Experts and Doctors on base sequence in Seoul, South Korea

Summary

Locale: Seoul, South Korea
Topic: base sequence

Top Publications

  1. Kwon J, Chun J, Lee H, Cheon C, Song E, Min K, et al. Cloning of the histidine biosynthetic genes from Corynebacterium glutamicum: organization and analysis of the hisG and hisE genes. Can J Microbiol. 2000;46:848-55 pubmed
    ..Computer analysis revealed that the amino acid sequences of the hisG and hisE gene products were similar to those of other bacteria...
  2. Kim H, Kim Y, Lee M, Lee H. Gene lmrB of Corynebacterium glutamicum confers efflux-mediated resistance to lincomycin. Mol Cells. 2001;12:112-6 pubmed
    ..In addition, the putative protein contained a motif for major facilitators, suggesting a role in efflux-mediated resistance to lincomycin. ..
  3. Kim K, Hong Y, Joe Y, Lee Y, Shin J, Park H, et al. Anti-angiogenic activity of the recombinant kringle domain of urokinase and its specific entry into endothelial cells. J Biol Chem. 2003;278:11449-56 pubmed
  4. Lee S, Kim S, Park C, Park J, Kim J, Chun T. Molecular cloning and expression analysis of pig CD79alpha. Vet Immunol Immunopathol. 2008;125:368-74 pubmed publisher
    ..Future study will be focused on defining the functional role of CD79alpha during the course of pig infectious diseases and the formation of neoplasm. ..
  5. Park Y, Ahn H, Chang H, Kim J, Huh K, Kim M, et al. The RhoGDI-alpha/JNK signaling pathway plays a significant role in mycophenolic acid-induced apoptosis in an insulin-secreting cell line. Cell Signal. 2009;21:356-64 pubmed publisher
    ..This RhoGDI-alpha/JNK pathway might be the focus of therapeutic target for the prevention of MPA-induced islet apoptosis. ..
  6. Hwang D, Lee J, Lee K, Rhee J, Han J, Lee J, et al. Cloning and expression of ecdysone receptor (EcR) from the intertidal copepod, Tigriopus japonicus. Comp Biochem Physiol C Toxicol Pharmacol. 2010;151:303-12 pubmed publisher
    ..In addition, bisphenol A (100microg/L) repressed TJ-EcR expression. Our results suggest that TJ-EcR could be a biomarker for the monitoring of the impact of environmental stressors in copepods. ..
  7. Cho S, Choi K, Jeon J, Kim C, Shin D, Lee J, et al. Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer. Exp Mol Med. 2010;42:310-8 pubmed
    ..These results will provide a clue to future investigation aiming at delineating physiological and pathological roles of human transglutaminase 4. ..
  8. Park Y, Kim J, Gu S, Lee S, Lee M, Kang Y, et al. Full genome analysis of a novel adenovirus from the South Polar skua (Catharacta maccormicki) in Antarctica. Virology. 2012;422:144-50 pubmed publisher
    ..This is the first evidence of a novel adenovirus, SPSAdV, from a large polar seabird (family Stercorariidae) in Antarctica...
  9. Lim A, Song S, Lee J, Cho N, Kwon S. A novel HLA-A*31 allele, A*31:57, identified by sequence-based typing. Tissue Antigens. 2012;79:386-7 pubmed publisher
    ..The novel allele A*31:57 allele showed a single nucleotide difference with A*31:01:02 at nt 235 G>C in exon 2. ..

More Information

Publications308 found, 100 shown here

  1. Park Y, Lee Y, Kim S, Lee E, Kim K, Williams D, et al. Snail, a transcriptional regulator, represses adiponectin expression by directly binding to an E-box motif in the promoter. Metabolism. 2012;61:1622-32 pubmed publisher
    ..Snail is a novel regulator of adiponectin expression and probably has a role in regulating adipogenesis. ..
  2. Min S, Kim H, Jung E, Jung E, Jee C, Kim W. Prognostic significance of glutathione peroxidase 1 (GPX1) down-regulation and correlation with aberrant promoter methylation in human gastric cancer. Anticancer Res. 2012;32:3169-75 pubmed
    ..Loss of GPX1 expression was associated with aggressiveness and poor survival in patients with gastric cancer. ..
  3. Choi Y, Sim W, Choi H, Lee S, Lee B. ?-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway. Food Chem Toxicol. 2013;55:129-36 pubmed publisher
    ..Conversely, rapamycin co-treatment reversed ?-terpineol-induced SREBP-1 activation and fatty liver in mice. These data provide evidence that ?-terpineol causes fatty liver, an effect mediated by the AMPK/mTOR/SREBP-1 pathway. ..
  4. Hwang D, Byeon H, Lee J. Complete mitochondrial genome of the river lamprey, Lampetra japonica (Petromyzontiformes, Petromyzonidae). Mitochondrial DNA. 2013;24:406-8 pubmed publisher
    ..Of 13 protein-coding genes (PCGs), 1 gene (CO1) had incomplete stop codon. The base composition of L. japonica showed anti-G bias (4.65%) on the third position of PCGs. ..
