Experts and Doctors on signal transduction in Daejeon, South Korea


Locale: Daejeon, South Korea
Topic: signal transduction

Top Publications

  1. Chung K, Won M, Lee J, Ahn J, Hoe K, Kim D, et al. Yeast-based screening to identify modulators of G-protein signaling using uncontrolled cell division cycle by overexpression of Stm1. J Biotechnol. 2007;129:547-54 pubmed
    ..This study provides the yeast-based platform that allows robust cellular assays to identify novel modulators of G-protein signaling and MAP kinase pathway. ..
  2. Lee J, Kim I, Ryu J, Yun C. House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells. Cytokine. 2008;42:365-71 pubmed publisher
    ..This finding may contribute to the elucidation of the pathogenic mechanism triggered by DpE . ..
  3. Song Y, Cheon S, Lee K, Lee S, Lee B, Oh D, et al. Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans. Mol Biol Cell. 2008;19:5456-77 pubmed publisher
    ..Collectively, these results demonstrate that the RAM network is critically required for hyphal growth as well as normal vegetative growth in C. albicans. ..
  4. Lee J. Autophagy in neurodegeneration: two sides of the same coin. BMB Rep. 2009;42:324-30 pubmed
    ..In this review, the two sides of autophagy will be discussed in the context of several neurodegenerative diseases. ..
  5. Kim J, Oh M, Bernard L, Macara I, Zhang H. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons. J Biol Chem. 2011;286:37615-24 pubmed publisher
    ..Together, our findings uncover a role for the RhoG/ELMO1/Dock180 signaling module in spine morphogenesis in hippocampal neurons. ..
  6. Park J, Shin D, Lee Y, Cho C, Kim G, Kim W, et al. Apoptotic and anti-metastatic effects of the whole skin of Venenum bufonis in A549 human lung cancer cells. Int J Oncol. 2012;40:1210-9 pubmed publisher
    ..Our data also demonstrated that MMPs are critical targets of SVB-induced anti-invasiveness in A549 cells. ..
  7. Han E, Kim H, Choi J, Jang Y, Lee S, Kwon K, et al. Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation. Mol Nutr Food Res. 2012;56:797-809 pubmed publisher
    ..Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions. ..
  8. Kim J, Park S, Cho K. Discovery of a kernel for controlling biomolecular regulatory networks. Sci Rep. 2013;3:2223 pubmed publisher
    ..Intriguingly, the control kernel of the human signaling network included many drug targets and chemical-binding interactions, suggesting therapeutic application of the control kernel. ..
  9. Jung S, Kang J, Lee J, Song K, Ko J, Kim Y. PHLPP1 regulates contact inhibition by dephosphorylating Mst1 at the inhibitory site. Biochem Biophys Res Commun. 2014;443:1263-9 pubmed publisher
    ..Furthermore, loss of PHLPP1 resulted in a failure of the apoptotic control. It is interesting that down-regulated expression of PHLPP1 appears to mimic the loss of contact inhibition, a hallmark of cancer. ..

More Information

Publications196 found, 100 shown here

  1. Lee M, Kim J, Koh W. Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia. J Cell Biochem. 2004;93:629-38 pubmed
    ..These data suggest that the inhibition of Src-mediated tyrosine phosphorylation by PP2 may tilt the balance between each PKC isotypes, which in turn, activate NF-kappaB transcription factor, leading to apoptosis...
  2. Gim J, Kim H, Kim J, Choi M, Kim J, Chung Y, et al. A system-level investigation into the cellular toxic response mechanism mediated by AhR signal transduction pathway. Bioinformatics. 2010;26:2169-75 pubmed publisher
    ..Taken together, our study provides a system-level understanding of how AhR signal mediates various TCDD-induced toxicities under the presence of hypoxia and/or DNA damage in cells. ..
  3. Kang Y, Ji N, Han S, Lee C, Kim J, Yeom Y, et al. ESM-1 regulates cell growth and metastatic process through activation of NF-?B in colorectal cancer. Cell Signal. 2012;24:1940-9 pubmed publisher
    ..Based on our results, ESM-1 may be a useful therapeutic target for colorectal cancer. ..
