosis by interfering with the platelet shape change machinery. ..
  5. Rosado E, Rodriguez Vilarrupla A, Gracia Sancho J, Monclús M, Bosch J, García Pagán J. Interaction between NO and COX pathways modulating hepatic endothelial cells from control and cirrhotic rats. J Cell Mol Med. 2012;16:2461-70 pubmed publisher
    ..These strategies may have beneficial effects ameliorating the vasoconstrictor/vasodilator imbalance of the intrahepatic circulation of cirrhotic livers. ..
  6. Xargay Torrent S, Lopez Guerra M, Montraveta A, Saborit Villarroya I, Rosich L, Navarro A, et al. Sorafenib inhibits cell migration and stroma-mediated bortezomib resistance by interfering B-cell receptor signaling and protein translation in mantle cell lymphoma. Clin Cancer Res. 2013;19:586-97 pubmed publisher
  7. Berenguer J, Herrera A, Vuolo L, Torroba B, Llorens F, Sumoy L, et al. MicroRNA 22 regulates cell cycle length in cerebellar granular neuron precursors. Mol Cell Biol. 2013;33:2706-17 pubmed publisher
    ..Therefore, we conclude that, in addition to the previously described mechanisms, miR-22 plays a specific role on downstream BMPs through cerebellum growth. ..
  8. Simboeck E, Gutierrez A, Cozzuto L, Beringer M, Caizzi L, Keyes W, et al. DPY30 regulates pathways in cellular senescence through ID protein expression. EMBO J. 2013;32:2217-30 pubmed publisher
    ..Thus, our data indicate that DPY30 controls proliferation by regulating ID proteins expression, which in turn lead to senescence bypass. ..
  9. Zuin A, Carmona M, Morales Ivorra I, Gabrielli N, Vivancos A, Ayte J, et al. Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. EMBO J. 2010;29:981-91 pubmed publisher
    ..We conclude that calorie restriction favours oxidative metabolism, reactive oxygen species production and Sty1 MAP kinase activation, and this stress pathway favours lifespan extension. ..

More Information

Publications364 found, 100 shown here

  1. Arino J, Ramos J, Sychrova H. Alkali metal cation transport and homeostasis in yeasts. Microbiol Mol Biol Rev. 2010;74:95-120 pubmed publisher
  2. Campo S, Peris Peris C, Montesinos L, Peñas G, Messeguer J, San Segundo B. Expression of the maize ZmGF14-6 gene in rice confers tolerance to drought stress while enhancing susceptibility to pathogen infection. J Exp Bot. 2012;63:983-99 pubmed publisher
    ..Taken together, these results improve our understanding of the role of ZmGF14-6 in stress signalling pathways, while indicating that ZmGF14-6 inversely regulates the plant response to biotic and abiotic stresses. ..
  3. Villanueva A, Alsinet C, Yanger K, Hoshida Y, Zong Y, Toffanin S, et al. Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. Gastroenterology. 2012;143:1660-1669.e7 pubmed publisher
    ..Notch signaling is activated in human HCC samples and promotes formation of liver tumors in mice. The Notch signature is a biomarker of response to Notch inhibition in vitro. ..
  4. Tajes M, Gutierrez Cuesta J, Ortuño Sahagun D, Camins A, Pallas M. Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway. J Pineal Res. 2009;47:228-37 pubmed publisher
    ..Globally, these results add weight to the findings of previous reports, indicating a new role for melatonin in improving cell function gated to an increased neuroprotective role for the sirtuin 1 pathway. ..
  5. Thomson T, Guerra Rebollo M. Ubiquitin and SUMO signalling in DNA repair. Biochem Soc Trans. 2010;38:116-31 pubmed publisher
  6. Casali A. Self-induced patched receptor down-regulation modulates cell sensitivity to the hedgehog morphogen gradient. Sci Signal. 2010;3:ra63 pubmed publisher
  7. Beer R, Parsons M, Rovira M. Centroacinar cells: At the center of pancreas regeneration. Dev Biol. 2016;413:8-15 pubmed publisher
    ..However, whether CACs contribute to β-cell regeneration in adult mammals remains controversial. Here we review the current understanding of the role of CACs as endocrine progenitors during regeneration in zebrafish and mammals. ..
