Experts and Doctors on mice in Daejeon, South Korea

Summary

Locale: Daejeon, South Korea
Topic: mice

Top Publications

  1. Zhang E, Kim J, Shin N, Yin Y, Nan Y, Xu Y, et al. High Omega-3 Polyunsaturated Fatty Acids in fat-1 Mice Reduce Inflammatory Pain. J Med Food. 2017;20:535-541 pubmed publisher
  2. Cho C, Sung H, Kim K, Cheon H, Oh G, Hong H, et al. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Proc Natl Acad Sci U S A. 2006;103:4946-51 pubmed
    ..Taken together, these findings indicate that COMP-Ang1 can promote wound healing in diabetes through enhanced angiogenesis, lymphangiogenesis, and blood flow. ..
  3. Yang C, Yuk J, Shin D, Kang J, Lee S, Jo E. Secretory phospholipase A2 plays an essential role in microglial inflammatory responses to Mycobacterium tuberculosis. Glia. 2009;57:1091-103 pubmed publisher
  4. Hwang Y, Kim M, Song I, Lim J, Park B, Yun H. Anti-inflammatory effects of talosin A via inhibition of NF-kappaB activation in lipopolysaccharide-stimulated RAW264.7 cells. Biotechnol Lett. 2009;31:789-95 pubmed publisher
    ..05). Therefore, we confirmed anti-inflammatory activity of talosin A was via suppression of pro-inflammatory cytokines, NO production and NF-kappaB activation, suggesting a therapeutic candidate for inflammatory disorders. ..
  5. Lee J, Felipe P, Yang Y, Kim M, Kwon O, Sok D, et al. Effects of dietary supplementation with red-pigmented leafy lettuce (Lactuca sativa) on lipid profiles and antioxidant status in C57BL/6J mice fed a high-fat high-cholesterol diet. Br J Nutr. 2009;101:1246-54 pubmed publisher
  6. Ding Y, Liang C, Kim J, Lee Y, Hyun J, Kang H, et al. Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity. Bioorg Med Chem Lett. 2010;20:1528-31 pubmed publisher
    ..Among the compounds tested, compound 2 showed the strongest anti-inflammatory activity with the inhibition rate up to 38.40% at the concentration of 100nM, whereas other five compounds (2-6) exhibited moderate activity. ..
  7. Kim Y, Lee Y, Kim H, Kim J, Jang D, Kim J, et al. Anti-obesity effect of Morus bombycis root extract: anti-lipase activity and lipolytic effect. J Ethnopharmacol. 2010;130:621-4 pubmed
    ..This study evaluated anti-obesity effect of the ethanolic extract of Morus bombycis root on lipase activity and lipolysis in adipocytes and adipose tissues...
  8. Lee Y, Mollah M, Sohn K, Shi G, Kim D, Kim K, et al. ID3 mediates X-ray-induced apoptosis of keratinocytes through the regulation of ?-catenin. J Dermatol Sci. 2010;60:138-42 pubmed publisher
    ..Similarly, overexpression of ID3 led to remarkable reduction in ?-catenin level. These results suggest that ID3 plays a role as an apoptosis inducer in response to X-ray irradiation via the regulation of endogenous ?-catenin level. ..
  9. Lee H, Ha H, Lee J, Seo C, Lee N, Jung D, et al. The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice. Phytother Res. 2012;26:594-9 pubmed publisher
    ..farinae. These findings indicate that C. tricuspidata inhibits the development of AD-like skin lesions induced by repeated applications of D. farinae in sensitized NC/Nga by suppressing plasma concentrations of mTARC, histamine and IgE. ..

More Information

Publications186 found, 100 shown here

  1. Park A, Oh D, Lim S, Choi J, Moon J, Yu D, et al. Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT. J Cell Sci. 2012;125:4518-31 pubmed publisher
    ..We thus show conclusively that BCR is a novel substrate of PTPRT and that BCR is involved in the regulation of neuronal development via control of the BCR GTPase-activating domain function by PTPRT. ..
  2. Gil J, Kim E, Kim I, Ku B, Park W, Oh B, et al. Phosphoinositides differentially regulate protrudin localization through the FYVE domain. J Biol Chem. 2012;287:41268-76 pubmed publisher
    ..These results suggest that novel PtdInsP selectivity of the protrudin-FYVE domain is critical for its cellular localization and its role in neurite outgrowth. ..
  3. Chae J, Gil Hwang S, Lim D, Choi E. Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1. Free Radic Biol Med. 2012;53:2335-43 pubmed publisher
    ..Taken together, our results suggest that thioredoxin-1 functions as a molecular switch to turn off the oxidative stress-induced activation of MST1. ..
