Experts and Doctors on down regulation in Seoul, South Korea


Locale: Seoul, South Korea
Topic: down regulation

Top Publications

  1. Jeong J, Choi J, Jeon K, Jue D. Chloroquine decreases cell-surface expression of tumour necrosis factor receptors in human histiocytic U-937 cells. Immunology. 2002;105:83-91 pubmed
    ..Our results suggest that chloroquine down-regulates cell surface TNF receptors by retarding their transport to the cell surface, while cleavage of cell surface receptors is not inhibited by chloroquine. ..
  2. Seo B, Yoo C, Park H, Choi J, Seo K, Choi S, et al. Saucernetin-8 isolated from Saururus chinensis induced the differentiation of human acute promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 2004;27:1594-8 pubmed
    ..Taken together, our results suggest that saucernetin-8 may have potential as a therapeutic agent in human leukemia...
  3. Lee K, Im J, Song J, Lee S, Lee H, Ha H, et al. Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein. Neurobiol Dis. 2006;22:10-24 pubmed
    ..These results suggest that increased betaCTF99 expression is highly detrimental to the aging brain and that it produces a progressive and age-dependent AD-like pathogenesis. ..
  4. Lee S, Chu K, Park J, Kang L, Ko S, Jung K, et al. Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease. Brain Res. 2006;1118:199-207 pubmed
    ..Subsequently, memantine was found to have neuroprotective effects and save striatal cells with decreasing calpain levels in the 3NP model of Huntington's disease. ..
  5. Oh H, Lee E, Yoon S, Chung B, Cho K, Hong S. Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction. Prostate. 2007;67:1061-9 pubmed
    ..HPCD inhibited both EGFR/Akt and EGFR/ERK signal transduction. Lipid raft cholesterol regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK pathways. ..
  6. Han K, Yang D, Chang E, Lee Y, Huang H, Sung S, et al. Inhibition of osteoclast differentiation and bone resorption by sauchinone. Biochem Pharmacol. 2007;74:911-23 pubmed
    ..Also the in vivo effect of sauchinone on bone erosion strengthens the potential usefulness of this compound for diseases involving bone resorption. ..
  7. Lee E, Jo M, Rho S, Park K, Yoo Y, Park J, et al. Dkk3, downregulated in cervical cancer, functions as a negative regulator of beta-catenin. Int J Cancer. 2009;124:287-97 pubmed publisher
    ..We conclude from our finding that Dkk3 is a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway. ..
  8. Yi J, Kwon H, Cho J, Lee Y. Estrogen and hypoxia regulate estrogen receptor alpha in a synergistic manner. Biochem Biophys Res Commun. 2009;378:842-6 pubmed publisher
    ..These results provide evidence that hypoxia may stimulate yet unknown factor(s), which can further stimulate ERalpha signal transduction pathways. ..
  9. Kang G, Lee E, Kim J, Jung J, Lim J, Kim S, et al. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur J Pharmacol. 2009;611:17-21 pubmed publisher
    ..Taken together, these findings indicate that kaempferol-induced apoptosis by initiation of intrinsic caspase cascade and downregulation of PLK-1 expression. ..

More Information

Publications176 found, 100 shown here

  1. Bae H, Eun J, Noh J, Kim J, Jung K, Xie H, et al. Down-regulation of transforming growth factor beta receptor type III in hepatocellular carcinoma is not directly associated with genetic alterations or loss of heterozygosity. Oncol Rep. 2009;22:475-80 pubmed
    ..To clarify the role of TGFbetaRIII in hepatocellular tumor development and progression, functional analysis is needed in future studies. ..
  2. Won J, Shin J, Park H, Jung H, Koh D, Jo B, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010;76:251-7 pubmed publisher
    ..These results suggest that the anti-inflammatory properties of madecassic acid are caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. ..
  3. Kim J, Kim H, Lee S, Park J. The expression of GLTSCR2, a candidate tumor suppressor, is reduced in seborrheic keratosis compared to normal skin. Pathol Res Pract. 2010;206:295-9 pubmed publisher
    ..Our results show a down-regulation of this protein in SK, indicating that GLTSCR2 may have a protective effect on the development of SK. ..
  4. Min J, Lim S, Jung G. Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter. FEBS Lett. 2010;584:2427-32 pubmed publisher
    ..From these data, we suggest that ROS may downregulate catalase through the methylation of promoter during the development of HCC. ..