  8. Aranda G, Fernandez Rebollo E, Pradas Juni M, Hanzu F, Kalko S, Halperin I, et al. Effects of sex steroids on the pattern of methylation and expression of the promoter region of estrogen and androgen receptors in people with gender dysphoria under cross-sex hormone treatment. J Steroid Biochem Mol Biol. 2017;172:20-28 pubmed publisher
    ..Our results support that CHT is associated to epigenetic changes that might affect the response to treatment with sex steroids. ..
  9. Arderiu G, Diaz Ricart M, Domenech P, Escolar G, Ordinas A, Pujol Moix N. Phosphotyrosine proteins in platelets from patients with storage pool disease: direct relation between granule defects and defective signal transduction. Haematologica. 2002;87:629-36 pubmed
    ..A minimum amount of intraplatelet granules ensures signaling through tyrosine phosphorylation of proteins. ..
  10. Scaltriti M, Serra V, Normant E, Guzman M, Rodriguez O, Lim A, et al. Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer. Mol Cancer Ther. 2011;10:817-24 pubmed publisher
    ..IPI-504-mediated Hsp90 inhibition may represent a novel therapeutic approach in trastuzumab refractory HER2-positive breast cancer. ..
  11. Luisi P, Alvarez Ponce D, Dall Olio G, Sikora M, Bertranpetit J, Laayouni H. Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations. Mol Biol Evol. 2012;29:1379-92 pubmed publisher
    ..This observation indicates that the impact of positive selection on genes involved in the insulin/TOR pathway is affected by the pathway structure. ..
  12. Uribesalgo I, Benitah S, Di Croce L. From oncogene to tumor suppressor: the dual role of Myc in leukemia. Cell Cycle. 2012;11:1757-64 pubmed publisher
    ..Here, we discuss the role of c-Myc in balancing proliferation and differentiation and how modulating this previously unidentified c-Myc activity might provide alternative therapies against leukemia and possibly other types of tumors. ..
  13. Xu M, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, et al. Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. Gastroenterology. 2015;149:1030-41.e6 pubmed publisher
    ..Hepatic expression of FSP27/CIDEC is highly up-regulated in mice following chronic-plus-binge ethanol feeding and in patients with AH; this up-regulation contributes to alcohol-induced liver damage. ..
  14. Portugal J, Bataller M, Mansilla S. Cell death pathways in response to antitumor therapy. Tumori. 2009;95:409-21 pubmed
    ..We critically review herein how antitumor therapy may elicit the response of human cancers through different cell pathways leading to cell death...
  15. Lluis J, Llacuna L, von Montfort C, Bárcena C, Enrich C, Morales A, et al. GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway. PLoS ONE. 2009;4:e8059 pubmed publisher
    ..These findings underscore a role for GD3 in hypoxia susceptibility by disabling the c-Src/NF-kappaB survival pathway resulting in lower Mn-SOD expression, which may be of relevance in hepatocellular carcinoma therapy. ..
  16. Alvarez Ponce D, Aguade M, Rozas J. Comparative genomics of the vertebrate insulin/TOR signal transduction pathway: a network-level analysis of selective pressures. Genome Biol Evol. 2011;3:87-101 pubmed publisher
    ..Therefore, the polarity detected in Drosophila is neither specific nor incidental of this genus. Hence, although the underlying biological mechanisms remain unclear, these may be similar in both vertebrates and Drosophila. ..
  17. Wierer M, Verde G, Pisano P, Molina H, Font Mateu J, Di Croce L, et al. PLK1 signaling in breast cancer cells cooperates with estrogen receptor-dependent gene transcription. Cell Rep. 2013;3:2021-32 pubmed publisher
    ..Our results propose a mechanism for the tumor-suppressive role of PLK1 in mammals as an interphase transcriptional regulator. ..
