Experts and Doctors on gene expression regulation in Singapore, Central Singapore, Singapore


Locale: Singapore, Central Singapore, Singapore
Topic: gene expression regulation

Top Publications

  1. Grinchuk O, Jenjaroenpun P, Orlov Y, Zhou J, Kuznetsov V. Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns. Nucleic Acids Res. 2010;38:534-47 pubmed publisher
    ..The database is available from approximately jiangtao/sas/index3.php?link =about. ..
  2. Lee L, Soon G, Shen P, Yong E, Flexner C, Pham P. Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteers. Antivir Ther. 2010;15:275-9 pubmed publisher
    ..We studied MRP1 expression and function in healthy volunteers treated with darunavir/ritonavir and efavirenz...
  3. Zheng S, Moehlenbrink J, Lu Y, Zalmas L, Sagum C, Carr S, et al. Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell. 2013;52:37-51 pubmed publisher
    ..Our results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity. ..
  4. Liu T, Lee E, Lim B, Shyh Chang N. Concise Review: Balancing Stem Cell Self-Renewal and Differentiation with PLZF. Stem Cells. 2016;34:277-87 pubmed publisher
    ..This review aims to provide the reader with an in-depth understanding of the molecular mechanisms underlying PLZF and the potential applications in tissue regeneration. ..
  5. Tan X, Beuerman R, Poh C, Mehta J. WW Domain Containing Transcription Regulator regulates human conjunctiva epithelial cell proliferation via inhibiting TGF? signaling pathway [corrected]. Mol Vis. 2012;18:1402-10 pubmed
    ..Moreover, TGF? receptor antibody and TGF? receptor inhibitor rescued this anti-proliferative effect of TAZ siRNA. TAZ is involved in human conjunctiva epithelial cells proliferation via regulating TGF? signaling pathway. ..
  6. Ou X, Xu S, Lam K. Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival. Proc Natl Acad Sci U S A. 2012;109:15401-6 pubmed
    ..On the other hand, it regulates the survival of ASCs and plays an important role in humoral immunity. ..
  7. Chua L, Lim M, Wong B. The Kunitz-protease inhibitor domain in amyloid precursor protein reduces cellular mitochondrial enzymes expression and function. Biochem Biophys Res Commun. 2013;437:642-7 pubmed publisher
    ..Overall, this study demonstrated that up-regulation of the KPI-containing APP isoforms is likely to contribute to the impairment of metabolic enzymes and mitochondrial function in AD. ..
  8. Zheng Z, Bay B, Aw S, Lin V. A novel antiestrogenic mechanism in progesterone receptor-transfected breast cancer cells. J Biol Chem. 2005;280:17480-7 pubmed
    ..The findings open up a new window for a hitherto unknown functional relationship between the PR and ER. The antiestrogenic effect of transfected PR also provides a potential therapeutic strategy for estrogen-dependent breast cancer. ..
  9. Lim W, Chow V. Gene expression profiles of U937 human macrophages exposed to Chlamydophila pneumoniae and/or low density lipoprotein in five study models using differential display and real-time RT-PCR. Biochimie. 2006;88:367-77 pubmed
    ..The transcriptional alterations of critical human genes in response to C. pneumoniae infection and foam cell development provide insights into certain key molecular pathophysiological mechanisms of atherosclerosis. ..

More Information

Publications248 found, 100 shown here

  1. Fu J, Tay S, Ling E, Dheen S. High glucose alters the expression of genes involved in proliferation and cell-fate specification of embryonic neural stem cells. Diabetologia. 2006;49:1027-38 pubmed
    ..These changes may form the basis for the defective neural tube patterning observed in embryos of diabetic pregnancies. ..
  2. Toh H, Sun L, Soe Y, Wu Y, Phoon Y, Chia W, et al. G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo. Clin Immunol. 2009;132:83-92 pubmed publisher
    ..Th17 cells have been implicated in autoimmune diseases and GVHD pathophysiology. Our study is the first to report the effect of G-CSF on the Th17 subpopulation. ..
