Experts and Doctors on conjugated linoleic acids in Seoul, South Korea


Locale: Seoul, South Korea
Topic: conjugated linoleic acids

Top Publications

  1. Lee K, Lee H, Cho H, Kim Y. Role of the conjugated linoleic acid in the prevention of cancer. Crit Rev Food Sci Nutr. 2005;45:135-44 pubmed
    ..This article discusses characteristics of CLA in the prevention of cancer in both in vivo and in vitro studies and the possible underlying chemoprevention mechanisms. ..
  2. Lee H, Park J, Seok S, Baek M, Kim D, Lee K, et al. Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim Biophys Acta. 2006;1761:736-44 pubmed
    ..rhamnosus PL60 treatment; on the contrary it seemed to be normalized. Results showed that the amount of conjugated linoleic acid produced by Lactobacillus rhamnosus PL60 was enough to produce an anti-obesity effect. ..
  3. Lee K, Paek K, Lee H, Park J, Lee Y. Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice. J Appl Microbiol. 2007;103:1140-6 pubmed
    ..trans-10,cis-12-CLA-producing Lactobacillus can be a replacement for CLA for obesity treatment via the continuous production of trans-10,cis-12-CLA. The results provide a novel opportunity to develop foods with antiobesity activity. ..
  4. Jin Y, Lee H, Xu C, Han J, Choi S, Song M, et al. Proteomic analysis of endogenous conjugated linoleic acid biosynthesis in lactating rats and mouse mammary gland epithelia cells (HC11). Biochim Biophys Acta. 2010;1804:745-51 pubmed publisher
    ..Our results suggest that the identified proteins may be related to CLA biosynthesis in mammary tissue. ..
  5. Choi J, Jung M, Park H, Song J. Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition. 2004;20:1008-17 pubmed
    ..Possible mechanisms are increased fat oxidation and energy expenditure by increasing acyl coenzyme A oxidase and uncoupling protein-2 mRNA in the liver and/or skeletal muscle. ..
  6. Soel S, Choi O, Bang M, Yoon Park J, Kim W. Influence of conjugated linoleic acid isomers on the metastasis of colon cancer cells in vitro and in vivo. J Nutr Biochem. 2007;18:650-7 pubmed
    ..1% c9,t11 and t10,c12 CLA were equally effective in inhibiting colon cancer cell metastasis in vivo. However, in vitro, only c9,t11 but not t10,c12 inhibited colon cancer cell migration and MMP-9 activity. ..
  7. Seo J, Moon H, Kim I, Guo D, Lee H, Choi Y, et al. PEGylated conjugated linoleic acid stimulation of apoptosis via a p53-mediated signaling pathway in MCF-7 breast cancer cells. Eur J Pharm Biopharm. 2008;70:621-6 pubmed publisher
    ..Overall, the anti-cancer effects of PCLA on MCF-7 breast cancer cells may have therapeutic significance. ..
  8. Hashem M, Jun K, Lee E, Lim S, Choo H, Kwon Y. A rapid and sensitive screening system for human type I collagen with the aim of discovering potent anti-aging or anti-fibrotic compounds. Mol Cells. 2008;26:625-30 pubmed
    ..Lactic acid, EGCG, resveratrol, and retinol that can inhibit collagen synthesis effectively in a dose-dependent manner may be used for anti-fibrosis treatment purposes. ..
  9. Guo D, Xu C, Quan J, Song C, Jin H, Kim D, et al. Synergistic anti-tumor activity of paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel in vitro and in vivo. Biomaterials. 2009;30:4777-85 pubmed publisher
    ..The CLA-coupled poloxamer designed in this study has great potential as an effective injectable carrier of PTX. ..

More Information


  1. Lee J, Song Y, Lee J, Kim M, Jun S, Lee H. Optimization and oxidative stability of the microencapsulated conjugated linoleic acid. Int J Biol Macromol. 2009;45:348-51 pubmed publisher
    ..These results suggest that CLA-loaded microcapsules can be used as a means to enhance not only the entrapment efficiency but also the oxidative stability of CLA. ..
  2. Moon H, Lee H, Seo J, Chung C, Guo D, Kim T, et al. Leptin-induced matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated linoleic acid. Biochem Biophys Res Commun. 2007;356:955-60 pubmed
    ..These findings provide support for a role for t-CLA in the regulation of metabolism in leptin-induced adipose tissue development. ..
  3. Moon H, Lee H, Seo J, Guo D, Kim I, Chung C, et al. Lipolysis is stimulated by PEGylated conjugated linoleic acid through the cyclic adenosine monophosphate-independent signaling pathway in 3T3-L1 cells: activation of MEK/ERK MAPK signaling pathway and hyper-secretion of adipo-cytokines. J Cell Physiol. 2008;214:283-94 pubmed
    ..Overall, our findings provide support for a role for PCLA as a pro-drug in the regulation of metabolism in adipose tissue. ..
  4. Lee K, Lee Y. Production of c9,t11- and t10,c12-conjugated linoleic acids in humans by Lactobacillus rhamnosus PL60. J Microbiol Biotechnol. 2009;19:1617-9 pubmed
    ..Results showed that L. rhamnosus PL60 can survive in human intestines and produce CLAs in human. This is the first report that bacteria can produce CLAs in humans. ..