Experts and Doctors on lipopolysaccharides in Seoul, South Korea


Locale: Seoul, South Korea
Topic: lipopolysaccharides

Top Publications

  1. Kim J, Son D, Lee P, Lee K, Kim H, Kim S. Ethyl acetate soluble fraction of Cnidium officinale MAKINO inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolysaccharide-treated rat hippocampal slice cultures and microglia cells. J Pharmacol Sci. 2003;92:74-8 pubmed
    ..The ethyl acetate-soluble fraction of C. officinale reduced propidium iodide uptake and NO production in cultured media at the same time. ..
  2. Kim Y, Min H, Park H, Lee E, Park E, Hwang H, et al. Suppressive effects of nitric oxide production and inducible nitric oxide synthase (iNOS) gene expression by Calystegia soldanella methanol extract on lipopolysaccharide-activated RAW 264.7 cells. Eur J Cancer Prev. 2004;13:419-24 pubmed
  3. Shin K, Kim I, Park Y, Ha J, Choi J, Park H, et al. Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E2, nitric oxide and tumor necrosis factor-alpha production. Biochem Pharmacol. 2004;68:2327-36 pubmed
    ..Taken together, our data indicate that the anti-inflammatory properties of CM might result from the inhibition of iNOS, COX-2 and TNF-alpha expression through the down-regulation of NF-kappaB binding activity. ..
  4. Jang M, Kim C, Kim E, Kim M, Leem K, Kim J. Effects of Platycodon grandiflorum on lipopolysaccharide-stimulated production of prostaglandin E2, nitric oxide, and interleukin-8 in mouse microglial BV2 cells. J Med Food. 2006;9:169-74 pubmed
    ..These results suggest that P. grandiflorum inhibits PGE(2) and NO production through its suppression of LPS-induced COX-2 and iNOS expression, and also reduces IL-8 secretion by microglial cells. ..
  5. Won J, Kim J, Yun K, Lee J, Back N, Chung H, et al. Gigantol isolated from the whole plants of Cymbidium goeringii inhibits the LPS-induced iNOS and COX-2 expression via NF-kappaB inactivation in RAW 264.7 macrophages cells. Planta Med. 2006;72:1181-7 pubmed
    ..Thus, our studies suggest that gigantol inhibits LPS-induced iNOS and COX-2 expression by blocking NF- kappaB activation. ..
  6. Kim D, Jun J, Lee H, Woo K, Ryoo H, Kim G, et al. N-acetylcysteine prevents LPS-induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts. Arch Pharm Res. 2007;30:1283-92 pubmed
    ..Furthermore, this work suggests that antioxidants may be useful in adjunctive therapies that complement conventional periodontal treatments. ..
  7. Yoon J, Lim H, Lee H, Kim H, Jeon R, Ryu J. Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium. Bioorg Med Chem Lett. 2008;18:2179-82 pubmed publisher
    ..47, 11.2, 136.5 microM, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappaB through the inhibition of LPS-induced I-kappaB-alpha degradation in microglia...
  8. Lee K, Kim S, Sung S, Kim Y. Inhibitory constituents of lipopolysaccharide-induced nitric oxide production in BV2 microglia isolated from Amomum tsao-ko. Planta Med. 2008;74:867-9 pubmed publisher
    ..TSAO-KO using bioactivity-guided fractionation. All thirteen compounds significantly inhibited lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM...
  9. Son Y, Ahn S, Jang M, Moon Y, Kim S, Cho K, et al. Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus. Biochem Biophys Res Commun. 2008;376:599-604 pubmed publisher
    ..aureus-primed DCs without resistin. Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs. ..

More Information

Publications187 found, 100 shown here

  1. Lee S, Jun H, Lee H, Chung C, Choi B. Antibacterial and lipopolysaccharide (LPS)-neutralising activity of human cationic antimicrobial peptides against periodontopathogens. Int J Antimicrob Agents. 2010;35:138-45 pubmed publisher
    ..These results suggest that AMPs may be considered as preventive and therapeutic agents against mixed bacterial infections such as periodontitis by eliminating the pathogens themselves as well as reducing the activity of LPS. ..
  2. Kang S, Jeon J, Woo S, Yang J, Kim K, Yun C, et al. IFN-? renders human intestinal epithelial cells responsive to lipopolysaccharide of Vibrio cholerae by down-regulation of DMBT1. Comp Immunol Microbiol Infect Dis. 2012;35:345-54 pubmed publisher
    ..cholerae LPS. In conclusion, our study suggests that IFN-? primes IECs to become responsive to V. cholerae and its LPS by suppressing the expression of DMBT1. ..
  3. Han J, Wui S, Park S, Lee N, Kim K, Cho Y, et al. Comparison of the immune responses to the CIA06-adjuvanted human papillomavirus L1 VLP vaccine with those against the licensed HPV vaccine Cervarix™ in mice. Vaccine. 2012;30:4127-34 pubmed publisher
    ..Based on these data, we concluded that CIA06B may have potential as an adjuvant in a potent prophylactic vaccine against HPV infection. ..
