Genomes and Genes
Experts and Doctors on saccharomyces cerevisiae in Seoul, South Korea
Locale: Seoul, South Korea
Topic: saccharomyces cerevisiae
Publications103 found, 100 shown here
- Kim Y, Kim Y, Park J, Han I, Ajjappala B, Kang I, et al. Disruption of protein-protein interaction in the Mgl-1 oncoprotein. Oncol Rep. 2006;16:795-800 pubmed..These results indicate that the WD-40 repeat motif is important for cellular viability by regulating temperature-sensitivity and salt tolerance in yeast. ..
- Joo Y, Kim J, Baek J, Seong K, Han K, Song J, et al. Cooperative regulation of ADE3 transcription by Gcn4p and Bas1p in Saccharomyces cerevisiae. Eukaryot Cell. 2009;8:1268-77 pubmed publisher..Taking these results together, we concluded that Gcn4p is responsible for the basal and inducible expression of the ADE3 gene, while Bas1p is required for its basal expression. ..
- Jeon E, Hyeon J, Suh D, Suh Y, Kim S, Song K, et al. Production of cellulosic ethanol in Saccharomyces cerevisiae heterologous expressing Clostridium thermocellum endoglucanase and Saccharomycopsis fibuligera beta-glucosidase genes. Mol Cells. 2009;28:369-73 pubmed publisher..This indicates that the resultant yeast strain of this study acts efficiently as a whole cell biocatalyst...
- Chang M, Kang H, Baek I, Kang C, Park Y, Yun C. Kdx1 regulates RCK1 gene expression by interacting with Rlm1 in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2013;435:350-5 pubmed publisher..Taken together, these data suggest that Kdx1 interacts with Rlm1 to activate RCK1 gene expression in response to stress in Saccharomyces cerevisiae. ..
- Choi J, Choi S, Choi J, Cha M, Kim I, Shin W. Crystallization and preliminary X-ray analysis of a truncated mutant of yeast nuclear thiol peroxidase, a novel atypical 2-Cys peroxiredoxin. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:659-62 pubmed..54, c = 83.26 A. The asymmetric unit contains one molecule of truncated mutant nTPx, with a corresponding VM of 1.91 A3 Da(-1) and a solvent content of 35.5%. ..
- Ha S, Shin S, Lee Y, Kim S, Kim H, Namkoong H, et al. HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization. Int J Cancer. 2008;122:501-8 pubmed..Indeed, HCCRBP-1 decreased p21 promoter activity probably via p53 stabilization leading to the defective function. These results indicate that HCCRBP-1 oncogene induces p53 stabilization and thereby contributes to tumorigenesis. ..
- Song Y, Jhun M, Park T, Huh W. Quantitative proteomic analysis of ribosomal protein L35b mutant of Saccharomyces cerevisiae. Biochim Biophys Acta. 2010;1804:676-83 pubmed publisher..Furthermore, our approach of combining a library of GFP-tagged yeast strains and the SGA method provides an effective and highly sensitive method for dynamic analysis of the effects of various mutations on proteome expression. ..
- Park J, Song Y, Cheon S, Kwon O, Oh D, Jigami Y, et al. Essential role of YlMPO1, a novel Yarrowia lipolytica homologue of Saccharomyces cerevisiae MNN4, in mannosylphosphorylation of N- and O-linked glycans. Appl Environ Microbiol. 2011;77:1187-95 pubmed publisher..Mutant strains harboring the YlMPO1 gene disruption may serve as useful platforms for engineering Y. lipolytica glycosylation pathways for humanized glycans without any yeast-specific acidic modifications. ..
- Jung J, Yun H, Lee J, Oh M. Production of 1,2-propanediol from glycerol in Saccharomyces cerevisiae. J Microbiol Biotechnol. 2011;21:846-53 pubmed..19 g 1,2- propanediol/l titer was achieved in 1% (v/v) glycerolcontaining YEPD medium in engineered S. cerevisiae...
