Experts and Doctors on mitochondria in Daegu, South Korea


Locale: Daegu, South Korea
Topic: mitochondria

Top Publications

  1. Jeon S, Lee S, Kwon T, Kim K, Bae Y. NADPH oxidase is involved in protein kinase CKII down-regulation-mediated senescence through elevation of the level of reactive oxygen species in human colon cancer cells. FEBS Lett. 2010;584:3137-42 pubmed publisher
    ..These data demonstrate that CKII inhibition induces superoxide anion generation via NOX activation, and subsequent superoxide-dependent activation of p53 acts as a mediator of senescence in HCT116 cells after down-regulation of CKII. ..
  2. Park S, Kim T, Park C, Lee S, Kim J, Lee K, et al. hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. J Mol Endocrinol. 2013;50:151-66 pubmed publisher
    ..These findings suggest that hCG-induced ER stress plays important roles in steroidogenic enzyme expression via modulation of the ATF6 pathway as well as ER stress-mediated apoptosis in Leydig cells. ..
  3. Park H, Jeong H, Ko E, Lee G, Lee J, Lee S, et al. Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J Med Chem. 2017;60:7569-7578 pubmed publisher
    ..Therefore, the rationale and feasible guidelines for developing 12b can potentially be exploited to design a potent TRAP1 inhibitor. ..
  4. Jun D, Kim J, Park H, Song W, Bae Y, Kim Y. Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells. Toxicol Appl Pharmacol. 2007;222:190-201 pubmed
  5. Kim K, Kum Y, Park Y, Park J, Kim S, Lee W, et al. The protective effect of bee venom against ethanol-induced hepatic injury via regulation of the mitochondria-related apoptotic pathway. Basic Clin Pharmacol Toxicol. 2010;107:619-24 pubmed publisher
    ..These results suggest that bee venom could be an effective agent to reduce ethanol-induced hepatocyte apoptosis. ..
  6. Kim B, Park J, Chang K, Lee D. Peroxiredoxin 5 prevents amyloid-beta oligomer-induced neuronal cell death by inhibiting ERK-Drp1-mediated mitochondrial fragmentation. Free Radic Biol Med. 2016;90:184-94 pubmed publisher
    ..Thus, Prx5 may be a new therapeutic agent for treating AD. ..
  7. Park J, Choi H, Min J, Park S, Kim J, Park H, et al. Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells. J Neurochem. 2013;127:221-32 pubmed publisher
    ..This could represent a new therapeutic approach for preventing neurodegenerative diseases. ..
  8. Hwang J, Hwang I, Liu Q, Woo E, Lee D. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie. 2012;94:1784-93 pubmed publisher
    ..albicans. These results support the elucidation of the underlying antifungal mechanisms of (+)-Medioresinol. ..
  9. Park H, Jun D, Han C, Woo H, Kim Y. Proteasome inhibitor MG132-induced apoptosis via ER stress-mediated apoptotic pathway and its potentiation by protein tyrosine kinase p56lck in human Jurkat T cells. Biochem Pharmacol. 2011;82:1110-25 pubmed publisher