  4. Jung K, Chin Y, Yoon K, Chae H, Kim C, Yoo H, et al. Anti-inflammatory properties of a triterpenoidal glycoside from Momordica cochinchinensis in LPS-stimulated macrophages. Immunopharmacol Immunotoxicol. 2013;35:8-14 pubmed publisher
    ..7 cells. The mechanistic understanding of anti-inflammatory activities demonstrates that compound 2 inhibits lipopolysaccharide-induced expression of nitric oxide and IL-6 via NF-?B pathway...
  5. Han S, Lee J, Kim C, Nam D, Chung W, Lee S, et al. Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-?B activation. Immunopharmacol Immunotoxicol. 2013;35:34-42 pubmed publisher
  6. Yoo S, Abdelmegeed M, Song B. Activation of PPARα by Wy-14643 ameliorates systemic lipopolysaccharide-induced acute lung injury. Biochem Biophys Res Commun. 2013;436:366-71 pubmed publisher
    ..These results suggest that the pharmacological activation of PPARα might have a therapeutic effect on LPS-induced ALI. ..
  7. Lee H, Yeon J, Ko E, Yoon E, Suh S, Kang K, et al. Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease. World J Gastroenterol. 2015;21:12787-99 pubmed publisher
    ..PPAR-δ agonist reduces fatty acid-induced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. ..
  8. Hur J, Kim S, Kim H, Cha S, Lee M, Suk K. Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway. FEBS Lett. 2001;507:157-62 pubmed
    ..Inflammatory induction of caspase-11 in astrocytes may play an important role in both inflammatory responses involving these cells and auto-regulatory apoptosis of activated astrocytes in inflammatory sites. ..
  9. Kim R, Shin K, Kim Y, Jeong H, Ha J, Choi J, et al. Inhibition of methanol extract from the aerial parts of Saururus chinensis on lipopolysaccharide-induced nitric oxide and prostagladin E2 production from murine macrophage RAW 264.7 cells. Biol Pharm Bull. 2003;26:481-6 pubmed
    ..These results suggest that SCM inhibits LPS-induced iNOS and COX-2 expression by blocking NF-kappaB activation...
  10. Ryu J, Ahn H, Kim J, Kim Y. Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages. Phytother Res. 2003;17:485-9 pubmed
    ..These plants are promising candidates for the study of the activity-guided purification of active compounds and would be useful for the treatment of inflammatory diseases and endotoxemia accompanying overproduction of NO. ..
  11. Ryu J, Ahn H, Jin Lee H. Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia. 2003;74:350-4 pubmed
    ..2%) of nitric oxide (NO) in lipopolysaccharide activated macrophages. Kazinol B, an isoprenylated flavan, was identified as the active principle. It inhibits the NO synthesis with an IC(50) of 21.6 microM...
  12. Jang M, Lim S, Han S, Park H, Shin I, Kim J, et al. Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929. J Pharmacol Sci. 2003;93:367-71 pubmed
    ..These results suggest that Harpagophytum procumbens exerts anti-inflammatory and analgesic effects probably by suppressing cyclooxygenase-2 and iNOS expressions...
  13. Choi E, Hwang J. Effects of methanolic extract and fractions from Litsea cubeba bark on the production of inflammatory mediators in RAW264.7 cells. Fitoterapia. 2004;75:141-8 pubmed
    ..05 mg/ml), chloroform fraction (0.025-0.05 mg/ml) and butanol fraction (0.005 mg/ml). These findings suggest that L. cubeba is beneficial for inflammatory conditions and may contain compound(s) with anti-inflammatory properties...
  14. Chung H, Kang M, Cho C, Park S, Kim H, Yoon Y, et al. Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages. J Ethnopharmacol. 2005;102:412-7 pubmed
    ..These findings demonstrate that the inhibition of the LPS/rIFN-gamma-induced production of NO and TNF-alpha by LR involves the inhibition of NF-kappaB activation...
  15. Kim H, Yang J, Woo S, Kim S, Yun C, Kim K, et al. Lipoteichoic acid and muramyl dipeptide synergistically induce maturation of human dendritic cells and concurrent expression of proinflammatory cytokines. J Leukoc Biol. 2007;81:983-9 pubmed
    ..Furthermore, ELISA showed that secretions of TNF-alpha and IL-12 p40, but not IL-10, were induced in iDC by the costimulation. These results suggest that StLTA and MDP synergistically induce maturation and activation of human DC. ..
  16. Shim D, Chang S, Park S, Jang H, Carbis R, Czerkinsky C, et al. Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a. Vaccine. 2007;25:4828-36 pubmed
    ..It can also be surmised that a mucosal SRV vaccine would be particularly relevant in targeting shigellosis, which provokes inflammation in the human colon. ..