  4. Yi M, Lee Y, Kang J, Kim S, Oh S, Kim Y, et al. NFAT5-dependent expression of AQP4 in astrocytes. Cell Mol Neurobiol. 2013;33:223-32 pubmed publisher
    ..Our data demonstrate that NFAT5 is necessary for the transcriptional regulation of AQP4 expression and for local astrocyte swelling with accompanying restriction of the neuropil extracellular space in vivo. ..
  5. Yun K, Ryu C, Lee J, Noh J, Lee C, Lee H, et al. Hepatic metabolism of sulfur amino acids in db/db mice. Food Chem Toxicol. 2013;53:180-6 pubmed publisher
    ..The decreased hepatic hypotaurine may be attributable to the downregulation of cysteine dioxygenase. The major finding of this study is that db/db mice exhibited decreases in hepatic methionine and its sulfurcontaining metabolites. ..
  6. You S, Cho Y, Byun J, Shin E. Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo. Clin Exp Immunol. 2013;174:38-44 pubmed publisher
    ..Therefore, this model is well suited to future studies on the pathogenesis of vitiligo and the development of novel therapeutics for vitiligo. ..
  7. Kim J, Park S, Cho K. Discovery of a kernel for controlling biomolecular regulatory networks. Sci Rep. 2013;3:2223 pubmed publisher
    ..Intriguingly, the control kernel of the human signaling network included many drug targets and chemical-binding interactions, suggesting therapeutic application of the control kernel. ..
  8. Lee J, Chowdhury M, Moon H, Choi Y, Talactac M, Kim J, et al. The highly conserved HA2 protein of the influenza A virus induces a cross protective immune response. J Virol Methods. 2013;194:280-8 pubmed publisher
    ..Results suggest that recombinant proteins based on the highly conserved residues within HA2 are candidates for the development of vaccines against pandemic outbreaks of emergent influenza variants. ..
  9. Kamal A, Kim W, Cho K, Park A, Min J, Han B, et al. Investigation of adipocyte proteome during the differentiation of brown preadipocytes. J Proteomics. 2013;94:327-36 pubmed publisher
    ..CFL1 overexpressing cells showed lower deposition of brown fat droplets, and the brown marker genes of UCP1, PRDM16, PGC-1? and PPAR? were decreased through actin dynamics and polymerization. ..
  10. Park J, Jang H, Hwang S, Kim E, Kim D, Oh K, et al. ER stress-inducible ATF3 suppresses BMP2-induced ALP expression and activation in MC3T3-E1 cells. Biochem Biophys Res Commun. 2014;443:333-8 pubmed publisher
    ..Taken together, these data indicate that ATF3 is a novel negative regulator of osteoblast differentiation by specifically suppressing ALP gene expression in preosteoblasts. ..
  11. Lim J, Gopalappa R, Kim S, Ramakrishna S, Lee M, Kim W, et al. Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia. Am J Hum Genet. 2017;100:454-472 pubmed publisher
    ..These results show that brain somatic mutations in TSC1 and TSC2 cause FCD and that in utero application of the CRISPR-Cas9 system is useful for generating neurodevelopmental disease models of somatic mutations in the brain. ..
  12. Park B, Chun E, Choi J, Shin Y, Kho Y, Oh S, et al. Administration of Wasabia koreana Ameliorates Irritable Bowel Syndrome-Like Symptoms in a Zymosan-Induced Mouse Model. J Med Food. 2017;20:474-484 pubmed publisher
    ..These changes were accompanied by reduced FosB2 expression in the brain. Taken together, these data suggest that WK may have potential as a medicinal food for IBS by acting on inflammatory diarrhea and neural activity. ..
  13. Chee M, Jo S, Sohn K, Kim C, Lee J, Lee Y. Effects of Brn2 overexpression on eccrine sweat gland development in the mouse paw. Biochem Biophys Res Commun. 2017;490:901-905 pubmed publisher
    ..These results may be associated with dominant development of the epidermis by Brn2 overexpression in the paw skin. ..
  14. Yin J, Oh Y, Kim J, Kim S, Choi E, Kim T, et al. Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling. Cancer Res. 2017;77:4973-4984 pubmed publisher
    ..Collectively, our results indicate that TGM2 is a key molecular switch of necrosis-induced MES transdifferentiation and an important therapeutic target for MES GBM. Cancer Res; 77(18); 4973-84. ©2017 AACR. ..
  15. Cho C, Kammerer R, Lee H, Yasunaga K, Kim K, Choi H, et al. Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis. Proc Natl Acad Sci U S A. 2004;101:5553-8 pubmed
    ..Thus, COMP-Ang1 could be used as a therapeutic protein for specific protection against endothelial cell injury. ..