- Xu H, Kim S, Sorek H, Lee Y, Jeong D, Kim J, et al. PHO13 deletion-induced transcriptional activation prevents sedoheptulose accumulation during xylose metabolism in engineered Saccharomyces cerevisiae. Metab Eng. 2016;34:88-96 pubmed publisher..Therefore, we concluded that TAL1 upregulation, preventing the accumulation of sedoheptulose, is the most critical mechanism for the improved xylose metabolism by the pho13Î” mutant of engineered S. cerevisiae. ..
- Kim K, Heo D, Kim I, Suh J, Kim M. Exosome Cofactors Connect Transcription Termination to RNA Processing by Guiding Terminated Transcripts to the Appropriate Exonuclease within the Nuclear Exosome. J Biol Chem. 2016;291:13229-42 pubmed publisher..This suggests that Mpp6 and Trf4 may play a role in choosing a particular RNA processing route for Nrd1-terminated transcripts within the exosome by guiding the transcripts to the appropriate exonuclease. ..
- Han S, Lee Y, Gim B, Ryu G, Park S, Lane W, et al. Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation. Mol Cell Biol. 1999;19:979-88 pubmed
- Kim E, Park J, Um S. Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. Nucleic Acids Res. 2003;31:5356-67 pubmed..Therefore, Daxx is implicated in the regulation of the cell cycle and apoptosis through transcriptional regulation of p53 and possibly its family members. ..
- Park Y, Jeong H, Sung H, Yun C. Sed1p interacts with Arn3p physically and mediates ferrioxamine B uptake in Saccharomyces cerevisiae. Curr Genet. 2005;47:150-5 pubmed..Moreover, the Deltased1 strain showed low viability at high iron concentrations. Taken together, these results suggest that Sed1p mediates siderophore transport and confers iron resistance in S. cerevisiae. ..
- Hyeon J, Yu K, Suh D, Suh Y, Lee S, Lee J, et al. Production of minicellulosomes from Clostridium cellulovorans for the fermentation of cellulosic ethanol using engineered recombinant Saccharomyces cerevisiae. FEMS Microbiol Lett. 2010;310:39-47 pubmed publisher..34 g g(-1) from CMC. This result indicates that a one-step processing of cellulosic biomass in a consolidated bioprocessing configuration is technically feasible by recombinant yeast cells expressing functional minicellulosomes...
- Cho S, Lee Y, Park H, Ryoo K, Kang K, Park J, et al. Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J Biol Chem. 2001;276:12749-55 pubmed
- Kang H, Jeong S, Kim K, Baek I, Chang M, Kang C, et al. A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae. Biochem J. 2014;457:391-400 pubmed publisher..Taken together, Pho92 participates in cellular phosphate metabolism, specifically via the regulation of PHO4 mRNA stability by binding to the 3'-UTR in a phosphate-dependent manner. ..
- Lee J, Lee D, Ji I, Kim G, Kim H, Sohn J, et al. Purification of soluble beta-glucan with immune-enhancing activity from the cell wall of yeast. Biosci Biotechnol Biochem. 2001;65:837-41 pubmed..In conclusion, we purified water-soluble beta-glucan which was completely devoid of mannoprotein and effectively stimulated the macrophage function, enabling it to be used as an intravenous injection for sepsis. ..
- Kim J, Song K. The study of Bfa1p(E438K) suggests that Bfa1 control the mitotic exit network in different mechanisms depending on different checkpoint-activating signals. Mol Cells. 2006;21:251-60 pubmed..In addition, the viability of cdc5-2 delta bfa1 cells was not reduced by BFA1(E438K), suggesting that Cdc5p also regulates Bfa1p to activate mitotic exit by other mechanism(s), besides phosphorylation. ..
- Sung M, Ha C, Huh W. A vector system for efficient and economical switching of C-terminal epitope tags in Saccharomyces cerevisiae. Yeast. 2008;25:301-11 pubmed publisher..Furthermore, the plasmids also allow additional C-terminal epitope tagging of proteins in yeast cells that already carry MX6 module-based gene deletion or C-terminal epitope tag. ..