  17. Kim H, Kim J, Chung J, Han K, Cho H. Surface expression of neutrophil CXCR4 is down-modulated by bacterial endotoxin. Int J Hematol. 2007;85:390-6 pubmed
  18. Won J, Shin J, Park H, Jung H, Koh D, Jo B, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010;76:251-7 pubmed publisher
    ..These results suggest that the anti-inflammatory properties of madecassic acid are caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. ..
  19. Kwon H, Cho S. Pathogenicity of SG 9R, a rough vaccine strain against fowl typhoid. Vaccine. 2011;29:1311-8 pubmed publisher
    ..Therefore, the LPS defect may be one of the major mechanisms of SG 9R attenuation, and the possession of intact SPI-2, spvC, B, A, and R virulence genes may be associated with residual SG 9R virulence. ..
  20. Choi Y, Seok Y, Yeo S, Jeong M, Lim S. Protective changes of inflammation-related gene expression by the leaves of Eriobotrya japonica in the LPS-stimulated human gingival fibroblast: microarray analysis. J Ethnopharmacol. 2011;135:636-45 pubmed publisher
  21. Park M, Oh H, Heo Y, Park E, Cho M, Kim H, et al. Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts. Exp Mol Med. 2011;43:446-54 pubmed
    ..We showed that the mechanisms responsible for IDO regulation primarily involve MyD88 signaling in synovial fibroblasts, as demonstrated by siRNAmediated knockdown of MyD88. ..
  22. Moon E, Lee Y, Choi W, Lee M. Toll-like receptor 4-mediated cAMP production up-regulates B-cell activating factor expression in Raw264.7 macrophages. Exp Cell Res. 2011;317:2447-55 pubmed publisher
    ..With these data, it suggests that the activation of PKA and cAMP/Epac1/Rap1 pathways could be required for basal mBAFF expression, as well as being up-regulated in the TLR4-induced mBAFF expression. ..
  23. Joh E, Jeong J, Kim D. Kalopanaxsaponin B inhibits LPS-induced inflammation by inhibiting IRAK1 Kinase. Cell Immunol. 2012;279:103-8 pubmed publisher
    ..Kalopanaxsaponin B inhibited LPS-induced systemic inflammation in mice. Based on these findings, kalopanaxsaponin B ameliorates LPS-induced systemic inflammation by inhibiting IRAK1 kinase. ..
  24. Jung S, Kim S, Jun B, Lee K, Hong S, Oh M, et al. α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells. J Ethnopharmacol. 2013;147:208-14 pubmed publisher
    ..7 cells. The anti-inflammatory activity of α-cyperone is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells. ..
  25. Cho J, Lee J, Lee E, Nam D, Shim B, Song M, et al. 8?-hydroxy-3-oxopimar-15-ene exerts anti-inflammatory effects by inhibiting ROS-mediated activation of the TRAF6-ASK1-p38 signaling pathway. Immunopharmacol Immunotoxicol. 2013;35:549-57 pubmed publisher
    ..Therefore, we demonstrate here that OXO can potentially inhibit several biomarkers related to inflammation through inhibition of ROS-mediated activation of TRAF6-ASK1-p38 pathway. ..
  26. Park J, Kim S, Kim Y, Yang W, Kim Y, Hong S, et al. Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid. Mediators Inflamm. 2016;2016:1903849 pubmed publisher
    ..Our data strongly suggest that anthraquinones such as AQCA act as potent anti-inflammatory and antinociceptive components in vivo, thus contributing to the immune regulatory role of fruits and herbs. ..
  27. Yoon H, Kim G, Ju Y, Cheon I, Hong S, Kim D, et al. Distinct pattern of immune tolerance in dendritic cells treated with lipopolysaccharide or lipoteichoic acid. Mol Immunol. 2017;91:57-64 pubmed publisher
    ..Collectively, a distinct immune regulation appeared to be responsible for the LPS- and LTA-induced tolerance on cytokine production, expression of surface markers and intracellular proteins. ..
  28. Choi Y, Lee M, Lim S, Sung S, Kim Y. Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells. Br J Pharmacol. 2009;156:933-40 pubmed publisher
    ..This study indicates that torilin inhibited LPS-induced iNOS, COX-2 and IL-1beta via down-regulation of ERK1/2, p38 MAPK, NF-kappaB and CREB and suggests that torilin has a potential as an anti-inflammatory drug candidate. ..
  29. Ren J, Han E, Chung S. In vivo and in vitro anti-inflammatory activities of alpha-linolenic acid isolated from Actinidia polygama fruits. Arch Pharm Res. 2007;30:708-14 pubmed
    ..These results suggest that the anti-inflammatory activity of ALA might be due to the suppression of the expressions of iNOS and COX-2 mRNA...