  16. Park J, Park Y, Kang H, Kim C. Solvent effects on physicochemical behavior of estradiols recrystallized for transdermal delivery. Arch Pharm Res. 2008;31:111-6 pubmed
  17. Lee Y, Sohn K, Jang S, Lee Y, Hwang C, Kim K, et al. Anti-apoptotic role of S100A8 in X-ray irradiated keratinocytes. J Dermatol Sci. 2008;51:11-8 pubmed publisher
    ..Furthermore, overexpression of S100A8 significantly protected the X-ray-induced apoptosis. These results suggest that S100A8 have an anti-apoptotic role in X-ray irradiated keratinocytes. ..
  18. Chung H, Park T. Injectable cellular aggregates prepared from biodegradable porous microspheres for adipose tissue engineering. Tissue Eng Part A. 2009;15:1391-400 pubmed publisher
    ..Immunohistochemical studies showed that the aggregate-derived tissues with porous microspheres displayed histological characteristics similar to adipose tissues 4 weeks after injection...
  19. Jeon J, Lee J, Kim C, An Y, Choi C. Aqueous extract of the medicinal plant Patrinia villosa Juss. induces angiogenesis via activation of focal adhesion kinase. Microvasc Res. 2010;80:303-9 pubmed publisher
    ..Our results provide a rationale for the use of PVE in the treatment of peripheral vascular insufficiency; they indicate the need to identify the novel pro-angiogenic chemicals in the fractions of PVE...
  20. Lee N, Lee M, Lee J, Jung D, Seo C, Kim J, et al. Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model. Int J Mol Med. 2010;26:201-8 pubmed
    ..These results indicate that SOEE has therapeutic potential against bronchial asthma associated with allergic diseases that is due, at least in part, to HO-1 upregulation...
  21. Jung J, Lee K, Lee M, Jung D, Cho E, Son H. Antioxidant and antiasthmatic effects of saucerneol D in a mouse model of airway inflammation. Int Immunopharmacol. 2011;11:698-705 pubmed publisher
    ..These antioxidant effects were correlated with HO-1 induction. In our experiments, saucerneol D treatment reduced airway inflammation and suppressed oxidative stress in an OVA-induced asthma model...
  22. Lee K, Kim J, Kim S, Park H, Jeong Y, Lee N, et al. Altered Purkinje cell responses and calmodulin expression in the spontaneously ataxic mouse, Pogo. Eur J Neurosci. 2011;33:1493-503 pubmed publisher
    ..These results implicate alterations in PC responses and calmodulin content in the abnormal cerebellar function of Pogo mice. ..
  23. Song K, Li G, Kim J, Jing K, Kim T, Kim J, et al. Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/?-catenin in SW480 human colon cancer cells. BMC Cancer. 2011;11:307 pubmed publisher
    ..These data suggest that PL suppresses tumor growth, invasion, and angiogenesis through the inhibition of Wnt/?-catenin signaling in certain colon cancer cells. ..
  24. Nam J, Kim E, Song D, Choi Y, Kim J, Poo H. Emergence of mammalian species-infectious and -pathogenic avian influenza H6N5 virus with no evidence of adaptation. J Virol. 2011;85:13271-7 pubmed publisher
  25. Kim Y, Kim Y, Song W. Autophagic response to a single bout of moderate exercise in murine skeletal muscle. J Physiol Biochem. 2012;68:229-35 pubmed publisher
  26. Hung N, Sok D, Kim M. Prevention of 1-palmitoyl lysophosphatidylcholine-induced inflammation by polyunsaturated acyl lysophosphatidylcholine. Inflamm Res. 2012;61:473-83 pubmed publisher
    ..These results indicated that the pro-inflammatory activity of saturated acyl LPCs could be antagonized by the actions of polyunsaturated acyl LPCs, anti-inflammatory lipid mediators. ..
  27. Byun E, Kim W, Kim J, Jung I, Park Y, Kim H, et al. Mycobacterium tuberculosis Rv0577, a novel TLR2 agonist, induces maturation of dendritic cells and drives Th1 immune response. FASEB J. 2012;26:2695-711 pubmed publisher
    ..Taken together, these findings suggest that Rv0577 may regulate innate and adaptive immunity by interacting with TLR2, a finding that could be helpful in the design of new TB vaccines. ..
  28. Lee K, Jung S, Choi S, Yang E. Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells. BMC Complement Altern Med. 2012;12:196 pubmed publisher
    ..Taken together, we suggest that G-Re exerts a beneficial effect on neuroinflammatory events in neurodegenerative diseases. ..
