Genomes and Genes
Experts and Doctors on cell cycle in Barcelona, Catalonia, Spain
Locale: Barcelona, Catalonia, Spain
Topic: cell cycle
- Soto Cerrato V, Montaner B, Martinell M, Vilaseca M, Giralt E, Pérez Tomás R. Cell cycle arrest and proapoptotic effects of the anticancer cyclodepsipeptide serratamolide (AT514) are independent of p53 status in breast cancer cells. Biochem Pharmacol. 2005;71:32-41 pubmed..Our results indicate that AT514 induces cell cycle arrest and apoptosis in breast cancer cells irrespectively of p53 status, suggesting that it might represent a potential new chemotherapeutic agent. ..
- Martinez A, Bellosillo B, Bosch F, Ferrer A, Marcé S, Villamor N, et al. Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol. 2004;164:501-10 pubmed..The expression levels are strongly associated with the proliferative activity of the tumors and the survival of the patients, suggesting a potential role in cell cycle regulation and tumor progression. ..
- Gil Gomez G. Measurement of changes in apoptosis and cell cycle regulatory kinase Cdk2. Methods Mol Biol. 2004;282:131-44 pubmed..Methods for measuring Cdk2 changes in activity in quiescent cells undergoing apoptosis are detailed in this chapter. ..
- Sancho M, Diani E, Beato M, Jordan A. Depletion of human histone H1 variants uncovers specific roles in gene expression and cell growth. PLoS Genet. 2008;4:e1000227 pubmed publisher..Thus, specific phenotypes are observed in breast cancer cells depleted of individual histone H1 variants, supporting the theory that distinct roles exist for the linker histone variants. ..
- Fernandez M, Albor C, Ingelmo Torres M, Nixon S, Ferguson C, Kurzchalia T, et al. Caveolin-1 is essential for liver regeneration. Science. 2006;313:1628-32 pubmed..Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury. ..
- Ortiz C, Caja L, Sancho P, Bertran E, Fabregat I. Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion. Biochem Pharmacol. 2008;75:1935-45 pubmed publisher..In conclusion, targeting EGFR combined with other conventional pro-apoptotic drugs should potentially be effective in antineoplastic therapy towards liver cancer. ..
- Bataller M, Mendez C, Salas J, Portugal J. Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells. Cancer Lett. 2010;292:80-90 pubmed publisher..In contrast, caspase 3 was activated in wild-type HCT116 after treatment with MSK. ..
- Llorente Cortes V, Barbarigo V, Badimon L. Low density lipoprotein receptor-related protein 1 modulates the proliferation and migration of human hepatic stellate cells. J Cell Physiol. 2012;227:3528-33 pubmed publisher..These results suggest that HHSCs-LRP1 may play a key role in the modulation of factors determining hepatic fibrosis. ..
- Novoa I, Gallego J, Ferreira P, Mendez R. Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control. Nat Cell Biol. 2010;12:447-56 pubmed publisher..We conclude that regulation of poly(A) tail length is not only required to compensate for the lack of transcription in specialized cell divisions but also acts as a general mechanism to control mitosis. ..
- Nieves D, Moreno J. Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth. J Lipid Res. 2006;47:2681-9 pubmed..In conclusion, our results show that HETEs, probably produced by CYP450, are involved in the control of 3T6 fibroblast growth. ..
- Berdiel Acer M, Bohem M, Lopez Doriga A, Vidal A, Salazar R, Martínez Iniesta M, et al. Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death. Neoplasia. 2011;13:931-46 pubmed..Therefore, the liver microenvironment induces more efficiently the aggressiveness of colorectal cancer cells than other matched microenvironments do but secondarily evokes cell death. Resistant cells displayed higher stemness capacity. ..
- Pachón O, Azqueta A, Lavaggi M, López de Ceráin A, Creppy E, Collins A, et al. Antitumoral effect of phenazine N5,N10-dioxide derivatives on Caco-2 cells. Chem Res Toxicol. 2008;21:1578-85 pubmed publisher..We concluded that among the series of N(5), N(10)-dioxide phenazine derivatives analyzed, 1, which contains a nitro moiety and a chloroacetamide group, is the most promising as an antitumoral compound. ..
