Experts and Doctors on tubulin in Singapore, Central Singapore, Singapore


Locale: Singapore, Central Singapore, Singapore
Topic: tubulin

Top Publications

  1. Oliferenko S, Balasubramanian M. Astral microtubules monitor metaphase spindle alignment in fission yeast. Nat Cell Biol. 2002;4:816-20 pubmed
    ..We propose that astral microtubules are involved directly in monitoring orientation of the metaphase spindle and in controlling the timing of elongation in fission yeast. ..
  2. Lim A, Tiu S, Li Q, Qi R. Direct regulation of microtubule dynamics by protein kinase CK2. J Biol Chem. 2004;279:4433-9 pubmed
    ..Taken together, CK2 is a microtubule-associated protein that confers microtubule stability in a phosphorylation-independent manner. ..
  3. Ng D, Lin B, Lim C, Huang G, Zhang T, Poli V, et al. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol. 2006;172:245-57 pubmed
    ..Our results indicate that Stat3 modulates the MT network by binding to the COOH-terminal tubulin-interacting domain of stathmin and antagonizing its MT destabilization activity. ..
  4. Chua C, Tang B. Syntaxin 16 is enriched in neuronal dendrites and may have a role in neurite outgrowth. Mol Membr Biol. 2008;25:35-45 pubmed
    ..Syntaxin 16 may thus play a role in neurite outgrowth and perhaps other specific dendritic anterograde/retrograde traffic. ..
  5. Xie H, Yu H, Zheng J, Nie P, Foster L, Mok Y, et al. EseG, an effector of the type III secretion system of Edwardsiella tarda, triggers microtubule destabilization. Infect Immun. 2010;78:5011-21 pubmed publisher
    ..tarda pathogenesis. Moreover, the approach established in this study to identify type III effectors can be used to identify and characterize more type III and possible type VI effectors in Edwardsiella. ..
  6. Gan F, Nagle A, Ang X, Ho O, Tan S, Yang H, et al. Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. Apoptosis. 2011;16:856-67 pubmed publisher
    ..In summary, our results conclude that shogaols cause apoptosis by inducing aberrant mitosis at least through the attenuation of cell cycle and spindle assembly checkpoint proteins. ..
  7. Ng K, Srinivas V, Srinivasan R, Balasubramanian M. The Nitrosopumilus maritimus CdvB, but not FtsZ, assembles into polymers. Archaea. 2013;2013:104147 pubmed publisher
    ..maritimus. Thus, we propose that it is Cdv proteins, rather than FtsZ, that function as the cell division apparatus in N. maritimus. ..
  8. Chen K, Koe C, Xing Z, Tian X, Rossi F, Wang C, et al. Arl2- and Msps-dependent microtubule growth governs asymmetric division. J Cell Biol. 2016;212:661-76 pubmed publisher
    ..Therefore, Arl2- and Msps-dependent microtubule growth is a new paradigm regulating asymmetric division of neural stem cells. ..
  9. Zheng L, Schwartz C, Wee L, Oliferenko S. The fission yeast transforming acidic coiled coil-related protein Mia1p/Alp7p is required for formation and maintenance of persistent microtubule-organizing centers at the nuclear envelope. Mol Biol Cell. 2006;17:2212-22 pubmed
    ..When microtubule polymerization was allowed, MTOCs were efficiently assembled de novo. We propose a model where MTOC emergence is a self-organizing process requiring the continuous association of microtubules with nucleation sites. ..

More Information


  1. Thadani R, Huang D, Oliferenko S. Robust polarity specification operates above a threshold of microtubule dynamicity. Cytoskeleton (Hoboken). 2011;68:290-9 pubmed publisher
    ..We propose that there exists a threshold of microtubule dynamicity that allows robust cellular polarisation. ..
  2. Yang W, Guo X, Thein S, Xu F, Sugii S, Baas P, et al. Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of ?-tubulin. Biochem J. 2013;449:605-12 pubmed publisher