  4. Hwang Y, Choi J, Kim H, Choi J, Hwang S, Chung Y, et al. Cultivated ginseng suppresses ultraviolet B-induced collagenase activation via mitogen-activated protein kinases and nuclear factor ?B/activator protein-1-dependent signaling in human dermal fibroblasts. Nutr Res. 2012;32:428-38 pubmed publisher
    ..These results indicate that CG inhibits UVB-induced collagenolytic MMP production by interfering with MAPK/AP-1 and NF-?B signaling and thus may be useful in the prevention and treatment of skin photoaging. ..
  5. Bang J, Jeon W, Lee I, Han J, Kim B. Biphasic functional regulation in hippocampus of rat with chronic cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid artery. PLoS ONE. 2013;8:e70093 pubmed publisher
    ..The biphasic regulatory mechanism first reported here could provide molecular evidence of BCCAO-induced impaired memory in rats as well as mechanism of the development of vascular dementia. ..
  6. Jin W, Kim B, Kim J, Kim H, Ha H, Lee Z. Notch2 signaling promotes osteoclast resorption via activation of PYK2. Cell Signal. 2016;28:357-365 pubmed publisher
    ..Collectively, these results demonstrate that Notch2 in osteoclasts plays a role in the control of resorption activity via the PYK2-c-Src-microtubule signaling pathway. ..
  7. Oh J, Kim A, Park J, Kim S, Chung A. Ultraviolet B-induced matrix metalloproteinase-1 and -3 secretions are mediated via PTEN/Akt pathway in human dermal fibroblasts. J Cell Physiol. 2006;209:775-85 pubmed
  8. Lee H, Kim S, Kim H, Li S, Yun H, Song K, et al. Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. Int J Oncol. 2009;34:473-80 pubmed
  9. Kim T, Moon J, Lee H, Cho E, Paik S, Kim I. SM22alpha inhibits cell proliferation and protects against anticancer drugs and gamma-radiation in HepG2 cells: involvement of metallothioneins. FEBS Lett. 2009;583:3356-62 pubmed publisher
    ..This study provides the first demonstration of SM22alpha-induced blockage of cell proliferation and cellular resistance to overcome the detrimental effects of damaging agents. ..
  10. Ha H, Yu D. HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway. World J Gastroenterol. 2010;16:4932-7 pubmed
    ..Endogenously produced ROS also stimulated HBx expression. HBx induced ROS promoted Akt pathways via oxidized inactive PTEN. HBx and ROS maintained a positive regulatory loop, which aggravated carcinogenesis...
  11. Song D, Oh K, Yu H, Park C, Woo R, Jung S, et al. Role of activating transcription factor 3 in ischemic penumbra region following transient middle cerebral artery occlusion and reperfusion injury. Neurosci Res. 2011;70:428-34 pubmed publisher
    ..Consequently, it would be suggested that ATF3 seem to play an important role in caspase-dependent neuronal apoptotic signal transduction pathways caused by focal cerebral ischemia and reperfusion injury. ..
  12. Tran N, Trinh Q, Lee G, Han Y. Efficient differentiation of human pluripotent stem cells into mesenchymal stem cells by modulating intracellular signaling pathways in a feeder/serum-free system. Stem Cells Dev. 2012;21:1165-75 pubmed publisher
    ..The results demonstrated that functional MSCs could be generated efficiently from hPSCs by the combined modulation of signaling pathways. ..
  13. Park J, Lee M, Cha E, Lee J, Sul J, Song I, et al. Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway. Biol Pharm Bull. 2012;35:1614-20 pubmed
    ..Magnolol inhibited migration and invasion of HCT-116 cells through AMPK activation. These findings demonstrate that AMPK mediates the anticancer effects of magnolol through apoptosis in HCT-116 cells. ..
  14. Kim Y, Kang Y, Park H, Lee J, Yu D, Murata T, et al. STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance. Exp Mol Med. 2016;48:e212 pubmed publisher
    ..These data suggest that STEP inhibition may be a critical target for the treatment of withdrawal symptoms associated with morphine. ..
  15. Kim J, Lee C, Jin M, Lee C, Paik S, Lee H, et al. Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J Biol Chem. 2005;280:11347-51 pubmed
    ..Ligand diversity of CD14 could be explained by the generous size of the pocket, the considerable flexibility of the rim of the pocket, and the multiplicity of grooves available for ligand binding. ..