  5. Chen Q, Yoo S, Chung Y, Lee J, Min J, Choi J. Control of electrochemical signals from quantum dots conjugated to organic materials by using DNA structure in an analog logic gate. Bioelectrochemistry. 2016;111:1-6 pubmed publisher
    ..This could be further improved by choosing QDs, ionic conditions, or DNA sequences. This research provides a feasible method for fabricating an artificial intelligence system. ..
  6. Chung H, Kim E, Suh B, Choi J, Roe J. Duplicate genes for Fe-containing superoxide dismutase in Streptomyces coelicolor A3(2). Gene. 1999;231:87-93 pubmed
    ..Among 12 other Streptomyces species examined, only S. fradiae contained two FeSOD-like polypeptides. We postulate that the additional copy of the sodF gene (sodF2) was provided by the horizontal transfer from remotely related bacteria...
  7. You M, Oh S, Ok S, Cho S, Shin H, Jeung J, et al. Identification of putative MAPK kinases in Oryza minuta and O. sativa responsive to biotic stresses. Mol Cells. 2007;23:108-14 pubmed
    ..sativa ortholog OsMKK1 showed that both were induced by stress-related hormones and biotic stresses, but that the kinetics of their responses differed despite their high amino acid sequence identity (96%). ..
  8. Yoo H, Kim G, Lee D. Identification of new mutations in the ornithine transcarbamylase (OTC) gene in Korean families. J Inherit Metab Dis. 1996;19:31-42 pubmed
    ..This missense mutation has been described previously and is known to eliminate a TaqI recognition site in exon 5...
  9. Shim Y, Jang Y, Lim M, Lee J, Seong R, Hong S, et al. Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51(+) from Schizosaccharomyces pombe. Mol Cell Biol. 2000;20:8958-68 pubmed
    ..Furthermore, the DNA damage-dependent expression of rhp51(+) was significantly reduced in checkpoint mutants, raising the possibility that Rdp1 may mediate damage checkpoint-dependent transcription of rhp51(+). ..
  10. Lee M, Kim S, Choi J, Lee I, Choi Y, Jin J, et al. Upregulation of haptoglobin in reactive astrocytes after transient forebrain ischemia in rats. J Cereb Blood Flow Metab. 2002;22:1176-80 pubmed
    ..The Hp gene expression was also upregulated in C6 and A-172 glioblastoma cell lines after H O treatment. These findings suggest that Hp is synthesized in reactive astrocytes in response to ischemia-reperfusion injury. ..
  11. Kim M, Kim H, Choi J, Nahm D. Transforming growth factor-beta3 gene SfaN1 polymorphism in Korean nonsyndromic cleft lip and palate patients. J Biochem Mol Biol. 2003;36:533-7 pubmed
    ..001), but not in females. In conclusion, the polymorphism of the SfaN1 site in TGF-beta3 was significantly different between the NSCL/P patients and the control. This may be a good screening marker for NSCL/P patients among Koreans. ..
  12. Huh J, Yoon H, Lee H, Choi W, Yang S, Cho S. Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase. J Biol Chem. 2004;279:37491-8 pubmed
    ..No incorporation of [(32)P]2N(3)NAD(+) was observed for the G13E mutant. These results indicate that Gly-13 plays an important role for efficient binding of NAD(+) to human UGDH. ..
  13. Kim M, Kim E, Kim D, Choi I, Moon T, Yoon C, et al. Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling. Biochim Biophys Acta. 2004;1690:134-40 pubmed
    ..A possible model for the molecular pathogenesis of WAS has been proposed by analyzing the interactions of WASP and WIP using a molecular modeling study. ..
  14. Kim S, Choi S, Park J, Lee D. Regulation of the activity of Korean radish cationic peroxidase promoter during dedifferentiation and differentiation. Plant Physiol Biochem. 2004;42:763-72 pubmed
    ..We further show that the 142-bp fragment (-471 to -328) has at least one cis-element to bind to the nuclear proteins from Korean radish seedlings induced by dedifferentiation. ..
  15. Kim J, Jung J, Reyes J, Kim Y, Kim S, Chung K, et al. microRNA-directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems. Plant J. 2005;42:84-94 pubmed
    ..miR166-assisted ATHB15 repression is likely to be a conserved mechanism that regulates vascular development in all vascular plants. ..
  16. Nam T, Park Y, Jeong H, Ryu S, Seok Y. Glucose repression of the Escherichia coli sdhCDAB operon, revisited: regulation by the CRP*cAMP complex. Nucleic Acids Res. 2005;33:6712-22 pubmed
    ..cAMP level in the presence of glucose is the major determinant of the glucose repression of the sdhCDAB operon. ..
