Experts and Doctors on vertebrates in Singapore, Central Singapore, Singapore


Locale: Singapore, Central Singapore, Singapore
Topic: vertebrates

Top Publications

  1. Jung H, Mazzoni E, Soshnikova N, Hanley O, Venkatesh B, Duboule D, et al. Evolving Hox activity profiles govern diversity in locomotor systems. Dev Cell. 2014;29:171-87 pubmed publisher
    ..Thus, modulation of both Hoxc9 protein function and Hoxc9 gene expression likely contributed to evolutionary transitions between undulatory and ambulatory motor circuit connectivity programs. ..
  2. Rida P, Le Minh N, Jiang Y. A Notch feeling of somite segmentation and beyond. Dev Biol. 2004;265:2-22 pubmed
    ..We also discuss mathematical modeling and future directions in the end. ..
  3. Ravi V, Yu W, Pillai N, Lian M, Tay B, Tohari S, et al. Cyclostomes Lack Clustered Protocadherins. Mol Biol Evol. 2016;33:311-5 pubmed publisher
    ..In the absence of clustered protocadherins, cyclostomes might have evolved novel molecules or mechanisms for generating neuronal diversity which remains to be discovered. ..
  4. Venkatesh B, Lee A, Ravi V, Maurya A, Lian M, Swann J, et al. Elephant shark genome provides unique insights into gnathostome evolution. Nature. 2014;505:174-9 pubmed publisher
    ..It thus presents a new model for understanding the origin of adaptive immunity. ..
  5. Yu W, Rajasegaran V, Yew K, Loh W, Tay B, Amemiya C, et al. Elephant shark sequence reveals unique insights into the evolutionary history of vertebrate genes: A comparative analysis of the protocadherin cluster. Proc Natl Acad Sci U S A. 2008;105:3819-24 pubmed publisher
    ..The small and "stable" genome of the elephant shark is a valuable reference for understanding the evolution of vertebrate genomes...
  6. Ben J, Elworthy S, Ng A, van Eeden F, Ingham P. Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development. 2011;138:4969-78 pubmed publisher
    ..Our findings underline the importance of the primary cilium for Hh signaling in zebrafish and reveal the conservation of Ta3 function during vertebrate evolution...
  7. Vij S, Rink J, Ho H, Babu D, Eitel M, Narasimhan V, et al. Evolutionarily ancient association of the FoxJ1 transcription factor with the motile ciliogenic program. PLoS Genet. 2012;8:e1003019 pubmed publisher
  8. Zhang T, Tan Y, Fu J, Lui D, Ning Y, Jirik F, et al. The regulation of retina specific expression of rhodopsin gene in vertebrates. Gene. 2003;313:189-200 pubmed
    ..Our investigation suggests that the regulation of retinal specific expression is conserved in the pufferfish, frog and mouse and that the ancestral intron-containing rhodopsin gene has been displaced by an intronless copy in teleosts...
  9. Chou C, Loh C, Foo Y, Shen S, Fielding B, Tan T, et al. ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus). Gene. 2006;377:46-55 pubmed

More Information


  1. Ravi V, Lam K, Tay B, Tay A, Brenner S, Venkatesh B. Elephant shark (Callorhinchus milii) provides insights into the evolution of Hox gene clusters in gnathostomes. Proc Natl Acad Sci U S A. 2009;106:16327-32 pubmed publisher
  2. Bourque G. Transposable elements in gene regulation and in the evolution of vertebrate genomes. Curr Opin Genet Dev. 2009;19:607-12 pubmed publisher
    ..I will also summarize results that show how transposable elements have been a major catalyst of structural rearrangements throughout evolution. ..
  3. Lim G, Balke M, Meier R. Determining species boundaries in a world full of rarity: singletons, species delimitation methods. Syst Biol. 2012;61:165-9 pubmed publisher
  4. Lee A, Brenner S, Venkatesh B. Mouse transgenesis identifies conserved functional enhancers and cis-regulatory motif in the vertebrate LIM homeobox gene Lhx2 locus. PLoS ONE. 2011;6:e20088 pubmed publisher
    ..Other approaches such as sequence comparison between multiple mammals are required to identify and characterize such enhancers. ..
  5. Chauhan S, Zheng X, Tan Y, Tay B, Lim S, Venkatesh B, et al. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. Cell Mol Life Sci. 2012;69:3835-50 pubmed publisher
    ..Despite the interspecies variation, Speedy is conserved among most species examined. Our results provide a complete picture of the Speedy gene family and its evolution. ..
  6. Tay H, Ng Y, Manser E. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS ONE. 2010;5:e10125 pubmed publisher
    ..These events may mirror the requirement for PAK2 signaling essential for the proper formation of the blood-brain barrier. ..
  7. Ravi V, Bhatia S, Gautier P, Loosli F, Tay B, Tay A, et al. Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences. PLoS Genet. 2013;9:e1003177 pubmed publisher
    ..In summary, our study reveals that the pleiotropic functions of Pax6 in vertebrates are served by a divergent family of Pax6 genes, forged by ancient duplication events and by independent, lineage-specific gene losses. ..
  8. Venkatesh B, Ning Y, Brenner S. Late changes in spliceosomal introns define clades in vertebrate evolution. Proc Natl Acad Sci U S A. 1999;96:10267-71 pubmed
    ..Our intron-based cladogram establishes the difficult-to-ascertain phylogenetic relationships of some ray-finned fishes. For example, it shows that bichirs (Polypterus) are the sister group of all other extant ray-finned fishes...
  9. Lee A, Yang Y, Brenner S, Venkatesh B. TFCONES: a database of vertebrate transcription factor-encoding genes and their associated conserved noncoding elements. BMC Genomics. 2007;8:441 pubmed
    ..The conserved noncoding elements identified in TFCONES represent a catalog of highly prioritized putative cis-regulatory elements of TF-encoding genes and are candidates for functional assay. ..
  10. Liang D, Chang J, Chin A, Smith A, Kelly C, Weinberg E, et al. The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development. Mech Dev. 2001;108:29-43 pubmed
    ..Moreover, these effects are most dramatic when both vegf isoforms are co-expressed, indicating a synergistic effect of the expression of the two forms of the VEGF protein. ..
  11. Venkatesh B, Erdmann M, Brenner S. Molecular synapomorphies resolve evolutionary relationships of extant jawed vertebrates. Proc Natl Acad Sci U S A. 2001;98:11382-7 pubmed publisher
    ..Our study also provides molecular evidence to support the monophyly of living tetrapods and teleosts...