Experts and Doctors on animals in Sevilla, Andalusia, Spain


Locale: Sevilla, Andalusia, Spain
Topic: animals

Top Publications

  1. Morcuende S, Benitez Temino B, Pecero M, Pastor A, de la Cruz R. Abducens internuclear neurons depend on their target motoneurons for survival during early postnatal development. Exp Neurol. 2005;195:244-56 pubmed
    ..These results indicate that, during development, abducens internuclear neurons depend on their target motoneurons for survival, and that they lose this dependence with maturation. ..
  2. Vargas J, Lopez J, Portavella M. What are the functions of fish brain pallium?. Brain Res Bull. 2009;79:436-40 pubmed publisher
    ..This result allows discussion of homology proposals among lateral, dorsal, and medial pallia and hippocampus, isocortex, and pallial amygdala respectively. ..
  3. Romero Granados R, Fontán Lozano A, Delgado García J, Carrión A. From learning to forgetting: behavioral, circuitry, and molecular properties define the different functional states of the recognition memory trace. Hippocampus. 2010;20:584-95 pubmed publisher
    ..All these results indicate that the functional state of the recognition memory trace, from acquisition to forgetting, can be specifically defined by behavioral, circuitry, and molecular properties. ..
  4. Smani T, Calderón Sanchez E, Gómez Hurtado N, Fernandez Velasco M, Cachofeiro V, Lahera V, et al. Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes. Cardiovasc Res. 2010;87:459-66 pubmed publisher
    ..We propose that the marked increase in I(CaL) density induced by Ucn is mediated through CRF-R2 and involves PKC-dependent activation of the ERK1/2 pathway, whereas PKA and Epac signalling are not implicated. ..
  5. Lachaud C, Pezzolla D, Dominguez Rodriguez A, Smani T, Soria B, Hmadcha A. Functional vascular smooth muscle-like cells derived from adult mouse uterine mesothelial cells. PLoS ONE. 2013;8:e55181 pubmed publisher
    ..Thus, we show for the first time that UtMCs could recapitulate in vitro differentiative events of early cardiovascular differentiation and transdifferentiate in cells exhibiting molecular and functional characteristics of VSMCs. ..
  6. Sotillos S, Krahn M, Espinosa Vázquez J, Hombria J. Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. Development. 2013;140:1507-16 pubmed publisher
    ..This is the first time that a functional link between cell polarity, the JAK/STAT signalling pathway and the Src kinases has been established in a whole organism. ..
  7. Garcia Carbonero R, Carnero A, Paz Ares L. Inhibition of HSP90 molecular chaperones: moving into the clinic. Lancet Oncol. 2013;14:e358-69 pubmed publisher
    ..We also discuss novel strategies and future perspectives on how to optimise the therapeutic potential of this exciting new class of drugs. ..
  8. Pintado C, Pinto F, Pennefather J, Hidalgo A, Baamonde A, Sanchez T, et al. A role for tachykinins in female mouse and rat reproductive function. Biol Reprod. 2003;69:940-6 pubmed
    ..These data show that tachykinins of both neuronal and nonneuronal origin are differentially expressed in various types of reproductive cells and may play a role in female reproductive function. ..
  9. Villadiego J, Mendez Ferrer S, Valdés Sánchez T, Silos Santiago I, Farinas I, Lopez Barneo J, et al. Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation. J Neurosci. 2005;25:4091-8 pubmed
    ..Thus, glomus cells appear to be prototypical abundant sources of GDNF, ideally suited to be used as biological pumps for the endogenous delivery of trophic factors in PD and other neurodegenerative diseases. ..

More Information

Publications219 found, 100 shown here

  1. Gaubert P, Cordeiro Estrela P. Phylogenetic systematics and tempo of evolution of the Viverrinae (Mammalia, Carnivora, Viverridae) within feliformians: implications for faunal exchanges between Asia and Africa. Mol Phylogenet Evol. 2006;41:266-78 pubmed
    ..Couched in the context of the viverrid fossil record, our study calls for a revision of the paleontological data in order to fully appreciate the complexity of Afro-Asian faunal exchanges...
  2. Davis Lopez de Carrizosa M, Tena J, Benitez Temino B, Morado Díaz C, Pastor A, de la Cruz R. A chronically implantable device for the controlled delivery of substances, and stimulation and recording of activity in severed nerves. J Neurosci Methods. 2008;167:302-9 pubmed
    ..The IOD can also be efficiently used for the delivery of small volume of pharmacological substances or conventional retrograde markers. ..