  18. Roglans N, Vilà L, Farré M, Alegret M, Sanchez R, Vázquez Carrera M, et al. Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats. Hepatology. 2007;45:778-88 pubmed
    ..Hypertriglyceridemia and hepatic steatosis induced by fructose ingestion result from a reduction in the hepatic catabolism of fatty acids driven by a state of leptin resistance. ..
  19. Mercader J, Saus E, Aguera Z, Bayés M, Boni C, Carreras A, et al. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Hum Mol Genet. 2008;17:1234-44 pubmed publisher
    ..The reported data, in addition to the previous reported findings for BDNF and NTRK2, point neurotrophin signaling genes as key regulators of eating behavior and their altered cross-regulation as susceptibility factors for EDs. ..
  20. Bayascas J. Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways. Cell Cycle. 2008;7:2978-82 pubmed
    ..In contrast, the PIF-substrate binding pocket of PDK1 is not required for PKB activation, but is necessary for PDK1 to activate all of its other substrates. ..
  21. Inglés Esteve J, Espinosa L, Milner L, Caelles C, Bigas A. Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation. J Biol Chem. 2001;276:44873-80 pubmed
    ..Our results further indicate that Ser(2078) is a critical residue for phosphorylation and modulation of Notch2 activity in the context of G-CSF-induced differentiation of 32D cells. ..
  22. Diaz Ricart M, Arderiu G, Estebanell E, Perez Pujol S, Lozano M, White J, et al. Inhibition of cytoskeletal assembly by cytochalasin B prevents signaling through tyrosine phosphorylation and secretion triggered by collagen but not by thrombin. Am J Pathol. 2002;160:329-37 pubmed
    ..Moreover, the expression of a procoagulant surface in platelets still occurs even when platelet motility has been inhibited. ..
  23. Vicent G, Ballaré C, Zaurin R, Saragueta P, Beato M. Chromatin remodeling and control of cell proliferation by progestins via cross talk of progesterone receptor with the estrogen receptors and kinase signaling pathways. Ann N Y Acad Sci. 2006;1089:59-72 pubmed
    ..Thus, depending on the cellular context rapid kinase activation and transcriptional effect play different roles in the physiological response to progestins...
  24. Akizu N, Estarás C, Guerrero L, Marti E, Martínez Balbás M. H3K27me3 regulates BMP activity in developing spinal cord. Development. 2010;137:2915-25 pubmed publisher
    ..Together, our data reveal how the BMP signaling pathway restricts its own activity in developing spinal cord by modulating H3K27me3 levels at the Noggin promoter. ..
  25. Ruiz Riol M, Barnils M, Colobran Oriol R, Pla A, Borràs Serres F, Lucas Martin A, et al. Analysis of the cumulative changes in Graves' disease thyroid glands points to IFN signature, plasmacytoid DCs and alternatively activated macrophages as chronicity determining factors. J Autoimmun. 2011;36:189-200 pubmed publisher
  26. Sebastian D, Hernández Alvarez M, Segalés J, Sorianello E, Munoz J, Sala D, et al. Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci U S A. 2012;109:5523-8 pubmed publisher
    ..This study provides an important description of a unique unexpected role of Mfn2 coordinating mitochondria and endoplasmic reticulum function, leading to modulation of insulin signaling and glucose homeostasis in vivo. ..
  27. Ramirez S, Martins L, Jacas J, Carrasco P, Pozo M, Clotet J, et al. Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin. Diabetes. 2013;62:2329-37 pubmed publisher
  28. Llompart B, Castells E, Río A, Roca R, Ferrando A, Stiefel V, et al. The direct activation of MIK, a germinal center kinase (GCK)-like kinase, by MARK, a maize atypical receptor kinase, suggests a new mechanism for signaling through kinase-dead receptors. J Biol Chem. 2003;278:48105-11 pubmed
    ..As some GCK-related proteins connect cell-surface receptors to the intracellular MAPK cascades, the activation of MIK by direct interaction with MARK could illustrate a new mechanism for signaling through atypical RPKs. ..
