Experts and Doctors on metaphase in Singapore, Central Singapore, Singapore


Locale: Singapore, Central Singapore, Singapore
Topic: metaphase

Top Publications

  1. Oliferenko S, Balasubramanian M. Astral microtubules monitor metaphase spindle alignment in fission yeast. Nat Cell Biol. 2002;4:816-20 pubmed
    ..We propose that astral microtubules are involved directly in monitoring orientation of the metaphase spindle and in controlling the timing of elongation in fission yeast. ..
  2. Goh P, Surana U. Cdc4, a protein required for the onset of S phase, serves an essential function during G(2)/M transition in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:5512-22 pubmed
    ..Collectively, these observations suggest that, in addition to its involvement in the initiation of S phase, Cdc4 may also be required for the onset of anaphase. ..
  3. Bimbo A, Liu J, Balasubramanian M. Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis. Mol Biol Cell. 2005;16:3162-75 pubmed
    ..We also present evidence that the effects of Pdk1p on cytokinesis are likely mediated via the fission yeast anillin-related protein, Mid1p, and the septation initiation network. ..
  4. Ren J, Kan A, Leong S, Ooi L, Jeang K, Chong S, et al. FAT10 plays a role in the regulation of chromosomal stability. J Biol Chem. 2006;281:11413-21 pubmed
  5. Wachtler V, Huang Y, Karagiannis J, Balasubramanian M. Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe. Mol Biol Cell. 2006;17:3254-66 pubmed
    ..This suggests a mechanism where both SIN and Clp1p/Flp1p contribute to maintenance of the actomyosin ring in late mitosis through Cdc15p, possibly by regulating its phosphorylation status. ..
  6. Wang H, Cai Y, Chia W, Yang X. Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. EMBO J. 2006;25:5783-93 pubmed
    ..The Mira/Pros telophase rescue seen in inscuteable mutant NBs requires DTRAF1. Our data suggest that DTRAF1 binds to Baz and acts downstream of Egr in the Mira/Pros telophase rescue pathway. ..
  7. Chai C, Teh E, Yeong F. Unrestrained spindle elongation during recovery from spindle checkpoint activation in cdc15-2 cells results in mis-segregation of chromosomes. Mol Biol Cell. 2010;21:2384-98 pubmed publisher
    ..Our data indicate that a slower rate of transition through the cell division cycle can result in an inadequate level of Pds1p accumulation that can compromise recovery from spindle assembly checkpoint activation. ..
  8. Lee Y, Wong C, Chan K, Lai S, Koh C, Li H. In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase. PLoS ONE. 2012;7:e45836 pubmed publisher
    ..Our findings suggest an additional role of RanGTP beyond its known function in mitotic spindle assembly during the prometaphase-metaphase transition. ..
  9. Li C, Zhang Y, Yang Q, Ye F, Sun S, Chen E, et al. NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity. Sci Rep. 2016;6:18773 pubmed publisher
    ..Hence, this study provides new insights into the function of NuSAP in spindle formation during mitosis. ..

More Information


  1. Miao Y, Han X, Zheng L, Xie Y, Mu Y, Yates J, et al. Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast. Nat Commun. 2016;7:11265 pubmed publisher
    ..Overall, this work identifies fimbrin as a key target for cell cycle regulation of actin cable assembly in budding yeast, and suggests an underlying mechanism. ..