  16. Yun C, Choi S, Park E, Kim S, Chung A, Lee H, et al. Negative regulation of Activin/Nodal signaling by SRF during Xenopus gastrulation. Development. 2007;134:769-77 pubmed
    ..These results suggest that XSRF might act to ensure proper mesoderm induction in the appropriate region by inhibiting the mesoderm-inducing signals during early embryogenesis. ..
  17. Song K, Kim J, Yun E, Kim Y, Seo K, Park J, et al. Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. Autophagy. 2008;4:650-8 pubmed
  18. Ryu B, Hwang M, Park M, Lee K, Kim S. Thiourea compound AW00178 sensitizes human H1299 lung carcinoma cells to TRAIL-mediated apoptosis. Bioorg Med Chem Lett. 2012;22:3862-5 pubmed publisher
  19. Song I, Jun S, Na H, Kim H, Jung S, Ha G, et al. Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Gastroenterology. 2012;143:1341-1351 pubmed publisher
    ..TIPRL prevents prolonged activation of MKK7 and JNK and TRAIL-induced apoptosis by mediating the interaction between MKK7 and PP2Ac. ..
  20. Ryu S, Yoon J, Yim N, Choi K, Choi C. Downregulation of OPA3 is responsible for transforming growth factor-?-induced mitochondrial elongation and F-actin rearrangement in retinal pigment epithelial ARPE-19 cells. PLoS ONE. 2013;8:e63495 pubmed publisher
    ..Depletion of Mfn1 blocked the increase in cell length during TGF-?-mediated EMT. These results collectively substantiate the involvement of mitochondrial dynamics in TGF-?-induced EMT. ..
  21. Yang C, Yuk J, Kim J, Hwang J, Lee C, Kim J, et al. Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2. PLoS ONE. 2013;8:e63435 pubmed publisher
    ..These data strongly suggest that the SHP-inducing drug fenofibrate paves the way for novel therapies for systemic inflammation by targeting SHP. ..
  22. Oh Y, Jang D, Sonn J, Choe J. Histamine-HisCl1 receptor axis regulates wake-promoting signals in Drosophila melanogaster. PLoS ONE. 2013;8:e68269 pubmed publisher
    ..Taken together, these data clearly demonstrate that the histamine-HisCl1 receptor axis can activate and maintain the wake state in Drosophila and that wake-activating signals may travel via the PDF neurons. ..
  23. Li Z, Sohn K, Choi D, Shi G, Hong D, Lee H, et al. Roles of TLR7 in activation of NF-κB signaling of keratinocytes by imiquimod. PLoS ONE. 2013;8:e77159 pubmed publisher
  24. Kim M, Kim T, Johnson R, Lim D. Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ. Cell Rep. 2015;11:270-82 pubmed publisher
    ..Our demonstration of the transcriptional co-repressor activity of YAP/TAZ opens a new avenue for understanding the Hippo signaling pathway. ..
  25. Chen F, Zhang Y, ÅženbabaoÄŸlu Y, Ciriello G, Yang L, Reznik E, et al. Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. Cell Rep. 2016;14:2476-89 pubmed publisher
    ..Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset. ..
  26. Choi M, Shi J, Jung S, Chen X, Cho K. Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage. Sci Signal. 2012;5:ra83 pubmed publisher
    ..Thus, attractor landscape analysis of p53 network dynamics and its regulation can identify potential therapeutic strategies for treating cancer. ..
  27. Kim H, Oh Y, Song I, Kim S, Lee H, Yun H, et al. Endogenous stromal cell-derived factor-1 (CXCL12) supports autonomous growth of acute myeloid leukemia cells. Leuk Res. 2013;37:566-72 pubmed publisher
    ..These results indicate that endogenous SDF-1 expression by AML cells plays a role in the autonomous growth of the cells. ..
  28. Kim M, Koh Y, Kim K, Koh B, Nam D, Alitalo K, et al. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res. 2010;70:10411-21 pubmed publisher
    ..Our findings suggest that targeting the SDF-1/CXCR4 axis in addition to dacarbazine treatment could therapeutically block chemoresistant CD133(+) cell metastasis toward a lymphatic metastatic niche. ..