  3. Nasirudeen A, Liu D. Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis. J Med Virol. 2009;81:1069-81 pubmed publisher
    ..Gene silencing of caspase-1 or inhibition of caspase-1 activity led to reduction in dengue virus-induced apoptosis with minimal effect on virus replication. ..
  4. Fu X, Toh W, Liu H, Lu K, Li M, Hande M, et al. Autologous feeder cells from embryoid body outgrowth support the long-term growth of human embryonic stem cells more effectively than those from direct differentiation. Tissue Eng Part C Methods. 2010;16:719-33 pubmed publisher
    ..This study helps to standardize the autologous culture of hESCs. It also suggests a more definite direction for future development of xeno-free culture system for hESCs. ..
  5. Zhang H, Zhao C, Li X, Zhu Y, Gan C, Wang Y, et al. Study of monocyte membrane proteome perturbation during lipopolysaccharide-induced tolerance using iTRAQ-based quantitative proteomic approach. Proteomics. 2010;10:2780-9 pubmed publisher
    ..Together, these findings could be of significance in understanding the mechanism of LPS tolerance and provide values for designing new approaches for regulating monocytic responses in sepsis patients. ..
  6. Sepramaniam S, Ying L, Armugam A, Wintour E, Jeyaseelan K. MicroRNA-130a represses transcriptional activity of aquaporin 4 M1 promoter. J Biol Chem. 2012;287:12006-15 pubmed publisher
    ..In vivo studies revealed that LNA(TM) anti-miR-130a could up-regulate the AQP4 M1 transcript and its protein to bring about a reduction in cerebral infarct and promote recovery. ..
  7. Chua C, Lim Y, Lee M, Tang B. Non-classical membrane trafficking processes galore. J Cell Physiol. 2012;227:3722-30 pubmed publisher
    ..The routes of intracellular membrane transport and communications between eukaryotic organelles now appear far more complex that one would have imagined 10 years ago. ..
  8. Voon D, Wang H, Koo J, Chai J, Hor Y, Tan T, et al. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway. PLoS ONE. 2013;8:e70427 pubmed publisher
    ..These data show that the EGFR/Ras pathway requisite for the sustenance of gastric stem cells in vivo and in vitro is involved in the genesis and promotion of EMT-induced tumor-initiating cells. ..
  9. Rust W, Sadasivam A, Dunn N. Three-dimensional extracellular matrix stimulates gastrulation-like events in human embryoid bodies. Stem Cells Dev. 2006;15:889-904 pubmed
    ..Furthermore, we identify a synthetic three-dimensional scaffold capable of supporting EB formation that partially mimics the effects of Matrigel. ..
  10. Inoue K, Ito K, Osato M, Lee B, Bae S, Ito Y. The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons. J Biol Chem. 2007;282:24175-84 pubmed
    ..Taken together, Runx3 determines TrkC positive sensory neuron identities through the transcriptional repression of TrkB when Trk-BTrkC double positive neurons differentiate into TrkC single positive neurons. ..
  11. Tay S, Blythe J, Lipovich L. Global discovery of primate-specific genes in the human genome. Proc Natl Acad Sci U S A. 2009;106:12019-24 pubmed publisher
  12. Wan G, Zhou L, Lim Q, Wong Y, Too H. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFR?2 isoforms. Cell Signal. 2011;23:1727-37 pubmed publisher
  13. Wong H, Li M, Kroll J, Hibberd M, Langford P. Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. PLoS ONE. 2011;6:e26130 pubmed publisher
    ..lactamica differentially regulate host respiratory epithelial cell gene expression through colonisation and/or protein secretion, and that this may contribute to subsequent clinical outcomes associated with these bacteria...
  14. Singh B, Sinha R, Zhou J, Tripathi M, Ohba K, Wang M, et al. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016;291:198-214 pubmed publisher
    ..Our results showed that RICTOR/MTORC2-AKT can integrate convergent hormonal and metabolic signals to provide coordinated and sensitive regulation of hepatic FOXO1-target gene expression. ..
  15. Ling L, Camilleri E, Helledie T, Samsonraj R, Titmarsh D, Chua R, et al. Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells. Gene. 2016;576:292-303 pubmed publisher
    ..It also highlights the need for careful evaluation of the bone marrow compartment in patients receiving chronic heparin treatment. ..
