Experts and Doctors on saccharomyces cerevisiae proteins in Oviedo, Asturias, Spain


Locale: Oviedo, Asturias, Spain
Topic: saccharomyces cerevisiae proteins

Top Publications

  1. Herrero P, Flores L, de la Cera T, Moreno F. Functional characterization of transcriptional regulatory elements in the upstream region of the yeast GLK1 gene. Biochem J. 1999;343 Pt 2:319-25 pubmed
    ..e., silent in media with glucose and other preferred carbon sources, such as fructose or mannose, and increased levels of expression upon glucose depletion. ..
  2. de la Cera T, Herrero P, Moreno Herrero F, Chaves R, Moreno F. Mediator factor Med8p interacts with the hexokinase 2: implication in the glucose signalling pathway of Saccharomyces cerevisiae. J Mol Biol. 2002;319:703-14 pubmed
    ..We conclude that Hxk2p operates through the MED8 site, by interacting with Med8p, in the glucose signal transduction pathway of Saccharomyces cerevisiae. ..
  3. Gomez Diaz C, Martin F, Alcorta E. The cAMP transduction cascade mediates olfactory reception in Drosophila melanogaster. Behav Genet. 2004;34:395-406 pubmed
    ..These results suggest that even for a small number of tested odorants (5), cAMP cascade is involved in olfactory reception to an important extent. ..
  4. Palomino A, Herrero P, Moreno F. Rgt1, a glucose sensing transcription factor, is required for transcriptional repression of the HXK2 gene in Saccharomyces cerevisiae. Biochem J. 2005;388:697-703 pubmed
    ..The physiological significance of the connection between two glucose-signalling pathways, the Snf3/Rgt2 that causes glucose induction and the Mig1/Hxk2 that causes glucose repression, was also analysed. ..
  5. Riera A, Ahuatzi D, Herrero P, Garcia Gimeno M, Sanz P, Moreno F. Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell. Biochem J. 2008;415:233-9 pubmed publisher
    ..We also report that binding of GK(beta) to Mig1 allows the latter protein to be located at the mitochondrial network under low-glucose conditions. ..
  6. Pelaez R, Fernández García P, Herrero P, Moreno F. Nuclear import of the yeast hexokinase 2 protein requires ?/?-importin-dependent pathway. J Biol Chem. 2012;287:3518-29 pubmed publisher
    ..It is also demonstrated that Hxk2 nuclear import and its binding to Kap95 and Kap60 depend on the Gsp1-GTP/GDP protein levels. Thus, our study uncovers Hxk2 as a new cargo for the ?/?-importin pathway of S. cerevisiae. ..
  7. Cadinanos J, Schmidt W, Fueyo A, Varela I, Lopez Otin C, Freije J. Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans. Biochem J. 2003;370:1047-54 pubmed
    ..These results indicate that CeFACE-1 and CeFACE-2 are bona fide CaaX proteases and support the evolutionary conservation of this proteolytic system in eukaryotes. ..
  8. Cadinanos J, Varela I, Mandel D, Schmidt W, Diaz Perales A, Lopez Otin C, et al. AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes. J Biol Chem. 2003;278:42091-7 pubmed
    ..These results provide evidence for the existence of a previously unsuspected plant FACE-2/Rce1 ortholog and support the evolutionary conservation of dual CAAX proteolytic systems in eukaryotes. ..
  9. Ahuatzi D, Herrero P, de la Cera T, Moreno F. The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependent. J Biol Chem. 2004;279:14440-6 pubmed
    ..We conclude that Hxk2 operates by interacting with Mig1 to generate a repressor complex located in the nucleus of S. cerevisiae during growth in glucose medium. ..

More Information


  1. Palomino A, Herrero P, Moreno F. Tpk3 and Snf1 protein kinases regulate Rgt1 association with Saccharomyces cerevisiae HXK2 promoter. Nucleic Acids Res. 2006;34:1427-38 pubmed
    ..These results suggest that a novel silent-chromatin loop is responsible for Rgt1-dependent transcriptional regulation of the HXK2 gene. ..
  2. Ahuatzi D, Riera A, Pelaez R, Herrero P, Moreno F. Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution. J Biol Chem. 2007;282:4485-93 pubmed
    ..These results allow postulating that the Hxk2 operates by interacting both with Mig1 and Snf1 to inhibit the Mig1 phosphorylation at serine 311 during high glucose grown. ..
  3. Pelaez R, Herrero P, Moreno F. Nuclear export of the yeast hexokinase 2 protein requires the Xpo1 (Crm1)-dependent pathway. J Biol Chem. 2009;284:20548-55 pubmed publisher
    ..Our study uncovers a new cargo for the Xpo1 yeast exportin and identifies Hxk2 phosphorylation at serine 14 as a regulatory mechanism that controls its nuclear exit in function of the glucose levels. ..
  4. Fernández Cid A, Riera A, Herrero P, Moreno F. Glucose levels regulate the nucleo-mitochondrial distribution of Mig2. Mitochondrion. 2012;12:370-80 pubmed publisher
  5. Fernández García P, Pelaez R, Herrero P, Moreno F. Phosphorylation of yeast hexokinase 2 regulates its nucleocytoplasmic shuttling. J Biol Chem. 2012;287:42151-64 pubmed publisher
    ..Taken together, this study establishes a functional link between Hxk2, Reg1, and Snf1 signaling, which involves the regulation of Hxk2 nucleocytoplasmic shuttling by phosphorylation-dephosphorylation of serine 14. ..