  29. Lee S, Song K, Koo I, Lee K, Suh K, Kim B. Comparison of pathways associated with hepatitis B- and C-infected hepatocellular carcinoma using pathway-based class discrimination method. Genomics. 2012;99:347-54 pubmed publisher
    ..This study indicates the functional distinction and similarity on the pathways implicated in the development of HCV- and/or HBV-positive HCC. ..
  30. Park Y, Shin H, Kim S, Kim J, Kim J, Bang D, et al. iNOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation. Biochem Biophys Res Commun. 2013;435:244-9 pubmed publisher
    ..These findings provide a better understating of the mechanism involving HBx-mediated hepatic tumorigenesis and selective inhibition of iNOS may have therapeutic applications in HBx-associated HCC. ..
  31. Kim M, Kim M, Park S, Lee C, Lim D. Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. EMBO Rep. 2016;17:64-78 pubmed publisher
    ..Furthermore, ubiquitinated AMOTL2 can bind to the UBA domain of LATS kinase, and this domain is required for the function of LATS. Our results provide novel insights into the activation mechanisms of core Hippo pathway components. ..
  32. An H, Maeng O, Kang K, Lee J, Kim Y, Paik S, et al. Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem. 2006;281:33939-48 pubmed
    ..These results suggest that NO-induced death of macrophages is mediated, at least in part, by BNIP3 induction. ..
  33. Lee E, Chuang H, Kim J, Ideker T, Lee D. Inferring pathway activity toward precise disease classification. PLoS Comput Biol. 2008;4:e1000217 pubmed publisher
    ..e., non-conditional) definition of pathways. Within a pathway, the identified CORGs may facilitate the development of better diagnostic markers and the discovery of core alterations in human disease. ..
  34. Lee Y, Park S, Kim Y, Park O. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. Ann N Y Acad Sci. 2009;1171:489-94 pubmed publisher
    ..These results indicate that AMPK is crucial in apoptosis induced by curcumin and further that the pAkt-AMPK-COX-2 cascade or AMPK-pAkt-COX-2 pathway is important in cell proliferation and apoptosis in colon cancer cells. ..
  35. Kim H, Kim J. Compartmentalization of vertebrate optic neuroephithelium: external cues and transcription factors. Mol Cells. 2012;33:317-24 pubmed publisher
    ..This review focuses on the molecular signatures of OV subdomains and the external factors that direct the development of tissues originating from the OV. ..
  36. Lee S, Birhanu B, Awji E, Kim M, Park J, Suh J, et al. BaeR protein acts as an activator of nuclear factor-kappa B and Janus kinase 2 to induce inflammation in murine cell lines. Can J Microbiol. 2016;62:753-61 pubmed publisher
  37. Lee J, Kim T, Yang T, Koo B, Oh S, Lee K, et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008;27:1231-42 pubmed publisher
    ..Collectively, these data provide compelling evidence that WW45 is a key mediator of MST1 signalling in the coordinate coupling of proliferation arrest with terminal differentiation for proper epithelial tissue development in mammals. ..
  38. Piao Z, Kim M, Jeong M, Yun S, Lee S, Sun H, et al. VDUP1 exacerbates bacteremic shock in mice infected with Pseudomonas aeruginosa. Cell Immunol. 2012;280:1-9 pubmed publisher
    ..Overall, VDUP1 aggravates bacteremic shock; thus, VDUP1 can be considered a target molecule for the inhibition of P. aeruginosa-induced bacteremic shock. ..
  39. Kwak S, Hong S, Bajracharya R, Yang S, Lee K, Yu K. Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion. PLoS ONE. 2013;8:e68641 pubmed publisher
    ..This study demonstrates a new adipokine signaling in Drosophila and provides insights for the mammalian adiponectin receptor function in pancreatic beta cells, which could be useful for therapeutic application. ..
  40. Kim S, Lee Y, Kim N, Hwang Y, Hwang B, Min J, et al. Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability. Oncogene. 2013;32:3638-47 pubmed publisher
    ..Taken together, these data demonstrate that PAUF has a novel function in promoting angiogenesis and vascular permeability. Our findings suggest new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases. ..