  29. Song S, Jang S, Park J, Bang S, Choi S, Kwon K, et al. Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. J Biol Chem. 2013;288:5660-72 pubmed publisher
    ..We believe that this study provides the basis for understanding the molecular and physiological functions of various PINK1 mutations and provides insights into the pathogenic mechanisms of PINK1-linked PD. ..
  30. Shin I, Lee M, Jeon W, Shin N, Seo C, Ha H. EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. Int J Mol Med. 2013;31:982-8 pubmed publisher
    ..Therefore, EBM84 has potential as a useful medicine for the treatment of allergic asthma...
  31. Ahn J, Lee H, Jung C, Jeon T, Ha T. MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade. EMBO Mol Med. 2013;5:1602-12 pubmed publisher
    ..Therefore, the miR-146b/SIRT1 pathway could be a potential target for obesity prevention and treatment. ..
  32. Kim Y, Moon J, Kim E, Lee S, Kang S, Kim S, et al. Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model. Cancer Lett. 2014;344:223-31 pubmed publisher
    ..Taken together, these results imply that PAUF-targeting TSR can contribute to successful targeted gene therapy for pancreatic cancer. ..
  33. Yoo J, Kim T, Kong S, Lee J, Choi W, Kim K, et al. Role of Mig-6 in hepatic glucose metabolism. J Diabetes. 2016;8:86-97 pubmed publisher
    ..This is the first report of Mig-6 involvement in hepatic insulin resistance and a new mechanism that explains hepatic insulin resistance. ..
  34. Cho J, Yi H, Jang E, Lee M, Lee J, Kang C, et al. Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection. Biochem Biophys Res Commun. 2017;494:298-304 pubmed publisher
    ..These results indicated that MMF could represent a novel inhibitor of viral replication and a potent immunomodulator for the treatment of H5N1 virus infection...
  35. Song H, Oh S, Oh H, Lim D. Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem Biophys Res Commun. 2010;391:969-73 pubmed publisher
  36. Jiang J, Yang E, Baek M, Kim S, Lee S, Choi S. Anti-inflammatory effects of electroacupuncture in the respiratory system of a symptomatic amyotrophic lateral sclerosis animal model. Neurodegener Dis. 2011;8:504-14 pubmed publisher
    ..Our findings suggest that EA could be an effective anti-inflammatory treatment for the respiratory impairment that occurs in ALS animal models. ..
  37. Zhang W, Lee J, Kim I, Kim Y, Myung C. Stimulation of glucose uptake and improvement of insulin resistance by aromadendrin. Pharmacology. 2011;88:266-74 pubmed publisher
    ..These findings suggest that aromadendrin may represent a potential therapeutic candidate for the management of type 2 DM. ..
  38. Sung Y, Yang W, Lee A, Kim D, Nho K, Kim Y, et al. Topical application of an ethanol extract prepared from Illicium verum suppresses atopic dermatitis in NC/Nga mice. J Ethnopharmacol. 2012;144:151-9 pubmed publisher
    ..However, its usefulness in the treatment of allergic diseases remains unclear. This study evaluated the anti-inflammatory and antiallergic effects of I. verum extract (IVE) in a mouse model of atopic dermatitis...
  39. Ryu M, Kim S, Choi M, Kim Y, Lee M, Lee S, et al. Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPAR? agonist-induced adipogenesis. Mol Cells. 2013;35:134-41 pubmed publisher
    ..Rosiglitazone treatment did not induce adipogenesis or mitochondria biogenesis in Crif1 knockout ADSCs. These results show that mitochondrial OXPHOS and Crif1 are required for rosiglitazone- and hormone-induced adipogenesis. ..
  40. Lee M, Kim J, Koh W. Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia. J Cell Biochem. 2004;93:629-38 pubmed
    ..These data suggest that the inhibition of Src-mediated tyrosine phosphorylation by PP2 may tilt the balance between each PKC isotypes, which in turn, activate NF-kappaB transcription factor, leading to apoptosis...
  41. Lee S, Gang J, Jeon S, Choo S, Lee B, Kim Y, et al. Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2). Biochem Biophys Res Commun. 2007;360:633-9 pubmed
  42. Zhang W, Lee J, Kim I, Kim Y, Park J, Myung C. 7-O-methylaromadendrin stimulates glucose uptake and improves insulin resistance in vitro. Biol Pharm Bull. 2010;33:1494-9 pubmed
    ..Therefore, these results suggest that 7-O-MA might stimulate glucose uptake via PPARgamma2 activation and improve insulin resistance via PI3K and AMPK-dependent pathways, and be a potential candidate for the management of type 2 DM. ..