  3. Lopes C, Casares F. hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit. Dev Biol. 2010;339:78-88 pubmed publisher
    ..We integrate these results in a model of the early steps of eye development that links proliferation control and differential gene expression with patterning signals. ..
  4. Barragan I, Borrego S, Pieras J, Gonzalez del Pozo M, Santoyo J, Ayuso C, et al. Mutation spectrum of EYS in Spanish patients with autosomal recessive retinitis pigmentosa. Hum Mutat. 2010;31:E1772-800 pubmed
    ..Along with the detection of three recurrent mutations in Caucasian population, our hypothesis of EYS being the first prevalent gene in arRP has been reinforced in the present study. ..
  5. Gaytan S, Pasaro R. Neonatal caffeine treatment up-regulates adenosine receptors in brainstem and hypothalamic cardio-respiratory related nuclei of rat pups. Exp Neurol. 2012;237:247-59 pubmed publisher
    ..Up-regulation of adenosinergic maturation in central cardio-respiratory areas in caffeine-treated neonatal rats could explain the pharmacological effects of caffeine observed in premature infants. ..
  6. Santos Gally R, Pérez Barrales R, Simón V, Arroyo J. The role of short-tongued insects in floral variation across the range of a style-dimorphic plant. Ann Bot. 2013;111:317-28 pubmed publisher
    ..The results highlight the importance of different pollinators in determining the presence of style polymorphism. ..
  7. Muñoz Lobato F, Rodríguez Palero M, Naranjo Galindo F, Shephard F, Gaffney C, Szewczyk N, et al. Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases. Antioxid Redox Signal. 2014;20:217-35 pubmed publisher
  8. Cuervo J, Belliure J, Negro J. Coloration reflects skin pterin concentration in a red-tailed lizard. Comp Biochem Physiol B Biochem Mol Biol. 2016;193:17-24 pubmed publisher
    ..In this way, ventral orange/red coloration would accurately reflect pterin concentration, which provides the basis for a signaling function, while dorsal coloration would become less conspicuous as an anti-predatory mechanism. ..
  9. Navarro López J, Alvarado J, Márquez Ruiz J, Escudero M, Delgado Garcia J, Yajeya J. A cholinergic synaptically triggered event participates in the generation of persistent activity necessary for eye fixation. J Neurosci. 2004;24:5109-18 pubmed
    ..These findings suggest that a slow, cholinergic, synaptically triggered event participates in the generation of persistent activity characteristic of PH neurons carrying eye position signals. ..
  10. Cutillas C, Oliveros R, de Rojas M, Guevara D. Determination of Trichuris skrjabini by sequencing of the ITS1-5.8S-ITS2 segment of the ribosomal DNA: comparative molecular study of different species of trichurids. J Parasitol. 2004;90:648-52 pubmed
    ..ovis, T. leporis, T. muris, and T. arvicolae suggested that the combined use of sequence data from both spacers would be useful in the molecular characterization of trichurid parasites. ..
  11. Flores J, Galan Rodriguez B, Ramiro Fuentes S, Fernandez Espejo E. Role for dopamine neurons of the rostral linear nucleus and periaqueductal gray in the rewarding and sensitizing properties of heroin. Neuropsychopharmacology. 2006;31:1475-88 pubmed
    ..D(2) dopamine receptors within the RLi/PAG region participate in these effects. ..
  12. Garcia Delgado M, Garcia Miranda P, Peral M, Calonge M, Ilundain A. Ontogeny up-regulates renal Na(+)/Cl(-)/creatine transporter in rat. Biochim Biophys Acta. 2007;1768:2841-8 pubmed
  13. Herrera A, de Pablos R, Carreño Müller E, Villarán R, Venero J, Tomás Camardiel M, et al. The intrastriatal injection of thrombin in rat induced a retrograde apoptotic degeneration of nigral dopaminergic neurons through synaptic elimination. J Neurochem. 2008;105:750-62 pubmed publisher
    ..Our results point out the possible relationship between synapse elimination and retrograde degeneration in the nigral dopaminergic system...
  14. Fernández Miñán A, Cobreros L, González Reyes A, Martin Bermudo M. Integrins contribute to the establishment and maintenance of cell polarity in the follicular epithelium of the Drosophila ovary. Int J Dev Biol. 2008;52:925-32 pubmed publisher
    ..Finally, we provide evidence to suggest that integrins are required to orientate epithelial polarity in vivo. ..