  41. Song S, Choi K, Ryu S, Kang S, Choi C. TRAIL promotes caspase-dependent pro-inflammatory responses via PKC? activation by vascular smooth muscle cells. Cell Death Dis. 2011;2:e223 pubmed publisher
    ..We propose that the TRAIL/TRAIL receptor system has a critical role in the pathogenesis of inflammatory vascular disorders by transducing pro-inflammatory signals via caspase-mediated PKC? cleavage and subsequent NF-?B activation. ..
  42. Park A, Oh D, Lim S, Choi J, Moon J, Yu D, et al. Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT. J Cell Sci. 2012;125:4518-31 pubmed publisher
    ..We thus show conclusively that BCR is a novel substrate of PTPRT and that BCR is involved in the regulation of neuronal development via control of the BCR GTPase-activating domain function by PTPRT. ..
  43. Park E, Kim J, Ha T, Choi J, Soo Hong K, Rho J. TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts. Exp Mol Med. 2013;45:e35 pubmed publisher
    ..Thus, TDAG51 deficiency promotes apoptotic cell death in MEFs, and these results indicate that TDAG51 has a protective role in oxidative stress-induced cell death in MEFs. ..
  44. Kim J, Jo E. NLRP3 inflammasome and host protection against bacterial infection. J Korean Med Sci. 2013;28:1415-23 pubmed publisher
    ..Understanding the roles and regulatory mechanisms of the NLRP3 inflammasome is essential for developing potential treatment approaches against pathogenic infections. ..
  45. Kim S, Yang J, Kim M, Roh S, Kim H, Lee K, et al. Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells. Free Radic Biol Med. 2008;45:537-46 pubmed publisher
  46. Sohn E, Kim J, Kim C, Lee Y, Kim J. Extract of Polygonum cuspidatum Attenuates Diabetic Retinopathy by Inhibiting the High-Mobility Group Box-1 (HMGB1) Signaling Pathway in Streptozotocin-Induced Diabetic Rats. Nutrients. 2016;8:140 pubmed publisher
    ..The oral administration of PCE may significantly help to suppress the development of diabetic retinopathy in patients with diabetes. ..
  47. Park K, Byun H, Won M, Yang K, Shin S, Piao L, et al. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Carcinogenesis. 2007;28:71-80 pubmed
  48. Shin S, Rath O, Choo S, Fee F, McFerran B, Kolch W, et al. Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. J Cell Sci. 2009;122:425-35 pubmed publisher
    ..When overexpressed, RKIP also causes delayed and reduced responses of ERK. Thus, positive- and negative-feedback loops and RKIP work together to shape the response pattern and dynamical characteristics of the ERK pathway. ..
  49. Poudel B, Ki H, Luyen B, Lee Y, Kim Y, Kim D. Triticumoside induces apoptosis via caspase-dependent mitochondrial pathway and inhibits migration through downregulation of MMP2/9 in human lung cancer cells. Acta Biochim Biophys Sin (Shanghai). 2016;48:153-60 pubmed publisher
    ..Collectively, these results suggest that triticumoside induces apoptosis through caspase-dependent mitochondrial pathway and suppresses migration via inhibition of MMP2/9 in NSCLC A549 cells. ..
  50. Choi K, Choi C. Differential regulation of c-Jun N-terminal kinase and NF-kappaB pathway by caffeic acid phenethyl ester in astroglial and monocytic cells. J Neurochem. 2008;105:557-64 pubmed
  51. Park Y, Choi S, Kim B, Kim J, Song E, Kang S, et al. Induction of Mac-2BP by nerve growth factor is regulated by the PI3K/Akt/NF-kappaB-dependent pathway in the HEK293 cell line. BMB Rep. 2008;41:784-9 pubmed
    ..Collectively, these results suggest that NGF induces Mac-2BP expression via the PI3K/Akt/NF-kappaB pathway. ..
  52. Kang W, Sung P, Park S, Yoon S, Chang D, Kim S, et al. Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8+ T cell effector functions. Gastroenterology. 2014;146:1351-60.e1-4 pubmed publisher
    ..This appears to be an important mechanism by which HCV circumvents antiviral adaptive immune responses. ..
  53. Joo H, Kim H, Park S, Cho H, Kim H, Lim D, et al. Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells. Blood. 2011;118:2094-104 pubmed publisher
    ..We conclude that Ang1/Tie2 signaling has a pivotal role in ESC-EC differentiation and that this effect can be exploited to expand EC populations. ..