  16. Kilpeläinen T, Carli J, Skowronski A, Sun Q, Kriebel J, Feitosa M, et al. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun. 2016;7:10494 pubmed publisher
    ..Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health. ..
  17. Hong W. SNAREs and traffic. Biochim Biophys Acta. 2005;1744:493-517 pubmed
    ..In the post-genomic era, a fairly complete list of "all" SNAREs in several organisms (including human) can now be made. This review aims to summarize the key properties and the mechanism of action of SNAREs in mammalian cells...
  18. Yang S, Leow C, Tan T. Expression patterns of cytokine, growth factor and cell cycle-related genes after partial hepatectomy in rats with thioacetamide-induced cirrhosis. World J Gastroenterol. 2006;12:1063-70 pubmed
  19. Maubach G, Lim M, Zhuo L. Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells. Mol Biol Cell. 2008;19:4238-48 pubmed publisher
    ..These findings indicate a possible link between nuclear cathepsin F activity and the transcriptional regulation of hepatic stellate cell activation markers. ..
  20. Pott S, Kamrani N, Bourque G, Pettersson S, Liu E. PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouse. PLoS ONE. 2012;7:e48102 pubmed publisher
    ..1-dependent manner and yet permit for nuanced regulatory changes in individual species. ..
  21. Arora P, Baena A, Yu K, Saini N, Kharkwal S, Goldberg M, et al. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity. 2014;40:105-16 pubmed publisher
    ..These findings show flexibility in the outcome of two-way communication between CD8?(+) dendritic cells and iNKT cells, providing a mechanism for biasing toward either proinflammatory or anti-inflammatory responses. ..
  22. Badowski C, Sim A, Verma C, Szeverenyi I, Natesavelalar C, Terron Kwiatkowski A, et al. Modeling the Structure of Keratin 1 and 10 Terminal Domains and their Misassembly in Keratoderma. J Invest Dermatol. 2017;137:1914-1923 pubmed publisher
  23. Eng G, Edison -, Virshup D. Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2. PLoS ONE. 2017;12:e0177834 pubmed publisher
    ..The regulation of CK1δ by site-specific phosphorylation via the cell cycle and other signaling pathways provides a mechanism to couple external stimuli to regulation of CK1δ-dependent pathways including the circadian clock. ..
  24. Kwok Z, Tay Y. Long noncoding RNAs: lincs between human health and disease. Biochem Soc Trans. 2017;45:805-812 pubmed publisher
    ..We also discuss the potential of lncRNAs as diagnostic and therapeutic targets for clinical applications. ..
  25. Luo L, Siah C, Cai Y. Engrailed acts with Nejire to control decapentaplegic expression in the Drosophila ovarian stem cell niche. Development. 2017;144:3224-3231 pubmed publisher
    ..Therefore, our study defines the molecular pathway controlling dpp expression in the Drosophila ovarian stem cell niche. ..
  26. Ang E, Wong P, Moochhala S, Ng Y. Neuroprotection associated with running: is it a result of increased endogenous neurotrophic factors?. Neuroscience. 2003;118:335-45 pubmed
    ..The present findings suggest that neuroprotection after physical exercise may be a result of an increase in an endogenous neurotrophic factor nerve growth factor and the proliferation of its receptive cholinergic neurons. ..
  27. Beguin P, Mahalakshmi R, Nagashima K, Cher D, Takahashi A, Yamada Y, et al. 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity. J Cell Sci. 2005;118:1923-34 pubmed
  28. Xue L, Lu J, Cao Q, Hu S, Ding P, Ling E. Müller glial cells express nestin coupled with glial fibrillary acidic protein in experimentally induced glaucoma in the rat retina. Neuroscience. 2006;139:723-32 pubmed
  29. Lim S, Luo M, Koh M, Yang M, bin Abdul Kadir M, Tan J, et al. Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone. Mol Cell Biol. 2007;27:4105-20 pubmed
  30. Feng B, Jiang J, Kraus P, Ng J, Heng J, Chan Y, et al. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol. 2009;11:197-203 pubmed publisher
    ..Our findings also indicate that it is possible to reprogram MEFs without exogenous Klf transcription factors and link a nuclear receptor to somatic cell reprogramming. ..