- Yu K, Jung J, Ramzi A, Kim S, Park C, Han S. Improvement of ethanol yield from glycerol via conversion of pyruvate to ethanol in metabolically engineered Saccharomyces cerevisiae. Appl Biochem Biotechnol. 2012;166:856-65 pubmed publisher..0 g/L ethanol produced). In summary, it is possible to improve the ethanol yield by overexpression of the genes involved in the conversion of pyruvate to ethanol in engineered S. cerevisiae using glycerol as substrate. ..
- Chang M, Kang C, Park Y, Yun C. Rck1 up-regulates pseudohyphal growth by activating the Ras2 and MAP kinase pathways independently in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2014;444:656-61 pubmed publisher..Interestingly, Ras2 and phospho-Kss1 were up-regulated by Rck1 independently. Together, these results suggest that Rck1 promotes pseudohyphal growth by activating Ras2 and Kss1 via independent pathways in S. cerevisiae. ..
- Kim J, Kim H, Kim G, Yang J, Boeke J, Nam K. Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants. Nucleic Acids Res. 2000;28:3666-73 pubmed..Comparison of the amino acid sequence of hDBR1 with the other DBR protein sequences showed several conserved regions, with 40, 44 and 43% identity to the S. cerevisiae, S. pombe and C. elegans debranching enzymes, respectively. ..
- Woo M, Hur S, Park S, Kim H. Study of cell-mediated response in mice by HPV16 L1 virus-like particles expressed in Saccharomyces cerevisiae. J Microbiol Biotechnol. 2007;17:1738-41 pubmed..Splenocytes proliferation was significantly increased and a mixed Th1/Th2 response was indicated. IgG subtype immunoresponses were strongly induced and IgG1 titers were higher than those of IgG2a...
- Jung C, Kim Y, Lee K, Im H. Retarded protein folding of the human Z-type ??-antitrypsin variant is suppressed by Cpr2p. Biochem Biophys Res Commun. 2014;445:191-5 pubmed publisher..Our results indicate that ER peptidyl-prolyl isomerases may rescue Z-type ?1-antitrypsin molecules from retarded folding and eventually relieve clinical symptoms caused by this pathological ?1-antitrypsin. ..
- Kim J, Kohane I, Ohno Machado L. Visualization and evaluation of clusters for exploratory analysis of gene expression data. J Biomed Inform. 2002;35:25-36 pubmed
- Choi I, Jeong M, Ham M, Sung H, Yun C. Novel Ree1 regulates the expression of ENO1 via the Snf1 complex pathway in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2008;377:395-399 pubmed publisher..Taken together, these results suggest that Ree1p functions in the galactose metabolic pathway via the Gal83 protein and that it may control the level of Eno1p, which is also affected by the Snf1 complex, in S. cerevisiae. ..
- Cho S, Choi K, Jeon J, Kim C, Shin D, Lee J, et al. Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer. Exp Mol Med. 2010;42:310-8 pubmed..These results will provide a clue to future investigation aiming at delineating physiological and pathological roles of human transglutaminase 4. ..
- Heo D, Baek I, Kang H, Kim J, Chang M, Kang C, et al. Cd2+ binds to Atx1 and affects the physical interaction between Atx1 and Ccc2 in Saccharomyces cerevisiae. Biotechnol Lett. 2012;34:303-7 pubmed publisher..These results imply that Atx1 delivers Cd(2+) to Ccc2 and that this delivery is, at least in part, responsible for Cd(2+) toxicity in S. cerevisiae. ..
- Kim S, Seo S, Jin Y, Seo J. Production of 2,3-butanediol by engineered Saccharomyces cerevisiae. Bioresour Technol. 2013;146:274-281 pubmed publisher..In fed-batch fermentation with optimum aeration, 2,3-BD concentration increased up to 96.2 g/L. These results suggest that S. cerevisiae might be a promising host for producing 2,3-BD for industrial applications. ..
