Experts and Doctors on antifungal agents in Bratislava, Bratislavský, Slovakia

Summary

Locale: Bratislava, Bratislavský, Slovakia
Topic: antifungal agents

Top Publications

  1. Kaclíková E, Lachowicz T, Gbelska Y, Subik J. Fumaric acid overproduction in yeast mutants deficient in fumarase. FEMS Microbiol Lett. 1992;70:101-6 pubmed
    ..This accumulation was observed only in growing cultures and required functional mitochondrial electron transport from succinate dehydrogenase to oxygen. ..
  2. Vollekova A, Kostalova D, Sochorova R. Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp. Folia Microbiol (Praha). 2001;46:107-11 pubmed
    ..The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range < or = 50-> or = 1000 mg/L...
  3. Cernáková M, Kostalova D. Antimicrobial activity of berberine--a constituent of Mahonia aquifolium. Folia Microbiol (Praha). 2002;47:375-8 pubmed
    ..subtilis > Z. ramigera > C. albicans > S. cerevisiae > A. pullulans B (black) > A. pullulans W (white) > T. viride Br (brown) > M. gypseum > A. niger > F. nivale > P. chrysogenum > T. viride G (green)...
  4. Vollekova A, Kost álová D, Kettmann V, Tóth J. Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids. Phytother Res. 2003;17:834-7 pubmed
    ..5 to >100 micro g/mL. Our results suggest that jatrorrhizine may serve as a leading compound for further studies to develop new antifungal agents with highly potent antifungal activity and low host toxicity...
  5. Dzugasova V, Subik J. Synthetic lethal interaction between the pel1 and op1 mutations in Saccharomyces cerevisiae. Folia Microbiol (Praha). 2005;50:293-9 pubmed
  6. Sidorova M, Drobna E, Dzugasova V, Hikkel I, Subik J. Loss-of-function pdr3 mutations convert the Pdr3p transcription activator to a protein suppressing multidrug resistance in Saccharomyces cerevisiae. FEMS Yeast Res. 2007;7:254-64 pubmed
  7. Farkas V, Takeo K, Maceková D, Ohkusu M, Yoshida S, Sipiczki M. Secondary cell wall formation in Cryptococcus neoformans as a rescue mechanism against acid-induced autolysis. FEMS Yeast Res. 2009;9:311-20 pubmed publisher
    ..The cell lysis and the formation of the secondary cell walls could be suppressed by buffering the growth medium between pH 4.5 and 6.5...
  8. Batova M, Klobucnikova V, Oblasova Z, Gregan J, Zahradnik P, Hapala I, et al. Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine). BMC Genomics. 2010;11:153 pubmed publisher
    ..We conclude that CTBT causes intracellular superoxide production and oxidative stress in fungal cells and is thus enhancing antimycotic drug effects by a secondary stress. ..
  9. Holesova Z, Jakubkova M, Zavadiakova I, Zeman I, Tomaska L, Nosek J. Gentisate and 3-oxoadipate pathways in the yeast Candida parapsilosis: identification and functional analysis of the genes coding for 3-hydroxybenzoate 6-hydroxylase and 4-hydroxybenzoate 1-hydroxylase. Microbiology. 2011;157:2152-63 pubmed publisher
    ..Finally, we showed that the overexpression of MNX1 or MNX2 increases the tolerance of C. parapsilosis cells to the antifungal drug terbinafine. ..

More Information

Publications10

  1. Lukác M, Mrva M, Garajová M, Mojzisová G, Varinska L, Mojzis J, et al. Synthesis, self-aggregation and biological properties of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride. Eur J Med Chem. 2013;66:46-55 pubmed publisher
    ..The relationship between structure, physicochemical properties and biological activity of the tested compounds is discussed. ..