  54. Shin D, Yang C, Lee J, Lee S, Choi H, Lee H, et al. Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages. Cell Microbiol. 2008;10:1893-905 pubmed publisher
    ..In addition, PKCzeta targets to lipid rafts and may act as a critical adaptor molecule to regulate lipid raft dynamics during TLR2 signalling. ..
  55. Song E, Kang M, Kim Y, Kim S, Lee S, Kim C, et al. Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5. Int J Mol Med. 2011;28:115-9 pubmed publisher
    ..These findings suggest that TLR5 may play an important role in tumor progression of gastric cancer via the regulation of cell proliferation. ..
  56. Hong S, Kim J, Seo J, Jung K, Hong S, Hong S. Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities. J Med Chem. 2012;55:5337-49 pubmed publisher
    ..Representative derivatives showed desirable activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited noteworthy antiangiogenic activity. ..
  57. Choi J, Jin S, Park B, Kim H, Khanal T, Han H, et al. Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-?/IFN-?-induced TARC activation in HaCaT cells. Food Chem Toxicol. 2013;56:195-203 pubmed publisher
  58. Choi K, Park J, Lee J, Han E, Choi C. Mutant ubiquitin attenuates interleukin-1?- and tumor necrosis factor-?-induced pro-inflammatory signaling in human astrocytic cells. PLoS ONE. 2013;8:e67891 pubmed publisher
    ..Collectively, these results suggest that UBB(+1) may affect proinflammatory signaling in the central nervous system via inhibitory mechanisms of ubiquitin-dependent signaling in human astrocytes. ..
  59. Maddirevula S, Anuppalle M, Huh T, Kim S, Rhee M. Rnf11-like is a novel component of NF-κB signaling, governing the posterior patterning in the zebrafish embryos. Biochem Biophys Res Commun. 2012;422:602-6 pubmed publisher
    ..All these findings indicate that Rnf11-like is an essential component of NF-κB signaling pathway for specification of the posterior somites in zebrafish embryos. ..
  60. Kim M, Lee S, Park K, Jeong E, Ryu C, Choi D, et al. Comparative microarray analysis of programmed cell death induced by proteasome malfunction and hypersensitive response in plants. Biochem Biophys Res Commun. 2006;342:514-21 pubmed
    ..Based on these results, these two PCD pathways appear to be differentially regulated, but some overlapping mechanism exists, which involves core regulators of plant PCD. ..
  61. Jeon J, Lee J, Park K, Byun H, Lee H, Lee Y, et al. Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. Biochem Pharmacol. 2014;89:515-25 pubmed publisher
    ..Taken together, the results suggest that the anti-IKK activity of brazilin is induced by targeting IKK upstream signaling components and subsequently disrupting proximal IL-1 receptor signaling complex formation. ..
  62. Kim D, Chung K, Choi S, Jung Y, Park S, Han G, et al. RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. Int J Cancer. 2009;125:2520-7 pubmed publisher
    ..In conclusion, we found that RhoB interacts with TNFAIP1 to regulate apoptosis via a SAPK/JNK-mediated signal transduction mechanism. ..
  63. Kim J, Jo K, Kim O, Kim B, Kang D, Lee K, et al. Parenteral 17beta-estradiol decreases fasting blood glucose levels in non-obese mice with short-term ovariectomy. Life Sci. 2010;87:358-66 pubmed publisher
    ..short-term parenteral 17beta-estradiol treatment decreases the fasting blood glucose levels not via insulin sensitivity of the skeletal muscle in non-obese mice with short-term ovariectomy. ..
  64. Kim J, Kim J, Kang Y, Kim K, Lee S, Choi S, et al. NDRG2 and PRA1 interact and synergistically inhibit T-cell factor/?-catenin signaling. FEBS Lett. 2012;586:3962-8 pubmed publisher
    ..Results suggest that NDRG2 and PRA1 might act synergistically to prevent signaling of TCF/?-catenin. ..
  65. Kim C, Yang H, Fukushima Y, Saw P, Lee J, Park J, et al. Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell. 2014;25:102-17 pubmed publisher
    ..These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects. ..