  15. Espina A, Méndez Vidal C, Moreno Mateos M, Saez C, Romero Franco A, Japon M, et al. Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation. Mol Biol Cell. 2009;20:3353-62 pubmed publisher
  16. Cobreros Reguera L, Fernández Miñán A, Fernández Espartero C, Lopez Schier H, González Reyes A, Martin Bermudo M. The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila. EMBO Rep. 2010;11:943-9 pubmed publisher
    ..The msn gene functions to modulate the levels and/or distribution of Drosophila E-cadherin to promote the invasive migratory behaviour of border cells. ..
  17. Quesada A, Aguilera Y, Caparrós R, Prada F, Santano C, López López R, et al. Myelin oligodendrocyte-specific protein is expressed in Müller cells of myelinated vertebrate retinas. J Neurosci Res. 2011;89:674-88 pubmed publisher
    ..Altogether, our results suggest that the MC in myelinated retinas might contribute MOSP to myelin. ..
  18. Fedriani J, Zywiec M, Delibes M. Thieves or mutualists? Pulp feeders enhance endozoochore local recruitment. Ecology. 2012;93:575-87 pubmed
    ..thieves, cheaters, or exploiters might be misleading. ..
  19. Carrasco M, Delgado I, Soria B, Martin F, Rojas A. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012;122:3504-15 pubmed publisher
    ..Our results place GATA factors at the top of the transcriptional network hierarchy controlling pancreas organogenesis...
  20. Aguilar Hidalgo D, Domínguez Cejudo M, Amore G, Brockmann A, Lemos M, Cordoba A, et al. A Hh-driven gene network controls specification, pattern and size of the Drosophila simple eyes. Development. 2013;140:82-92 pubmed publisher
    ..In addition, we discuss some general implications our model may have in some Hh-driven gene networks. ..
  21. Horrillo A, Pezzolla D, Fraga M, Aguilera Y, Salguero Aranda C, Tejedo J, et al. Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment. Cell Death Dis. 2013;4:e570 pubmed publisher
    ..Our results indicate that zebularine regulates mesodermal differentiation of mESCs, controls promoter methylation of crucial cardiac genes and may help to improve cardiomyogenic differentiation. ..
  22. Rodriguez Moyano M, Diaz I, Dionisio N, Zhang X, Ávila Médina J, Calderón Sanchez E, et al. Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation. Cardiovasc Res. 2013;100:297-306 pubmed publisher
  23. Remaut K, De Clercq E, Andries O, Rombouts K, Van Gils M, Cicchelero L, et al. Aerosolized Non-viral Nucleic Acid Delivery in the Vaginal Tract of Pigs. Pharm Res. 2016;33:384-94 pubmed publisher
  24. Aguilera A. Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. Curr Opin Cell Biol. 2005;17:242-50 pubmed
    ..New findings suggest that mRNP assembly is a genetically controlled process that plays a key role in gene expression and other cellular processes, including the maintenance of genome integrity. ..
  25. Silva Hucha S, Hernández R, Benitez Temino B, Pastor A, de la Cruz R, Morcuende S. Extraocular motoneurons of the adult rat show higher levels of vascular endothelial growth factor and its receptor Flk-1 than other cranial motoneurons. PLoS ONE. 2017;12:e0178616 pubmed publisher
  26. Rodriguez Hernandez M, Cuberos L, Pichardo C, Caballero F, Moreno I, Jiménez Mejías M, et al. Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains. J Antimicrob Chemother. 2001;47:479-82 pubmed
    ..baumannii, with an MIC up to 4 mg/L, provided that doses reach a t > MIC similar to that of imipenem. The activity of sulbactam was time dependent. ..
  27. Gruart A, Streppel M, Guntinas Lichius O, Angelov D, Neiss W, Delgado Garcia J. Motoneuron adaptability to new motor tasks following two types of facial-facial anastomosis in cats. Brain. 2003;126:115-33 pubmed
    ..In conclusion, adult mammal facial premotor circuits maintain their motor programmes when motoneurons are induced to reinnervate a foreign muscle, or even a new set of muscle fibres. ..
  28. Delgado Garcia J, Gruart A. The role of interpositus nucleus in eyelid conditioned responses. Cerebellum. 2002;1:289-308 pubmed
  29. Troncoso J, Múnera A, Delgado García J. Classical conditioning of eyelid and mystacial vibrissae responses in conscious mice. Learn Mem. 2004;11:724-6 pubmed
    ..This finding suggests that evolutionary pressure has selected a sensorimotor system capable of constructing conditioned responses on the basis of temporal relationships of stimuli, independently of any putative functional purpose. ..