  31. Kwong S, Woods A, Mirtschin P, Ge R, Kini R. The recruitment of blood coagulation factor X into snake venom gland as a toxin: the role of promoter cis-elements in its expression. Thromb Haemost. 2009;102:469-78 pubmed publisher
    ..VERSE is primarily responsible for the increase of trocarin D expression. The insertions/deletions within trocarin D intron 1 need to be characterised for their role in tissue-specific and inducible expression of trocarin D. ..
  32. Du J, Zeng J, Zhao Y, Boulaire J, Wang S. The combined use of viral transcriptional and post-transcriptional regulatory elements to improve baculovirus-mediated transient gene expression in human embryonic stem cells. J Biosci Bioeng. 2010;109:1-8 pubmed publisher
    ..This new viral vector for temporary transgene expression might become a useful tool for developmental biology studies and biomedical applications of hES cells. ..
  33. Li P, Wong J, Sum C, Sin W, Ng K, Koh M, et al. IRF8 and IRF3 cooperatively regulate rapid interferon-? induction in human blood monocytes. Blood. 2011;117:2847-54 pubmed publisher
    ..Therefore, we propose a model for the rapid induction of IFN-? in monocytes, whereby IRF8 and PU.1 form a scaffold complex on the IFN-? promoter to facilitate the recruitment of IRF3, thus enabling rapid IFN-? transcription. ..
  34. Sivakumar V, Foulds W, Luu C, Ling E, Kaur C. Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. J Pathol. 2011;224:245-60 pubmed publisher
    ..Our results suggest that activated microglial cells in hypoxic neonatal retina produce increased amounts of TNF-? and IL-1? that could induce RGC death. ..
  35. Cheng C, Ho W, Goh F, Guan S, Kong L, Lai W, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS ONE. 2011;6:e20932 pubmed publisher
    ..These findings provide a novel therapeutic value for artesunate in the treatment of allergic asthma. ..
  36. Kam S, Hennessy T, Chua S, Gan C, Philp R, Hon K, et al. Characterization of the human gastric fluid proteome reveals distinct pH-dependent protein profiles: implications for biomarker studies. J Proteome Res. 2011;10:4535-46 pubmed publisher
    ..Consequently, sample stratification, choice of proteomic approaches, and validation strategy can profoundly affect the interpretation of biomarker findings. These observations should help to refine gastric fluid biomarker studies. ..
  37. Zhang W, Thompson B, Hietakangas V, Cohen S. MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 2011;7:e1002429 pubmed publisher
    ..The MAPK/ERK pathway acts via the ETS-1 transcription factor Pointed. This mechanism permits physiological adjustment of insulin sensitivity and subsequent maintenance of circulating glucose at appropriate levels. ..
  38. Yu H, Lui Y, Xiong S, Leong W, Wen F, Nurkahfianto H, et al. Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells. Stem Cells Dev. 2013;22:136-47 pubmed publisher
    ..This technology increases our toolkit choice for controlled differentiation in muscle engineering. ..
  39. Dai L, Aye Thu C, Liu X, Xi J, Cheung P. TAK1, more than just innate immunity. IUBMB Life. 2012;64:825-34 pubmed publisher
    ..This review will focus on recent developments and also examine the regulation of TAK1 in response to a diverse range of other stimuli including DNA damage, transforming growth factor-?, Wnt, osmotic stress, and hypoxia. ..
  40. Chia J, Goh G, Racine V, Ng S, Kumar P, Bard F. RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells. Mol Syst Biol. 2012;8:629 pubmed publisher
    ..Our results provide a genetic overview of the signaling pathways that control the Golgi apparatus in human cells. ..
  41. Lim C, Cao X. Serine phosphorylation and negative regulation of Stat3 by JNK. J Biol Chem. 1999;274:31055-61 pubmed
    ..The inhibitory effect was not observed for Stat1. Our results suggest that Stat3 is a target of JNK that may regulate Stat3 activity via both Ser-727 phosphorylation-dependent and -independent mechanisms. ..