  17. Lee H, Moon S, Ryu H, Kim Y, Cho S, Chung G, et al. Usefulness of the recombinant liver stage antigen-3 for an early serodiagnosis of Plasmodium falciparum infection. Korean J Parasitol. 2006;44:49-54 pubmed
    ..0%), in which blood stage antigens were not detected. These results indicate that the LSA-3 is a useful antigen for an early serodiagnosis of P. falciparum infection. ..
  18. Kim E, Kim J, Lee I, Rhee H, Lee J. Superoxide generation by chlorophyllide a reductase of Rhodobacter sphaeroides. J Biol Chem. 2008;283:3718-30 pubmed
    ..Thus, superoxide is generated not from FMN of BchX but from heme of BchZ. Consistently, the heme of BchZ muteins was half-reduced in its redox state compared with that of wild-type BchZ. ..
  19. Jeong E, Kim M, Nam H, Min C, Lee S, Chung Y, et al. Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. Clin Cancer Res. 2008;14:3716-21 pubmed publisher
    ..The data suggest that some of the JAK1 and JAK3 mutations may to be functional and contributes to cancer development, especially to T-ALL development. ..
  20. Kim Y, Cho S, Yun C, Moon Y, Lee T, Kim S. Transcriptional activation of Cidec by PPARgamma2 in adipocyte. Biochem Biophys Res Commun. 2008;377:297-302 pubmed publisher
    ..These results suggest that PPARgamma2 is required for the transcriptional activity of Cidec during adipogenesis, which could be contributed to understand the molecular mechanism of lipid droplet formation in adipocytes. ..
  21. Hwang K, Cho S, Lee S, Park J, Kwon D, Choi Y, et al. Depigmentation of skin and hair color in the somatic cell cloned pig. Dev Dyn. 2009;238:1701-8 pubmed publisher
    ..This down-regulation of gene expression may result in a previously undescribed phenotype that shows melanocyte instability, leading to progressive loss of pigmentation. ..
  22. Kim S, Kim S, Kang H, Chung H, Choi I, Cheon Y, et al. Molecular cloning and expression analysis of pig lymphocyte activation gene-3 (LAG-3; CD223). Vet Immunol Immunopathol. 2010;133:72-9 pubmed publisher
    ..These results indicated that the structure and expression pattern of pig LAG-3 are conserved among mammalian species. ..
  23. Park S, Kim J, Oh J, Lee H, Park H, Chung S, et al. Polymyxin B, scavenger of endotoxin, enhances isolation yield and in vivo function of islets. Transpl Int. 2010;23:325-32 pubmed publisher
    ..Thus, polymyxin B could serve as a useful agent in the protection of islets from endotoxin-induced inflammation and apoptosis. ..
  24. Yoon J, Lee G, Lee S, Park C, Yoo J, Park H. Prevalence of genes for enterotoxins, toxic shock syndrome toxin 1 and exfoliative toxin among clinical isolates of Staphylococcus pseudintermedius from canine origin. Vet Dermatol. 2010;21:484-9 pubmed publisher
    ..pseudintermedius such as pyoderma or chronic otitis. ..
  25. Gu B, Park J, Baek K. Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome. Int J Mol Med. 2010;26:107-12 pubmed
    ..08). In haplotype analysis, Ser680Asn and Ala307Thr polymorphisms are not related with PCOS. Consequently, the Ser680Asn polymorphism of FSHR might significantly affect PCOS patients, separately from the Ala307Thr polymorphism. ..
  26. Hwang S, Kim K, Lee W, Lee G. Aberrant expression of IFN-? in Th2 cells from Th2 LCR-deficient mice. Biochem Biophys Res Commun. 2012;424:512-8 pubmed publisher
    ..These results suggest that expression of the ifng gene and chromatin remodeling of the ifng locus are under the control of a Th2 LCR-mediated Th2 differentiation program. ..
  27. Park H, Ko A, Ki C, Lee S, Kim J, Cho S, et al. Five novel mutations of GALNS in Korean patients with mucopolysaccharidosis IVA. Am J Med Genet A. 2013;161A:509-17 pubmed publisher
    ..725C>G (p.S242C), c.752G>A (p.R251Q), and c.1000C>T (p.Q334X). Two other mutations were c.1156C>T (p.R386C) and c.1243-1G>A. Two mutations, c.451C>A and c.1000C>T, accounted for 58% of all mutations in this sample. ..
  28. Lee K, Seymen F, Ko J, Yildirim M, Tuna E, Gencay K, et al. RUNX2 mutations in cleidocranial dysplasia. Genet Mol Res. 2013;12:4567-74 pubmed publisher
    ..We believe that this finding will broaden the understanding of the mechanism of supernumerary teeth formation and CCD-related phenotypes...
  29. Shin J, Baek J, Cho S, Huh H, Lee N, Song J, et al. blaNDM-5-Bearing IncFII-Type Plasmids of Klebsiella pneumoniae Sequence Type 147 Transmitted by Cross-Border Transfer of a Patient. Antimicrob Agents Chemother. 2016;60:1932-4 pubmed publisher
    ..Sequences of two plasmids were almost the same, and genetic structures, including blaNDM-5, of these plasmids were similar to plasmids of NDM-1-producing Escherichia coli ST131 isolates found in Europe. ..