  5. Shin K, Park J, Kwon H, Chung C, Kang M. Opposite effect of intracellular Ca2+ and protein kinase C on the expression of inwardly rectifying K+ channel 1 in mouse skeletal muscle. J Biol Chem. 1997;272:21227-32 pubmed
    ..Based on these observations, we conclude that intracellular calcium and protein kinase C are oppositely involved in the muscle activity-dependent regulation of IRK1 gene expression and that both act at the level of mRNA stability. ..
  6. Kwon H, Lee D, Lee J, Edenberg H, Ahn Y, Hur M. Posttranscriptional regulation of human ADH5/FDH and Myf6 gene expression by upstream AUG codons. Arch Biochem Biophys. 2001;386:163-71 pubmed
    ..This structure reduced expression; removing two of these AUGs led to a doubling of activity in CV-1, HeLa, and NIH/3T3 cells. ..
  7. Lim J, Lee J, Wee W, Joo C. Downregulated expression of ADAM9 in anterior polar cataracts. J Cataract Refract Surg. 2002;28:697-702 pubmed
    ..The functions of this protein in lens pathology require further investigation. ..
  8. Rho S, Chung H, Kang M, Lee E, Cho C, Kim H, et al. Inhibition of production of reactive oxygen species and gene expression profile by treatment of ethanol extract of Moutan Cortex Radicis in oxidative stressed PC12 cells. Biol Pharm Bull. 2005;28:661-6 pubmed
    ..These findings suggest that MCR inhibits the production of ROS and cytotoxicity by oxidative-stressed PC12 cells through over-expression of HO and COMT. ..
  9. Park C, Hahm E, Lee J, Jung K, Rhee H, Yang C. Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. Carcinogenesis. 2005;26:1929-33 pubmed
  10. Gol Choe J, Kim Y, Kim K, Choo H, Shin J, Lee Y, et al. Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary DNA microarray. Nucl Med Commun. 2005;26:1155-62 pubmed
    ..The identification of changes in the patterns of gene expression may provide a better understanding of the response of molecular mechanisms to NIS gene transfection. ..
  11. Lee K, Choi Y, Kim J, Choi J, Sohn D, Lee C, et al. Down-regulation of the SWI/SNF chromatin remodeling activity by TCR signaling is required for proper thymocyte maturation. J Immunol. 2007;178:7088-96 pubmed
    ..Our results state, for the first time, that the chromatin remodeling activity needs to be finely controlled for proper thymocyte selection and maturation processes. ..
  12. Kim Y, Shin M, Lee J, Chung J, Lee M. Decreased expression of KAI1/CD82 metastasis suppressor gene is associated with loss of heterozygosity in melanoma cell lines. Oncol Rep. 2009;21:159-64 pubmed
    ..In conclusion, this study suggests that down-regulation of KAI1/CD82 mRNA expression in human melanoma cell lines is related to LOH or allelic imbalance, but not to methylation of the KAI1/CD82 gene region. ..
  13. Jin L, Choi J, Kim B, Cho H, Kim J, Kim Ha J, et al. Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation. Mol Cell Biol. 2009;29:1515-25 pubmed publisher
    ..Our observations reveal a novel connection between the Notch and Toll/IMD signaling pathways and demonstrate a coactivating role for Spen in activating Notch-dependent genes in differentiating cells. ..
  14. Kang S, Kim E, Moon A. Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009;21:1317-22 pubmed
  15. Cho W, Nam J, Kang H, Windono T, Seo E, Lee K. Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-kappaB pathway in LPS-stimulated murine macrophages. Int Immunopharmacol. 2009;9:1049-57 pubmed publisher
    ..These relations reveal, in part, the mechanism underlying the anti-inflammatory properties of zedoarondiol. ..
  16. Lee J, Lee M, Moon B, Shim S, Fornace A, Cha H. Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways. Stem Cells. 2009;27:1963-75 pubmed publisher
    ..Based on these results, we suggest that senescent growth arrest in hMSCs may result from activation of stress signaling pathways and consequent onset of stress responses, due in part to ROS production during prolonged in vitro culture. ..