  30. Oh Y, Youn J, Ji Y, Lee S, Lim K, Choi J, et al. HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism. J Immunol. 2009;182:5800-9 pubmed publisher
  31. Lee S, Lee J, Kim J, Jung J, You G, Park S, et al. C-peptide stimulates nitrites generation via the calcium-JAK2/STAT1 pathway in murine macrophage Raw264.7 cells. Life Sci. 2010;86:863-8 pubmed publisher
    ..These results suggest that C-peptide may elicit immune modulatory function via modulation of the calcium/JAK-STAT pathway. ..
  32. Joh E, Kim D. Lancemaside A inhibits lipopolysaccharide-induced inflammation by targeting LPS/TLR4 complex. J Cell Biochem. 2010;111:865-71 pubmed publisher
    ..Based on these findings, lancemaside A expressed anti-inflammatory effects by regulating both the binding of LPS to TLR4 on macrophages. ..
  33. Kang S, Ryu Y, Baik J, Yun C, Lee K, Chung D, et al. Lipoteichoic acid from Lactobacillus plantarum induces nitric oxide production in the presence of interferon-? in murine macrophages. Mol Immunol. 2011;48:2170-7 pubmed publisher
    ..Collectively, these results suggest that LTA from L. plantarum alone has no inflammatory potential but does induce NO production under conditions of inflammation, such as the presence of IFN-?. ..
  34. Joh E, Gu W, Kim D. Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-?B and MAPK pathways. Biochem Pharmacol. 2012;84:331-40 pubmed publisher
    ..On the basis of these findings, echinocystic acid, a metabolite of lancemaside A, may express anti-inflammatory effects by inhibiting the binding of LPS to TLR4 on macrophages. ..
  35. Chung H, Kim H, Bae H. Phenelzine (monoamine oxidase inhibitor) increases production of nitric oxide and proinflammatory cytokines via the NF-?B pathway in lipopolysaccharide-activated microglia cells. Neurochem Res. 2012;37:2117-24 pubmed publisher
    ..These findings suggest that high doses of phenelzine could aggravate inflammatory responses in microglia cells that are mediated by NO and TNF-?. ..
  36. Yang W, Kim J, Han N, Lee E, Park S. 1,25-Dihydroxyvitamin D3 Attenuates the Effects of Lipopolysaccharide by Causing ADAM10-Dependent Ectodomain Shedding of Toll-Like Receptor 4. Cell Physiol Biochem. 2017;41:2104-2116 pubmed publisher
    ..1,25D3 causes ectodomain shedding of TLR4 and thereby decreases the responsiveness of cells to LPS. ADAM10, activated by extracellular Ca2+ influx, was implicated in the ectodomain cleavage of TLR4. ..
  37. Lee S, Kim J, Yang W, Kim S, Park S, Park J. Exogenous nitric oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells. Role of cyclic GMP and NF-kappaB. Nephron. 2002;90:447-54 pubmed
    ..These results suggest that exogenous NO inhibits VCAM-1 expression via suppression of NF-kappaB through a cGMP-independent pathway. ..
  38. Park J, Kim H, Lee J, Kim K, Jang M, Lee J, et al. Macrolide-affected Toll-like receptor 4 expression from Helicobacter pylori-infected monocytes does not modify interleukin-8 production. FEMS Immunol Med Microbiol. 2005;44:171-6 pubmed
    ..pylori lipopolysaccharide. However, Toll-like receptor 4 activation was possibly not the main cause in the induction of inflammation during H. pylori infection. ..
  39. Lee J, Jhun B, Oh Y, Lee J, Choe W, Baik H, et al. Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells. Neurosci Lett. 2006;396:1-6 pubmed
    ..Taken together, these results suggest that adenosine A3 receptor activation suppresses TNF-alpha production by inhibiting PI 3-kinase/Akt and NF-kappaB activation in LPS-treated BV2 microglial cells. ..
  40. Cheon J, Kim J, Kim J, Kim N, Jung H, Song I. Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis. Inflamm Bowel Dis. 2006;12:1152-61 pubmed
    ..Guggulsterone blocks NF-kappaB signaling pathway by targeting IKK complex in IEC and attenuates DSS-induced acute murine colitis, which suggests that guggulsterone could be an attractive therapeutic option in the treatment of IBD. ..
  41. Yang H, Chang H, Lee J, Kim Y, Kim H, Lee M, et al. Amygdalin suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. Neurol Res. 2007;29 Suppl 1:S59-64 pubmed
    ..These results show that amygdalin exerts anti-inflammatory and analgesic effects and it dose so probably by suppressing the mRNA expressions of COX-2 and iNOS. ..
  42. Han Y. Rutin has therapeutic effect on septic arthritis caused by Candida albicans. Int Immunopharmacol. 2009;9:207-11 pubmed publisher
    ..albicans. Ultimately, it can be suggested that the dual effects of rutin, anti-arthritic and anti-candidal may be helpful as an all-in-one treatment for septic arthritis. ..