  43. Chang K, Park Y, Park H, Homanics G, Kim J, Kim D. Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor. Biochem Biophys Res Commun. 2011;410:19-23 pubmed publisher
    ..These results suggest that ?1(-/-)/?(1G)(-/-) mice are a novel mouse model for a distinct subtype of ET in human and that Ca(V)3.1 T-type Ca(2+) channels play a role in motor coordination under pathological conditions. ..
  44. Song I, Jun S, Na H, Kim H, Jung S, Ha G, et al. Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Gastroenterology. 2012;143:1341-1351 pubmed publisher
    ..TIPRL prevents prolonged activation of MKK7 and JNK and TRAIL-induced apoptosis by mediating the interaction between MKK7 and PP2Ac. ..
  45. Choi Y, Yoon B, Won Y, Lee C, Hyun B, Kim H, et al. Cytokine responses in mice infected with Clonorchis sinensis. Parasitol Res. 2003;91:87-93 pubmed
    ..The results of this study suggest that susceptibility to C. sinensis infection is associated with Th2 cytokine production, especially IL-4 which is predominant in relatively susceptible FVB mice...
  46. Kim Y, Song J, Lipatov A, Choi S, Lee J, Donis R, et al. Increased immunogenicity of avian influenza DNA vaccine delivered to the skin using a microneedle patch. Eur J Pharm Biopharm. 2012;81:239-47 pubmed publisher
    ..Overall, this study shows that DNA vaccine delivery by microneedles can be a promising approach for improved vaccination to mitigate an influenza pandemic. ..
  47. Hong S, Lee K, Kwak S, Kim A, Bai H, Jung M, et al. Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet. 2012;8:e1002857 pubmed publisher
    ..Our findings demonstrate that Mnb/Dyrk1a regulates food intake through the evolutionary conserved Sir2-FOXO-sNPF/NPY pathway in Drosophila melanogaster and mammals...
  48. Han Y, Kwon T, Kim S, Ha H, Lee T, Kim J, et al. Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress. BMB Rep. 2012;45:560-4 pubmed
  49. Sul J, Park M, Shin J, Kim Y, Yoo S, Kong Y, et al. Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration. Hum Mol Genet. 2013;22:1558-73 pubmed publisher
    ..Taken together, these results suggest a new role for FAF1: that of a positive modulator for PD. ..
  50. Yang C, Kim J, Lee S, Hwang J, Lee C, Lee M, et al. TLR3-triggered reactive oxygen species contribute to inflammatory responses by activating signal transducer and activator of transcription-1. J Immunol. 2013;190:6368-77 pubmed publisher
    ..Collectively, these results provide a novel insight into the crucial role that TLR3-ROS signaling plays in innate immune responses by activating STAT1. ..
  51. Kim H, Koo S, Ahn B, Park O, Park D, Seo D, et al. NecroX as a novel class of mitochondrial reactive oxygen species and ONOO? scavenger. Arch Pharm Res. 2010;33:1813-23 pubmed publisher
    ..Thus, these chemical molecules are potential therapeutic agents in mitochondria-related human diseases involving necrotic tissue injury. ..
  52. Noh J, Kim Y, Gang G, Hwang J, Lee H, Ly S, et al. Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice. Food Chem Toxicol. 2011;49:1537-43 pubmed publisher
    ..These results suggest that CISE has protective effects against ethanol-induced oxidative damage, possibly by inhibition of lipid accumulation, peroxidation and increase of antioxidant defense system in the liver. ..
  53. Ryu M, Kim S, Kim Y, Choi M, Tadi S, Lee M, et al. Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. PLoS Genet. 2013;9:e1003356 pubmed publisher
    ..These findings indicate that the OXPHOS status of adipose tissue determines its metabolic and inflammatory responses, and may cause systemic inflammation and insulin resistance. ..
  54. Kim J, Kim T, Lee H, Nikapitiya C, Uddin M, Park M, et al. Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization. J Virol. 2017;91: pubmed publisher
    ..The results of this study will increase our understanding of the role of negative-feedback mechanisms that regulate type I IFN signaling and maintain immune homeostasis. ..
  55. Lee M, Lee N, Seo C, Lee J, Jung D, Kim J, et al. Alpinia katsumadai seed extract attenuate oxidative stress and asthmatic activity in a mouse model of allergic asthma. Food Chem Toxicol. 2010;48:1746-52 pubmed publisher
    ..These findings indicate that oxidative stress may play a crucial role in the pathogenesis of OVA-induced asthma model and that AK may have applications in the treatment of asthma. ..