- Pérez Tomás R, Vinas M. New insights on the antitumoral properties of prodiginines. Curr Med Chem. 2010;17:2222-31 pubmed..The molecular targets of prodiginines are discussed and the mechanism of action for these molecules is a current topic in biomedicine with a real therapeutica potential in the clinic. ..
- Roma J, Masià A, Reventos J, Sánchez de Toledo J, Gallego S. Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro. Clin Cancer Res. 2011;17:505-13 pubmed publisher..Pharmacological or genetic blockage of the pathway significantly reduced invasiveness of RMS cell lines, thereby suggesting a possible role of the Notch pathway in the regulation of the metastatic process in RMS. ..
- Rodriguez Bravo V, Guaita Esteruelas S, Florensa R, Bachs O, Agell N. Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. Cancer Res. 2006;66:8672-9 pubmed
- Pérez Torras S, Vidal Pla A, Cano Soldado P, Huber Ruano I, Mazo A, Pastor Anglada M. Concentrative nucleoside transporter 1 (hCNT1) promotes phenotypic changes relevant to tumor biology in a translocation-independent manner. Cell Death Dis. 2013;4:e648 pubmed publisher..Thereby, hCNT1 fits the profile of a transceptor in a substrate translocation-independent manner and is likely to be relevant to tumor biology. ..
- Alvarez Rodriguez R, Barzi M, Berenguer J, Pons S. Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. J Biol Chem. 2007;282:37170-80 pubmed..All together, these data strongly suggest that the BMP2 pathway triggers cell cycle exit and differentiation as two separated but coordinated processes, where TIEG-1 acts as a mediator of the cell cycle arrest. ..
- Nadal Ribelles M, Sol C, Xu Z, Steinmetz L, de Nadal E, Posas F. Control of Cdc28 CDK1 by a stress-induced lncRNA. Mol Cell. 2014;53:549-61 pubmed publisher..The increase in the levels of Cdc28 results in cells able to reenter the cell cycle more efficiently after stress. This may represent a general mechanism to prime expression of genes needed after stresses are alleviated...
- Pérez Luna M, Aguasca M, Perearnau A, Serratosa J, Martínez Balbás M, Jesús Pujol M, et al. PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27 Kip1. Nucleic Acids Res. 2012;40:6520-33 pubmed publisher..We also observed that knockdown of skp2 did not affect the PCAF induced degradation of p27. In conclusion, our data suggest that the p27 acetylation by PCAF regulates its stability. ..
- Abate Daga D, Garcia Rodríguez L, Sumoy L, Fillat C. Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells. Biochim Biophys Acta. 2010;1803:1175-85 pubmed publisher..Moreover it points out, for the first time at Chk1 activation as a key factor to mediate TK/GCV cytotoxicity. ..
- Mateo F, Vidal Laliena M, Pujol M, Bachs O. Acetylation of cyclin A: a new cell cycle regulatory mechanism. Biochem Soc Trans. 2010;38:83-6 pubmed publisher..Interestingly, these four lysine residues in cyclin A also participate in the regulation of cyclin A-Cdk (cyclin-dependent kinase) activity by modulating its interaction with Cdks. ..
- Herranz H, Milan M. Signalling molecules, growth regulators and cell cycle control in Drosophila. Cell Cycle. 2008;7:3335-7 pubmed
- Sardon T, Peset I, Petrova B, Vernos I. Dissecting the role of Aurora A during spindle assembly. EMBO J. 2008;27:2567-79 pubmed publisher..Altogether, our data show that AurA exerts an effect as a key regulator of MT assembly during M phase and therefore of bipolar spindle formation. ..
- de Nadal E, Clotet J, Posas F, Serrano R, Gomez N, Arino J. The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A. 1998;95:7357-62 pubmed..Therefore, Hal3p might modulate diverse physiological functions of the Ppz1 phosphatase, such as salt stress tolerance and cell cycle progression, by acting as a inhibitory subunit. ..