  42. Zhang T, Tan Y, Fu J, Lui D, Ning Y, Jirik F, et al. The regulation of retina specific expression of rhodopsin gene in vertebrates. Gene. 2003;313:189-200 pubmed
    ..Our investigation suggests that the regulation of retinal specific expression is conserved in the pufferfish, frog and mouse and that the ancestral intron-containing rhodopsin gene has been displaced by an intronless copy in teleosts...
  43. Howe H, Cheung P, Kong K, Badsha H, Thong B, Leong K, et al. Transforming growth factor beta-1 and gene polymorphisms in oriental ankylosing spondylitis. Rheumatology (Oxford). 2005;44:51-4 pubmed
    ..Activation of AS PBMCs led to enhanced TGFbeta1 production accompanied by reduction of TNFalpha and IFNgamma while the converse was observed in normal controls. ..
  44. Sabapathy K, Wagner E. JNK2: a negative regulator of cellular proliferation. Cell Cycle. 2004;3:1520-3 pubmed
    ..These data therefore suggests that JNK2, in contrast to JNK1, is a negative regulator of cellular proliferation in multiple cell types. ..
  45. Wang H, Tan J, Emelyanov A, Korzh V, Gong Z. Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio. Gene. 2005;356:91-100 pubmed
    ..In situ hybridization experiments confirmed that the extrahepatic expression was actually in adipocytes associated with several organs such as the intestine, ovary, and E2-induced testis. ..
  46. Wang H, Wong P, Spiess J, Zhu Y. Cholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats. Neurosci Biobehav Rev. 2005;29:1361-73 pubmed
    ..CCK(2) receptor expression was greater in PVG hooded than in SD rats in the cortex and hippocampus. Genetic studies also demonstrated four differences in the DNA sequence of the CCK(2) receptor gene between the two rat strains. ..
  47. Tan A, Wong S, Lam K. Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells. J Biol Chem. 2006;281:28666-78 pubmed
    ..Taken together, our findings indicate that Fyn-calcineurin-NFATc2 and MEK2-ERK1/2 are two independent signaling pathways that cooperate to control T cell receptor-mediated ICOS induction. ..
  48. Lim C, Yao F, Wong J, George J, Xu H, Chiu K, et al. Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell. 2007;27:622-35 pubmed
    ..Global gene expression profiling subsequently revealed a spectrum of NF-kappaB target genes that are positively regulated by E2F1, further demonstrating the critical role of E2F1 in the Toll-like receptor 4 pathway. ..
  49. Tavintharan S, Lim S, Sum C. Effects of niacin on cell adhesion and early atherogenesis: biochemical and functional findings in endothelial cells. Basic Clin Pharmacol Toxicol. 2009;104:206-10 pubmed publisher
    ..Apart from its lipid-modifying effects, these pleiotropic effects of niacin may potentially contribute to the beneficial effects of risk reduction for atherosclerotic disease. ..
  50. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, et al. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev. 2009;23:2388-93 pubmed publisher
  51. Zhu H, Riau A, Beuerman R. Epithelial microfilament regulators show regional distribution in mouse conjunctiva. Mol Vis. 2010;16:2215-24 pubmed
    ..This study was designed to investigate the distribution and levels of expression of a subset of microfilament regulators in the forniceal, palpebral, and bulbar conjunctival epithelia...
  52. Fu X, Toh W, Liu H, Lu K, Li M, Cao T. Establishment of clinically compliant human embryonic stem cells in an autologous feeder-free system. Tissue Eng Part C Methods. 2011;17:927-37 pubmed publisher
    ..Overall, this study suggested a strategy for efficient propagation of clinically compliant hESCs in an autologous feeder-free culture system. ..
  53. Wong T, Zhou L, Li J, Tong L, Zhao S, Li X, et al. Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication. Invest Ophthalmol Vis Sci. 2011;52:7385-91 pubmed publisher
    ..To identify the tear proteins associated with the long-term use of glaucoma medication by using proteomic analysis and to compare these proteins to those previously reported in primary dry eye disease...
  54. Sundaram J, Chan E, Poore C, Pareek T, Cheong W, Shui G, et al. Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration. J Neurosci. 2012;32:1020-34 pubmed publisher
    ..Together, our findings delineate a potential therapeutic target for the reduction of neuroinflammation in neurodegenerative diseases including AD. ..