More Information


  1. Jun D, Kim J, Park H, Han C, Fang Z, Woo M, et al. Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade. Carcinogenesis. 2007;28:1303-13 pubmed
  2. Park J, Min J, Chae U, Lee J, Song K, Lee H, et al. Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission. J Neuroimmunol. 2017;306:46-52 pubmed publisher
    ..Our findings suggest a potential role of oleuropein in microglial inflammation-mediated neurodegenerative disorders. ..
  3. Dong G, Jang E, Kang S, Cho I, Park S, Kim S, et al. Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway. BMC Complement Altern Med. 2013;13:64 pubmed publisher
    ..Our results demonstrate that RGE has the ability to protect cells from AA + iron-induced ROS production and mitochondrial impairment through AMPK activation. ..
  4. Kim H, Kim H, Lee K, Kim J, Kim H, Kim J, et al. ?-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway. J Cell Mol Med. 2012;16:273-86 pubmed publisher
  5. Jun D, Han C, Choi M, Bae M, Woo M, Kim Y. Effect of mollugin on apoptosis and adipogenesis of 3T3-L1 preadipocytes. Phytother Res. 2011;25:724-31 pubmed publisher
  6. Kim J, Kim D, Park M, Cho H, Zervos A, Bonventre J, et al. Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2010;298:F1332-40 pubmed publisher
    ..In conclusion, Omi/HtrA2 is associated with apoptotic signaling pathways in tubular epithelial cells activated by unilateral ureteral obstruction, thereby resulting in kidney fibrosis. ..
  7. Chang E, Son S, Ko H, Baek S, Kim J, Kim J. Induction of apoptosis by the overexpression of an alternative splicing variant of mitochondrial thioredoxin reductase. Free Radic Biol Med. 2005;39:1666-75 pubmed
    ..These results suggest that TrxR2A may play a vital role in the regulation of TrxR2 and may confer functional complexity onto the thioredoxin system. ..
  8. Kim S, Park H, Jun D, Woo H, Woo M, Yang C, et al. Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL. Toxicol Appl Pharmacol. 2009;241:210-20 pubmed publisher
  9. Jun D, Kim H, Jang W, Lee J, Fukui K, Kim Y. Ectopic overexpression of LAPTM5 results in lysosomal targeting and induces Mcl-1 down-regulation, Bak activation, and mitochondria-dependent apoptosis in human HeLa cells. PLoS ONE. 2017;12:e0176544 pubmed publisher
  10. Hwang I, Lee J, Jin H, Woo E, Lee D. Amentoflavone stimulates mitochondrial dysfunction and induces apoptotic cell death in Candida albicans. Mycopathologia. 2012;173:207-18 pubmed publisher
    ..albicans cells and is associated with the mitochondrial dysfunction. Besides, amentoflavone-induced hydroxyl radicals may play a significant role in mitochondria-mediated apoptosis...
  11. Lee J, Ryu T, Cho C, Kim D. Different characteristics of mitochondrial microsatellite instability between uterine leiomyomas and leiomyosarcomas. Pathol Oncol Res. 2011;17:201-5 pubmed publisher
    ..01). Distinctive characteristics of mitochondrial genetic instability in uterine leiomyomas and leiomyosarcomas suggested the potential of mtMSI as a marker for differential diagnosis between them. ..
  12. Kim K, Jang W, Lee J, Jun D, Ko J, Yun Y, et al. Kaempferol Activates Gâ‚‚-Checkpoint of the Cell Cycle Resulting in Gâ‚‚-Arrest and Mitochondria-Dependent Apoptosis in Human Acute Leukemia Jurkat T Cells. J Microbiol Biotechnol. 2016;26:287-94 pubmed publisher
  13. Seo S, Cho H, Min K, Woo S, Kim S, Park J, et al. Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression. Cell Death Dis. 2017;8:e2599 pubmed publisher
    ..hy926). Collectively, our study demonstrates that combined treatment with carboplatin and thioridazine induces apoptosis through proteasomal degradation of Mcl-1 and c-FLIP by upregulation of Nrf2-dependent PSMA5 expression. ..
  14. Kang H, Park J, Choi K, Choi H, Jung C, Kim G, et al. Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome. Aging Cell. 2017;16:541-550 pubmed publisher
    ..Thus, our study reveals a novel mechanism through which alleviation of the HGPS phenotype is mediated by the recovery of mitochondrial function upon ROCK inactivation. ..
  15. Kim J, Park K, Moon K, Lee M, Choi J, Yee S, et al. Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix. Food Chem Toxicol. 2008;46:3753-8 pubmed publisher
    ..These results indicate that SPR inhibits HT-29 cell proliferation by inducing apoptosis, which may be mediated via both caspase-dependent and -independent pathways. ..
  16. Yun J, Hwang J, Lee D. The antifungal activity of the peptide, periplanetasin-2, derived from American cockroach Periplaneta americana. Biochem J. 2017;474:3027-3043 pubmed publisher
    ..In summary, the antifungal peptide periplanetasin-2 activates apoptotic signals in the mitochondria by induction of oxidative stress. ..
  17. Guo Z, Sevrioukova I, Denisov I, Zhang X, Chiu T, Thomas D, et al. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol. 2017;24:1259-1275.e6 pubmed publisher
    ..CYP3A4 AA epoxygenase inhibition by biguanides thus demonstrates convergence between eicosanoid activity in mitochondria and biguanide action in cancer, opening a new avenue for cancer drug discovery. ..