Experts and Doctors on phosphoprotein phosphatase in Barcelona, Catalonia, Spain


Locale: Barcelona, Catalonia, Spain
Topic: phosphoprotein phosphatase

Top Publications

  1. Ruiz A, Munoz I, Serrano R, González A, Simon E, Arino J. Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. J Biol Chem. 2004;279:34421-30 pubmed
    ..These results indicate that, besides its role as Ppz1 inhibitory subunit, Vhs3 (and probably Hal3) might have important Ppz-independent functions. ..
  2. Simon E, Clotet J, Calero F, Ramos J, Arino J. A screening for high copy suppressors of the sit4 hal3 synthetically lethal phenotype reveals a role for the yeast Nha1 antiporter in cell cycle regulation. J Biol Chem. 2001;276:29740-7 pubmed
  3. Munoz I, Ruiz A, Marquina M, Barceló A, Albert A, Arino J. Functional characterization of the yeast Ppz1 phosphatase inhibitory subunit Hal3: a mutagenesis study. J Biol Chem. 2004;279:42619-27 pubmed
    ..In contrast, the mutation of His378 did not. This finding suggests that Hal3 may have both Ppz1-dependent and independent functions involving different structural elements. ..
  4. Bosch M, Serras F, Martin Blanco E, Baguna J. JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs. Dev Biol. 2005;280:73-86 pubmed
    ..Differences with such processes are also highlighted...
  5. Ruiz A, del Carmen Ruiz M, Sánchez Garrido M, Arino J, Ramos J. The Ppz protein phosphatases regulate Trk-independent potassium influx in yeast. FEBS Lett. 2004;578:58-62 pubmed
  6. de Nadal E, Clotet J, Posas F, Serrano R, Gomez N, Arino J. The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A. 1998;95:7357-62 pubmed
    ..Therefore, Hal3p might modulate diverse physiological functions of the Ppz1 phosphatase, such as salt stress tolerance and cell cycle progression, by acting as a inhibitory subunit. ..
  7. Puig Butille J, Malvehy J, Potrony M, Trullas C, Garcia Garcia F, Dopazo J, et al. Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters. Exp Dermatol. 2013;22:494-6 pubmed publisher
    ..001). Low CPI-17 levels were directly associated with pro-inflammatory genes such as TNF (P = 0.012) and IL-1B (P = 0.07). Our results suggest a role for CPI-17 in restoring skin homoeostasis in CFC lesions. ..
  8. Montori Grau M, Guitart M, Garcia Martinez C, Orozco A, Gomez Foix A. Differential pattern of glycogen accumulation after protein phosphatase 1 glycogen-targeting subunit PPP1R6 overexpression, compared to PPP1R3C and PPP1R3A, in skeletal muscle cells. BMC Biochem. 2011;12:57 pubmed publisher
    ..PPP1R6 protein translocates from a Golgi to cytosolic location in response to glucose. The molecular size and subcellular location of myotube glycogen particles is determined by the PPP1R6, PTG and G(M) scaffolding. ..
  9. Ferrer Dalmau J, González A, Platara M, Navarrete C, Martinez J, Barreto L, et al. Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis. Biochem J. 2010;426:355-64 pubmed publisher
    ..Remarkably, the evidence collected indicates that the role of Ref2 in cation homoeostasis may be unrelated to its previously identified function in the formation of mRNA via the APT (for associated with Pta1) complex. ..