- Hernández Ortega S, Bru S, Ricco N, Ramirez S, Casals N, Jimenez J, et al. Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation. J Biol Chem. 2013;288:4704-14 pubmed publisher..This new previously unknown mechanism for G(1) cyclin degradation that we report here could help elucidate the specific roles of the redundant CDK-cyclin complexes in G(1). ..
- Real S, Meo Evoli N, Espada L, Tauler A. E2F1 regulates cellular growth by mTORC1 signaling. PLoS ONE. 2011;6:e16163 pubmed publisher..From these studies, E2F1 emerges as a key protein that integrates cell division and growth, both of which are essential for cell proliferation. ..
- Menoyo S, Ricco N, Bru S, Hernandez Ortega S, Escote X, Aldea M, et al. Phosphate-activated cyclin-dependent kinase stabilizes G1 cyclin to trigger cell cycle entry. Mol Cell Biol. 2013;33:1273-84 pubmed publisher..Taken together, our data indicate that Cln3 is a molecular target of the Pho85 kinase that is required to modulate cell cycle entry in response to environmental changes in nutrient availability. ..
- Pizarro J, Folch J, Vazquez De la Torre A, Verdaguer E, Junyent F, Jordan J, et al. Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line. Free Radic Res. 2009;43:985-94 pubmed publisher..In summary, this study describes the molecular mechanisms involved in cell cycle alterations induced by oxidative stress in B65 cells. These findings highlight the relevance of ATM in the regulation of cell cycle after oxidative stress. ..
- Abril J, Cebria F, Rodríguez Esteban G, Horn T, Fraguas S, Calvo B, et al. Smed454 dataset: unravelling the transcriptome of Schmidtea mediterranea. BMC Genomics. 2010;11:731 pubmed publisher..However, a detailed description of the planarian transcriptome is essential for future investigation into regenerative processes using planarians as a model system...
- Christen B, Robles V, Raya M, Paramonov I, Izpisua Belmonte J. Regeneration and reprogramming compared. BMC Biol. 2010;8:5 pubmed publisher..We therefore propose a link between partially reprogrammed induced pluripotent stem cells and the half way state of blastema cells and suggest that a common mechanism might be regulating these two processes. ..
- Ramalho Carvalho J, Graça I, Gomez A, Oliveira J, Henrique R, Esteller M, et al. Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer. J Hematol Oncol. 2017;10:43 pubmed publisher..Altogether, these data demonstrate that miR-130b~301b cluster overexpression might effectively induce PCa cell growth arrest through epigenetic regulation of proliferation-blocking genes and activation of cellular senescence. ..
- Herranz H, Hong X, Perez L, Ferreira A, Olivieri D, Cohen S, et al. The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. EMBO J. 2010;29:1688-98 pubmed publisher..Thus, regulation of tissue growth by the miRNA pathway involves a double repression mechanism to control dMyc protein levels in a highly proliferative and growing epithelium. ..
- Clotet J, Gari E, Aldea M, Arino J. The yeast ser/thr phosphatases sit4 and ppz1 play opposite roles in regulation of the cell cycle. Mol Cell Biol. 1999;19:2408-15 pubmed
- Pizarro J, Folch J, Esparza J, Jordan J, Pallas M, Camins A. A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286. J Cell Mol Med. 2009;13:3906-17 pubmed publisher..We conclude that inhibitors of GSK-3 induced cell-cycle arrest, mediated by the phosphorylation of cdc2 and, in the case of SB-415286, SIRT2 expression, which induced apoptosis in a caspase-independent manner...
- Vera J, Jaumot M, Estanyol J, Brun S, Agell N, Bachs O. Heterogeneous nuclear ribonucleoprotein A2 is a SET-binding protein and a PP2A inhibitor. Oncogene. 2006;25:260-70 pubmed..As hnRNPA2 is overexpressed in a variety of human tumors, our results suggest that hnRNPA2 might participate in oncogenesis by stimulating cell proliferation. ..
- Jaime M, Pujol M, Serratosa J, Pantoja C, Canela N, Casanovas O, et al. The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers. Hepatology. 2002;35:1063-71 pubmed..In conclusion, premature translocation of CDC25A to the nucleus might be involved in the advanced induction of cyclin E/CDK2 activity and DNA replication in cells from animals lacking p21(Cip1). ..