  55. Sabapathy K. Role of the JNK pathway in human diseases. Prog Mol Biol Transl Sci. 2012;106:145-69 pubmed publisher
  56. Lokireddy S, Wijesoma I, Sze S, McFarlane C, Kambadur R, Sharma M. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Am J Physiol Cell Physiol. 2012;303:C512-29 pubmed publisher
  57. Teng T, Foo S, Simamarta D, Lum F, Teo T, Lulla A, et al. Viperin restricts chikungunya virus replication and pathology. J Clin Invest. 2012;122:4447-60 pubmed publisher
  58. Shei W, Liu J, Htoon H, Aung T, Vithana E. Differential expression of the Slc4 bicarbonate transporter family in murine corneal endothelium and cell culture. Mol Vis. 2013;19:1096-106 pubmed
    ..Moreover, as cell culture can affect expression levels of Slc4 genes, caution and careful design of experiments are necessary when undertaking studies of Slc4-mediated ion transport in cultured cells. ..
  59. Lim A, Lorthongpanich C, Chew T, Tan C, Shue Y, Balu S, et al. The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles. Development. 2013;140:3819-25 pubmed publisher
    ..However, these null-mutant females, unlike their male counterparts, are fertile, uncoupling retrotransposon activation from sterility. ..
  60. Han S, Ang H, Poh R, Chaurasia S, Peh G, Liu J, et al. Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy. Invest Ophthalmol Vis Sci. 2013;54:6179-89 pubmed publisher
    ..Our Slc4a11 KO mouse model successfully represents clinical manifestations of human CHED. We were able to show chronological corneal progression for the first time in a knockout mouse model as well as renal abnormalities. ..
  61. Lim K, Wong L. Finding consistent disease subnetworks using PFSNet. Bioinformatics. 2014;30:189-96 pubmed publisher
    .. ..
  62. Yu F, Goh S, Dai R, Luo Y. Adenosine-containing molecules amplify glucose signaling and enhance txnip expression. Mol Endocrinol. 2009;23:932-42 pubmed publisher
    ..The regulatory role of these molecules may be exerted via amplifying glucose signaling. Hence, this revelation may pave the way for interventions aimed toward metabolic disorders resulting from abnormal glucose homeostasis. ..
  63. Li Z, Lin Q, Chen J, Wu J, Lim T, Loh S, et al. Shotgun identification of the structural proteome of shrimp white spot syndrome virus and iTRAQ differentiation of envelope and nucleocapsid subproteomes. Mol Cell Proteomics. 2007;6:1609-20 pubmed
    ..A comprehensive identification of WSSV structural proteins and their localization should facilitate the studies of its assembly and mechanism of infection...
  64. Liao W, Bao Z, Cheng C, Mok Y, Wong W. Dendritic cell-derived interferon-gamma-induced protein mediates tumor necrosis factor-alpha stimulation of human lung fibroblasts. Proteomics. 2008;8:2640-50 pubmed publisher
    ..We have demonstrated for the first time that DCIP is upregulated by TNF-alpha and also mediates TNF-alpha stimulation of human lung fibroblasts. Further studies on the role of DCIP in airway inflammation and remodeling are warranted. ..
  65. Ruedl C, Khameneh H, Karjalainen K. Manipulation of immune system via immortal bone marrow stem cells. Int Immunol. 2008;20:1211-8 pubmed publisher
    ..This allows time consuming and cumulative in vitro experimental manipulations without sacrificing their ability to differentiate in vivo or in vitro to any hematopoietic lineage. ..
  66. Lai W, Irwan A, Goh H, Howe H, Yu D, Valle Oñate R, et al. Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. J Immunol. 2008;181:8010-7 pubmed
    ..Together, these results demonstrate SphK modulation may provide a novel approach in treating chronic autoimmune conditions such as RA by inhibiting the release of pro-inflammatory cytokines. ..
  67. Yu H, Kunarso G, Hong F, Stanton L. Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem. 2009;284:31327-35 pubmed publisher
    ..These data demonstrate that Zfp206 is a key component of the core transcriptional regulatory network and together with Oct4 and Sox2 regulates differentiation of ESC. ..