  30. Park M, Lee Y, Jang H, Lee O, Park S, Kim J, et al. SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes. Sci Rep. 2016;6:20980 pubmed publisher
    ..Taken together, our data suggest that SOHLH2 is critical for the formation of synaptonemal complexes via its regulation of Sycp1 expression during mouse spermatogonial differentiation. ..
  31. Kim B, Bang I, Lee S, Hong S, Bang S, Lee I, et al. Expression of cspH, encoding the cold shock protein in Salmonella enterica serovar Typhimurium UK-1. J Bacteriol. 2001;183:5580-8 pubmed
    ..The 14-base downstream box located 12 bases downstream of the initiation codon of cspH mRNA was essential for its cold shock activation. ..
  32. Cho B, Lim Y, Lee D, Park S, Lee H, Kim W, et al. Identification and characterization of a novel cancer/testis antigen gene CAGE. Biochem Biophys Res Commun. 2002;292:715-26 pubmed
    ..This suggests that CAGE might play a role in cellular proliferation. Because CAGE is expressed in a variety of cancers but not in normal tissues except testis, this gene can be a target of antitumor immunotherapy. ..
  33. Han J, Kang S, Lee H, Kim H, Hwang D. Sequential binding of SeqA to paired hemi-methylated GATC sequences mediates formation of higher order complexes. J Biol Chem. 2003;278:34983-9 pubmed
    ..Aggregation might be indicative of SeqA foci, which appear to track replication forks in vivo. Studies of the properties of SeqA binding will contribute to our understanding of the function of SeqA. ..
  34. Ku J, Kang S, Shin Y, Kang H, Hong S, Kim I, et al. Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. Oncogene. 2004;23:6736-42 pubmed
  35. Cheong H, Kang J, Lee J, Ha I, Kim S, Komoda F, et al. Mutational analysis of idiopathic renal hypouricemia in Korea. Pediatr Nephrol. 2005;20:886-90 pubmed
    ..This is the first study of SLC22A12 mutations in a country other than Japan. W258X was found to be the predominant SLC22A12 mutation in Korean renal hypouricemia patients, as has been reported in Japan. ..
  36. Jang S, Kim Y, Kim Y, Sung H, Ko J. Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. J Biol Chem. 2007;282:11092-100 pubmed
    ..Our findings suggest that transcription factor NF-kappaB plays an important role in regulation of LZIP expression, and LZIP expression regulates the monocyte cell migration induced by Lkn-1. ..
  37. Gomez D, Baeck G, Kim J, Choresca C, Park S. Molecular detection of betanodavirus in wild marine fish populations in Korea. J Vet Diagn Invest. 2008;20:38-44 pubmed
  38. Hur C, Choe C, Kim G, Cho S, Park J, Hong S, et al. Expression and localization of two-pore domain K(+) channels in bovine germ cells. Reproduction. 2009;137:237-44 pubmed publisher
    ..These results suggest that K(2P) channels might contribute to the background K(+) conductance of germ cells and regulate various physiological processes, such as maturation, fertilization, and development. ..
  39. Koo B, Kim H, Park M, Jeon O, Kim D. Membrane type-1 matrix metalloprotease-independent activation of pro-matrix metalloprotease-2 by proprotein convertases. FEBS J. 2009;276:6271-84 pubmed publisher
    ..Thus, our experimental data, taken together with the broad expression of proprotein convertases, suggest that the proprotein convertase-mediated processing may be a general activation mechanism for pro-matrix metalloprotease-2 in vivo. ..
  40. Seo S, Yang H, Lee K, Kim H, Cho S, Choi Y, et al. The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis. Hum Reprod. 2010;25:1251-8 pubmed publisher
    ..There were no significant differences between the two groups in TRX and TBP-2 levels in serum or peritoneal fluid. Aberrant expression of TRX and TBP-2 in the endometrium may be associated with the establishment of endometriosis. ..
  41. Lee H, Kweon J, Kim E, Kim S, Kim J. Targeted chromosomal duplications and inversions in the human genome using zinc finger nucleases. Genome Res. 2012;22:539-48 pubmed publisher
    ..In addition, our method raises the possibility of correcting genetic defects caused by chromosomal rearrangements and holds new promise in gene and cell therapy...
  42. Bae S, Jung J, Kim K, An I, Kim S, Lee J, et al. TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation. FEBS Lett. 2012;586:3057-63 pubmed publisher
    ..Moreover, TRIAD1 binds to the C-terminus of p53 to promote its dissociation from MDM2. These results implicate TRIAD1 as a novel regulatory factor of p53-MDM2. ..