- Calvo M, Bartrons R, Castano E, Perales J, Navarro Sabate A, Manzano A. PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells. FEBS Lett. 2006;580:3308-14 pubmed..These data underscore the potential for uPFK-2 as an effective tumor therapeutic target. ..
- Carujo S, Estanyol J, Ejarque A, Agell N, Bachs O, Pujol M. Glyceraldehyde 3-phosphate dehydrogenase is a SET-binding protein and regulates cyclin B-cdk1 activity. Oncogene. 2006;25:4033-42 pubmed..All these results suggest that GAPDH might be involved in cell cycle regulation by modulating cyclin B-cdk1 activity. ..
- de Jaime Soguero A, Aulicino F, Ertaylan G, Griego A, Cerrato A, Tallam A, et al. Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus. PLoS Genet. 2017;13:e1006682 pubmed publisher..All together, here we showed that Wnt signaling controls mESC pluripotency and proliferation through non-overlapping functions of distinct Tcf factors. ..
- Simon E, Clotet J, Calero F, Ramos J, Arino J. A screening for high copy suppressors of the sit4 hal3 synthetically lethal phenotype reveals a role for the yeast Nha1 antiporter in cell cycle regulation. J Biol Chem. 2001;276:29740-7 pubmed
- Rodrigues A, Christen B, Marti M, Izpisua Belmonte J. Skeletal muscle regeneration in Xenopus tadpoles and zebrafish larvae. BMC Dev Biol. 2012;12:9 pubmed publisher..We set out to study whether dedifferentiation was present during muscle regeneration of the tadpole limb and zebrafish larval tail, mainly by cell tracing and histological observations...
- Pifarre P, Baltrons M, Földi I, Garcia A. NO-sensitive guanylyl cyclase beta1 subunit is peripherally associated to chromosomes during mitosis. Novel role in chromatin condensation and cell cycle progression. Int J Biochem Cell Biol. 2009;41:1719-30 pubmed publisher..We postulate that beta1 is a multifunctional protein that regulates chromatin condensation and cell cycle progression, in addition to being an obligate monomer in functional GC(NO) heterodimers. ..
- Meijsing B, Carbó N, Lopez Soriano F, Argiles J. Effects of the phosphodiesterase-IV inhibitor EMD 95832/3 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma. Cancer Lett. 2002;188:53-8 pubmed..It is concluded that the drug is unable to reverse the cachectic state in this particular experimental tumour model...
- Sancho E, Vila M, Sanchez Pulido L, Lozano J, Paciucci R, Nadal M, et al. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. Mol Cell Biol. 1998;18:576-89 pubmed..This was accompanied with a profound inhibition of the mitotic kinase, cdk1. These results suggest that UEV proteins are involved in the control of differentiation and could exert their effects by altering cell cycle distribution. ..
- Calbo J, Serna C, Garriga J, Grana X, Mazo A. The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity. Cell Death Differ. 2004;11:1055-65 pubmed..Our data suggest that, after CDK4/6 inactivation, the fate of pancreatic tumor cells depends on the ability to modulate CDK2 activity. ..
- Moreno Romero J, Armengot L, Marquès Bueno M, Cadavid Ordóñez M, Martinez M. About the role of CK2 in plant signal transduction. Mol Cell Biochem. 2011;356:233-40 pubmed publisher..The high pleiotropy of CK2 was sustained by analysis of global transcript profiles that showed a huge number of genes affected, involved in a wide variety of cellular processes. ..
- Saade M, Gutiérrez Vallejo I, Le Dreau G, Rabadán M, Miguez D, Buceta J, et al. Sonic hedgehog signaling switches the mode of division in the developing nervous system. Cell Rep. 2013;4:492-503 pubmed publisher..As a result, we propose a challenging model in which the external Sonic hedgehog signal dictates stem cell identity, reflected in the consequent readjustment of cell-cycle parameters...
- Ninov N, Martin Blanco E. Changing gears in the cell cycle: histoblasts and beyond. Fly (Austin). 2009;3:286-9 pubmed..We have recently uncovered in histoblasts an internal logic modulating cell cycle transitions that should constitute a reference paradigm for the study of other equivalent processes in stem cell, cancer or developmental biology. ..