- Kim H, Cho J, Ryoo N, Shin D, Park Y, Hwang Y, et al. Role of rice cytosolic hexokinase OsHXK7 in sugar signaling and metabolism. J Integr Plant Biol. 2016;58:127-35 pubmed publisher..This result suggests the distinct role that OsHXK7 plays in sugar metabolism and efficient germination by enforcing glycolysis-mediated fermentation in O2 -deficient rice. ..
- Jo J, Park Y, Jin Y, Seo J. Construction of efficient xylose-fermenting Saccharomyces cerevisiae through a synthetic isozyme system of xylose reductase from Scheffersomyces stipitis. Bioresour Technol. 2017;241:88-94 pubmed publisher..These results suggest that the introduction of the XR-based synthetic isozyme system is a promising strategy to develop efficient xylose-fermenting strains. ..
- Choi Y, Kim H, Lee J, Kang H, Kim H. Chromatographically-purified capsid proteins of red-spotted grouper nervous necrosis virus expressed in Saccharomyces cerevisiae form virus-like particles. Protein Expr Purif. 2013;89:162-8 pubmed publisher..We suggest that RGNNV capsid protein expressed in S. cerevisiae and purified by heparin chromatography, is of sufficient quality for use as a vaccine. ..
- Park S, Koh S, Chun J, Hwang H, Kang H. Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:2044-50 pubmed..These findings indicate that Nrg1 acts as a DNA-binding repressor and mediates glucose repression of the STA1 gene expression by recruiting the Ssn6-Tup1 complex. ..
- Jung S, Lee J, Kim J. Yeast ribosomal protein S3 has an endonuclease activity on AP DNA. Mol Cells. 2001;12:84-90 pubmed..From these results, both the mammalian rpS3 and Rps3p appear to be involved in DNA damage processing, but in different modes. ..
- Choi J, Choi S, Chon J, Choi J, Cha M, Kim I, et al. Crystal structure of the C107S/C112S mutant of yeast nuclear 2-Cys peroxiredoxin. Proteins. 2005;61:1146-9 pubmed
- Sohn D, Lee K, Lee C, Oh J, Chung H, Jeon S, et al. SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation. J Biol Chem. 2007;282:10614-24 pubmed..Taken together, these results suggest the critical role of SRG3 in the post-transcriptional stabilization of the major components of the SWI/SNF complex. ..
- Kim J, Jeong J, Song K. The C-terminus of Bfa1p in budding yeast is essential to induce mitotic arrest in response to diverse checkpoint-activating signals. Genes Cells. 2004;9:399-418 pubmed
- Lee K, Kim M, Kim D, Lee Y. Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter. Neurochem Res. 2004;29:1405-9 pubmed
- Kim S, Hong J, Lee S, Sohn K, Jung H, Hwang B. CAZFP1, Cys2/His2-type zinc-finger transcription factor gene functions as a pathogen-induced early-defense gene in Capsicum annuum. Plant Mol Biol. 2004;55:883-904 pubmed publisher..tomato, but also the drought tolerance. These results suggest that the CAZFP1 gene functions as an early-defense gene to enhance disease resistance and drought tolerance...
- Kim M, Go Y, Lee S, Kim Y, Shin J, Min M, et al. Seed-expressed casein kinase I acts as a positive regulator of the SeFAD2 promoter via phosphorylation of the SebHLH transcription factor. Plant Mol Biol. 2010;73:425-37 pubmed publisher..This co-expression revealed that SeCKI enhanced the SebHLH-mediated transactivation of the SeFAD2 gene promoter via phosphorylation of the SebHLH transcription factor...