  56. Jang H, Lee O, Lee Y, Yoon H, Chang E, Park M, et al. Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary. J Pineal Res. 2016;60:336-47 pubmed publisher
  57. Choi J, Lim Y, Cho S, Lee J, Jeong J, Kim E, et al. Mycobacterial HBHA induces endoplasmic reticulum stress-mediated apoptosis through the generation of reactive oxygen species and cytosolic Ca2+ in murine macrophage RAW 264.7 cells. Cell Death Dis. 2013;4:e957 pubmed publisher
    ..These results indicate that the ER stress pathway has an important role in the HBHA-induced apoptosis during mycobacterial infection. ..
  58. Lee G, Lee H, Kim T, Kim J, Sohn K, Jo E. Mycobacterium fortuitum induces A20 expression that impairs macrophage inflammatory responses. Pathog Dis. 2016;74: pubmed publisher
    ..Taken together, these results suggest that MF-induced activation of host proinflammatory responses is negatively regulated through TLR2-dependent A20 expression. ..
  59. Hung T, Na M, Dat N, Ngoc T, Youn U, Kim H, et al. Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii. J Ethnopharmacol. 2008;119:74-80 pubmed publisher
    ..05). These results indicated that Corydalis turtschaninovii due to its alkaloids have anti-cholinesterase activity and pseudoberberine and other alkaloids have anti-amnesic activities that may be useful for cognitive impairment treatment...
  60. Kim K, Park K, Song S, Kim K. Insulin represses transcription of the thyroid stimulating hormone beta-subunit gene through increased recruitment of nuclear factor I. J Biol Chem. 2010;285:32003-11 pubmed publisher
    ..Taken together, this study provides new insights of the delicate regulations of energy metabolism and hormonal homeostasis. ..
  61. Nhiem N, Kiem P, Minh C, Tai B, Quang T, Soung K, et al. Anti-inflammatory activity on LPS-stimulated dendritic cells of lupanetype triterpenoids from the leaves of Acanthopanax koreanum. Arch Pharm Res. 2011;34:1593-8 pubmed publisher
    ..0 to 84.5% at a concentration of 50 ?M. These results warrant further studies concerning the potential anti-inflammatory benefits of medicinal foods containing the leaves of A. koreanum. ..
  62. Ha H, An H, Shim K, Kim T, Lee K, Hwang Y, et al. Ethanol extract of Atractylodes macrocephala protects bone loss by inhibiting osteoclast differentiation. Molecules. 2013;18:7376-88 pubmed publisher
  63. Chen Q, Lee J, Jin W, Youn U, Kim H, Lee I, et al. Cytotoxic constituents from angelicae sinensis radix. Arch Pharm Res. 2007;30:565-9 pubmed
    ..45 +/- 0.19 and 9.87 +/- 0.14 microM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 +/- 0.90 and 2.87 +/- 0.49 microM, respectively. ..
  64. Kim J, Baek S, Kim D, Choi T, Yoon T, Hwang J, et al. Downregulation of melanin synthesis by haginin A and its application to in vivo lightening model. J Invest Dermatol. 2008;128:1227-35 pubmed
  65. Lee S, Choi Y, Kim Y, Park S, Kwak H, Min Y, et al. Physcion-8-O-beta-D-glucopyranoside enhances the commitment of mouse mesenchymal progenitors into osteoblasts and their differentiation: Possible involvement of signaling pathways to activate BMP gene expression. J Cell Biochem. 2010;109:1148-57 pubmed publisher
    ..In conclusion, physcion-Glu could enhance the commitment of mesenchymal progenitors into osteoblasts and their differentiation by activating signaling pathways to induce BMP gene expression. ..
  66. Jeong Y, Park J, Ko Y, Kang Y. JHDM3A module as an effector molecule in guide-directed modification of target chromatin. J Biol Chem. 2011;286:4461-70 pubmed publisher
  67. Kim Y, Lee Y, Choi E. Linarin isolated from Buddleja officinalis prevents hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells. Cell Immunol. 2011;268:112-6 pubmed publisher
    ..These results demonstrate that linarin can protect osteoblasts against hydrogen peroxide-induced osteoblastic dysfunction and may exert anti-resorptive actions, at least in part, via the reduction of RANKL and oxidative damage...
  68. Lee E, Shon H, Lee T, Kim S, Moon D. The regional ratio of cholesteryl palmitate to cholesteryl oleate measured by ToF-SIMS as a key parameter of atherosclerosis. Atherosclerosis. 2013;226:378-84 pubmed publisher
    ..Our results indicate that the regional ratio of CEs as measured by ToF-SIMS might be a valuable new marker of atherosclerotic progression. ..