  68. Chua L, Lim M, Chong P, Hu Z, Cheung N, Wong B. Impaired neuronal insulin signaling precedes A?42 accumulation in female A?PPsw/PS1?E9 mice. J Alzheimers Dis. 2012;29:783-91 pubmed publisher
    ..Although the exact mechanisms underlining this connection remain unclear, our results suggest a possible early role for insulin signaling impairment leading to amyloid accumulation in A?PPsw/PS1?E9 mice. ..
  69. Kamran N, Takai Y, Miyoshi J, Biswas S, Wong J, Gasser S. Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells. PLoS ONE. 2013;8:e54406 pubmed publisher
    ..Our data suggest that CD155 regulates T(h)2 differentiation. Targeting of CD155 in immunization protocols using peptides may represent a promising new approach to boost protective humoral immunity in viral vaccines. ..
  70. Zhu H, Yeo S, Ng J, Htoon H, Beuerman R. Moesin as a key cytoskeleton regulator in corneal fibrosis. Ocul Surf. 2013;11:119-32 pubmed publisher
    ..58-, 0.53-, and 0.47-fold of control at the same PO days. : Moesin may be a potential drug target for inhibiting corneal fibrosis, and the details of moesin-related signaling pathways would be critical for understanding corneal fibrosis. ..
  71. Balasubramanian S, Poh K, Ong C, Kreyling W, Ong W, Yu L. The effect of primary particle size on biodistribution of inhaled gold nano-agglomerates. Biomaterials. 2013;34:5439-52 pubmed publisher
    ..Together, results in this study indicate disintegration of nanosized agglomerates after inhalation and show impact of primary size of particles on subsequent biodistribution...
  72. Khor C, Miyake M, Chen L, Shi Y, Barathi V, Qiao F, et al. Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. Hum Mol Genet. 2013;22:5288-94 pubmed publisher
    ..These new data advance our understanding of the molecular pathogenesis of severe myopia. ..
  73. Zhang T, Kee W, Seow K, Fung W, Cao X. The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6. Mol Cell Biol. 2000;20:7132-9 pubmed
    ..Finally, we demonstrate a direct binding of Stat3 to the receptor. Taken together, our data reveal a novel role for the coiled-coil domain that regulates the early events in Stat3 activation and function. ..
  74. Wang H, Zhu Y, Farook J, Moochhala S, Teo A, Lee L, et al. Genetic variations in CCK2 receptor in PVG hooded and Sprague-Dawley rats and its mRNA expression on cat exposure. Behav Neurosci. 2003;117:385-90 pubmed
    ..Acute treatment with a CCK2 agonist (CCK-4) or antagonist (LY225910) did not alter the level of CCK2 receptor expression, indicating no difference between the 2 strains in sensitivity of the CCK2 receptor to drugs. ..
  75. Rodda D, Chew J, Lim L, Loh Y, Wang B, Ng H, et al. Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem. 2005;280:24731-7 pubmed
    ..These studies extend the understanding of the pluripotent genetic regulatory network within which the Sox2-Oct4 complex are at the top of the regulatory hierarchy. ..
  76. Tan A, Goh S, Wong S, Lam K. T helper cell-specific regulation of inducible costimulator expression via distinct mechanisms mediated by T-bet and GATA-3. J Biol Chem. 2008;283:128-36 pubmed
  77. Yang Y, Ho S, Yap M. Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells. Biotechnol Bioeng. 2009;102:1152-60 pubmed publisher
    ..It will have wide-ranging applications in fields related to the study of biosynthesis of multi-subunit proteins, proteomic research on protein interactions, and multi-gene metabolic engineering. ..
  78. Li M, Shen Q, Wong F, Xu H, Hong N, Zeng L, et al. Germ cell sex prior to meiosis in the rainbow trout. Protein Cell. 2011;2:48-54 pubmed publisher
  79. Xia J, He X, Bai Z, Yue G. Identification and characterization of 63 MicroRNAs in the Asian seabass Lates calcarifer. PLoS ONE. 2011;6:e17537 pubmed publisher
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