  30. Millan J, Mateo R, Taggart M, López Bao J, Viota M, Monsalve L, et al. Levels of heavy metals and metalloids in critically endangered Iberian lynx and other wild carnivores from Southern Spain. Sci Total Environ. 2008;399:193-201 pubmed publisher
    ..However, given the critical status of the Iberian lynx, a continuous monitoring scheme remains necessary...
  31. Pozo M, De Vega C, Canto A, Herrera C. Presence of yeasts in floral nectar is consistent with the hypothesis of microbial-mediated signaling in plant-pollinator interactions. Plant Signal Behav. 2009;4:1102-4 pubmed
  32. Cabeza J, Acosta J, Ales E. Dynamics and regulation of endocytotic fission pores: role of calcium and dynamin. Traffic. 2010;11:1579-90 pubmed publisher
    ..Between calcium mediators, dynamin functions as a catalyst to increase the speed of single vesicle endocytosis. ..
  33. Cordero M, Sánchez Alcázar J, Bautista Ferrufino M, Carmona López M, Illanes M, Rios M, et al. Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugs. Anticancer Drugs. 2010;21:932-44 pubmed publisher
    ..In conclusion, based on the capacity of generating ROS and inhibiting antioxidants in tumor cells, amitriptyline emerges as a promising new drug to be tested for anticancer therapy. ..
  34. Galván I, Gangoso L, Grande J, Negro J, Rodríguez A, Figuerola J, et al. Antioxidant machinery differs between melanic and light nestlings of two polymorphic raptors. PLoS ONE. 2010;5:e13369 pubmed publisher
    ..We suggest that the need to maintain low GSH levels for eumelanogenesis in dark morph individuals may represent a physiological constraint that helps regulate the evolution and maintenance of polymorphisms. ..
  35. Stouffer D, Rezende E, AMARAL L. The role of body mass in diet contiguity and food-web structure. J Anim Ecol. 2011;80:632-9 pubmed publisher
    ..5. Our investigation of the role of body mass in food webs thus helps us to better understand the important features of community food-web structure and the evolutionary forces that have led us to the communities we observe. ..
  36. Gavilan M, Pintado C, Gavilán E, García Cuervo L, Castaño A, Rios R, et al. Age-related differences in the dynamics of hippocampal proteasome recovery. J Neurochem. 2012;123:635-44 pubmed publisher
    ..These data strongly suggest that age-dependent differences in proteasome level and composition could contribute to neurodegeneration induced by proteasome dysfunction in normal and pathological aging. ..
  37. Bogdanovi O, Delfino Mach n M, Nicol s P rez M, Gavil n M, Gago Rodrigues I, Fern ndez Mi n A, et al. Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis. Dev Cell. 2012;23:782-95 pubmed publisher
    ..We propose that developmental regulator Opo enables polarized integrin localization by modulating Numb/Numbl, thus directing the basal constriction that shapes the vertebrate retina epithelium...
  38. Garnacho C. Intracellular Drug Delivery: Mechanisms for Cell Entry. Curr Pharm Des. 2016;22:1210-26 pubmed
  39. Miró G, Montoya A, Checa R, Gálvez R, Mínguez J, Marino V, et al. First detection of Onchocerca lupi infection in dogs in southern Spain. Parasit Vectors. 2016;9:290 pubmed publisher
    ..This first report of O. lupi infection in dogs in southern Spain expands the range of geographical distribution of this parasite and sounds an alarm bell for practitioners and physicians working in that area. ..
  40. Asencio C, Rodríguez Aguilera J, Vazquez R, Baylis H, Cabello J, Schnabel R, et al. Differential expression pattern of coq-8 gene during development in Caenorhabditis elegans. Gene Expr Patterns. 2006;6:433-9 pubmed
    ..In elderly nematodes expression was only observed in nervous system, whilst expression in larvae was also detected in hypodermis, muscles and coelomocytes. Global expression provide a regulated pattern during life cycle of the nematode. ..
  41. Cutillas C, de Rojas M, Ariza C, Ubeda J, Guevara D. Molecular identification of Trichuris vulpis and Trichuris suis isolated from different hosts. Parasitol Res. 2007;100:383-9 pubmed
    ..8S-ITS2 sequence data of Trichuris ovis, Trichuris leporis, Trichuris muris, Trichuris arvicolae, and Trichuris skrjabini was carried out. A common homology zone was detected in the ITS1 sequence of all species of trichurids. ..