- Francisco R, Pérez Perarnau A, Cortés C, Gil J, Tauler A, Ambrosio S. Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. Cancer Lett. 2012;318:42-52 pubmed publisher..Therefore, the autophagy induction is a relevant event in the NB response to HDACis, and it should be considered in the design of new treatments for this malignancy...
- Drews Elger K, Ortells M, Rao A, Lopez Rodriguez C, Aramburu J. The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS ONE. 2009;4:e5245 pubmed publisher..We conclude that NFAT5 facilitates cell proliferation under hypertonic conditions by inducing an osmoadaptive response that enables cells to express fundamental regulators needed for cell cycle progression. ..
- Bazzocco S, Dopeso H, Cartón García F, Macaya I, Andretta E, Chionh F, et al. Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. Clin Cancer Res. 2015;21:3695-704 pubmed publisher..We have characterized at the transcriptomic level the differences between colorectal cancer cells that vary in their growth rates, and identified novel candidate chemotherapeutic targets for the treatment of colorectal cancer. ..
- Yeste Velasco M, Alvira D, Sureda F, Rimbau V, Forsby A, Pallas M, et al. DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons. Neurotoxicology. 2008;29:309-17 pubmed publisher..Present data may help to a better understanding of the molecular mechanisms involved in cytoskeletal degradation-induced apoptosis in neurons. ..
- Villalonga N, Martínez Mármol R, Roura Ferrer M, David M, Valenzuela C, Soler C, et al. Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation. Biochim Biophys Acta. 2008;1783:728-36 pubmed publisher..Our results indicate that the cell cycle-dependent expression of Kv1.5 is involved in skeletal muscle cell proliferation. ..
- Soriano A, ParÃs Coderch L, Jubierre L, MartÃnez A, Zhou X, Piskareva O, et al. MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes. Oncotarget. 2016;7:9271-87 pubmed publisher..MiR-497 targets multiple genes related to the DDR, cell cycle, survival and angiogenesis, which renders this molecule a promising candidate for NB therapy. ..
- Ninov N, Manjón C, Martin Blanco E. Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts. PLoS Biol. 2009;7:e1000079 pubmed publisher..It sets the stage for the comprehensive understanding of the coordination of cell growth and cell-cycle progression in complex multicellular eukaryotes. ..
- Rebollo E, Roldán M, Gonzalez C. Spindle alignment is achieved without rotation after the first cell cycle in Drosophila embryonic neuroblasts. Development. 2009;136:3393-7 pubmed publisher..Therefore, predetermined spindle orientation is not restricted to larval NBs. On the contrary, it actually applies to all but the first cell cycle of embryonic NBs. ..
- Valdes R, Casado F, Pastor Anglada M. Cell-cycle-dependent regulation of CNT1, a concentrative nucleoside transporter involved in the uptake of cell-cycle-dependent nucleoside-derived anticancer drugs. Biochem Biophys Res Commun. 2002;296:575-9 pubmed..These data indicate that CNT1 adapts to cell-cycle progression and responds to nucleos(t)ide metabolism status, a feature that might contribute to the cytotoxic action of cell-cycle-dependent anticancer drugs. ..
- Santamaria A, Fernandez P, Farre X, Benedit P, Reventos J, Morote J, et al. PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. Am J Pathol. 2003;162:897-905 pubmed..These observations suggest that overexpression of PTOV1 can contribute to the proliferative status of prostate tumor cells and thus to their biological behavior. ..
- Aymerich I, Duflot S, Fernandez Veledo S, Guillen Gomez E, Huber Ruano I, Casado F, et al. The concentrative nucleoside transporter family (SLC28): new roles beyond salvage?. Biochem Soc Trans. 2005;33:216-9 pubmed..Animal and cell models genetically modified to alter nucleoside transporter expression levels may help to elucidate the particular roles of CNT proteins in cell physiology. ..
- Santamaria A, Castellanos E, Gómez V, Benedit P, Renau Piqueras J, Morote J, et al. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol. 2005;25:1900-11 pubmed..These observations suggest that PTOV1 assists flotillin-1 in its translocation to the nucleus and that both proteins are required for cell proliferation. ..