  43. Rim H, Cho W, Sung S, Lee K. Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-?B pathways and protects mice from lethal endotoxin shock. J Pharmacol Exp Ther. 2012;342:654-64 pubmed publisher
    ..Taken together, our data suggest that nodakenin down-regulates the expression of the proinflammatory iNOS, COX-2, TNF-?, IL-6, and IL-1? genes in macrophages by interfering with the activation of TRAF6, thus preventing NF-?B activation. ..
  44. Chun J, Choi R, Khan S, Lee D, Kim Y, Nam Y, et al. Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells. Int Immunopharmacol. 2012;14:375-83 pubmed publisher
    ..7 cells by suppressing NF-κB activation and MAPKs phophorylation via downregulation of the MyD88 signaling pathway. Thus, alantolactone may provide a useful therapeutic approach for inflammation-associated diseases. ..
  45. Um S, Pyee Y, Kim E, Lee S, Shin J, Oh D. Thalassospiramide G, a new ?-amino-acid-bearing peptide from the marine bacterium Thalassospira sp. Mar Drugs. 2013;11:611-22 pubmed publisher
    ..Thalassospiramides A and D (2-3) inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells, with IC(50) values of 16.4 and 4.8 ?M, respectively. ..
  46. Ha J, Lee Y, Kim H. CXCL2 mediates lipopolysaccharide-induced osteoclastogenesis in RANKL-primed precursors. Cytokine. 2011;55:48-55 pubmed publisher
    ..More significantly, CXCL2-neutralization prevented bone destruction in mice treated with LPS. Therefore, CXCL2 might be a useful therapeutic target for inflammatory bone destructive diseases. ..
  47. Park S, Jung H, Son M, Jung J, Kim D, Jung I, et al. Neuroprotective effects of INM-176 against lipopolysaccharide-induced neuronal injury. Pharmacol Biochem Behav. 2012;101:427-33 pubmed publisher
    ..These results suggest that the neuroprotective and cognition ameliorating effects of INM-176 against LPS-induced damage are mediated, in part, by its anti-inflammatory activities. ..
  48. Choi J, Yoo B, Shin C, Ryu M, Ryu J, El Kouni M, et al. Uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase. Neurosci Res. 2006;56:111-8 pubmed
    ..These results provide the first evidence that uridine protects immunostimulated astrocytes against the glucose deprivation-induced death by preserving intracellular ATP through the action of uridine phosphorylase. ..
  49. Cho E, An H, Shin J, Choi H, Ko J, Cho Y, et al. Roxatidine suppresses inflammatory responses via inhibition of NF-?B and p38 MAPK activation in LPS-induced RAW 264.7 macrophages. J Cell Biochem. 2011;112:3648-59 pubmed publisher
    ..Taken together, these results indicate that the anti-inflammatory properties of roxatidine in LPS-treated RAW 264.7 macrophages are mediated by the inhibition of NF-?B transcriptional activity and the p38 MAP kinase pathway. ..
  50. Lee J, Ha Y, Jeong C, Kim Y, Park Y. Isolation and tandem mass fragmentations of an anti-inflammatory compound from Aralia elata. Arch Pharm Res. 2009;32:831-40 pubmed publisher
    ..All observed tandem mass fragmentation spectra provided valuable elatoside F structural information when unknown samples from crude extracts are under screening by mass spectrometry. ..
  51. Nah S, Ha E, Mun S, Won H, Chung J. Effects of melittin on the production of matrix metalloproteinase-1 and -3 in rheumatoid arthritic fibroblast-like synoviocytes. J Pharmacol Sci. 2008;106:162-6 pubmed
    ..Taken together, these findings suggest that melittin may exert its anti-rheumatoid effects, at least in part, by inhibiting MMP3 production, most likely through inhibition of NF-kappaB activity. ..
  52. Oh Y, Youn J, Min H, Kim D, Lee S, Choi I, et al. CKD712, (S)-1-(?-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C. Int Immunopharmacol. 2011;11:1160-5 pubmed publisher
    ..Thus, we suggest that CKD712 could inhibit LPS- and LTA-stimulated HMGB1 secretion through the inhibition of HMGB1 phosphorylation by inhibiting PI3K-PKC signaling pathway. ..
  53. Chung E, Bok E, Chung Y, Baik H, Jin B. Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase. Brain Res. 2012;1451:110-6 pubmed publisher
    ..The present data suggest that cannabinoids may be beneficial for the treatment of neurodegenerative diseases, such as PD, that are associated with microglial activation. ..
  54. Hong S, Baik J, Kang S, Yun C, Seo D, Han S. Lipoteichoic acid of Streptococcus mutans interacts with Toll-like receptor 2 through the lipid moiety for induction of inflammatory mediators in murine macrophages. Mol Immunol. 2014;57:284-91 pubmed publisher
    ..In conclusion, our results suggest that the Sm.LTA interacts with TLR2 through the lipid moiety for the induction of inflammatory mediators in macrophages...