  29. Astigarraga S, Grossman R, Diaz Delfin J, Caelles C, Paroush Z, Jiménez G. A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J. 2007;26:668-77 pubmed
    ..Finally, we describe differences in the modes of Capicua downregulation by Torso and EGFR signaling, raising the possibility that such differences contribute to the tissue specificity of both signals. ..
  30. Tapia M, González Navarrete I, Dalmases A, Bosch M, Rodriguez Fanjul V, Rolfe M, et al. Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin. Cell Cycle. 2007;6:2284-92 pubmed
    ..These findings suggest that selective inhibition of the canonical NF kappa B pathway is sufficient to improve doxorubicin antitumor effects. ..
  31. Serra V, Markman B, Scaltriti M, Eichhorn P, Valero V, Guzman M, et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res. 2008;68:8022-30 pubmed publisher
    ..In summary, NVP-BEZ235 inhibits the PI3K/mTOR axis and results in antiproliferative and antitumoral activity in cancer cells with both wild-type and mutated p110-alpha. ..
  32. Arpa L, Valledor A, Lloberas J, Celada A. IL-4 blocks M-CSF-dependent macrophage proliferation by inducing p21Waf1 in a STAT6-dependent way. Eur J Immunol. 2009;39:514-26 pubmed publisher
    ..Thus, IL-4 and IFN-gamma blocked M-CSF-induced macrophage proliferation through distinct mechanisms. ..
  33. Rodríguez Asiain A, Ruiz Babot G, Romero W, Cubi R, Erazo T, Biondi R, et al. Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment. Biochim Biophys Acta. 2011;1811:1124-35 pubmed publisher
    ..Importantly, SMV also enhanced the activity of a constitutively active BRSK1 (T189E), underpinning that interaction with lipid rafts represents a new mechanism of BRSK1 activity modulation, additional to T-loop phosphorylation. ..
  34. Karachaliou N, Codony Servat J, Teixidó C, Pilotto S, Drozdowskyj A, Codony Servat C, et al. BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer. Sci Rep. 2015;5:17499 pubmed publisher
    ..These data suggest that the combination of EGFR TKI with mTOR or PDE4 inhibitors could be adequate therapy for EGFR-mutant NSCLC patients with high pretreatment levels of BIM and mTOR. ..
  35. Tur J, Vico T, Lloberas J, Zorzano A, Celada A. Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity. Adv Immunol. 2017;133:1-36 pubmed publisher
    ..Here we discuss the intricate relationship between mitochondria, metabolism, intracellular signaling, and innate immune responses in macrophages. ..
  36. Jimenez G, Guichet A, Ephrussi A, Casanova J. Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Genes Dev. 2000;14:224-31 pubmed
    ..cic has been evolutionarily conserved, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms. ..
  37. Ciruela F, Escriche M, Burgueno J, Angulo E, Casado V, Soloviev M, et al. Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes. J Biol Chem. 2001;276:18345-51 pubmed
  38. Pacheco R, Ciruela F, Casado V, Mallol J, Gallart T, Lluis C, et al. Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation. J Biol Chem. 2004;279:33352-8 pubmed
    ..This is a novel non-inhibitory action mechanism for glutamate in lymphocyte activation. mGlu1R and mGlu5R thus mediate opposite glutamate effects in human lymphocytes. ..
  39. Surralles J, Jackson S, Jasin M, Kastan M, West S, Joenje H. Molecular cross-talk among chromosome fragility syndromes. Genes Dev. 2004;18:1359-70 pubmed
  40. Sanz E, Quintana A, Battaglia V, Toninello A, Hidalgo J, Ambrosio S, et al. Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells. J Neurochem. 2008;105:2404-17 pubmed publisher
    ..Thus, PF9601N is a novel molecule with an apparently novel mechanism of action which has a promising potential as a therapeutic agent in the treatment of neurodegenerative diseases. ..