  17. Jin Q, Shim W, Choi M, Tian G, Song I, Yang S, et al. Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp. Xenobiotica. 2009;39:711-21 pubmed publisher
  18. Cho E, Hwang J, Han S, Chung S, Koh J, Lee J. Endogenous zinc mediates apoptotic programmed cell death in the developing brain. Neurotox Res. 2010;17:156-66 pubmed publisher
    ..The present study demonstrates that intracellular zinc acts as a key mediator of developmental apoptosis and therefore provides the first in vivo evidence that endogenous labile zinc causes neuronal apoptosis. ..
  19. Jang H, Choi S, Cho E, Youn H. Cabin1 restrains p53 activity on chromatin. Nat Struct Mol Biol. 2009;16:910-5 pubmed publisher
    ..Thus, Cabin1 inhibits p53 function on chromatin in the quiescent state; the presence of inactive p53 on some promoters might allow a prompt response upon DNA damage. ..
  20. Kim J, Kim P, Jung K, Noh J, Eun J, Bae H, et al. Decreased expression of annexin A10 in gastric cancer and its overexpression in tumor cell growth suppression. Oncol Rep. 2010;24:607-12 pubmed
    ..In addition, ANXA10 may play a role, as a tumor suppressor, in the development and progression of gastric cancer. ..
  21. Shrotriya S, Kundu J, Na H, Surh Y. Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling. Cancer Res. 2010;70:1932-40 pubmed publisher
    ..Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis...
  22. Ko M, Ahn J, Lee C, Chung H, Jeon S, Chung H, et al. E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression. J Biol Chem. 2004;279:21916-23 pubmed
    ..Taken together, these results suggest that Id3 may enhance the viability of immature thymocytes by at least rendering them resistant to GCs through SRG3 down-regulation. ..
  23. Kim H, Yoon Y, Kim J, Han S, Hur H, Park J, et al. Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2. PLoS ONE. 2009;4:e5933 pubmed publisher
    ..These results demonstrate that lapatinib inhibits the nuclear translocation of EGFR and HER2 and downregulates TS, thus sensitizing cancer cells to fluoropyrimidine. ..
  24. Kang J, Bae S, Kim H, Kim Y, Kim D, Cho B, et al. Interleukin-18 increases metastasis and immune escape of stomach cancer via the downregulation of CD70 and maintenance of CD44. Carcinogenesis. 2009;30:1987-96 pubmed publisher
    ..Our data suggest that endogenous IL-18 might facilitate stomach cancer cell immune escape by suppressing CD70 and increasing metastatic ability by upregulating CD44 and VEGF. ..
  25. Ko M, Jang J, Ahn J, Lee K, Chung H, Jeon S, et al. T cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3 expression via Ras activation. J Biol Chem. 2004;279:21903-15 pubmed
    ..Taken together, these observations suggest that TCR signals result in GC desensitization in immature T cells by repressing SRG3 gene expression via Ras activation. ..
  26. Park H, Kim H, Lee J, Lee J, Cho B, Kang J, et al. Corticotropin-releasing hormone (CRH) downregulates interleukin-18 expression in human HaCaT keratinocytes by activation of p38 mitogen-activated protein kinase (MAPK) pathway. J Invest Dermatol. 2005;124:751-5 pubmed
    ..CRH also inhibited production of IL-18 in human primary keratinocytes. These results suggest that CRH regulates IL-18 production through the MAPK signaling pathway in human keratinocytes. ..
  27. Yoo E, Chung J, Choe S, Kim K, Kim J. Down-regulation of histone deacetylases stimulates adipocyte differentiation. J Biol Chem. 2006;281:6608-15 pubmed
    ..Together, these results suggest that the regulation of not only adipogenic transcription factors, but also chromatin-modifying enzymes is crucial for the execution of bona fide adipogenesis. ..
  28. Kang M, Kang N, Jang Y, Lee K, Lee H. Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2. Ann N Y Acad Sci. 2009;1171:514-20 pubmed publisher
    ..Collectively, these findings suggest that the combined effects of dietary phenolic phytochemicals on oxidative neuronal cell death and antioxidants differ in ROS-mediated neuronal cell death. ..
  29. Choi B, Kim C, Lim Y, Shin S, Lee Y. Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway. Cancer Lett. 2008;259:111-8 pubmed
    ..Thus, curcumin can contribute to the reversal of the MDR phenotype, probably due to the suppression of P-gp expression via the inhibition of the PI3K/Akt/NF-kappa B signaling pathway...