  55. Kim H, Kim J, Chung J, Kim Y, Kang S, Han K, et al. Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line. Blood Coagul Fibrinolysis. 2007;18:157-64 pubmed
    ..Regulation of the THP-1 thrombomodulin expression by lipopolysaccharide depends on the presence of serum. ..
  56. Park H, Jung H, Park E, Kim J, Lee W, Bae Y. Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol. 2004;173:3589-93 pubmed
    ..Taken together, these results indicate that direct interaction of TLR4 with Nox4 is involved in LPS-mediated ROS generation and NF-kappaB activation. ..
  57. Ma J, Hwang Y, Cho W, Han S, Hwang J, Han J. Macelignan attenuates activations of mitogen-activated protein kinases and nuclear factor kappa B induced by lipopolysaccharide in microglial cells. Biol Pharm Bull. 2009;32:1085-90 pubmed
    ..These results suggest that macelignan has an anti-inflammatory effect on the affected brain through regulation of the inflammation through the MAPK signal pathway. ..
  58. Lee T, Rhim T, Kim S. Prothrombin kringle-2 domain has a growth inhibitory activity against basic fibroblast growth factor-stimulated capillary endothelial cells. J Biol Chem. 1998;273:28805-12 pubmed
    ..As in angiostatin, the recombinant rabbit prothrombin kringle-2 domain also inhibited angiogenesis in the chorioallantoic membrane of chick embryos. ..
  59. Kim N, Ryu J. Butanolides from Machilus thunbergii and their inhibitory activity on nitric oxide synthesis in activated macrophages. Phytother Res. 2003;17:372-5 pubmed
    ..36, 3.70 and 6.19 micro m, respectively. These new inhibitors of iNOS may have potential in the treatment of endotoxaemia and inflammation accompanied by the overproduction of NO. ..
  60. Choi R, Shin E, Jung H, Choi J, Kim Y. Inhibitory effects of kaurenoic acid from Aralia continentalis on LPS-induced inflammatory response in RAW264.7 macrophages. Phytomedicine. 2011;18:677-82 pubmed publisher
    ..continentalis shows anti-inflammatory activity and the inhibition of iNOS and COX-2 expression might be one of the mechanisms responsible for its anti-inflammatory properties. ..
  61. Kim E, Hong H, Cho D, Han J, Kim S, Kim T. Enhancement of toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells. Immunology. 2011;134:73-81 pubmed publisher
    ..Collectively, these results demonstrate that the AIMP1 protein enhances TLR2-mediated immune responses via the up-regulation of TLR2 expression. ..
  62. Kang J, Choi S, Cho M, Kim H, Kim J, Lim J, et al. A proinflammatory cytokine interleukin-32beta promotes the production of an anti-inflammatory cytokine interleukin-10. Immunology. 2009;128:e532-40 pubmed publisher
    ..Taken together, our results suggest that IL-32beta upregulates the production of an anti-inflammatory cytokine IL-10, and then IL-10 suppresses proinflammatory cytokines. ..
  63. Lee D, Yang S, Kim H, Joo K, Lim C, Chae D, et al. Recombinant uteroglobin prevents the experimental crescentic glomerulonephritis. Kidney Int. 2004;66:1061-7 pubmed
    ..This study demonstrates the preventive effects of recombinant uteroglobin in an experimental model of crescentic glomerulonephritis, and suggests the therapeutic implications of uteroglobin for human chronic glomerulonephritis. ..
  64. Jeong Y, Hong S, Kim J, Jin D, Kang J, Lee W, et al. Vitamin C-treated murine bone marrow-derived dendritic cells preferentially drive naïve T cells into Th1 cells by increased IL-12 secretions. Cell Immunol. 2011;266:192-9 pubmed publisher
    ..These data provide us a new insight on the role of vitamin C in modulating immune responses. ..
  65. Lee H, Lim H, Lee D, Jung H, Kim M, Moon D, et al. Carabrol suppresses LPS-induced nitric oxide synthase expression by inactivation of p38 and JNK via inhibition of I-kappaBalpha degradation in RAW 264.7 cells. Biochem Biophys Res Commun. 2010;391:1400-4 pubmed publisher
    ..Taken together, these results suggest that carabrol can be a modulator of pro-inflammatory signal transduction pathway in RAW 264.7 cells. ..
  66. Choi I, Lee J, Ju C, Hwang S, Cho G, Lee H, et al. A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats. Am J Pathol. 2011;179:2042-52 pubmed publisher
    ..The present findings indicate that postischemic activation of A3AR and the resultant reduction of inflammatory response should provide a promising therapeutic strategy for the treatment of ischemic stroke. ..