- Lee P, Paik S, Shin C, Huh W, Hahn J. Regulation of yeast Yak1 kinase by PKA and autophosphorylation-dependent 14-3-3 binding. Mol Microbiol. 2011;79:633-46 pubmed publisher..Since the binding of 14-3-3 proteins to Yak1 coincides with PKA activity, such regulatory mechanisms might allow cytoplasmic retention of an inactive form of Yak1 under high glucose conditions. ..
- Kim J, Ogden R, Kim H. A method to identify differential expression profiles of time-course gene data with Fourier transformation. BMC Bioinformatics. 2013;14:310 pubmed publisher..The proposed method is general and can be potentially used to identify genes which have the same patterns or biological processes, and help facing the present and forthcoming challenges of data analysis in functional genomics. ..
- Lee Y, Min S, Gim B, Kim Y. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. Mol Cell Biol. 1997;17:4622-32 pubmed..A database search revealed the existence of MED6-related genes in humans and Caenorhabditis elegans, suggesting that the role of mediator in transcriptional activation is conserved throughout the evolution. ..
- Choi Y, Kim S, Park K, Choi K. Differential transmission of G1 cell cycle arrest and mating signals by Saccharomyces cerevisiae Ste5 mutants in the pheromone pathway. Biochem Cell Biol. 1999;77:459-68 pubmed..cerevisiae. In addition, the roles of Asp-248 and Tyr-421, which are important for pheromone signal transduction were further characterized by site-directed mutagenesis studies. ..
- Ha E, Lee K, Park S, Kim S, Nam H, Lee H, et al. Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity. Dev Cell. 2009;16:386-97 pubmed publisher..These results demonstrate that the Galphaq-PLCbeta-Ca(2+)-DUOX-ROS signaling pathway acts as a bona fide first line of defense that enables gut epithelia to dynamically control yeast during the Drosophila life cycle. ..
- Jeong M, Kang C, Kim J, Heo D, Chang M, Baek I, et al. A novel function of Aft1 in regulating ferrioxamine B uptake: Aft1 modulates Arn3 ubiquitination in Saccharomyces cerevisiae. Biochem J. 2009;422:181-91 pubmed publisher..Furthermore, we found Aft1 affected Arn3 ubiquitination. These results suggest that Aft1 interacts with Arn3 and may regulate the ubiquitination of Arn3 in the cytosolic compartment. ..
- Jung J, Kim T, Ng C, Oh M. Characterization of GCY1 in Saccharomyces cerevisiae by metabolic profiling. J Appl Microbiol. 2012;113:1468-78 pubmed publisher..cerevisiae, particularly under micro-aerobic conditions. Metabolic profiling of the GLY dissimilation pathway was successfully demonstrated in S. cerevisiae, and the function of GCY1 was explained by the results. ..
- Lee H, Kim Y, Kim K, Heo I, Kim S, Kim O, et al. Structural and functional insights into Dom34, a key component of no-go mRNA decay. Mol Cell. 2007;27:938-50 pubmed publisher..We also demonstrate that domain 1 of Dom34 has an endoribonuclease activity against defined RNA substrates containing a stem loop, which supports a direct catalytic role of yeast Dom34 in no-go mRNA decay...
- Chae Y, Kim S, An Y. InÂ vivo visual evaluation of nanoparticle transfer in a three-species terrestrial food chain. Chemosphere. 2016;151:101-7 pubmed publisher..This study showed the transfer of NPs through a model terrestrial food chain and indicated the potential hazards of released NPs for organisms at different trophic levels. ..
- Shin S, Shin S, Kang M, Lee D, Yang M, Jang Y, et al. Enhancement of protective immune responses by oral vaccination with Saccharomyces cerevisiae expressing recombinant Actinobacillus pleuropneumoniae ApxIA or ApxIIA in mice. J Vet Sci. 2007;8:383-92 pubmed..These results suggested that immunity to the ApxIA antigen is required for optimal protection. ..