  30. Lim J, Kim K, Kim H. NF-kappaB p65 regulates nuclear translocation of Ku70 via degradation of heat shock cognate protein 70 in pancreatic acinar AR42J cells. Int J Biochem Cell Biol. 2008;40:2065-77 pubmed publisher
    ..The results suggest that the involvement of NF-kappaB p65 in nuclear translocation of Ku70 may be mediated by Hsc70 degradation, which may play a key role in cell proliferation of pancreatic acinar AR42J cells. ..
  31. Kang S, Lee E, Yoon H, Randazzo P, Lee S. PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1. J Biol Chem. 2010;285:26013-21 pubmed publisher
    ..These results demonstrate that PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells. ..
  32. Lee M, Kim E, Kwon H, Kim Y, Kang H, Kang H, et al. Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol Cell Endocrinol. 2002;188:47-54 pubmed
    ..These results suggest that radicicol disrupts the ER-Hsp90 heterodimeric complex, thereby generating ERalpha that is susceptible to ubiquitin/proteasome-induced degradation. ..
  33. Jeong S, Lee K, Shin D, Chung H, Jeon S, Seong R. Nitric oxide inhibits glucocorticoid-induced apoptosis of thymocytes by repressing the SRG3 expression. J Biol Chem. 2004;279:34373-9 pubmed
    ..These observations strongly suggest that NO may be involved in protecting immature thymocytes from GC-induced apoptosis by repressing the SRG3 expression in thymus. ..
  34. Cho D, Choi Y, Jo S, Nam J, Jung S, Jo I. Retinoic acid decreases nitric oxide production in endothelial cells: a role of phosphorylation of endothelial nitric oxide synthase at Ser(1179). Biochem Biophys Res Commun. 2005;326:703-10 pubmed
    ..Thus, atRA decreases eNOS-Ser(1179) phosphorylation through a mechanism that depends on VEGF-KDR/Flk-1-mediated Akt phosphorylation but is independent of RARE, leading to reduction in NO production. ..
  35. Kang S, Chang W, Cho S, Kim I. Modification of promyelocytic leukemia zinc finger protein (PLZF) by SUMO-1 conjugation regulates its transcriptional repressor activity. J Biol Chem. 2003;278:51479-83 pubmed
    ..These results demonstrate that PLZF is modified by SUMO-1 conjugation and that this modification regulates the biological functions of PLZF. ..
  36. Bae M, Jeong J, Kim S, Kim S, Kang H, Kim D, et al. Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha. Cancer Res. 2005;65:2520-5 pubmed
    ..These findings propose that Tid-1(L) may play a critical role in pVHL-mediated tumor suppression by modulating the pVHL-dependent HIF-1alpha stability. ..
  37. Jeon Y, Park C, Kim K, Li Y, Kim J, Kim Y, et al. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation. J Pathol. 2007;213:170-9 pubmed
  38. Hong J, Kim E, Ahn K, Jung K, Yun Y, Park Y, et al. Inhibitory effect of glycolic acid on ultraviolet-induced skin tumorigenesis in SKH-1 hairless mice and its mechanism of action. Mol Carcinog. 2001;31:152-60 pubmed
    ..In addition, the inhibition of activation of transcription factors AP-1 and NF-kappaB could contribute significantly to the inhibitory effect of glycolic acid. ..
  39. Choi K, Kim S, Ha J, Kim S, Son J. A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem. 2010;112:366-76 pubmed publisher
    ..Our findings present evidence for the presence of a novel class of molecule involved in autophagic cell death triggered by OS in dopamine neurons. ..
  40. Kim J, Kim B, Cai L, Choi H, Ohgi K, Tran C, et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature. 2005;434:921-6 pubmed
  41. Son S, Yu E, Ahn Y, Choi E, Lee H, Choi J. Retinoic acid attenuates promyelocytic leukemia protein-induced cell death in breast cancer cells by activation of the ubiquitin-proteasome pathway. Cancer Lett. 2007;247:213-23 pubmed
  42. Jung J, Lee J, Kim J, Lee S, You G, Park S, et al. Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. J Cell Physiol. 2010;223:408-14 pubmed publisher
    ..Together, these results suggest that quercetin may have anti-tumor effects on HeLa cells via AMPK-induced HSP70 and down-regulation of EGFR. ..
  43. Son Y, Kwak C, Lee Y, Yang D, Park B, Lee W, et al. Ginsenoside Re enhances survival of human CD4+ T cells through regulation of autophagy. Int Immunopharmacol. 2010;10:626-31 pubmed publisher
    ..Our results demonstrate that ginsenoside Re enhanced viability of CD4(+) T cells through the regulation of IFN-gamma-dependent autophagy activity. ..
