Experts and Doctors on hepatocytes in Daejeon, South Korea


Locale: Daejeon, South Korea
Topic: hepatocytes

Top Publications

  1. Kim H, Kim J, Choi Y, Chun H, Im I, Han Y, et al. Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells. Sci Rep. 2016;6:21684 pubmed publisher
    ..Our results indicate that hPSC-HLCs can be used to screen toxic substances related to AHR signaling and to identify potential AHR-targeted therapeutics. ..
  2. Kim S, Kim J, Kim H, Ahn J. Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression. IUBMB Life. 2005;57:651-8 pubmed
    ..In addition, it also turned out that the mRNA levels of FasL are higher than those of Fas in HepG2-X. Taken together, HBx sensitizes the apoptosis of UV-irradiated liver cells by transcriptional transactivation of FasL gene. ..
  3. Zhang W, Lee J, Kim I, Kim Y, Myung C. Stimulation of glucose uptake and improvement of insulin resistance by aromadendrin. Pharmacology. 2011;88:266-74 pubmed publisher
    ..These findings suggest that aromadendrin may represent a potential therapeutic candidate for the management of type 2 DM. ..
  4. Hong J, Song S, Shin J. A novel microfluidic co-culture system for investigation of bacterial cancer targeting. Lab Chip. 2013;13:3033-40 pubmed publisher
    ..We also demonstrate that alpha-fetoprotein (AFP) is one of the key chemo-attractants for S. typhimurium in targeting liver cancer. ..
  5. Song I, Jun S, Na H, Kim H, Jung S, Ha G, et al. Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Gastroenterology. 2012;143:1341-1351 pubmed publisher
    ..TIPRL prevents prolonged activation of MKK7 and JNK and TRAIL-induced apoptosis by mediating the interaction between MKK7 and PP2Ac. ..
  6. Kim D, Ryu J, Son M, Oh J, Chung K, Lee S, et al. A liver-specific gene expression panel predicts the differentiation status of in vitro hepatocyte models. Hepatology. 2017;66:1662-1674 pubmed publisher
    ..Moreover, three-dimensional cultured HepaRG cells and human pluripotent stem cell-derived hepatocyte-like cells showed liver similarity scores of 59.14% and 32%, respectively, although general liver-specific markers were detected...
  7. Yao L, Chen W, Song K, Han C, Gandhi C, Lim K, et al. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury. PLoS ONE. 2017;12:e0176106 pubmed publisher
    ..Therefore, induction of 15-PGDH expression or utilization of 15-keto-PGE2 analogue may have therapeutic benefits for the treatment of endotoxin-associated liver inflammation/injury. ..
  8. Chang S, Sung P, Lee J, Park J, Shin E, Choi C. Prolonged silencing of diacylglycerol acyltransferase-1 induces a dedifferentiated phenotype in human liver cells. J Cell Mol Med. 2016;20:38-47 pubmed publisher
    ..Microarray data analysis and immunostaining of patient tissue samples clearly showed decreased expression levels of DGAT1 and integrin β1 in patients who have nodular cirrhosis without fatty degeneration. ..
  9. Lee S, So J, Kim H, Choi J, Lee M, Choi S, et al. Angiopoietin-like 3 regulates hepatocyte proliferation and lipid metabolism in zebrafish. Biochem Biophys Res Commun. 2014;446:1237-42 pubmed publisher
    ..Together, our findings propose a novel role for Angptl3 in liver cell proliferation and maintenance during zebrafish embryogenesis. Finally, angptl3 morphants will serve as a good model for understanding the pathophysiology of FHBL2. ..

More Information


  1. Kim D, Jeong J, Lee J, Kim K, Park S, Kim Y, et al. Inverse agonist of estrogen-related receptor ? controls Salmonella typhimurium infection by modulating host iron homeostasis. Nat Med. 2014;20:419-24 pubmed publisher
    ..typhimurium infection, thereby improving host survival. Taken together, these findings suggest an alternative approach to control multidrug-resistant intracellular bacteria by modulating host iron homeostasis. ..
  2. Tung N, Ra J, Sohn D, Kim Y. A new diarylheptanoid from the bark of Alnus japonica. J Asian Nat Prod Res. 2010;12:921-4 pubmed publisher
    ..Their structures were elucidated on the basis of extensive spectroscopic evidence. The new compound 1 showed significant hepatoprotective activity on the basis of t-butylhydroperoxide-induced hepatocyte injury in vitro assay. ..
  3. Kim G, Jang H. Flavonol content in the water extract of the mulberry (Morus alba L.) leaf and their antioxidant capacities. J Food Sci. 2011;76:C869-73 pubmed publisher
  4. Hwang Y, Kim H, Choi J, Do M, Chung Y, Jeong T, et al. S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. J Nutr Biochem. 2013;24:1469-78 pubmed publisher
    ..Our results demonstrate that SAC activates AMPK through CaMKK and inhibits SREBP-1-mediated hepatic lipogenesis. Therefore, SAC has therapeutic potential for preventing nonalcoholic fatty liver disease. ..
  5. Lee J, Joung H, Kim M, Park C. Graphene-based chemiluminescence resonance energy transfer for homogeneous immunoassay. ACS Nano. 2012;6:2978-83 pubmed publisher
    ..The graphene-based CRET platform was successfully applied to the detection of CRP in human serum samples in the range observed during acute inflammatory stress. ..
  6. Hwang Y, Choi J, Han E, Kim H, Wee J, Jung K, et al. Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate-activated protein kinase in human HepG2 cells and obese mice. Nutr Res. 2011;31:896-906 pubmed publisher
    ..The beneficial effects of AF on HFD-induced hepatic lipid accumulation are thus mediated through AMPK signaling pathways, suggesting a potential target for the prevention of obesity. ..
  7. Yeon J, Na D, Park J. Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device. Electrophoresis. 2010;31:3167-74 pubmed publisher
    ..This novel assay system enabled us to analyze in vivo-like hepatotoxicity in a microfluidic device by exploiting microstructures to mimic the microenvironment of the liver. ..
  8. Noh J, Gang G, Kim Y, Yang K, Hwang J, Lee H, et al. Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice. Food Chem Toxicol. 2010;48:3177-83 pubmed publisher
    ..The CISE might be useful for the prevention of oxidative damage in liver cells and tissues...
  9. Kang S, Yi H, Choi M, Ryu M, Jung S, Chung H, et al. ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21. J Endocrinol. 2017;233:105-118 pubmed publisher
    ..In conclusion, mitochondrial OXPHOS function governs the expression of ANGPTL6, which is an essential factor for FGF21 production in adipose tissue and cultured adipocytes. ..
  10. Lee J, Felipe P, Yang Y, Kim M, Kwon O, Sok D, et al. Effects of dietary supplementation with red-pigmented leafy lettuce (Lactuca sativa) on lipid profiles and antioxidant status in C57BL/6J mice fed a high-fat high-cholesterol diet. Br J Nutr. 2009;101:1246-54 pubmed publisher
  11. An S, Jang Y, Park J, Kwon B, Paik Y, Jeong T. Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes. Exp Mol Med. 2008;40:407-17 pubmed