  67. Yeom J, Lee Y, Park W. Effects of non-ionic solute stresses on biofilm formation and lipopolysaccharide production in Escherichia coli O157:H7. Res Microbiol. 2012;163:258-67 pubmed publisher
    ..coli O157:H7. Our data suggest that sucrose and PEG resulted in biofilm formation of E. coli O157:H7, not as a result of oxidative stress and EPS production, but via increases in membrane rigidity and LPS production. ..
  68. Jin C, Park H, So Y, Nam B, Han S, Kim J. Comparison of the Anti-Inflammatory Activities of Supercritical Carbon Dioxide versus Ethanol Extracts from Leaves of Perilla frutescens Britt. Radiation Mutant. Molecules. 2017;22: pubmed publisher
    ..Taken together, supercritical carbon dioxide extraction is considered the optimal process for obtaining high IK content and anti-inflammatory activities in leaf extracts from the P. frutescens Britt. radiation mutant. ..
  69. Kim J, Lee H, Lee M, Kim J, Jin C, Ryu J. Luteolin inhibits LPS-stimulated inducible nitric oxide synthase expression in BV-2 microglial cells. Planta Med. 2006;72:65-8 pubmed
    ..Luteolin may have beneficial effects in the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression. ..
  70. Lee Y, Han J, Byun J, Park H, Park E, Chong Y, et al. Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-?B activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury. J Leukoc Biol. 2012;91:921-32 pubmed publisher
    ..These results indicate that Mer plays as an intrinsic feedback inhibitor of the TLR4- and inflammatory mediator-driven immune responses during acute lung injury. ..
  71. Ryu J, Yoo J, Kim M, Hwang S, Ahn K, Ryu J, et al. Distinct TLR-mediated pathways regulate house dust mite-induced allergic disease in the upper and lower airways. J Allergy Clin Immunol. 2013;131:549-61 pubmed publisher
  72. Kim H, Yeom S, Kim M, Shim J, Paek I, Lee M. Nitric oxide and prostaglandin E2 synthesis inhibitory activities of diarylheptanoids from the barks of Alnus japonica steudel. Arch Pharm Res. 2005;28:177-9 pubmed
  73. Park H, Park O, Shin J. Receptor activator of NF-kappaB ligand enhances the activity of macrophages as antigen presenting cells. Exp Mol Med. 2005;37:524-32 pubmed
    ..Collectively, RANKL augmented the activity of macrophages especially as antigen presenting cells, suggesting its new role in immune regulation. ..
  74. Jang M, Son Y, Kim G, Lee Y, Lee W, Cha S, et al. Synergistic production of interleukin-23 by dendritic cells derived from cord blood in response to costimulation with LPS and IL-12. J Leukoc Biol. 2009;86:691-9 pubmed publisher
    ..Taken together, CBDCs, costimulated with LPS and IL-12, show a synergistic increase in IL-23 production via enhanced phosphorylation of ERK1/2 and p38 MAPK and consequently, an induction of IFN-gamma production in the memory cells. ..
  75. Han J, Kim M, Lee M, Kim T, Lee M, Kim H, et al. Modulation of human beta-defensin-2 expression by 17beta-estradiol and progesterone in vaginal epithelial cells. Cytokine. 2010;49:209-14 pubmed publisher
  76. Woo K, Suh W, Subedi L, Kim S, Kim A, Lee K. Bioactive lignan derivatives from the stems of Firmiana simplex. Bioorg Med Chem Lett. 2016;26:730-733 pubmed publisher
    ..05 and 0.929 μM, respectively) without cell toxicity in murine microglia BV-2 cells. Compounds 11-13 and 17 also exhibited strong inhibitory effects on NO production, with IC50 values ranging from 7.07 to 15.28 μM. ..
  77. An H, Jeong H, Um J, Park Y, Park R, Kim E, et al. Fructus Ligustrum lucidi inhibits inflammatory mediator release through inhibition of nuclear factor-kappaB in mouse peritoneal macrophages. J Pharm Pharmacol. 2007;59:1279-85 pubmed
    ..Our study suggested that FLL reduced inflammation via an important molecular mechanism, which might explain its beneficial effect in the regulation of inflammatory reactions...
  78. Chung H, Kang H, Bae E, Lee I, Kim S, Lee M. Effects of E. Coli lipopolysaccharide on the pharmacokinetics of ipriflavone and its metabolites, M1 and M5, after intravenous and oral administration of ipriflavone to rats: decreased metabolism of ipriflavone due to decreased expression of hepatic . J Pharm Sci. 2008;97:5024-36 pubmed publisher
    ..This could have also been due to a significantly decreased expression of hepatic CYP1A2 and 2C11 in ECLPS rats. The formation of M1 and M5 could be mediated via CYP1A2 and/or 2C11 in rats. ..
  79. Lee B, Lee T, Jung J, Oh D, Choi J, Shin J, et al. The role of keratinocyte-derived chemokine in hemorrhage-induced acute lung injury in mice. J Korean Med Sci. 2009;24:775-81 pubmed publisher
    ..6 pg/mL/mg by ELISA) (P<0.05). By immunohistochemical staining, lung neutrophils stained positive for KC. Increased KC was also observed in bronchoalveolar lavage fluid and plasma. KC plays an important role in hemorrhage-induced ALI. ..