  44. Choi Y, Jeon S, Jang J, Han S, Kim J, Chung H, et al. Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression. Proc Natl Acad Sci U S A. 2001;98:10267-72 pubmed
    ..Expression of transgenic SRG3 resulted in the restoration of GC sensitivity in thymocytes expressing transgenic Notch1. These results suggest that SRG3 is the downstream target of Notch1 in regulating GC sensitivity of thymocytes. ..
  45. Kim H, Kim J, Chung J, Kim Y, Kang S, Han K, et al. Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line. Blood Coagul Fibrinolysis. 2007;18:157-64 pubmed
    ..Regulation of the THP-1 thrombomodulin expression by lipopolysaccharide depends on the presence of serum. ..
  46. Lee M, Choi B, Kundu J, Shin Y, Na H, Surh Y. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009;69:7449-58 pubmed publisher
    ..Taken together, eEF1A2 may be considered as a potential molecular target for the antiproliferative effects of resveratrol in PA-1 ovarian cancer cells. ..
  47. Kim H, Kim H, Lee C, Chung D. T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production. J Immunol. 2010;184:4095-106 pubmed publisher
    ..Thus, as a differential regulator of the immune response, TIM1 on NKT cells may be a useful therapeutic target for immune diseases. ..
  48. Lee Y, Ryu J, Chang H, Sohn J, Lee K, Woo C, et al. In vivo MR evaluation of the effect of the CCR2 antagonist on macrophage migration. Magn Reson Med. 2010;64:72-9 pubmed publisher
    ..MRI successfully demonstrated the effect of the CCR2 antagonist on the directional migration of macrophages. ..
  49. Kim J, Hong J, Pih K, Hwang I. Identification and isolation of differentially expressed genes in osmotically stressed human oral keratinocytes. Arch Oral Biol. 2001;46:335-41 pubmed
  50. Kim W, Lee J, Suh Y, Lee H, Lee S, Oh Y, et al. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cell Signal. 2007;19:791-805 pubmed
    ..Collectively, these data demonstrate that AMPK activation potentiates beta-cell apoptosis induced by chronic high glucose through augmented GCK downregulation mediated by enhanced ROS production. ..
  51. Kim S, Moon S, Kim Y, Kim J, Ryu H, Kim Y, et al. TNFR1 promoter -329G/T polymorphism results in allele-specific repression of TNFR1 expression. Biochem Biophys Res Commun. 2008;368:395-401 pubmed publisher
    ..Furthermore, in the polymorphic TNFR1 -329G/T site, the T allele resulted in the repression of TNFR1 expression. Therefore, our results suggest that TNFR1 -329G/T polymorphism may play an important role in the development of HCC. ..
  52. Kim K, Kim Y, Koh B, Hwang S, Kim S, Lepine F, et al. HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-kappaB pathway. Immunology. 2010;129:578-88 pubmed publisher
    ..Our results suggest that HHQ and PQS produced by P. aeruginosa actively suppress host innate immune responses. ..
  53. Park J, Lee J, Sato T, Koh J. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat. J Neurosci. 2000;20:9096-103 pubmed
    ..Our results suggest that co-induction of p75(NTR) and NADE plays a role in zinc-triggered neuronal death in vitro and in vivo. ..
  54. Chung Y, Kim S, Joo K, Kim Y, Lee W, Yun K, et al. Age-related changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats. Brain Res. 2004;1018:141-6 pubmed
  55. Jun H, Park T, Lee C, Kang M, Park M, Kang H, et al. Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2. Food Chem Toxicol. 2007;45:708-15 pubmed
    ..In contrast, there were no alterations in the levels of Bax in capsaicin-treated cells. Collectively, these findings indicate that capsaicin-induces apoptosis of B16-F10 melanoma cells via down-regulation the Bcl-2. ..
  56. Kim H, Kim J, Chung J, Han K, Cho H. Surface expression of neutrophil CXCR4 is down-modulated by bacterial endotoxin. Int J Hematol. 2007;85:390-6 pubmed
  57. Sim S, Yeom J, Shin C, Song W, Shin E, Kim H, et al. Escherichia coli ribonuclease III activity is downregulated by osmotic stress: consequences for the degradation of bdm mRNA in biofilm formation. Mol Microbiol. 2010;75:413-25 pubmed publisher
    ..These findings indicate that the Rcs signalling system has an additional regulatory pathway that functions to modulate bdm expression and consequently, adapt E. coli cells to osmotic stress. ..