  42. Martinez Cruz B, Godoy J, Negro J. Population fragmentation leads to spatial and temporal genetic structure in the endangered Spanish imperial eagle. Mol Ecol. 2007;16:477-86 pubmed
  43. Alarcon P, Rodríguez Seguel E, Fernández González A, Rubio R, Gomez Skarmeta J. A dual requirement for Iroquois genes during Xenopus kidney development. Development. 2008;135:3197-207 pubmed publisher
    ..Subsequently, Irx genes are required for proper formation of the intermediate tubule. Finally, we find that retinoic acid signalling activates both Irx1 and Irx3 genes in the pronephros. ..
  44. García Delgado M, Peral M, Duran J, García Miranda P, Calonge M, Ilundáin A. Ontogeny of Na(+)/L-carnitine transporter and of gamma-trimethylaminobutyraldehyde dehydrogenase and gamma-butyrobetaine hydroxylase genes expression in rat kidney. Mech Ageing Dev. 2009;130:227-33 pubmed publisher
    ..Some of these results were published as an abstract (García-Delgado et al., 2003). ..
  45. Sánchez Campusano R, Gruart A, Delgado Garcia J. Dynamic associations in the cerebellar-motoneuron network during motor learning. J Neurosci. 2009;29:10750-63 pubmed publisher
    ..Thus, it can be proposed that the cerebellum is always looking back and reevaluating its own function, using the information acquired in the process, to play a modulating-reinforcing role in motor learning. ..
  46. Davis Lopez de Carrizosa M, Morado Díaz C, Morcuende S, de la Cruz R, Pastor A. Nerve growth factor regulates the firing patterns and synaptic composition of motoneurons. J Neurosci. 2010;30:8308-19 pubmed publisher
    ..On the other hand, p75(NTR) activation regulates recruitment threshold, which impacts on firing regularity. To our knowledge, this is the first report showing powerful synaptotrophic effects of NGF on motoneurons in vivo. ..
  47. Rozas J, G mez S nchez L, Tom s Zapico C, Lucas J, Fern ndez Chac n R. Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease. J Neurosci. 2011;31:1106-13 pubmed publisher
    ..Our findings could be relevant to understand synaptic toxic effects of proteins with abnormal polyQ repeats...
  48. Eleore L, López Ramos J, Guerra Narbona R, Delgado Garcia J. Role of reuniens nucleus projections to the medial prefrontal cortex and to the hippocampal pyramidal CA1 area in associative learning. PLoS ONE. 2011;6:e23538 pubmed publisher
    ..In conclusion, reuniens nucleus projections to prefrontal and hippocampal circuits seem to participate in the acquisition of associative learning through a mechanism that does not required the development of LTP. ..
  49. Romero Granados R, Fontán Lozano A, Aguilar Montilla F, Carrión A. Postnatal proteasome inhibition induces neurodegeneration and cognitive deficiencies in adult mice: a new model of neurodevelopment syndrome. PLoS ONE. 2011;6:e28927 pubmed publisher
  50. Castellano Pozo M, Garcia Muse T, Aguilera A. R-loops cause replication impairment and genome instability during meiosis. EMBO Rep. 2012;13:923-9 pubmed publisher
    ..Importantly, RNase H partially suppressed the replication impairment and the DNA-damage accumulation. We conclude that R-loops can form during meiosis causing replication impairment with deleterious results. ..
  51. Andrade Talavera Y, Duque Feria P, Sihra T, Rodríguez Moreno A. Pre-synaptic kainate receptor-mediated facilitation of glutamate release involves PKA and Ca(2+) -calmodulin at thalamocortical synapses. J Neurochem. 2013;126:565-78 pubmed publisher
  52. Giménez J, Marçalo A, Ramirez F, Verborgh P, Gauffier P, Esteban R, et al. Diet of bottlenose dolphins (Tursiops truncatus) from the Gulf of Cadiz: Insights from stomach content and stable isotope analyses. PLoS ONE. 2017;12:e0184673 pubmed publisher
    ..Both approaches provide different insights, e.g. determination of consumed fish biomass for the management of fish stocks (SCA) or identification of important assimilated prey species to the consumer (SIA). ..
  53. Blumer R, Streicher J, Davis Lopez de Carrizosa M, de la Cruz R, Pastor A. Palisade Endings of Extraocular Muscles Develop Postnatally Following Different Time Courses. Invest Ophthalmol Vis Sci. 2017;58:5105-5121 pubmed publisher
    ..To analyze in a frontal-eyed mammal (cat) the postnatal development of palisade endings in extraocular muscles (EOMs) and to compare the spatiotemporal and quantitative patterns of palisade endings among individual rectus muscles...
