Experts and Doctors on oxidative phosphorylation in Daejeon, South Korea
Locale: Daejeon, South Korea
Topic: oxidative phosphorylation
Hwang S, Kwak S, Bhak J, Kang H, Lee Y, Koo B, et al
. Gene expression pattern in transmitochondrial cytoplasmic hybrid cells harboring type 2 diabetes-associated mitochondrial DNA haplogroups. PLoS ONE. 2011;6:e22116 pubmed publisher
Kim S, Kwon M, Ryu M, Chung H, Tadi S, Kim Y, et al
. CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane. Cell Metab. 2012;16:274-83 pubmed publisher
..g., Tid1. Taken together, these results suggest that CRIF1 plays a critical role in the integration of OXPHOS polypeptides into the mitochondrial membrane in mammals. ..
Ryu M, Kim S, Choi M, Kim Y, Lee M, Lee S, et al
. Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPAR? agonist-induced adipogenesis. Mol Cells. 2013;35:134-41 pubmed publisher
..Rosiglitazone treatment did not induce adipogenesis or mitochondria biogenesis in Crif1 knockout ADSCs. These results show that mitochondrial OXPHOS and Crif1 are required for rosiglitazone- and hormone-induced adipogenesis. ..
Ryu M, Kim S, Kim Y, Choi M, Tadi S, Lee M, et al
. Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. PLoS Genet. 2013;9:e1003356 pubmed publisher
..These findings indicate that the OXPHOS status of adipose tissue determines its metabolic and inflammatory responses, and may cause systemic inflammation and insulin resistance. ..
Kang S, Yi H, Choi M, Ryu M, Jung S, Chung H, et al
. ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21. J Endocrinol. 2017;233:105-118 pubmed publisher
..In conclusion, mitochondrial OXPHOS function governs the expression of ANGPTL6, which is an essential factor for FGF21 production in adipose tissue and cultured adipocytes. ..