- Yi M, Park J, Ahn J, Lee Y. MoSNF1 regulates sporulation and pathogenicity in the rice blast fungus Magnaporthe oryzae. Fungal Genet Biol. 2008;45:1172-81 pubmed publisher..Our results suggest that MoSNF1 is a functional homolog of yeast Snf1, but its contribution to sporulation, vegetative growth and pathogenicity is critical in M. oryzae...
- Kim T, Ha C, Huh W. Differential subcellular localization of ribosomal protein L7 paralogs in Saccharomyces cerevisiae. Mol Cells. 2009;27:539-46 pubmed publisher..Taken together, these results suggest that although Rpl7a and Rpl7b are paralogous and functionally replaceable with each other, their precise physiological roles may not be identical. ..
- Seo J, Kang S, Seo B, Jung J, Kim K. Mutational analysis of interaction between coat protein and helper component-proteinase of Soybean mosaic virus involved in aphid transmission. Mol Plant Pathol. 2010;11:265-76 pubmed publisher..Based on the combination of our current results with previous findings, the possibility that aphid transmission may be regulated by more complex molecular interactions than the simple involvement of HC-Pro as a bridge is discussed...
- Lee I, Lehner B, Vavouri T, Shin J, Fraser A, Marcotte E. Predicting genetic modifier loci using functional gene networks. Genome Res. 2010;20:1143-53 pubmed publisher..This work thus suggests that a high-quality integrated human gene network will provide a powerful resource for modifier locus discovery in many different diseases. ..
- Chang M, Kang H, Baek I, Kang C, Park Y, Yun C. Rck1 up-regulates Hog1 activity by down-regulating Slt2 activity in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2013;440:119-24 pubmed publisher..Together, our results suggest that Rck1 inhibits Slt2 MAP kinase pathway activity and then Ptp2, which subsequently activates Hog1. ..
- Nam K, Lee G, Trambley J, Devine S, Boeke J. Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradation. Mol Cell Biol. 1997;17:809-18 pubmed..The growth defect of the S. pombe dbr1::leu1+ strain suggests that debranching activity is critical for efficient intron RNA degradation and that blocking this pathway interferes with cell growth. ..
- Eo H, Jo K, Lee S, Kim C, Kim W. A combined approach for locating box H/ACA snoRNAs in the human genome. Mol Cells. 2005;20:35-42 pubmed..With our novel method 12 known box H/ACA snoRNAs, and one strong candidate were identified in 30 nucleolar protein genomic sequences. ..
- Cha S, Seo T. hSNF5 is required for human papillomavirus E2-driven transcriptional activation and DNA replication. Intervirology. 2011;54:66-77 pubmed publisher..These results suggest that the SWI/SNF complex is involved in HPV E2-driven transcription and DNA replication via interaction with E2...
- Ha C, Huh W. Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae. Nucleic Acids Res. 2011;39:1336-50 pubmed publisher..Taken together, our findings suggest that inhibition of TORC1 signaling stabilizes the rDNA locus by enhancing association of Sir2 with rDNA, thereby leading to extension of replicative lifespan in S. cerevisiae. ..
- Shim E, Park S. Identification of a novel Ser/Thr protein phosphatase Ppq1 as a negative regulator of mating MAP kinase pathway in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2014;443:252-8 pubmed publisher..Overall, the data suggest that Ppq1 functions as a negative regulator of mating MAPK pathway by dephosphorylating target pathway protein(s) and plays a key role in the control of the background signaling noise. ..
- Lee Y, Kim Y. Requirement for a functional interaction between mediator components Med6 and Srb4 in RNA polymerase II transcription. Mol Cell Biol. 1998;18:5364-70 pubmed..Our results suggest not only the existence of a specific interaction between Med6 and Srb4 but also the requirement of this interaction in transcriptional regulation of RNA polymerase II holoenzyme. ..
- Kim M, Park B, Kang Y, Kim H, Park J, Kang J, et al. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. Nat Genet. 2003;34:330-6 pubmed..Thus, this work identified a new activity of p38 as a mediator of TGF-beta signaling and its functional importance in the control of c-myc during lung differentiation. ..