  54. Galván I, Mousseau T, Møller A. Bird population declines due to radiation exposure at Chernobyl are stronger in species with pheomelanin-based coloration. Oecologia. 2011;165:827-35 pubmed publisher
  55. Kenny N, Chan K, Nong W, Qu Z, Maeso I, Yip H, et al. Ancestral whole-genome duplication in the marine chelicerate horseshoe crabs. Heredity (Edinb). 2016;116:190-9 pubmed publisher
    ..This study provides evidence of ancient WGD in the ecdysozoan lineage, and reveals new opportunities for studying genomic and regulatory evolution after WGD in the Metazoa. ..
  56. Ramos B, Baglietto Vargas D, del Rio J, Moreno Gonzalez I, Santa Maria C, Jimenez S, et al. Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease. Neurobiol Aging. 2006;27:1658-72 pubmed
    ..Therefore, SOM and NPY neuropeptides could constitute important biomarkers to assess the efficacy of potential early AD treatments. ..
  57. Madejón P, Murillo J, Marañón T, Espinar J, Cabrera F. Accumulation of As, Cd and selected trace elements in tubers of Scirpus maritimus L. from Doñana marshes (South Spain). Chemosphere. 2006;64:742-8 pubmed
    ..An exhaustive study of macrophytes and other plant species in this area is recommended to identify potential risks to wildlife...
  58. Roques S, Fox C, Villasana M, Rico C. The complete mitochondrial genome of the whiting, Merlangius merlangus and the haddock, Melanogrammus aeglefinus: a detailed genomic comparison among closely related species of the Gadidae family. Gene. 2006;383:12-23 pubmed publisher
    ..This comparison may be particularly useful in phylogenetic analyses of such a diverse fish family, as well as for the understanding of the patterns of nucleotide substitution of the mtDNA at low levels of divergence...
  59. Baos R, Blas J, Bortolotti G, Marchant T, Hiraldo F. Adrenocortical response to stress and thyroid hormone status in free-living nestling white storks (Ciconia ciconia) exposed to heavy metal and arsenic contamination. Environ Health Perspect. 2006;114:1497-501 pubmed
  60. Giraldez Perez R, Gaytan S, Ruano D, Torres B, Pasaro R. Distribution of NADPH-diaphorase and nitric oxide synthase reactivity in the central nervous system of the goldfish (Carassius auratus). J Chem Neuroanat. 2008;35:12-32 pubmed
    ..Cognizing that a direct comparison of the present results with those reported in other vertebrates is not clear-cut because of homologies; we conclude that the nitrergic system is roughly similar from fish to mammals. ..
  61. Sotillos S, Díaz Meco M, Moscat J, Castelli Gair Hombría J. Polarized subcellular localization of Jak/STAT components is required for efficient signaling. Curr Biol. 2008;18:624-9 pubmed publisher
    ..Our results also suggest that receptor polarization in the ectoderm cell membrane restricts the cell's response to ligands provided by neighboring cells. ..
  62. Bautista L, Castro M, Lopez Barneo J, Castellano A. Hypoxia inducible factor-2alpha stabilization and maxi-K+ channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning. Circ Res. 2009;104:1364-72 pubmed publisher
    ..Our work provides new perspectives for research on cardiac preconditioning. ..
  63. Malartre M, Ayaz D, Amador F, Martín Bermudo M. The guanine exchange factor vav controls axon growth and guidance during Drosophila development. J Neurosci. 2010;30:2257-67 pubmed publisher
    ..Thus, we propose that vav acts in coordination with other GEFs to regulate axon growth and guidance during development by linking guidance signals to the cytoskeleton via the modulation of Rac activity. ..
  64. Figuerola J, Charalambidou I, Santamaria L, Green A. Internal dispersal of seeds by waterfowl: effect of seed size on gut passage time and germination patterns. Naturwissenschaften. 2010;97:555-65 pubmed publisher
  65. Cacho Valadez B, Muñoz Lobato F, Pedrajas J, Cabello J, Fierro González J, Navas P, et al. The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in ?-amyloid peptide toxicity. Antioxid Redox Signal. 2012;16:1384-400 pubmed publisher
    ..The nematode strains characterized in this work make C. elegans an ideal model organism to study the pathophysiology of the mitochondrial thioredoxin system at the level of a complete organism. ..