  69. Yoo C, Na H, Lee D, Heo S, An Y, Cha J, et al. Endothelial progenitor cells from human dental pulp-derived iPS cells as a therapeutic target for ischemic vascular diseases. Biomaterials. 2013;34:8149-60 pubmed publisher
    ..2F hDPC-hiPSCs have a robust capability for the generation of angiogenic and vasculogenic EPCs, representing a strategy for patient-specific EPC therapies and disease modeling, particularly for ischemic vascular diseases. ..
  70. Park H, Lee S, Heo W. Protein Inactivation by Optogenetic Trapping in Living Cells. Methods Mol Biol. 2016;1408:363-76 pubmed publisher
    ..In the protocol, we focus on the inhibition of proteins that modulate cytoskeleton and cell cycle, and describe how to transfect, conduct a photo-stimulation, and analyze the data. ..
  71. Park M, Jang H, Lee S, Lee K, Kim E. Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. J Biol Chem. 2004;279:2544-9 pubmed
    ..e. NF-kappaB activity suppressor by cytoplasmic retention of NF-kappaB p65 via physical interaction. ..
  72. Kang Y, Choi M, Lee J, Koh G, Kwon K, Choi C. Quantitative analysis of peripheral tissue perfusion using spatiotemporal molecular dynamics. PLoS ONE. 2009;4:e4275 pubmed publisher
    ..We propose that this novel NIR-imaging-based strategy is a powerful tool for biomedical studies related to the evaluation of therapeutic interventions directed at stimulating angiogenesis. ..
  73. Zhang W, Lee J, Kim Y, Kim I, Park J, Myung C. Amelioration of insulin resistance by scopoletin in high-glucose-induced, insulin-resistant HepG2 cells. Horm Metab Res. 2010;42:930-5 pubmed publisher
    ..With its lower adipogenic property, scopoletin may be a useful candidate for managing metabolic disorders, including type 2 diabetes mellitus. ..
  74. Thambi T, Deepagan V, Yoon H, Han H, Kim S, Son S, et al. Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery. Biomaterials. 2014;35:1735-43 pubmed publisher
    ..As consequence, drug-loaded HR-NPs exhibited high anti-tumor activity in vivo. Overall, the HR-NPs might have a potential as nanocarriers for drug delivery to treat hypoxia-associated diseases. ..
  75. Cho S, Park I, Kim H, Jeong M, Lim M, Lee E, et al. Generation, characterization and preclinical studies of a human anti-L1CAM monoclonal antibody that cross-reacts with rodent L1CAM. MAbs. 2016;8:414-25 pubmed publisher
    ..Ab417 significantly inhibited tumor growth in a human cholangiocarcinoma xenograft nude mouse model and did not induce any adverse effect in in vivo studies. Thus, Ab417 may have potential as an anticancer agent...
  76. Lee Y, Park S, Kim Y, Kim D, Lee W, Surh Y, et al. Suppression of mTOR via Akt-dependent and -independent mechanisms in selenium-treated colon cancer cells: involvement of AMPKalpha1. Carcinogenesis. 2010;31:1092-9 pubmed publisher
    ..These findings suggest that the antiproliferative effect of selenium is mediated by an Akt-independent AMPKalpha(1)/mTORC1 pathway or by the Akt/tuberous sclerosis complex 2 /mTORC1 pathway. ..
  77. Yoon T, Lee D, Lee A, Choi G, Choo B, Kim H. Anti-inflammatory effects of Glehnia littoralis extract in acute and chronic cutaneous inflammation. Immunopharmacol Immunotoxicol. 2010;32:663-70 pubmed publisher
    ..These results suggest that G. littoralis is an effective anti-inflammatory agent in murine phorbol ester-induced dermatitis and may have therapeutic potential in a variety of immune-related cutaneous diseases. ..
  78. Kwak S, Jeong M, Choi J, Kim D, Min H, Yoon Y, et al. Amelioration of behavioral abnormalities in BH(4)-deficient mice by dietary supplementation of tyrosine. PLoS ONE. 2013;8:e60803 pubmed publisher
    ..The present study proposes that brain mTORC1 signaling pathway is one of the potential targets in understanding abnormal motor behaviors associated with BH4-deficiency. ..
  79. Kim A, Yim N, Ma J. Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cells. BMC Complement Altern Med. 2013;13:233 pubmed publisher
    ..SSE may be as a potent traditional herbal medicine for treating malignancies. ..