  66. Kim S, Kim H, Park M, Cho S, Goughnour P, Han D, et al. Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells. J Cell Biol. 2017;216:2201-2216 pubmed publisher
  67. Jeong K, Kim H, Kang J. Investigation of the functional difference between the pathological itching and neuropathic pain-induced rat brain using manganese-enhanced MRI. Acta Radiol. 2016;57:861-8 pubmed publisher
    ..These findings provide clear information of the signal transduction in the brain regarding PI or NP that share a similar neuronal pathway. ..
  68. Sohn B, Shim J, Kim S, Jang K, Kim S, Kim J, et al. Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma. Clin Cancer Res. 2016;22:1256-64 pubmed publisher
    ..001). Inactivation of the Hippo pathway in HCC is significantly associated with poor prognosis. ..
  69. Yang C, Lee D, Song C, An S, Li S, Kim J, et al. Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J Exp Med. 2007;204:583-94 pubmed
  70. Ahn J, Lee H, Jung C, Jeon T, Ha T. MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade. EMBO Mol Med. 2013;5:1602-12 pubmed publisher
    ..Therefore, the miR-146b/SIRT1 pathway could be a potential target for obesity prevention and treatment. ..
  71. Lee S, Yun S, Lee J, Kim M, Piao Z, Jeong M, et al. RasGRP1 is required for human NK cell function. J Immunol. 2009;183:7931-8 pubmed publisher
    ..Moreover, our data suggest that RasGRP1 might act as an important bridge between phospholipase-gamma activation and NK cell effector functions via the Ras-MAPK pathway. ..
  72. Shim K, Ma C, Kim D, Ma J. Yukmijihwang-tang inhibits receptor activator for nuclear Factor-?B ligand-induced osteoclast differentiation. J Med Food. 2011;14:1439-47 pubmed publisher
    ..As such, YMT may have therapeutic potential in bone diseases. ..
  73. Lee Y, Jang M, Lee J, Choi E, Kim E. SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification. EMBO Rep. 2005;6:949-55 pubmed
    ..This study shows that SUMO-1 exerts a negative regulatory effect on ASK 1 activation through physical interaction and not through covalent modification. ..
  74. Kim J, Kim K, Kim C, Sohn E, Lee Y, Jo K, et al. Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress. Free Radic Biol Med. 2012;53:357-65 pubmed publisher
  75. Park J, Nguyen K, Park E, Jeon J, Choi G. DELLA proteins and their interacting RING Finger proteins repress gibberellin responses by binding to the promoters of a subset of gibberellin-responsive genes in Arabidopsis. Plant Cell. 2013;25:927-43 pubmed publisher
    ..Taken together, our results indicate that the DELLA and BOI proteins inhibit GA responses by interacting with each other, binding to the same promoters of GA-responsive genes, and repressing these genes. ..
  76. Hong C, Kwon S, Park J. Biocontrol activity of Paenibacillus polymyxa AC-1 against Pseudomonas syringae and its interaction with Arabidopsis thaliana. Microbiol Res. 2016;185:13-21 pubmed publisher
    ..The results showed in this work will help to expand our understanding of the mode of action of AC-1 as a biological control agent and consequently, its application in agriculture. ..
  77. Kim Y, Jung D, Lee I, Pyun B, Kim J. Osteomeles schwerinae extracts inhibits the binding to receptors of advanced glycation end products and TGF-?1 expression in mesangial cells under diabetic conditions. Phytomedicine. 2016;23:388-97 pubmed publisher
  78. Jung D, Kim Y, Kim N, Lee J, Jang D, Kim J. Extract of Cassiae Semen and its major compound inhibit S100b-induced TGF-beta1 and fibronectin expression in mouse glomerular mesangial cells. Eur J Pharmacol. 2010;641:7-14 pubmed publisher
    ..These findings suggest that CS, especially CS-A, has potential as a preventive agent for advanced glycation end products-related diabetic complications. ..
  79. Lee K, Jung S, Choi S, Yang E. Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells. BMC Complement Altern Med. 2012;12:196 pubmed publisher
    ..Taken together, we suggest that G-Re exerts a beneficial effect on neuroinflammatory events in neurodegenerative diseases. ..