  43. Jang E, Jeong H, Han K, Kwon H, Hong J, Hwang E. TAZ suppresses NFAT5 activity through tyrosine phosphorylation. Mol Cell Biol. 2012;32:4925-32 pubmed publisher
    ..Collectively, the data suggest that TAZ modulates cellular responses to hyperosmotic stress through fine-tuning of NFAT5 activity via tyrosine phosphorylation. ..
  44. Yoon Y, Lee D, Ki C, Lee S, Kim J, Lee Y, et al. SLC22A5 mutations in a patient with systemic primary carnitine deficiency: the first Korean case confirmed by biochemical and molecular investigation. Ann Clin Lab Sci. 2012;42:424-8 pubmed
    ..The plasma free carnitine level normalized to 66.6 ?mol/L at 4 weeks after treatment. To the best of our knowledge, this is the first report of a CDSP patient confirmed by molecular genetic investigation. ..
  45. Jung M, Kim K, Lee N, Kang Y, Hwang Y, Kim Y, et al. Expression of taurine transporter (TauT) is modulated by heat shock factor 1 (HSF1) in motor neurons of ALS. Mol Neurobiol. 2013;47:699-710 pubmed publisher
    ..Taken together, our results suggest that TauT is a novel pathological marker for stressed motor neurons in ALS and that modulation of TauT and taurine may slow neuronal degeneration in ALS. ..
  46. Park J, Ahn S, Kim S, Lee J, Nam J, Shin C. Degradome sequencing reveals an endogenous microRNA target in C. elegans. FEBS Lett. 2013;587:964-9 pubmed publisher
    ..In addition, expression of the ZK637.6 transcript was strongly dependent on the expression of miR-249. These findings may lead to a better understanding of miRNA-mediated gene regulation in nematodes...
  47. Huh J, Lee S. IL-6 is produced by adipose-derived stromal cells and promotes osteogenesis. Biochim Biophys Acta. 2013;1833:2608-2616 pubmed publisher
    ..Our results thus establish TLRs as novel regulators of ASCs which signal through IL-6/STAT3 pathway and induce osterix expression as a part of the osteogenesis. ..
  48. Kim S, Seo S, Jin Y, Seo J. Production of 2,3-butanediol by engineered Saccharomyces cerevisiae. Bioresour Technol. 2013;146:274-281 pubmed publisher
    ..In fed-batch fermentation with optimum aeration, 2,3-BD concentration increased up to 96.2 g/L. These results suggest that S. cerevisiae might be a promising host for producing 2,3-BD for industrial applications. ..
  49. Lee Y, Kim Y, Ji J, Sohn J, Song G. Fas promoter -670 polymorphism is associated with development of anti-RNP antibodies in systemic lupus erythematosus. J Rheumatol. 2001;28:2008-11 pubmed
    ..Our data suggest that the Fas promoter -670 polymorphism is associated with development of anti-RNP antibodies in SLE. ..
  50. Lee S, Kim S, Lee Y, Yamada K, Yamada Y, Chi J. The structure of the rat ameloblastin gene and its expression in amelogenesis. Mol Cells. 2003;15:216-25 pubmed
    ..From the above results we propose that ameloblastin II plays an important role in the mineralization of ameloblasts during the maturation stages. ..
  51. Lee Y, Williams T, Jung S, Lee J. cDNA cloning and expression of a cytochrome P450 1A (CYP1A) gene from the hermaphroditic fish Rivulus marmoratus. Mar Pollut Bull. 2005;51:769-75 pubmed
    ..marmoratus to 4-nonylphenol, and found a small induction of CYP1A mRNA in the treated animals. In this paper, we discuss the characteristics of R. marmoratus CYP1A gene as well as its potential use in a biomonitoring assay. ..
  52. Kim S, Choi J, Park M, Jeong S, Han K, Kim H. Identification of the +1 ribosomal frameshifting site of LRV1-4 by mutational analysis. Arch Pharm Res. 2005;28:956-62 pubmed
    ..These results indicate that the frameshift site in LRV1-4's is in the 71bp region where ORF2 and ORF3 overlap, and that nt. 2644-2659 (the upward hairpin stem) play a key role in generating the +1 frameshift...
  53. Lee J, Choi S. Coactivation of Vibrio vulnificus putAP operon by cAMP receptor protein and PutR through cooperative binding to overlapping sites. Mol Microbiol. 2006;60:513-24 pubmed
    ..Accordingly, the present results revealed that PutR and CRP coactivate the expression of Pput and exert their effect by cooperatively binding to the promoter. ..
  54. Kim M, Hahn M, Cho Y, Cho S, Roe J. Positive and negative feedback regulatory loops of thiol-oxidative stress response mediated by an unstable isoform of sigmaR in actinomycetes. Mol Microbiol. 2009;73:815-25 pubmed publisher
    ..We observed that sigH gene, the sigR orthologue in Mycobacterium smegmatis, produces an unstable larger isoform of sigma(H) upon induction by thiol-oxidative stress...