  58. Choi J, Choi J, Kang C, Chen X, Wu C, Ko K, et al. Hydrogen peroxide induces the death of astrocytes through the down-regulation of the constitutive nuclear factor-kappaB activity. Free Radic Res. 2007;41:555-62 pubmed
    ..These results indicate that the constitutive activity of NF-kappaB in astrocytes is required for their survival under oxidative stress such as H(2)O(2). ..
  59. Jun H, Kim Y, Kwon Y, Hong S, Kim K, Shin J, et al. Wondonin, a novel compound, inhibits hypoxia-induced angiogenesis through hypoxia-inducible factor 1 alpha. FEBS Lett. 2007;581:4977-82 pubmed
    ..Taken together, these results suggested that wondonin had the potential to become the anti-angiogenic therapeutic agent to target HIF-1alpha. ..
  60. Nam H, Hahn H, Nam K, Choi W, Jeong Y, Kim D, et al. Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery. Int J Pharm. 2008;363:199-205 pubmed publisher
    ..These results suggest that biodegradable and non-toxic e-PAM-R may be useful carriers for the gene including plasmid DNA, antisense ODNs and si-RNA. ..
  61. Youn J, Lee J, Na H, Kundu J, Surh Y. Resveratrol and piceatannol inhibit iNOS expression and NF-kappaB activation in dextran sulfate sodium-induced mouse colitis. Nutr Cancer. 2009;61:847-54 pubmed publisher
    ..Oral administration of resveratrol or piceatannol (10 mg/kg body weight each) for 7 constitutive days attenuated the DSS-induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappaB, STAT3, and ERK. ..
  62. Byun D, Cho K, Ryu B, Lee M, Kang M, Kim H, et al. Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. Cancer Res. 2003;63:7068-75 pubmed
    ..Collectively, our study suggests that epigenetic silencing of XAF1 by aberrant promoter methylation may contribute to the malignant progression of human gastric tumors. ..
  63. Jahng J, Lee J, Kim G, Kim Y, Houpt T, Kim D. Adrenalectomy abolishes fasting-induced down-regulation of NADPH-diaphorase in the rat paraventricular nucleus. Yonsei Med J. 2004;45:123-8 pubmed
    ..The effect of ADX or dexamethasone was limited to the parvocellular subdivision of PVN. These results suggest that the adrenal glucocorticoids may down-regulate nNOS expression in the PVN during food deprivation. ..
  64. Kim J, Song P, Jeong M, An J, Lee S, Jang S, et al. TIP60 represses transcriptional activity of p73beta via an MDM2-bridged ternary complex. J Biol Chem. 2008;283:20077-86 pubmed publisher
    ..It is important to note that our findings contribute to a functional linkage between TIP60 and p73beta through MDM2 in the transcriptional regulation of cellular apoptosis. ..
  65. Choi K, Jung M, Lee Y, Yoon J, Kwon S, Kang H, et al. Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res. 2009;69:583-92 pubmed publisher
    ..These results show the crucial role of acetylation in the development of inflammatory-related diseases. ..
  66. Oh Y, Kwon Y, Kim J, Bae S, Lee B, Yoo S, et al. Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nat Cell Biol. 2009;11:295-302 pubmed publisher
    ..Coincident with these changes, cells arrest in the G1 phase of the cell cycle and become less invasive. Collectively, our data suggest that Chfr functions as a tumour suppressor by regulating HDAC1. ..
  67. Yoon S, Lee Y, Kim H, Lee Z, Hyung S, Lee S, et al. Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling. FEBS Lett. 2009;583:1164-70 pubmed publisher
    ..Our study provides the first evidence of the involvement of Lyn in the negative regulation of osteoclastogenesis by RANKL. ..
  68. Jung S, Kim Y, Youn D, Lim M, Ko J, Ahn Y, et al. Down-modulation of Bis sensitizes cell death in C6 glioma cells induced by oxygen-glucose deprivation. Brain Res. 2010;1349:1-10 pubmed publisher
  69. Lee K, Lee H, Hong J, Han J, Lee J, Whang K. High-dose intravenous immunoglobulin downregulates the activated levels of inflammatory indices except erythrocyte sedimentation rate in acute stage of Kawasaki Disease. J Trop Pediatr. 2005;51:98-101 pubmed
    ..High-dose IVIG causes immediate changes in the levels of various proteins, except IgA and IgM, and downregulates the activated levels of inflammatory indices, except ESR, in the acute stage of KD. ..