  80. Igbalajobi O, Yu J, Shin K. Characterization of the rax1 gene encoding a putative regulator of G protein signaling in Aspergillus fumigatus. Biochem Biophys Res Commun. 2017;487:426-432 pubmed publisher
    ..In summary, Rax1 positively controls growth and development, and modulates intracellular trehalose amount, cell wall melanin levels in conidia, and spore resistance to H2O2. ..
  81. Murray P, Kang J, Mirams G, Shin S, Byrne H, Maini P, et al. Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts. Biophys J. 2010;99:716-25 pubmed publisher
    ..The model simulations suggest that cell crowding caused by increased proliferation and decreased cell loss may be sufficient for a mutant cell population to colonize a neighboring healthy crypt. ..
  82. Kim J, Kim T, Lee H, Nikapitiya C, Uddin M, Park M, et al. Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization. J Virol. 2017;91: pubmed publisher
    ..The results of this study will increase our understanding of the role of negative-feedback mechanisms that regulate type I IFN signaling and maintain immune homeostasis. ..
  83. Lee K, Jeon J, Choi I, Kwon O, Yu K, You K. Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability. Biochem Biophys Res Commun. 2008;366:905-9 pubmed
    ..We also found that CLU was involved in Smad2/3 stability at the protein level. These findings suggest that CLU regulates TGF-beta signaling pathway by modulating the stability of Smad2/3 proteins. ..
  84. Lee K, Hong S, Kim A, Ju S, Kwon O, Yu K. Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster. FEBS Lett. 2009;583:2573-7 pubmed publisher
    ..These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK-insulin pathway in Drosophila. ..
  85. Hwang Y, Oh K, Yun H, Jeong H. The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells. J Dermatol Sci. 2011;61:23-31 pubmed publisher
    ..They may thus be potentially useful in the prevention and treatment of skin photoaging. ..
  86. Jang S, Park J, Cha H, Jung S, Lee J, Jung S, et al. Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation. Int J Nanomedicine. 2012;7:1329-43 pubmed publisher
    ..In summary, silver NPs substantially suppressed mucus hypersecretion and PI3K/HIF-1?/VEGF signaling pathway in an allergic airway inflammation...
  87. Kim H, Han E, Jang W, Choi J, Khanal T, Park B, et al. Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-?B, C/EBP and AP-1 signaling pathways in murine macrophages. Food Chem Toxicol. 2012;50:2342-8 pubmed publisher
    ..These findings demonstrate that piperine effectively attenuates COX-2 production, and provide further insight into the signal transduction pathways involved in the anti-inflammatory effects of piperine. ..
  88. Hong S, Lee K, Kwak S, Kim A, Bai H, Jung M, et al. Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet. 2012;8:e1002857 pubmed publisher
    ..Our findings demonstrate that Mnb/Dyrk1a regulates food intake through the evolutionary conserved Sir2-FOXO-sNPF/NPY pathway in Drosophila melanogaster and mammals...
  89. Park S, Jin Y, Park Y, Yeon S, Xu J, Han R, et al. IL-25-induced activation of nasal fibroblast and its association with the remodeling of chronic rhinosinusitis with nasal polyposis. PLoS ONE. 2017;12:e0181806 pubmed publisher NPDFs and increased expression of IL-25 were also involved in the pathogenesis of nasal polyposis by affecting nasal fibroblasts in chronic rhinosinusitis with nasal polyps. ..
  90. Song H, Oh S, Oh H, Lim D. Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem Biophys Res Commun. 2010;391:969-73 pubmed publisher
  91. Jang K, Lee J, Kim S, Kang M, Na M, Lee C, et al. The C-terminus of Hsp70-interacting protein promotes Met receptor degradation. J Thorac Oncol. 2011;6:679-87 pubmed publisher
    ..Finally, we confirmed these results by tumor xenograft model. Based on these findings, we conclude that CHIP is a suppressor of Met function, serving to regulate cellular receptor levels by promoting Met receptor degradation. ..
  92. Lee H, Yuk J, Kim K, Jang J, Kang G, Park J, et al. Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1. Immunol Cell Biol. 2012;90:601-10 pubmed publisher
    ..Taken together, these data demonstrate the induction mechanism of the NLRP3/ASC inflammasome and its role in innate immunity to Mabc infection. ..