- Ninov N, Chiarelli D, Martin Blanco E. Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis. Development. 2007;134:367-79 pubmed..Finally, we show that histoblast spreading and the death of larval cells depend on a mutual exchange of signals and are non-autonomous processes. ..
- Perdiguero E, Ruiz Bonilla V, Serrano A, Munoz Canoves P. Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connection. Cell Cycle. 2007;6:1298-303 pubmed..We discuss these findings in the context of the emerging crosstalk of p38 and JNK signaling pathways in controlling cell growth and differentiation. ..
- Bogliolo M, Lyakhovich A, Callen E, Castella M, Cappelli E, Ramirez M, et al. Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO J. 2007;26:1340-51 pubmed..Consequently, histone H2AX is functionally connected to the FA/BRCA pathway to resolve stalled replication forks and prevent chromosome instability. ..
- Perdiguero E, Ruiz Bonilla V, Gresh L, Hui L, Ballestar E, Sousa Victor P, et al. Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J. 2007;26:1245-56 pubmed..This study provides novel evidence of a fundamental role of p38alpha in muscle formation in vitro and in vivo. ..
- Moreno Moreno O, Torras Llort M, Azorín F. Proteolysis restricts localization of CID, the centromere-specific histone H3 variant of Drosophila, to centromeres. Nucleic Acids Res. 2006;34:6247-55 pubmed..However, cells showing reduced amounts of mislocalized CID show normal cell cycle progression. ..
- Arpa L, Valledor A, Lloberas J, Celada A. IL-4 blocks M-CSF-dependent macrophage proliferation by inducing p21Waf1 in a STAT6-dependent way. Eur J Immunol. 2009;39:514-26 pubmed publisher..Thus, IL-4 and IFN-gamma blocked M-CSF-induced macrophage proliferation through distinct mechanisms. ..
- Simon E, Barceló A, Arino J. Mutagenesis analysis of the yeast Nha1 Na+/H+ antiporter carboxy-terminal tail reveals residues required for function in cell cycle. FEBS Lett. 2003;545:239-45 pubmed..The later is rather conserved in other related antiporters, while the former is not. ..
- Hawkins K, Moschidou D, Faccenda D, Wruck W, Martin Trujillo A, Hau K, et al. Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency. Mol Ther. 2017;25:427-442 pubmed publisher..Our data identify, for the first time, the pluripotent transcriptional and molecular signature and metabolic status of human chemically induced pluripotent stem cells. ..
- Nicolas O, Gavin R, Del Río J. New insights into cellular prion protein (PrPc) functions: the "ying and yang" of a relevant protein. Brain Res Rev. 2009;61:170-84 pubmed publisher..In this review, we summarize new findings on PrP(c) functions, especially those related to neural degeneration and cell signaling. ..
- Chugh P, Clark A, Smith M, Cassani D, Dierkes K, Ragab A, et al. Actin cortex architecture regulates cell surface tension. Nat Cell Biol. 2017;19:689-697 pubmed publisher..Our results indicate that actin network architecture, alongside myosin activity, is key to cell surface tension regulation. ..
- Kieffer Kwon K, Nimura K, Rao S, Xu J, Jung S, Pekowska A, et al. Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation. Mol Cell. 2017;67:566-578.e10 pubmed publisher..Our results thus define the nature and transcriptional impact of chromatin decondensation and reveal an unexpected role for Myc in the establishment of nuclear topology in mammalian cells. ..
- Scaltriti M, Rojo F, Ocana A, Anido J, Guzman M, Cortes J, et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst. 2007;99:628-38 pubmed..029). Breast tumors that express p95HER2 are resistant to trastuzumab and may require alternative or additional anti-HER2-targeting strategies. ..
- Bertran M, Sdelci S, Regué L, Avruch J, Caelles C, Roig J. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J. 2011;30:2634-47 pubmed publisher..Our results provide a basis to understand signalling downstream of Plk1 and shed light on the role of Eg5, Plk1 and the NIMA-family kinases in the control of centrosome separation and normal mitotic progression. ..