  55. Hemavathi -, Upadhyaya C, Akula N, Young K, Chun S, Kim D, et al. Enhanced ascorbic acid accumulation in transgenic potato confers tolerance to various abiotic stresses. Biotechnol Lett. 2010;32:321-30 pubmed publisher
    ..These results further demonstrated that the overexpression of GLOase gene enhanced basal levels of AsA in potato tubers and also the transgenics showed better survival under various abiotic stresses. ..
  56. Yim Y, Kwon Y, Nam J, Yoon H, Lee K, Kim D, et al. Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases. Proc Natl Acad Sci U S A. 2013;110:4057-62 pubmed publisher
    ..Taken together, these data suggest that combinatorial interactions of Slitrks with LAR-RPTP family members maintain synapse formation to coordinate excitatory-inhibitory balance. ..
  57. Park S, Lee H, Lee S. Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. J Biochem. 1996;119:235-9 pubmed
    ..Human PTK7 is 72% identical to chick KLG, suggesting that PTK7 is homologous or possibly orthologous to chick KLG, and that these represent a new subfamily of RPTKs. ..
  58. Nam K, Lee G, Trambley J, Devine S, Boeke J. Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradation. Mol Cell Biol. 1997;17:809-18 pubmed
    ..The growth defect of the S. pombe dbr1::leu1+ strain suggests that debranching activity is critical for efficient intron RNA degradation and that blocking this pathway interferes with cell growth. ..
  59. Jeong J, Rhee D, Cho S, Hae K, Kim D, Won M, et al. Cloning and characterization of the kinesin-related protein, Krp1p, in Schizosaccharomyces pombe. Mol Cells. 2002;13:389-98 pubmed
    ..AF351206). The data from the overexpression and two-hybrid study of Krplp may provide information that Krplp can have roles in cytokinesis with myosin. ..
  60. Kim H, Chang D, Lee J, Lee Y, Kaang B. Identification of nuclear/nucleolar localization signal in Aplysia learning associated protein of slug with a molecular mass of 18 kDa homologous protein. Neurosci Lett. 2003;343:134-8 pubmed
    ..Analysis of deletion mutants of ApLLP-EGFP showed that the N-terminal and the C-terminal nucleolar and nucleus localization signal sequences are important for localization to the nucleus and the nucleoli. ..
  61. Kim I, Kim M, Lee C, Yim H, Cha S, Kang S. Crystallization and preliminary X-ray crystallographic analysis of the DNA-binding domain of BldD from Streptomyces coelicolor A3(2). Acta Crystallogr D Biol Crystallogr. 2004;60:1115-7 pubmed
    ..2, b = 31.8, c = 33.6 angstroms, beta = 105.1 degrees. Analysis of the packing density shows that the asymmetric unit probably contains one molecule, with a solvent content of 43.6%. ..
  62. Kim M, Yoo K, Kang I, Chung H, Baek K. A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells. Int J Oncol. 2004;25:373-9 pubmed
    ..Interestingly, the expression was hardly seen in the brain. Localization study indicates that HeLa DUB-1 proteins are present in both the cytoplasm and nucleus. ..
  63. Lee M, Lee D, Choi J, Moon K, Koh J. Failure to detect clonality in eosinophilic pustular folliculitis with follicular mucinosis. Acta Derm Venereol. 2004;84:305-7 pubmed
    ..All cases were negative for heteroduplex-PCR analysis. The failure to demonstrate clonality may be consistent with a reactive nature of eosinophilic pustular folliculitis with follicular mucinosis. ..
  64. Han Y, Lee T, Han K, Yun S, Lee Y. Functional analysis of the homoserine O-acetyltransferase gene and its identification as a selectable marker in Gibberella zeae. Curr Genet. 2004;46:205-12 pubmed
    ..Genetic complementation of the G. zeae methionine auxotroph with an intact copy of the Aspergillus nidulans metE and GzmetE genes suggests that the HOA gene can be used as a selectable marker for transformation of G. zeae. ..
  65. Song C, Kim B, Hong H, Lee H. Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-beta signaling in mesangial cells. Kidney Int. 2005;67:1743-52 pubmed
    ..Thus, progression of glomerular disease may be promoted by PAI-1 up-regulation in human mesangial cells mediated by the Ox-LDL-induced TGF-beta/Smad signaling pathways. ..
  66. Lee Y, Chang S, Jung S, Kweon H, Lee J. Cloning and expression of alpha class glutathione S-transferase gene from the small hermaphroditic fish Rivulus marmoratus (Cyprinodontiformes, Rivulidae). Mar Pollut Bull. 2005;51:776-83 pubmed
    ..marmoratus GSTalpha mRNA in the treated animals. In this paper, we discuss the characteristics of the R. marmoratus GSTalpha gene as well as its potential use in relation to environmental pollution. ..
  67. Lee G, Kim H, Lee S, Kang M, Kim D, Lee C, et al. Characterization of pig vasa homolog gene and specific expression in germ cell lineage. Mol Reprod Dev. 2005;72:320-8 pubmed
    ..Our results suggest that Pvh gene can be a useful marker for germ cell development in pigs. ..
