Experts and Doctors on recombinant proteins in Cerdanyola del Vallès, Catalonia, Spain
Locale: Cerdanyola del Vallès, Catalonia, Spain
Topic: recombinant proteins
Chaib Oukadour I, Gil C, Rodriguez Alvarez J, Ortega A, Aguilera J. Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity. Mol Cell Neurosci. 2009;41:297-303 pubmed publisher
..Taken together, our results strongly suggest that the recombinant H(C) fragment of tetanus toxin can act as a neuroprotector in a model of MPP(+)-triggered apoptosis. ..
Pulido D, Moussaoui M, Andreu D, Nogués M, Torrent M, Boix E. Antimicrobial action and cell agglutination by the eosinophil cationic protein are modulated by the cell wall lipopolysaccharide structure. Antimicrob Agents Chemother. 2012;56:2378-85 pubmed publisher
..The results highlight the correlation between the protein's antimicrobial activity and its ability to interact with the LPS outer layer and promote bacterial agglutination. ..
Pulido D, Moussaoui M, Nogués M, Torrent M, Boix E. Towards the rational design of antimicrobial proteins: single point mutations can switch on bactericidal and agglutinating activities on the RNase A superfamily lineage. FEBS J. 2013;280:5841-52 pubmed publisher
..This study provides an example of how structure-guided protein engineering can successfully reproduce an evolution selection process towards the emergence of new physiological roles. ..
Torrent M, Sanchez D, Buzon V, Nogués M, Cladera J, Boix E. Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7. Biochim Biophys Acta. 2009;1788:1116-25 pubmed publisher
..Their distinct mechanism of action at the membrane level may reflect different in vivo antipathogen functions. ..
Molero C, Petrényi K, González A, Carmona M, Gelis S, Abrie J, et al
. The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Mol Microbiol. 2013;90:367-82 pubmed publisher
..Therefore, Sp?hal3 represents a fusion event that joined three different functional activities in the same gene. The possible advantage derived from this surprising combination of essential proteins is discussed. ..