  41. Aranda S, Alvarez M, Turró S, Laguna A, De La Luna S. Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. Mol Cell Biol. 2008;28:5899-911 pubmed publisher
    ..Our results suggest, therefore, that DYRK1A positively regulates FGF-mitogen-activated protein kinase signaling by phosphorylation-dependent impairment of the inhibitory activity of Sprouty2. ..
  42. Valledor A, Arpa L, Sánchez Tilló E, Comalada M, Casals C, Xaus J, et al. IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation. Blood. 2008;112:3274-82 pubmed publisher
    ..These data suggest that subtle changes in the time course of activity of members of the MAPK family contribute to the antiproliferative effects of IFN-gamma in macrophages. ..
  43. Gorostiza P, Isacoff E. Optical switches for remote and noninvasive control of cell signaling. Science. 2008;322:395-9 pubmed publisher
    ..Of particular interest is the development of chemically engineered proteins that are directly sensitive to light...
  44. Nicolas O, Gavin R, Del Río J. New insights into cellular prion protein (PrPc) functions: the "ying and yang" of a relevant protein. Brain Res Rev. 2009;61:170-84 pubmed publisher
    ..In this review, we summarize new findings on PrP(c) functions, especially those related to neural degeneration and cell signaling. ..
  45. Rocher Ros V, Marco S, Mao J, Gines S, Metzger D, Chambon P, et al. Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene. 2010;29:2950-61 pubmed publisher
    ..These findings establish a novel role for PS on epidermal growth and transformation by reciprocally regulating the EGFR and Notch signaling pathways through Fbw7. ..
  46. Colome N, Collado J, Bech Serra J, Liiv I, Anton L, Peterson P, et al. Increased apoptosis after autoimmune regulator expression in epithelial cells revealed by a combined quantitative proteomics approach. J Proteome Res. 2010;9:2600-9 pubmed publisher
    ..Data were confirmed by Western blot and flow cytometry analysis. Apoptosis assays with annexin V and etoposide demonstrated that AIRE-positive cells suffer more spontaneous apoptosis and are less resistant to apoptosis induction. ..
  47. Corvelo A, Hallegger M, Smith C, Eyras E. Genome-wide association between branch point properties and alternative splicing. PLoS Comput Biol. 2010;6:e1001016 pubmed publisher
    ..The reported association between BP features and the splicing outcome suggests that this, so far disregarded but yet crucial, element buries information that can complement current acceptor site models. ..
  48. Hervera A, Negrete R, Leánez S, Martín Campos J, Pol O. Peripheral effects of morphine and expression of μ-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signaling. Mol Pain. 2011;7:25 pubmed publisher
  49. Andreu M, González Pérez E, Ajuria L, Samper N, González Crespo S, Campuzano S, et al. Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila. Development. 2012;139:1110-4 pubmed publisher
    ..Thus, related RTK-Cic repressor circuits regulate the early stages of Drosophila DV and AP body axis formation. ..
  50. Zamora C, Cantó E, Nieto J, Angels Ortiz M, Juarez C, Vidal S. Functional consequences of CD36 downregulation by TLR signals. Cytokine. 2012;60:257-65 pubmed publisher
    ..Characterization this complex regulation may help us to understand this innate response and develop specific therapeutic drugs for each mechanism. ..
  51. Tingaud Sequeira A, Lozano J, Zapater C, Otero D, Kube M, Reinhardt R, et al. A rapid transcriptome response is associated with desiccation resistance in aerially-exposed killifish embryos. PLoS ONE. 2013;8:e64410 pubmed publisher
    ..The exceptional transcriptomic plasticity observed in killifish embryos provides an important insight as to how the embryos are able to rapidly adapt to non-lethal desiccation conditions. ..