  68. Soung Y, Lee J, Kim S, Wang Y, Jo K, Moon S, et al. Somatic mutations of the ERBB4 kinase domain in human cancers. Int J Cancer. 2006;118:1426-9 pubmed
  69. Kim J, Kang Y, Choi O, Jeong Y, Jeong J, Lim J, et al. Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae. Mol Microbiol. 2007;64:165-79 pubmed publisher
    ..The finding that functional flagella play critical roles in the pathogenicity of B. glumae suggests that either QS or flagellum formation constitutes a good target for the control of rice grain rot...
  70. Yang H, Cho E, Han K, Kim H, Kim S. Characterization of a novel mouse brain gene (mbu-1) identified by digital differential display. Gene. 2007;395:144-50 pubmed
  71. Rhee J, Seo J, Raisuddin S, Ki J, Lee K, Kim I, et al. Gonadotropin-releasing hormone receptor (GnRHR) gene expression is differently modulated in gender types of the hermaphroditic fish Kryptolebias marmoratus by endocrine disrupting chemicals. Comp Biochem Physiol C Toxicol Pharmacol. 2008;147:357-65 pubmed publisher
    ..This is the first report of a GnRHR gene from K. marmoratus and modulation of its expression by EDCs. This study provides an insight into the molecular mechanism of endocrinological functions of this unique fish. ..
  72. Mun H, Park J, Kim H, Yu H, Park Y, Cha C, et al. Mycobacterium senuense sp. nov., a slowly growing, non-chromogenic species closely related to the Mycobacterium terrae complex. Int J Syst Evol Microbiol. 2008;58:641-6 pubmed publisher
    ..The name Mycobacterium senuense sp. nov. is proposed, with the type strain 05-832(T) (=DSM 44999(T) =KCTC 19147(T)). ..
  73. Park M, Kim M, Lee K, Hwang S, Ahn T. Characterization of a cryptic plasmid from an alpha-proteobacterial endosymbiont of Amoeba proteus. Plasmid. 2009;61:78-87 pubmed publisher
    ..9 plasmid evolved by the passage through Bacillus species. We hypothesize that the plasmid-encoded PGPase may have contributed to the establishment of bacterial symbiosis within the hostile environment of amoeba cytoplasm...
  74. Lee Y, Choi S, Kim T, Lee J, Kim H, Kim H, et al. Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai. Proc Natl Acad Sci U S A. 2008;105:18602-7 pubmed publisher
    ..Among these, we further demonstrated that the Ap-eIF3e plays a key role in 5-HT-induced long-term facilitation (LTF) as a positive regulator. ..
  75. Ra H, Kim H, Lee H, Kim Y. Essential role of p53 in TPEN-induced neuronal apoptosis. FEBS Lett. 2009;583:1516-20 pubmed publisher
    ..Inhibition of p53 blocked cytochrome C release from mitochondria to cytosol and prevented caspase-3 activation. Therefore, p53 may be an essential regulatory factor for TPEN-induced neuronal apoptosis...
  76. Kim H, Luo Y, Moon H, Park S, Keum H, Rho S, et al. Phylogenetic and recombination analysis of genomic sequences of PCV2 isolated in Korea. Virus Genes. 2009;39:352-8 pubmed publisher
    ..01). A recombination site was predicted to exist in ORF1 of both viruses. This additional evidence of PCV2 recombination in Korea further supports the important role of recombination in genetic evolution. ..
  77. Jo Y, Park J, Kim J, Song W, Hur C, Lee Y, et al. Complete sequencing and comparative analyses of the pepper (Capsicum annuum L.) plastome revealed high frequency of tandem repeats and large insertion/deletions on pepper plastome. Plant Cell Rep. 2011;30:217-29 pubmed publisher
    ..Secondly, tandem repeat sequences were particularly frequent in the pepper plastome. Taken together, our study represents unique features of evolution of pepper plastome among solanaceous plastomes. ..
  78. Ha N, Cho N, Kim Y, Choi M, Kim I. An autotransporter protein from Orientia tsutsugamushi mediates adherence to nonphagocytic host cells. Infect Immun. 2011;79:1718-27 pubmed publisher
    ..Taken together, these results demonstrate that ScaC is involved in the interaction of O. tsutsugamushi with mammalian host cells and suggest that ScaC may play a critical role in bacterial pathogenesis...
  79. Jung J, Oh J, Kim Y, Shin M, Lee D, Chung J. Acute UV irradiation increases heparan sulfate proteoglycan levels in human skin. J Korean Med Sci. 2012;27:300-6 pubmed publisher
    ..Acute UV irradiation increases HS and HSPG levels in human skin, but their increase may not be mediated through their transcriptional regulation. ..
  80. Kim Y, Kweon J, Kim A, Chon J, Yoo J, Kim H, et al. A library of TAL effector nucleases spanning the human genome. Nat Biotechnol. 2013;31:251-8 pubmed publisher
    ..Compared with cells treated with short interfering RNAs, these cells showed unambiguous suppression of signal transduction. ..