  66. Zambrano S, Blanca A, Ruiz Armenta M, Miguel Carrasco J, Arevalo M, Vazquez M, et al. L-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-? expression. Biochem Pharmacol. 2013;85:937-44 pubmed publisher
  67. Freedman A, Gronau I, Schweizer R, Ortega Del Vecchyo D, Han E, Silva P, et al. Genome sequencing highlights the dynamic early history of dogs. PLoS Genet. 2014;10:e1004016 pubmed publisher
    ..This result, in combination with dog-wolf admixture during the process of domestication, suggests that a re-evaluation of past hypotheses regarding dog origins is necessary. ..
  68. Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Acevedo Arozena A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12:1-222 pubmed publisher
  69. Galván I, Solano F. Bird Integumentary Melanins: Biosynthesis, Forms, Function and Evolution. Int J Mol Sci. 2016;17:520 pubmed publisher
  70. Akdi K, Vilaplana R, Kamah S, González Vílchez F. Effects of Tris and Hepes buffers on the interaction of palladium-diaminopropane complexes with DNA. J Inorg Biochem. 2005;99:1360-8 pubmed
    ..Moreover, the level of DNA modifications produced by palladium complexes in 10 mM NaClO(4) remains unchanged after transferring the samples into the medium required for subsequent biophysical or biochemical analyses. ..
  71. Vergel M, Carnero A. Bypassing cellular senescence by genetic screening tools. Clin Transl Oncol. 2010;12:410-7 pubmed publisher
    ..The identification of genes and pathways regulating senescence/immortalisation could provide novel molecular targets for the treatment and/or prevention of cancer. ..
  72. Sebé Pedrós A, Ballaré C, Parra Acero H, Chiva C, Tena J, Sabidó E, et al. The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity. Cell. 2016;165:1224-1237 pubmed publisher
    ..Overall, our results indicate that the emergence of animal multicellularity was linked to a major shift in genome cis-regulatory complexity, most notably the appearance of distal enhancer regulation. ..
  73. Romero F, Multon M, Ramos Morales F, Dominguez A, Bernal J, Pintor Toro J, et al. Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. Nucleic Acids Res. 2001;29:1300-7 pubmed
    ..We propose that hPTTG might connect DNA damage-response pathways with sister chromatid separation, delaying the onset of mitosis while DNA repair occurs. ..
  74. Venero J, Absi E, Cano J, Machado A. Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus. J Pineal Res. 2002;32:6-14 pubmed
    ..We conclude that melatonin administration, that combines antioxidant capacity and a tissue-specific TH inducing effect, may be useful as a pharmacological agent to protect dopaminergic neurons from degeneration. ..
  75. Cutillas C, Oliveros R, de Rojas M, Guevara D. Determination of Trichuris muris from murid hosts and T. arvicolae (Nematoda) from arvicolid rodents by amplification and sequentiation of the ITS1-5.8S-ITS2 segment of the ribosomal DNA. Parasitol Res. 2002;88:574-82 pubmed
    ..arvicolae. This corroborates the existence of two separate Trichuris species in murid and arvicolid hosts. Furthermore, a phylogenetic analysis was carried out and endonucleases restriction maps were elaborated for both species. ..
  76. Serrato A, P rez Ruiz J, Sp nola M, Cejudo F. A novel NADPH thioredoxin reductase, localized in the chloroplast, which deficiency causes hypersensitivity to abiotic stress in Arabidopsis thaliana. J Biol Chem. 2004;279:43821-7 pubmed publisher
    ..An Arabidopsis NTRC knock-out mutant showed growth inhibition and hypersensitivity to methyl viologen, drought, and salt stress. These results suggest that the NTRC gene is involved in plant protection against oxidative stress...
  77. Echevarria M, Muñoz Cabello A, Sánchez Silva R, Toledo Aral J, Lopez Barneo J. Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression. J Biol Chem. 2007;282:30207-15 pubmed
    ..Moreover, lung AQP-1 is markedly up-regulated in animals exposed to hypoxia. These data suggest that AQP-1 has O(2) permeability and thus could facilitate O(2) diffusion across the cell membrane. ..
  78. Garcia Fernandez M, Ortega Saenz P, Castellano A, Lopez Barneo J. Mechanisms of low-glucose sensitivity in carotid body glomus cells. Diabetes. 2007;56:2893-900 pubmed
    ..Altogether, these data support the view that the CB is a multimodal chemoreceptor with a physiological role in glucose homeostasis. ..
  79. Martínez Cruz B, Godoy J. Genetic evidence for a recent divergence and subsequent gene flow between Spanish and Eastern imperial eagles. BMC Evol Biol. 2007;7:170 pubmed
    ..This model enables estimation of population sizes at split, and inference of gene flow after divergence...