  52. Barceló C, Paco N, Beckett A, Alvarez Moya B, Garrido E, Gelabert M, et al. Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status. J Cell Sci. 2013;126:4553-9 pubmed publisher
  53. Curatolo P, Bjørnvold M, Dill P, Ferreira J, Feucht M, Hertzberg C, et al. The Role of mTOR Inhibitors in the Treatment of Patients with Tuberous Sclerosis Complex: Evidence-based and Expert Opinions. Drugs. 2016;76:551-65 pubmed publisher
    ..Safety considerations regarding mTOR inhibitor therapy are also reviewed. With evidence of beneficial effects in neurological and non-neurological TSC manifestations, mTOR inhibitors may represent a systemic treatment for TSC. ..
  54. Hernandez C, Dal Monte M, Simo R, Casini G. Neuroprotection as a Therapeutic Target for Diabetic Retinopathy. J Diabetes Res. 2016;2016:9508541 pubmed publisher
    ..However, clinical trials to determine not only the effectiveness and safety but also the compliance of a noninvasive route of drug administration are needed. ..
  55. Villapol S, Acarin L, Faiz M, Castellano B, Gonzalez B. Distinct spatial and temporal activation of caspase pathways in neurons and glial cells after excitotoxic damage to the immature rat brain. J Neurosci Res. 2007;85:3545-56 pubmed
    ..In astrocytes, caspase-3 is not widely correlated with caspase-8, caspase-9, or p53, except in layer VI-cc astrocytes, where activation of upstream cascades occurs. ..
  56. Alvira D, Ferrer I, Gutierrez Cuesta J, Garcia Castro B, Pallas M, Camins A. Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease. Parkinsonism Relat Disord. 2008;14:309-13 pubmed
    ..Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD. ..
  57. Bellido Martin L, de Frutos P. Vitamin K-dependent actions of Gas6. Vitam Horm. 2008;78:185-209 pubmed publisher
    ..The fact that these proteins are affected by anti-vitamin K therapy is discussed in detail. ..
  58. Espinosa L, Cathelin S, D Altri T, Trimarchi T, Statnikov A, Guiu J, et al. The Notch/Hes1 pathway sustains NF-?B activation through CYLD repression in T cell leukemia. Cancer Cell. 2010;18:268-81 pubmed publisher
  59. Marti Solano M, Guixà González R, Sanz F, Pastor M, Selent J. Novel insights into biased agonism at G protein-coupled receptors and their potential for drug design. Curr Pharm Des. 2013;19:5156-66 pubmed
    ..Finally, we will discuss which of these strategies could be used for the rational design of biased ligands and give some examples of the potential therapeutic value of this class of compounds. ..
  60. Bazzocco S, Dopeso H, Cartón García F, Macaya I, Andretta E, Chionh F, et al. Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. Clin Cancer Res. 2015;21:3695-704 pubmed publisher
    ..We have characterized at the transcriptomic level the differences between colorectal cancer cells that vary in their growth rates, and identified novel candidate chemotherapeutic targets for the treatment of colorectal cancer. ..
  61. Friguls B, Petegnief V, Justicia C, Pallas M, Planas A. Activation of ERK and Akt signaling in focal cerebral ischemia: modulation by TGF-alpha and involvement of NMDA receptor. Neurobiol Dis. 2002;11:443-56 pubmed
    ..This study illustrates that neuroprotection results from a fine balance between death and survival signaling pathways. ..
  62. Moore Carrasco R, Garcia Martinez C, Busquets S, Ametller E, Barreiro E, Lopez Soriano F, et al. The AP-1/CJUN signaling cascade is involved in muscle differentiation: implications in muscle wasting during cancer cachexia. FEBS Lett. 2006;580:691-6 pubmed
    ..In conclusion, the gene therapy approach presented here clearly suggests an important role for AP-1 in muscle signaling during catabolic states. ..