  70. Oh J, Kook J, Min B. Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway. J Biol Chem. 2005;280:21629-37 pubmed
    ..Lastly, it was observed that beta ig-h3-mediated keratinocyte differentiation was caused by promotion of cell adhesion and not by calcium regulation. ..
  71. Yang H, Do H, Kim D, Park J, Chang W, Chung H, et al. Transcriptional regulation of human Oct4 by steroidogenic factor-1. J Cell Biochem. 2007;101:1198-209 pubmed
    ..Thus, our data indicate that SF-1 plays a crucial role in the regulation of hOct4 transcription through direct binding to the 1st SF-1 in CR1 of the hOct4 proximal promoter. ..
  72. Ryu H, Kim S, Park H, You J, Kim B, Lee J, et al. Modulations of AtGSTF10 expression induce stress tolerance and BAK1-mediated cell death. Biochem Biophys Res Commun. 2009;379:417-22 pubmed publisher
  73. Kim E, Kim H, Lee S, Kang J, Lee D, Choi H, et al. Melphalan modulates the expression of E7-specific biomarkers in E7-Tg mice. Anticancer Res. 2010;30:2773-83 pubmed
    ..These results suggest that melphalan inhibits carcinogenesis via modulating E7-specific genes and proteins expressed in the lung tissues of E7 Tg mice. ..
  74. Jeong S, Koo S, Choi J, Park J, Ha J, Park H, et al. Intermedeol isolated from the leaves of Ligularia fischeri var. spiciformis induces the differentiation of human acute promyeocytic leukemia HL-60 Cells. Planta Med. 2002;68:881-5 pubmed
    ..Taken together, our results suggest that intermedeol may have potential as a therapeutic agent in human leukemia. ..
  75. Jung H, Lee J, Kim J, Ryu K, Kang S, Park C, et al. STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell. FEBS Lett. 2005;579:3941-6 pubmed
    ..Taken together, our results indicate that STAT1 and Nmi are downstream targets of Ets-1 in MCF-7 human breast cancer cells. ..
  76. Jung C, Jung H, Shin Y, Park J, Jun C, Kim H, et al. Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage. J Ethnopharmacol. 2007;113:183-7 pubmed
    ..In using the standard inhibitors (MAPKs and Akt), our results show that Eleutherococcus senticosus downregulates inflammatory iNOS expression by blocking JNK and Akt activation. ..
  77. Cho Y, Kim C, Park J. Involvement of HIF-1alpha in UVB-induced epidermal hyperplasia. Mol Cells. 2009;28:537-43 pubmed publisher
    ..This work provides insight of the molecular mechanism underlying UV-induced photoageing and skin cancer development. ..
  78. Thorenoor N, Lee J, Lee S, Cho S, Kim Y, Kim K, et al. Localization of the death effector domain of Fas-associated death domain protein into the membrane of Escherichia coli induces reactive oxygen species-involved cell death. Biochemistry. 2010;49:1435-47 pubmed publisher
    ..Our results provide a common mechanistic feature of ROS-involved cell death throughout prokaryotes and eukaryotes. ..
  79. Kim M, Park E, Park S. A glucose-inducible gene in Schizosaccharomyces pombe, rrg1+, is involved in negative regulation of G2/M progression. Mol Cells. 2002;14:312-7 pubmed
    ..In addition, the rrg1+ mRNA level showed cell-cycle dependent changes, peaking at G2/M. These results demonstrate that Rrg1 might be involved in the negative regulation of cell proliferation and G2/M progression for cell size control. ..
  80. Kim K, Kim J, Han S, Lim J, Kim K, Cho D, et al. Adiponectin is a negative regulator of NK cell cytotoxicity. J Immunol. 2006;176:5958-64 pubmed
    ..These results clearly demonstrate that adiponectin is a potent negative regulator of IL-2-induced NK cell activation and thus may act as an in vivo regulator of anti-inflammatory functions. ..
  81. Yang M, Mun C, Choi Y, Baik J, Park K, Lee W, et al. Agmatine inhibits matrix metalloproteinase-9 via endothelial nitric oxide synthase in cerebral endothelial cells. Neurol Res. 2007;29:749-54 pubmed
    ..Our study supports that the down-regulation of MMP-9 by agmatine runs parallel to the up-regulation of eNOS and the maintenance of functional NO release. ..