  80. Hidalgo Vila J, Díaz Paniagua C, Pérez Santigosa N, de Frutos Escobar C, Herrero Herrero A. Salmonella in free-living exotic and native turtles and in pet exotic turtles from SW Spain. Res Vet Sci. 2008;85:449-52 pubmed publisher
    ..These results confirm the risk of transmission of Salmonella from free-living and pet turtles to humans, demanding the necessity of regulation of pet turtle trade in Europe. ..
  81. Pascual A, Hidalgo Figueroa M, Piruat J, Pintado C, Gómez Díaz R, Lopez Barneo J. Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nat Neurosci. 2008;11:755-61 pubmed publisher
    ..These data unequivocally demonstrate that GDNF is indispensable for adult catecholaminergic neuron survival and also show that, under physiologic conditions, downregulation of a single trophic factor can produce massive neuronal death. ..
  82. Santiago M, Hernández Romero M, Machado A, Cano J. Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not. Eur J Pharmacol. 2009;609:58-64 pubmed publisher
    ..Our model to study toxicity in the striatal dopaminergic terminals suggests that Zocor Forte (simvastatin) could prevent the neurotoxic damage produced by LPS, but not that produced by MPP+. ..
  83. Munoz M, Rosso M, Coveñas R. The NK-1 receptor: a new target in cancer therapy. Curr Drug Targets. 2011;12:909-21 pubmed
    ..In sum, the NK-1 receptor may be a new and promising target in the treatment of human cancer. ..
  84. Roques S, Adrados B, Chavez C, Keller C, Magnusson W, Palomares F, et al. Identification of neotropical felid faeces using RCP-PCR. Mol Ecol Resour. 2011;11:171-5 pubmed publisher
    ..This approach proved reliable and provides high identification success rates from faeces. Its simplicity and cost effectiveness should facilitate its application for routine surveys of presence and abundance of these species...
  85. Pozo M, Lachance M, Herrera C. Nectar yeasts of two southern Spanish plants: the roles of immigration and physiological traits in community assembly. FEMS Microbiol Ecol. 2012;80:281-93 pubmed publisher
  86. Negrete Díaz J, Duque Feria P, Andrade Talavera Y, Carrión M, Flores G, Rodríguez Moreno A. Kainate receptor-mediated depression of glutamatergic transmission involving protein kinase A in the lateral amygdala. J Neurochem. 2012;121:36-43 pubmed publisher
    ..Taken together our results indicate that KARs present at this synapse are pre-synaptic and their activation mediate the inhibition of glutamate release through a mechanism that involves the activation of protein kinase A. ..
  87. Hidalgo Figueroa M, Bonilla S, Gutierrez F, Pascual A, Lopez Barneo J. GDNF is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after injury of the nigrostriatal pathway. J Neurosci. 2012;32:864-72 pubmed publisher
    ..Stimulation of the GDNF-producing striatal PV+ ensemble in PD patients could have therapeutic effects. ..
  88. Carnero A. Spinophilin: a new tumor suppressor at 17q21. Curr Mol Med. 2012;12:528-35 pubmed
    ..Therefore, Spn may be the tumor suppressor gene that is located at 17q21.33 and that its tumor suppressive function is dependent on the absence of p53. ..
  89. Gaillard H, Aguilera A. Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis. Biochim Biophys Acta. 2013;1829:141-50 pubmed publisher
    ..This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation. ..
  90. Bogdanovic O, Fernández Miñán A, Tena J, de la Calle Mustienes E, Gomez Skarmeta J. The developmental epigenomics toolbox: ChIP-seq and MethylCap-seq profiling of early zebrafish embryos. Methods. 2013;62:207-15 pubmed publisher
    ..Our MethylCap-seq data concur with previous DNA methylation studies of early zebrafish development rendering this method highly suitable for the global assessment of DNA methylation in early vertebrate embryos. ..
  91. Vengut Climent E, Terrazas M, Lucas R, Arévalo Ruiz M, Eritja R, Morales J. Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates. Bioorg Med Chem Lett. 2013;23:4048-51 pubmed publisher
    ..Such modifications contribute positively to the stability of oligoribonucleotides against 5'-exonuclease degradation. ..
  92. Giraldez Perez R, Gaytan S, Pasaro R. Cholinergic and nitrergic neuronal networks in the goldfish telencephalon. Acta Neurobiol Exp (Wars). 2013;73:338-53 pubmed
    ..The distribution of these elements could help to elucidate the role of cholinergic and nitrergic neuronal networks in the goldfish telencephalon. ..