  80. Choi M, Shim H, Nam Y, Kim H, Kang J, Lee D, et al. Synthesis and evaluation of an (125)I-labeled azide prosthetic group for efficient and bioorthogonal radiolabeling of cyclooctyne-group containing molecules using copper-free click reaction. Bioorg Med Chem Lett. 2016;26:875-878 pubmed publisher
    ..These results clearly demonstrated that [(125)I]1 could be used as an useful radiotracer for in vivo pre-targeted imaging as well as efficient in vitro radiolabeling of DBCO containing molecules. ..
  81. Kim S, Kim H, Park M, Cho S, Goughnour P, Han D, et al. Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells. J Cell Biol. 2017;216:2201-2216 pubmed publisher
  82. Lee J, Poo H, Han D, Hong S, Kim K, Cho M, et al. Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice. J Virol. 2006;80:4079-87 pubmed
    ..These results indicate that mucosal immunization with recombinant L. casei expressing SARS-associated coronavirus S protein on its surface provides an effective means for eliciting protective immune response against the virus. ..
  83. An S, Han J, Kim M, Park J, Han J, Baek N, et al. Ethanolic extracts of Brassica campestris spp. rapa roots prevent high-fat diet-induced obesity via beta(3)-adrenergic regulation of white adipocyte lipolytic activity. J Med Food. 2010;13:406-14 pubmed publisher
    ..These results suggest that EBR may have potential as a safe and effective anti-obesity agent via the inhibition of adipocyte lipid accumulation and the stimulation of beta(3)-AR-dependent lipolysis. ..
  84. Kim S, Lee Y, Kim N, Hwang Y, Hwang B, Min J, et al. Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability. Oncogene. 2013;32:3638-47 pubmed publisher
    ..Taken together, these data demonstrate that PAUF has a novel function in promoting angiogenesis and vascular permeability. Our findings suggest new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases. ..
  85. Seo E, Basu Roy U, Gunaratne P, Coarfa C, Lim D, Basilico C, et al. SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage. Cell Rep. 2013;3:2075-87 pubmed publisher
    ..We demonstrate a Hippo-independent regulation of YAP1 by SOX2 that cooperatively antagonizes Wnt/?-catenin signals and regulates PPAR? to determine osteogenic or adipocytic fates. ..
  86. Park J, Park E, Jung C, Kang S, Kim B, Jung Y, et al. Oral proteasome inhibitor with strong preclinical efficacy in myeloma models. BMC Cancer. 2016;16:247 pubmed publisher
    ..In view of the in vitro, in vivo, and ex vivo profiles, further investigation of additional LC compounds in preclinical studies is warranted for the nomination of a clinical development candidate. ..
  87. Jo C, Yook H, Lee M, Kim J, Song H, Kwon J, et al. Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in methanol. Food Chem Toxicol. 2003;41:1329-36 pubmed
    ..Results indicated that irradiation decreased the gossypol concentration dissolved in methanol, resulting in a reduction of embryotoxicity in mice. ..
  88. Park K, Park Y, Han J, Im K, Lee B, Jeong I, et al. Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata. Bioorg Med Chem Lett. 2006;16:5580-3 pubmed
    ..However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1. ..
  89. Cheon M, Yoon T, Lee D, Choi G, Moon B, Lee A, et al. Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol. 2009;122:473-7 pubmed publisher
    ..Our results suggest that the anti-inflammatory properties of CIE might result from the inhibition of inflammatory mediators, such as NO, PGE(2), TNF-alpha, and IL-1beta, via suppression of MAPKs and NF-kappaB-dependent pathways. ..
  90. Choi S, Oh J, Kim S. Ginsenoside Rh2 induces Bcl-2 family proteins-mediated apoptosis in vitro and in xenografts in vivo models. J Cell Biochem. 2011;112:330-40 pubmed publisher
    ..Our data suggest that Rh2 used in traditional oriental medicine for the treatment of various ailments, may be an attractive agent for the treatment and/or prevention of human breast cancers. ..
  91. Lee H, Kyung T, Yoo J, Kim T, Chung C, Ryu J, et al. Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics. Nat Commun. 2013;4:1505 pubmed publisher
    ..Our approach allows us to probe the previously hidden, dynamic aspects of weak protein-protein interactions. It also suggests a path forward towards precision molecular diagnostics at the protein-protein interaction level. ..
  92. Park E, Chae J, Lyu J, Yoon C, Kim S, Yeom C, et al. Ambient fine particulate matters induce cell death and inflammatory response by influencing mitochondria function in human corneal epithelial cells. Environ Res. 2017;159:595-605 pubmed publisher
    ..Taken together, we suggest that AFP induces cell death and inflammatory response by influencing mitochondrial function in HCET cells. In addition, we recommend that stringent air quality regulations are needed for eye health. ..