More Information


  1. Legnaioli T, Cuevas J, Mas P. TOC1 functions as a molecular switch connecting the circadian clock with plant responses to drought. EMBO J. 2009;28:3745-57 pubmed publisher
    ..Genetic studies with TOC1 and ABAR over-expressing and RNAi plants showed defective responses to drought, which support the notion that clock-dependent gating of ABA function is important for cellular homeostasis under dry environments. ..
  2. Alvarez Errico D, Sayos J, Lopez Botet M. The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase. J Immunol. 2007;178:808-16 pubmed
    ..e., wortmannin and LY-294002). Altogether, these data reveal a putative functional duality of the IREM-1 myeloid cell receptor. ..
  3. Ruiz A, Yenush L, Arino J. Regulation of ENA1 Na(+)-ATPase gene expression by the Ppz1 protein phosphatase is mediated by the calcineurin pathway. Eukaryot Cell. 2003;2:937-48 pubmed
    ..In conclusion, we have identified a novel role for calcineurin, but not alkalinization, in the control of ENA1 expression in ppz1 mutants. ..
  4. Lerin C, Montell E, Nolasco T, Clark C, Brady M, Newgard C, et al. Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content. Diabetes. 2003;52:2221-6 pubmed
    ..The conditional loss of function of the COOH-terminal deleted G(M) construct may help to explain the reported association of truncation mutation of G(M) with insulin resistance in human subjects. ..
  5. de Nadal E, Calero F, Ramos J, Arino J. Biochemical and genetic analyses of the role of yeast casein kinase 2 in salt tolerance. J Bacteriol. 1999;181:6456-62 pubmed
    ..The possible causes for the salt sensitivity phenotype of casein kinase mutants are discussed in the light of these findings. ..
  6. Clotet J, Gari E, Aldea M, Arino J. The yeast ser/thr phosphatases sit4 and ppz1 play opposite roles in regulation of the cell cycle. Mol Cell Biol. 1999;19:2408-15 pubmed
  7. Alvarez Errico D, Aguilar H, Kitzig F, Brckalo T, Sayos J, Lopez Botet M. IREM-1 is a novel inhibitory receptor expressed by myeloid cells. Eur J Immunol. 2004;34:3690-701 pubmed
    ..Finally, cross-linking of IREM-1 results in the inhibition of FcRepsilon-induced activation. Our results indicate that IREM-1 is a novel inhibitory receptor of the Ig superfamily in myeloid cells. ..
  8. Ruiz A, González A, García Salcedo R, Ramos J, Arino J. Role of protein phosphatases 2C on tolerance to lithium toxicity in the yeast Saccharomyces cerevisiae. Mol Microbiol. 2006;62:263-77 pubmed
    ..These results indicate that Ptc1p modulates the function of Ena1p by regulating the Hal3/Ppz1,2 pathway. In conclusion, overexpression of PTC3 and lack of PTC1 affect lithium tolerance in yeast, although through different mechanisms. ..
  9. González A, Ruiz A, Casamayor A, Arino J. Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1. Mol Cell Biol. 2009;29:2876-88 pubmed publisher
    ..All of these results provide the first evidence showing that a type 2C protein phosphatase is required for the normal functioning of the TOR pathway. ..
  10. Saavedra A, García Martínez J, Xifro X, Giralt A, Torres Peraza J, Canals J, et al. PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum. Cell Death Differ. 2010;17:324-35 pubmed publisher
    ..In the striatum, these reduced levels of PHLPP1 can contribute to maintain high levels of activated Akt that may delay cell death and allow the recovery of neuronal viability after mutant huntingtin silencing. ..
  11. Rodriguez Hernandez C, Guinovart J, Murguia J. Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition. FEBS Lett. 2012;586:270-6 pubmed publisher
    ..Therefore tungstate alleviates nutrient stress in yeast by in vivo inhibition of Glc7p. These data uncover a potential role for tungstate in the treatment of PP1 and GCN related diseases. ..
  12. Vera J, Jaumot M, Estanyol J, Brun S, Agell N, Bachs O. Heterogeneous nuclear ribonucleoprotein A2 is a SET-binding protein and a PP2A inhibitor. Oncogene. 2006;25:260-70 pubmed
    ..As hnRNPA2 is overexpressed in a variety of human tumors, our results suggest that hnRNPA2 might participate in oncogenesis by stimulating cell proliferation. ..
  13. Montori Grau M, Guitart M, Lerin C, Andreu A, Newgard C, Garcia Martinez C, et al. Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle. Biochem J. 2007;405:107-13 pubmed
    ..G(L) activates GS regardless of glucose, does not regulate GP and stimulates glycogenesis in combination with insulin and glucose depletion. ..
  14. Bosch M, Baguna J, Serras F. Origin and proliferation of blastema cells during regeneration of Drosophila wing imaginal discs. Int J Dev Biol. 2008;52:1043-50 pubmed publisher
    ..Finally, clonal analysis shows a close relationship between the size and shape of clones and disparities in the positional values of the apposed surfaces. ..
  15. Clotet J, Posas F, de Nadal E, Arino J. The NH2-terminal extension of protein phosphatase PPZ1 has an essential functional role. J Biol Chem. 1996;271:26349-55 pubmed
    ..These results indicates that the NH2-terminal half of the protein contains structural determinants that are specific for certain functions and that the phosphatase activity is required but not sufficient for full PPZ1 function. ..