  81. Kim S, Park G, Han K, Kim A, Koo J, Chang S, et al. Prevalence of p.V37I variant of GJB2 in mild or moderate hearing loss in a pediatric population and the interpretation of its pathogenicity. PLoS ONE. 2013;8:e61592 pubmed publisher
    ..V37I variant of GJB2 in 18.2% of Koreans with mild hearing loss strongly suggests its contribution to the pathogenesis of milder hearing loss, which might justify sequencing of GJB2 from these subjects in the Korean population. ..
  82. Kwon J, Lee J. Biological significance of a universally conserved transcription mediator in metazoan developmental signaling pathways. Development. 2001;128:3095-104 pubmed
    ..In addition, RNAi experiments in rde-1 background showed that maternal and zygotic med-6 activities have distinct roles in development. ..
  83. Kim H, Jang Y, Baek I, Lee J, Park M, Chung Y, et al. Polymorphism and expression of isoflavone synthase genes from soybean cultivars. Mol Cells. 2005;19:67-73 pubmed
    ..In addition, we found that the levels of CHI, F3H, and IFS mRNAs were under circadian control. We also showed that IFS was induced by wounding and by application of methyl jasmonate to etiolated soybean seedlings. ..
  84. Kim H, Hyun E, Kim Y, Lee Y, Oh D. Characterization of an Agrobacterium tumefaciens D-psicose 3-epimerase that converts D-fructose to D-psicose. Appl Environ Microbiol. 2006;72:981-5 pubmed
    ..The equilibrium ratio between D-psicose and D-fructose was 32:68 at 30 degrees C. D-Psicose was produced at 230 g/liter from 700-g/liter D-fructose at 50 degrees C after 100 min, corresponding to a conversion yield of 32.9%. ..
  85. Choe Y, Ko J, Seo J, Han J, Shim J, Koh Y, et al. Novel CFTR mutations in a Korean infant with cystic fibrosis and pancreatic insufficiency. J Korean Med Sci. 2010;25:163-5 pubmed publisher
    ..This is the first report of a Korean patient with CF demonstrating pancreatic insufficiency. CF should therefore be considered in the differential diagnosis of infants with steatorrhea and failure to thrive. ..
  86. Jeon S, Kang M, Kim Y, Jin Y, Lee C, Chung H, et al. A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line. J Exp Med. 1997;185:1827-36 pubmed
    ..These results suggest that the SRG3 protein is involved in the glucocorticoid-induced apoptosis in the thymoma cell line. This implicates that the SRG3 may play an important regulatory role during T cell development in thymus. ..
  87. Lee J, Lee S. Cloning and characterization of cDNA encoding zebrafish Danio rerio NM23-B gene. Gene. 2000;245:75-9 pubmed
    ..coli and characterized by binding and UV-cross-linking to a single-stranded telomeric repeat (TTAGGG)(6). This is the first report to show that fish have a NM23-H2 homologue that is similar to that in humans. ..
  88. Lee W, Kim S, Kim Y, Han S, Park K, Ryu J, et al. Inhibition of mitogen-activated protein kinase by a Drosophila dual-specific phosphatase. Biochem J. 2000;349 Pt 3:821-8 pubmed
    ..When DMKP was expressed in yeast, it down-regulated the fus1-lacZ trans-reporter gene of the pheromone MAPK pathway without any significant effect on the high-osmolarity-glycerol-response pathway. ..
  89. Lyu J, Costantini F, Jho E, Joo C. Ectopic expression of Axin blocks neuronal differentiation of embryonic carcinoma P19 cells. J Biol Chem. 2003;278:13487-95 pubmed
    ..Overall, our data show that Wnt-3a/canonical beta-catenin signaling through the down-regulation of Axin may play an important role in neuronal differentiation. ..
  90. Yang S, Lee H, Park C, Kim Y, Moon T, Park K. Enzymatic analysis of an amylolytic enzyme from the hyperthermophilic archaeon Pyrococcus furiosus reveals its novel catalytic properties as both an alpha-amylase and a cyclodextrin-hydrolyzing enzyme. Appl Environ Microbiol. 2004;70:5988-95 pubmed
    ..These results confirm that PFTA possesses novel catalytic properties characteristic of both alpha-amylase and cyclodextrin-hydrolyzing enzyme. ..
  91. Park K, Shin H, Park B, Cheong H, Cho Y, Lee H, et al. Polymorphisms in the leptin receptor (LEPR)--putative association with obesity and T2DM. J Hum Genet. 2006;51:85-91 pubmed
    ..02) and gene dose-dependent genetic effects were observed. The present study provides information about additional genetic polymorphisms in LEPR and positive associations of those polymorphisms with BMI in the Korean population. ..
  92. Hwang D, Kundu J, Shin J, Lee J, Lee H, Surh Y. cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt. Carcinogenesis. 2007;28:363-71 pubmed
    ..Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects. ..