  63. Torres Peraza J, Giralt A, García Martínez J, Pedrosa E, Canals J, Alberch J. Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling. Neurobiol Dis. 2008;29:409-21 pubmed
    ..The specific regulation of MAGUKs and alpha CaMKII in striatal neurons may reflect a protective mechanism against expression of mutant huntingtin exon-1. ..
  64. Vázquez Echeverría C, Dominguez Frutos E, Charnay P, Schimmang T, Pujades C. Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain. Dev Biol. 2008;322:167-78 pubmed publisher
    ..These results highlight the importance of hindbrain-derived signals in the regulation of otic neurogenesis. ..
  65. Catasus L, Gallardo A, Cuatrecasas M, Prat J. Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis. Mod Pathol. 2009;22:522-9 pubmed publisher
    ..000) than patients with only p53 alterations. Such a relationship was lost when we considered exon 9 PIK3CA mutations. Our results contribute to further characterize the molecular genetic model for endometrial carcinogenesis. ..
  66. Ferrer G, Hodgson K, Montserrat E, Moreno C. B cell activator factor and a proliferation-inducing ligand at the cross-road of chronic lymphocytic leukemia and autoimmunity. Leuk Lymphoma. 2009;50:1075-82 pubmed publisher
    ..These two proteins, therefore, constitute a paradigm of pathophysiological defects linking neoplasia and autoimmunity, thereby providing a better understanding of chronic B cell lymphoproliferative disorders. ..
  67. Segarra M, Lozano E, Corbera Bellalta M, Vilardell C, Cibeira M, Esparza J, et al. Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways. Haematologica. 2010;95:456-63 pubmed publisher
    ..The unexpected effects of thalidomide on Akt activation indicate the need for further studies to elucidate whether the interference with Akt downstream effects would synergize with the anti-tumor activity of thalidomide. ..
  68. Trigo J, Martín García E, Berrendero F, Robledo P, Maldonado R. The endogenous opioid system: a common substrate in drug addiction. Drug Alcohol Depend. 2010;108:183-94 pubmed publisher
    ..In this review, we will describe the adaptive changes produced by different drugs of abuse on the EOS, and the current knowledge about the contribution of each component of this neurobiological system to their addictive properties. ..
  69. Campos Soriano L, Segundo B. New insights into the signaling pathways controlling defense gene expression in rice roots during the arbuscular mycorrhizal symbiosis. Plant Signal Behav. 2011;6:553-7 pubmed
    ..An excessive root colonization might change a mutualistic association into a parasitic association. ..
  70. Mayordomo C, García Recio S, Ametller E, Fernández Nogueira P, Pastor Arroyo E, Vinyals L, et al. Targeting of substance P induces cancer cell death and decreases the steady state of EGFR and Her2. J Cell Physiol. 2012;227:1358-66 pubmed publisher
    ..Thus, we propose a new therapeutic strategy for those cancers that express NK1 receptor and/or other tachykinin receptors, based in the immuno-blockade of the neuropeptide SP. ..
  71. Cela J, Chang C, Munné Bosch S. Accumulation of ?- rather than ?-tocopherol alters ethylene signaling gene expression in the vte4 mutant of Arabidopsis thaliana. Plant Cell Physiol. 2011;52:1389-400 pubmed publisher
    ..It is concluded that jasmonic acid and ethylene signaling pathways are down-regulated in mature leaves of salt-stressed vte4 plants. ..
  72. Sánchez Tilló E, de Barrios O, Siles L, Cuatrecasas M, Castells A, Postigo A. ?-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness. Proc Natl Acad Sci U S A. 2011;108:19204-9 pubmed publisher
    ..These results set ZEB1 as an effector of ?-catenin/TCF4 signaling in EMT and tumor progression. ..
  73. Martinez C, Vicario M, Ramos L, Lobo B, Mosquera J, Alonso C, et al. The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations. Am J Gastroenterol. 2012;107:736-46 pubmed publisher
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