- Kim Y, Song J, Kim Y, Kim I, Kang I, Baek K. Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene. Int J Oncol. 2003;23:1515-9 pubmed..5 to E18.5 with the strong expression at E10.5. The analysis of spatial expression showed that mgl-1 mRNA is detected in CNS, craniofacial region, eyes, limbs, and the gut. ..
- Ha E, Oh C, Bae Y, Lee W. A direct role for dual oxidase in Drosophila gut immunity. Science. 2005;310:847-50 pubmed..Thus, oxidant-mediated antimicrobial responses are not restricted to the phagocytes, but rather are used more broadly, including in mucosal barrier epithelia. ..
- Hong S, Kim B, Kim J, Song H. Structure of the autophagic E2 enzyme Atg10. Acta Crystallogr D Biol Crystallogr. 2012;68:1409-17 pubmed..The missing segment, which was termed the `FR-region', in Atg10 may be important for interaction with the E1 enzyme Atg7. This study provides a framework for understanding the E2 conjugation reaction in autophagy. ..
- Kappachery S, Yu J, Baniekal Hiremath G, Park S. Rapid identification of potential drought tolerance genes from Solanum tuberosum by using a yeast functional screening method. C R Biol. 2013;336:530-45 pubmed publisher..Orthologues of few genes identified here are previously known to increase osmotic stress tolerance of yeast and plants; however, specific studies are needed to confirm their role in the osmotic stress tolerance of potato. ..
- Lee K, Lee E, Son J, Hwang K. Crystal structure of tRNAHis guanylyltransferase from Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2017;490:400-405 pubmed publisher..In addition, two flexible protomers at the potential binding site (PBS) for tRNAHis were observed. We suggest that the PBS of the tetramer could also be one of the sites for interaction with partner proteins. ..
- Lee K, Jung J, Kim M, Guidotti G. Interaction of the alpha subunit of Na,K-ATPase with cofilin. Biochem J. 2001;353:377-85 pubmed
- Choi D, Hwang I, Hwang B. Requirement of the cytosolic interaction between PATHOGENESIS-RELATED PROTEIN10 and LEUCINE-RICH REPEAT PROTEIN1 for cell death and defense signaling in pepper. Plant Cell. 2012;24:1675-90 pubmed publisher..Together, these results suggest that the cytosolic LRR-PR10 complex is responsible for cell death-mediated defense signaling. ..
- Yu K, Jung J, Ramzi A, Choe S, Kim S, Park C, et al. Increased ethanol production from glycerol by Saccharomyces cerevisiae strains with enhanced stress tolerance from the overexpression of SAGA complex components. Enzyme Microb Technol. 2012;51:237-43 pubmed publisher..In conclusion, we successfully established that the co-expression of SPT3 and SPT15 that improved the fermentation performance of the engineered yeast strains which produced higher ethanol yields than stress-sensitive yeast strains. ..
- Shin M, Lee W, Jung M, Cha S, Shin S, Yoo A, et al. Oral immunization of mice with Saccharomyces cerevisiae expressing a neutralizing epitope of ApxIIA exotoxin from Actinobacillus pleuropneumoniae induces systemic and mucosal immune responses. Microbiol Immunol. 2013;57:417-25 pubmed publisher..Our findings suggest that surface-displayed ApxIIA#5-expressed on S. cerevisiae may be a promising candidate for an oral vaccine delivery system for eliciting systemic and mucosal immunity. ..
- Jeon S, Kang M, Kim Y, Jin Y, Lee C, Chung H, et al. A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line. J Exp Med. 1997;185:1827-36 pubmed..These results suggest that the SRG3 protein is involved in the glucocorticoid-induced apoptosis in the thymoma cell line. This implicates that the SRG3 may play an important regulatory role during T cell development in thymus. ..
