Experts and Doctors on centrosome in Singapore, Central Singapore, Singapore


Locale: Singapore, Central Singapore, Singapore
Topic: centrosome

Top Publications

  1. Cai Y, Yu F, Lin S, Chia W, Yang X. Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell. 2003;112:51-62 pubmed
    ..In sensory organ precursors, Bazooka/DaPKC and Pins/G alpha i localize to opposite sides of the cortex and function in opposition to generate a symmetric spindle. ..
  2. Zhao Z, Lim J, Ng Y, Lim L, Manser E. The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell. 2005;20:237-49 pubmed
    ..These observations may underlie reported effects of active PAK on cells, including histone H3 phosphorylation, alterations in centrosome number, and progression through mitosis. ..
  3. Crasta K, Huang P, Morgan G, Winey M, Surana U. Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins. EMBO J. 2006;25:2551-63 pubmed
  4. Wang H, Somers G, Bashirullah A, Heberlein U, Yu F, Chia W. Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 2006;20:3453-63 pubmed
    ..We have identified a novel mechanism for controlling the balance between self-renewal and neuronal differentiation during the asymmetric division of Drosophila larval NBs. ..
  5. Shreeram S, Hee W, Bulavin D. Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis. Mol Cell Biol. 2008;28:7442-50 pubmed publisher
    ..Our findings indicate that Cdc25A S123 phosphorylation is crucial for coupling centrosome duplication to DNA replication cycles after DNA damage and therefore is likely to play a role in the regulation of tumorigenesis. ..
  6. Tang J, Tan C, Li J, Siddique M, Guo K, Chan S, et al. VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers. Mol Cancer. 2010;9:128 pubmed publisher
    ..VHZ is able to facilitate G1/S cell cycle transition in a PTP activity-dependent manner. The upregulation of its protein levels in primary human cancers supports the clinical relevance of the protein in cancers. ..
  7. Wang C, Li S, Januschke J, Rossi F, Izumi Y, Garcia Alvarez G, et al. An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts. Dev Cell. 2011;21:520-33 pubmed publisher
    ..Our findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during NB asymmetric division. ..
  8. Lee S, Chan J. Proteomic identification of chaperonin-containing tail-less complex polypeptide-1 gamma subunit as a p53-responsive protein in colon cancer cells. Cancer Genomics Proteomics. 2012;9:101-8 pubmed
    ..Moreover, TCP-1? was found to be co-localized with centrosome. Our results implicate a novel cell signaling loop in HCt116 cells involving p53 and TCP1-? phosphorylation, which may be related to regulation and action of centrosomes. ..
  9. Chen K, Koe C, Xing Z, Tian X, Rossi F, Wang C, et al. Arl2- and Msps-dependent microtubule growth governs asymmetric division. J Cell Biol. 2016;212:661-76 pubmed publisher
    ..Therefore, Arl2- and Msps-dependent microtubule growth is a new paradigm regulating asymmetric division of neural stem cells. ..