Experts and Doctors on gene duplication in Singapore, Central Singapore, Singapore


Locale: Singapore, Central Singapore, Singapore
Topic: gene duplication

Top Publications

  1. Zhang L. From gene trees to species trees II: species tree inference by minimizing deep coalescence events. IEEE/ACM Trans Comput Biol Bioinform. 2011;8:1685-91 pubmed publisher
    ..2) The deep coalescence cost is always not less than the gene duplication cost in the reconciliation of an arbitrary gene tree and a species tree. 3) Species tree inference by minimizing deep coalescence events is NP-hard. ..
  2. Monroig Ã, Lopes Marques M, Navarro J, Hontoria F, Ruivo R, Santos M, et al. Evolutionary functional elaboration of the Elovl2/5 gene family in chordates. Sci Rep. 2016;6:20510 pubmed publisher
    ..Our findings illustrate how non-integrated "metabolic islands" evolve into fully wired pathways upon duplication and neofunctionalization. ..
  3. Teo S, Pawitan Y, Ku C, Chia K, Salim A. Statistical challenges associated with detecting copy number variations with next-generation sequencing. Bioinformatics. 2012;28:2711-8 pubmed publisher
  4. Xu Y, Teo L, Zhou J, Kumar P, Yu H. Floral organ identity genes in the orchid Dendrobium crumenatum. Plant J. 2006;46:54-68 pubmed
    ..However, gene duplication might have led to the divergence in gene expression and regulation, possibly followed by functional divergence, resulting in the unique floral ontogeny in orchids...
  5. Jiang S, Christoffels A, Ramamoorthy R, Ramachandran S. Expansion mechanisms and functional annotations of hypothetical genes in the rice genome. Plant Physiol. 2009;150:1997-2008 pubmed publisher
    ..Our analyses also provide a valuable means to facilitate the characterization and functional annotation of hypothetical genes in other organisms. ..
  6. Kiener T, Sleptsova Friedrich I, Hunziker W. Identification, tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio. Gene Expr Patterns. 2007;7:767-76 pubmed
    ..Interestingly, the differential tissue and developmental expression of the two tjp1 and tjp2 genes indicates that the duplicated genes have been adapted for distinct transcriptional regulations during evolution. ..
  7. Bartfai R, Orban L. The vasa locus in zebrafish: multiple RGG boxes from duplications. DNA Cell Biol. 2003;22:47-54 pubmed
    ..Mapping to two radiation hybrid panels strengthened the position of the gene on LG10 of zebrafish. ..
  8. Li M, Zhu F, Hong Y. Differential evolution of duplicated medakafish mitf genes. Int J Biol Sci. 2013;9:496-508 pubmed publisher
    ..Our finding reveals species-specific variations for mitf duplicate evolution, in agreement with enormous diversity of body coloration and patterning. ..
  9. Wu T, Zhang L. Structural properties of the reconciliation space and their applications in enumerating nearly-optimal reconciliations between a gene tree and a species tree. BMC Bioinformatics. 2011;12 Suppl 9:S7 pubmed publisher
    ..This work provides a new graph-theoretic framework for studying gene tree and species tree reconciliations. ..

More Information


  1. Christoffels A, Koh E, Chia J, Brenner S, Aparicio S, Venkatesh B. Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes. Mol Biol Evol. 2004;21:1146-51 pubmed
    ..These data strongly suggest a whole-genome duplication event early during the evolution of ray-finned fishes, probably before the origin of teleosts...
  2. Jiang S, Ramamoorthy R, Ramachandran S. Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes. Dev Biol. 2008;314:418-32 pubmed publisher
    ..Each member may play specialized roles in a specific tissue or stress condition and may function as regulators of environmental and hormonal signaling. ..
  3. Gwee P, Tay B, Brenner S, Venkatesh B. Characterization of the neurohypophysial hormone gene loci in elephant shark and the Japanese lamprey: origin of the vertebrate neurohypophysial hormone genes. BMC Evol Biol. 2009;9:47 pubmed publisher
    ..We have also analyzed the neurohypophysial hormone gene locus in an invertebrate chordate, the amphioxus (Branchiostoma floridae)...
  4. Reza M, Swarup S, Kini R. Structure of two genes encoding parallel prothrombin activators in Tropidechis carinatus snake: gene duplication and recruitment of factor X gene to the venom gland. J Thromb Haemost. 2007;5:117-26 pubmed
    ..Thus, we named this segment as VERSE (Venom Recruitment/Switch Element). To our knowledge, this is the first molecular evidence for the recruitment of a duplicated gene for expression in venom glands by a simple insertion. ..
  5. Reza M, Minh Le T, Swarup S, Manjunatha Kini R. Molecular evolution caught in action: gene duplication and evolution of molecular isoforms of prothrombin activators in Pseudonaja textilis (brown snake). J Thromb Haemost. 2006;4:1346-53 pubmed
    ..As vertebrates, the snakes also contain a system to activate prothrombin in their own blood during injury. These hemostatic factors are produced in the liver...
  6. Yu W, Brenner S, Venkatesh B. Duplication, degeneration and subfunctionalization of the nested synapsin-Timp genes in Fugu. Trends Genet. 2003;19:180-3 pubmed publisher
  7. Aparicio S, Chapman J, Stupka E, Putnam N, Chia J, Dehal P, et al. Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science. 2002;297:1301-10 pubmed
    ..Conserved linkages between Fugu and human genes indicate the preservation of chromosomal segments from the common vertebrate ancestor, but with considerable scrambling of gene order...
  8. Jiang S, Ma Z, Ramachandran S. Evolutionary history and stress regulation of the lectin superfamily in higher plants. BMC Evol Biol. 2010;10:79 pubmed publisher
    ..Our studies provide a new outline of the plant lectin gene superfamily and advance the understanding of plant lectin genes in lineage-specific expansion and their functions in biotic/abiotic stress-related developmental processes. ..
  9. Ku C, Pawitan Y, Sim X, Ong R, Seielstad M, Lee E, et al. Genomic copy number variations in three Southeast Asian populations. Hum Mutat. 2010;31:851-7 pubmed publisher
    ..Tens of loci show population differentiation and overlap with genes previously known to be associated with genetic risk of diseases. One of these loci is the CYP2A6 deletion, previously linked to reduced susceptibility to lung cancer. ..
  10. Loh Y, Christoffels A, Brenner S, Hunziker W, Venkatesh B. Extensive expansion of the claudin gene family in the teleost fish, Fugu rubripes. Genome Res. 2004;14:1248-57 pubmed
  11. Ravi V, Bhatia S, Gautier P, Loosli F, Tay B, Tay A, et al. Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences. PLoS Genet. 2013;9:e1003177 pubmed publisher
    ..In summary, our study reveals that the pleiotropic functions of Pax6 in vertebrates are served by a divergent family of Pax6 genes, forged by ancient duplication events and by independent, lineage-specific gene losses. ..