- Han S, Lee J, Kang J, Kim Y. Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes. J Biol Chem. 2001;276:37020-6 pubmed
- Sihn C, Suh E, Lee K, Kim T, Kim S. p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells. Cancer Lett. 2003;201:203-10 pubmed..Taken together, these results suggest that agents blocking the spindle checkpoint response may induce tumor cells to become more sensitive to spindle poison drugs, providing a powerful tool to improve chemotherapy. ..
- Chopra P, Kang J, Yang J, Cho H, Kim H, Lee M. Microarray data mining using landmark gene-guided clustering. BMC Bioinformatics. 2008;9:92 pubmed publisher..ncsu.edu/~pchopra/landmarks.html. The code is under active development to incorporate new clustering methods and analysis. ..
- Lee P, Cho B, Joo H, Hahn J. Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4. Mol Microbiol. 2008;70:882-95 pubmed publisher..These results suggest a central role for Yak1 in mediating PKA-dependent inhibition of Hsf1 and Msn2/Msn4. ..
- Choe Y, Ryu Y, Kim H, Seok Y. Increased [PSI+] appearance by fusion of Rnq1 with the prion domain of Sup35 in Saccharomyces cerevisiae. Eukaryot Cell. 2009;8:968-76 pubmed publisher..This study supports the occurrence of in vivo cross-seeding between Sup35 and Rnq1 and provides a new tool that can be used to dissect the mechanism of the de novo appearance of prions. ..
- Shin C, Kim S, Huh W. TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae. J Cell Sci. 2009;122:2089-99 pubmed publisher..Taken together, our findings highlight an intimate connection between the amino-acid-sensing pathway and the rapamycin-sensitive TOR signaling pathway. ..
- Yu K, Jung J, Kim S, Park C, Han S. Synthesis of FAEEs from glycerol in engineered Saccharomyces cerevisiae using endogenously produced ethanol by heterologous expression of an unspecific bacterial acyltransferase. Biotechnol Bioeng. 2012;109:110-5 pubmed publisher..This microbial system acts as a platform in applying metabolic engineering that allows the production of FAEEs from cheap and abundant substrates specifically glycerol through the use of endogenous bioethanol. ..
- Kwag H, Kim H, Chang D, Kim H. The production and immunogenicity of human papillomavirus type 58 virus-like particles produced in Saccharomyces cerevisiae. J Microbiol. 2012;50:813-20 pubmed publisher..Our findings provide a convenient method for obtaining substantial amounts of highly immunogenic HPV58 L1 from S. cerevisiae. ..
- Jung J, Yee A, Wu B, Arrowsmith C, Lee W. Solution structure of YKR049C, a putative redox protein from Saccharomyces cerevisiae. J Biochem Mol Biol. 2005;38:550-4 pubmed..A putative active site composed by two short helices and a single Cys97 was also well observed. Our findings suggest that YKR049C is a redox protein with a thioredoxin fold containing a single active cysteine. ..
- Kang H, Choi S, Heo D, Jeong M, Sung H, Yun C. A novel role for thioredoxin reductase in the iron metabolism of S. cerevisiae. Biochem Biophys Res Commun. 2008;371:63-8 pubmed publisher..cerevisiae. In this study, we identified the iron-binding activity of thioredoxin reductase, and our data suggest a potential role for this enzyme in intracellular iron transport. ..
- Seong K, Jung S, Kim H, Kim H, Jung Y, Choi S, et al. Yeast ribosomal protein S3 possesses a ?-lyase activity on damaged DNA. FEBS Lett. 2012;586:356-61 pubmed publisher..In addition, the repair enzyme activity of yeast Rps3p was confirmed by complementation in xth, nfo Escherichia coli cells in which the DNA repair process is defective. ..
- Hong S, Sung Y, Yu M, Lee M, Kleckner N, Kim K. The logic and mechanism of homologous recombination partner choice. Mol Cell. 2013;51:440-53 pubmed publisher..Cohesin and Dmc1 interactively modulate this extension, with program-appropriate effects. In accord with this model, Rad51-mediated recombination in vivo requires the presence of a sister. ..