Experts and Doctors on phosphotransferases in Seoul, South Korea


Locale: Seoul, South Korea
Topic: phosphotransferases

Top Publications

  1. Lee Y, Park I, Park M, Choi H, Cho B, Chung K, et al. Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma. J Cancer Res Clin Oncol. 2009;135:1647-54 pubmed publisher
    ..24% in mutated EGFR, P = 0.15). Activating mutations within the EGFR TK domain can be used to predict the risk of recurrence in curatively resected pulmonary adenocarcinoma. ..
  2. Lee J, Ko Y, Kim S, Bahn Y. Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans. Eukaryot Cell. 2011;10:998-1002 pubmed publisher
    ..Here, we report that Ypd1 is required for the viability of C. neoformans via the Hog1 mitogen-activated protein kinase (MAPK) pathway but plays multiple cellular roles in both a Hog1-dependent and -independent manner. ..
  3. Kim S, Kuzuyama T, Chang Y, Kwon H, Kim S. Cloning and functional characterization of 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (GbMECT) gene from Ginkgo biloba. Phytochemistry. 2006;67:1435-41 pubmed
    ..Full 88 N-terminal residues were necessary to deliver the protein into the chloroplast as shown by protein-targeting analysis with GFP as a reporter protein in Arabidopsis thaliana protoplasts. ..
  4. Yu T, Yun Y, Lee K, Ahn K, Suh J. Active site phosphoryl groups in the biphosphorylated phosphotransferase complex reveal dynamics in a millisecond time scale. FEBS Lett. 2012;586:1439-44 pubmed publisher
    ..The conformational dynamics in HPr may be important for its phosphotransfer reactions with multiple partner proteins. ..
  5. Chung H, Yoon S, Shin S, Koh Y, Lee S, Lee Y, et al. p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression. J Cell Physiol. 2006;209:131-41 pubmed
    ..They further suggest that Sps1 and its reaction product selenophosphate might be involved in cancer prevention in a p53-dependent manner and could be applied to development of a novel cancer therapy. ..
  6. Kim O, Richter H, Zaunm├╝ller T, Graf S, Unden G. Role of secondary transporters and phosphotransferase systems in glucose transport by Oenococcus oeni. J Bacteriol. 2011;193:6902-11 pubmed publisher
    ..The data suggest that the PTS is responsible for ?p-independent hexose transport at neutral pH and for the residual ?p-independent transport of hexoses at acidic pH. ..
  7. Shim M, Kim J, Jung H, Lee K, Xu X, Carlson B, et al. Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells. J Biol Chem. 2009;284:32881-94 pubmed publisher
  8. Lee Y, Cho H, Soh J, Jhon G, Cho C, Chung H, et al. Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation. Exp Cell Res. 2003;291:251-66 pubmed
    ..Based on the above results, we suggest for the first time that oxidative damage-induced apoptosis is mediated by ERK1/2 phosphorylation which is not only Ras-Raf dependent, but also both tyrosine kinase and PKCdelta dependent. ..
  9. Lee Y, Kim S, Kim J, Bang I, Lee I, Bang S, et al. A phosphotransferase system permease is a novel component of CadC signaling in Salmonella enterica. FEMS Microbiol Lett. 2013;338:54-61 pubmed publisher
    ..Our data suggest that the PTS permease STM4538 affects proteolytic processing, which is a necessary but not sufficient step for CadC activation, rendering CadC able to activate target genes. ..

More Information


  1. Lee K, Shim M, Kim J, Jung H, Lee E, Carlson B, et al. Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation. BMC Genomics. 2011;12:426 pubmed publisher
    ..These results indicate that SPS1 regulates vitamin B6 synthesis, which in turn impacts various cellular systems such as amino acid metabolism, defense and other important metabolic activities. ..
  2. Jung K, Oh S, Kim Y, Yoo K, Cui M, Shin J. Arabidopsis histidine-containing phosphotransfer factor 4 (AHP4) negatively regulates secondary wall thickening of the anther endothecium during flowering. Mol Cells. 2008;25:294-300 pubmed
    ..Our study indicates that AHP4 negatively regulates thickening of the secondary cell wall of the anther endothecium, and provides new insight into the role of cytokinins in formation of secondary cell walls via the action of AHP4. ..
  3. Park S, Choi J, Kang J, Choi S, Hwang S, Kim J, et al. Attenuated expression of interferon-induced protein kinase PKR in a simian cell devoid of type I interferons. Mol Cells. 2006;21:21-8 pubmed
    ..PKR-DE12 had no dominant negative effect but was weakly phosphorylated in trans by wild type PKR...
  4. Kim J, Lee K, Shim M, Shin H, Xu X, Carlson B, et al. Human selenophosphate synthetase 1 has five splice variants with unique interactions, subcellular localizations and expression patterns. Biochem Biophys Res Commun. 2010;397:53-8 pubmed publisher
    ..DeltaE2 expression peaked at mid-S phase and then gradually decreased. However, +E9/+E9a expression decreased gradually after cell cycle arrest. The possible involvement of SPS1 splice variants in cell cycle regulation is discussed. ..
  5. Jung S, Seol H, Jeon S, Son K, Lee J. Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge. Phytomedicine. 2009;16:327-35 pubmed publisher
    ..These insulin-sensitizing activities of tanshinones may be useful for developing a new class of specific IR activators as anti-diabetic agents. ..
  6. Jeong Y, Kim J, Yoo J, Lee S, Kim H, Suh Y. Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model. J Neurochem. 2011;119:1282-93 pubmed publisher
    ..These results strongly implicate the importance of environmental factors as a major modulator for the disease progression of AD. ..
  7. Ko J, Lee Y, Hwang S, Lee Y, Shin S, Hwang J, et al. Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Oncogene. 2003;22:4679-89 pubmed
    ..These results indicate that HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor. ..
  8. Rajesh T, Sung C, Kim H, Song E, Park H, Jeon J, et al. Phosphorylation of chloramphenicol by a recombinant protein Yhr2 from Streptomyces avermitilis MA4680. Bioorg Med Chem Lett. 2013;23:3614-9 pubmed publisher
    ..This study highlights that antibiotic resistance conferring genes could be easily expressed and functionalized in other organisms that do not produce the respective antibiotic...