  82. Lim K, Lee J, Lee S, Bae O, Noh J, Kim E, et al. Potent anti-inflammatory effects of two quinolinedione compounds, OQ1 and OQ21, mediated by dual inhibition of inducible NO synthase and cyclooxygenase-2. Br J Pharmacol. 2009;156:328-37 pubmed publisher
  83. Kim D, Jung J, Kim T, Seo S, Jung S, Park C. Oral administration of Uncariae rhynchophylla inhibits the development of DNFB-induced atopic dermatitis-like skin lesions via IFN-gamma down-regulation in NC/Nga mice. J Ethnopharmacol. 2009;122:567-72 pubmed publisher
    ..UR may suppress the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-gamma production. ..
  84. Song Y, Jhun M, Park T, Huh W. Quantitative proteomic analysis of ribosomal protein L35b mutant of Saccharomyces cerevisiae. Biochim Biophys Acta. 2010;1804:676-83 pubmed publisher
    ..Furthermore, our approach of combining a library of GFP-tagged yeast strains and the SGA method provides an effective and highly sensitive method for dynamic analysis of the effects of various mutations on proteome expression. ..
  85. Um S, Rhyu J, Kim E, Jeon K, Hwang E, Park J. Abrogation of IRF-1 response by high-risk HPV E7 protein in vivo. Cancer Lett. 2002;179:205-12 pubmed
  86. Cheong J, Chong S, Kim J, Eom J, Jeung H, Maeng H, et al. Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells. Clin Cancer Res. 2003;9:5018-27 pubmed
    ..This study provides the rationale to additionally investigate apicidin as a potential therapeutic agent for the drug-resistant Bcr-Abl-positive leukemia cells. ..
  87. Jin Q, Jhun B, Lee S, Lee J, Pi Y, Cho Y, et al. Differential regulation of phosphatidylinositol 3-kinase/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadione-induced oxidative stress in the kidney of young and old rats. Biochem Biophys Res Commun. 2004;315:555-61 pubmed
    ..In conclusion, the results suggest that the age-related down-regulation of PI 3-kinase/Akt pathway and up-regulation of JNK1, AMPK, and p53 pathways may be responsible for the increased susceptibility to oxidative stress. ..
  88. Park J, Bae E, Lee C, Yoon S, Chae Y, Ahn K, et al. RNA interference-directed caveolin-1 knockdown sensitizes SN12CPM6 cells to doxorubicin-induced apoptosis and reduces lung metastasis. Tumour Biol. 2010;31:643-50 pubmed publisher
    ..0004). The above results together suggest that caveolin-1 may confer a growth advantage to cancer cells during DXR chemotherapy and surviving HRCC cells eventually might develop lung metastasis...
  89. Kim J, Song E, Lee H, Oh Y, Park Y, Park J, et al. Chronic ethanol consumption-induced pancreatic {beta}-cell dysfunction and apoptosis through glucokinase nitration and its down-regulation. J Biol Chem. 2010;285:37251-62 pubmed publisher
    ..Peroxynitrite-induced ATF3 may also serve as a potent upstream regulator of GCK down-regulation and ?-cell apoptosis. ..
  90. Lim J, Kim J, Lee J, Joo C. Downregulated expression of integrin alpha6 by transforming growth factor-beta(1) on lens epithelial cells in vitro. Biochem Biophys Res Commun. 2001;284:33-41 pubmed
    ..These findings suggest that the reduced expression of integrin alpha6 caused by TGF-beta(1) might play a role in the activation of the cell cycle genes required during the fiber differentiation of the lens. ..
  91. Kim D, Park S, Park K. Transforming growth factor-beta1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation. Int J Biochem Cell Biol. 2004;36:1482-91 pubmed
    ..These results suggest that the ERK pathway may be involved in the melanogenic signaling cascade, and that delayed ERK activation by TGF-beta1 contributes to reduced melanin synthesis via MITF down-regulation. ..
  92. Kim E, Hong Y, Go S, Lee B, Jung S. Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease; implications for neuronal loss in Gaucher disease. Exp Mol Med. 2006;38:348-56 pubmed
    ..These results suggest that a reduction in neurotrophic factors could be involved in neuronal loss in Gaucher disease. ..