  80. Yoon J, Jeong E, Yang H, Kim S, Sung S, Kim Y. Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells. J Enzyme Inhib Med Chem. 2012;27:490-4 pubmed publisher
    ..The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production...
  81. Lee S, Chung J, Choi S, Auh Q, Lee Y, Lee S, et al. Sodium hydrogen sulfide inhibits nicotine and lipopolysaccharide-induced osteoclastic differentiation and reversed osteoblastic differentiation in human periodontal ligament cells. J Cell Biochem. 2013;114:1183-93 pubmed publisher
  82. Kang C, Kim W. The effect of vasopressin on organ blood flow in an endotoxin-induced rabbit shock model. J Invest Surg. 2006;19:361-9 pubmed
    ..Vasopressin increased renal blood flow and decreased hepatic arterial blood flow in this endotoxin-induced shock model, whereas norepinephrine did not. However, coronary blood flow was not changed by shock status or vasopressor type...
  83. Chung H, Kang M, Cho C, Parvez S, Park C, Kim D, et al. Inhibition of nitric oxide and tumor necrosis factor-alpha by moutan cortex in activated mouse peritoneal macrophages. Biol Pharm Bull. 2007;30:912-6 pubmed
    ..5 mg/ml. These findings demonstrate that the inhibition of the LPS/rIFN-gamma-induced production of NO and TNF-alpha by MC is due to the inhibition of NF-kappaB activation. ..
  84. Jung C, Jung H, Shin Y, Park J, Jun C, Kim H, et al. Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage. J Ethnopharmacol. 2007;113:183-7 pubmed
    ..In using the standard inhibitors (MAPKs and Akt), our results show that Eleutherococcus senticosus downregulates inflammatory iNOS expression by blocking JNK and Akt activation. ..
  85. Sung Y, Chang H, Kim S, Kim Y, Seo J, Shin M, et al. Anti-inflammatory and analgesic effects of the aqueous extract of corni fructus in murine RAW 264.7 macrophage cells. J Med Food. 2009;12:788-95 pubmed publisher
    ..The aqueous extract of corni fructus exerts anti-inflammatory and analgesic effects by suppressing COX-2 and iNOS expression through the down-regulation of NF-kappaB binding activity. ..
  86. Kim S, Kim M, Lee B, Park D, Hong S, Um J. Anti-Inflammatory activity of chrysophanol through the suppression of NF-kappaB/caspase-1 activation in vitro and in vivo. Molecules. 2010;15:6436-51 pubmed publisher
    ..These results provide novel insights into the pharmacological actions of chrysophanol as a potential molecule for use in the treatment of inflammatory diseases. ..
  87. Kim S, Ko I, Park C, Shin M, Kim C, Jee Y. Treadmill and wheel exercise alleviate lipopolysaccharide-induced short-term memory impairment by enhancing neuronal maturation in rats. Mol Med Rep. 2013;7:31-6 pubmed publisher
    ..From these results, it can be inferred that forced treadmill exercise and voluntary wheel exercise may improve memory function deteriorated by brain inflammation. ..
  88. Kim S, Oh O, Min H, Park E, Kim Y, Park H, et al. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci. 2003;73:337-48 pubmed
    ..This result suggests that eugenol might be a plausible lead candidate for further developing the COX-2 inhibitor as an anti-inflammatory or cancer chemopreventive agent. ..
  89. Park K, Chung K, Kim Y, Lee J, Joh T, Kim S. Transglutaminase 2 induces nitric oxide synthesis in BV-2 microglia. Biochem Biophys Res Commun. 2004;323:1055-62 pubmed
    ..Secretion of NO was reduced between 40 and 80% by TGase inhibition in a dose-dependent manner. This suggests that TGase 2 appears to control iNOS transcription. ..
  90. Kang J, Lee H, Kim H, Lee H, Castranova V, Lim C, et al. Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappaB, and serine and tyrosine phosphorylation of IkappaB-alpha in lipopolysaccharide-stimulated raw 264.7 macrophages. J Toxicol Environ Health A. 2005;68:1643-62 pubmed
  91. Cho I, Kim S. A novel mitogen-activated protein kinase phosphatase-1 and glucocorticoid receptor (GR) interacting protein-1-dependent combinatorial mechanism of gene transrepression by GR. Mol Endocrinol. 2009;23:86-99 pubmed publisher
  92. Lim S, Jeong J, Woo K, Han M, Kim D. Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression. Nutr Res. 2016;36:337-348 pubmed publisher
    ..We report that L sakei OK67 ameliorates HFD-induced hyperglycemia and obesity by reducing inflammation and increasing the expression of colon tight junction proteins in mice. ..