Experts and Doctors on transgenes in Moscow, Russia

Summary

Locale: Moscow, Russia
Topic: transgenes

Top Publications

  1. Logunov D, Ilyinskaya G, Cherenova L, Verhovskaya L, Shmarov M, Chumakov P, et al. Restoration of p53 tumor-suppressor activity in human tumor cells in vitro and in their xenografts in vivo by recombinant avian adenovirus CELO-p53. Gene Ther. 2004;11:79-84 pubmed
  2. Rodin S, Kyrchanova O, Pomerantseva E, Parshikov A, Georgiev P. New properties of Drosophila fab-7 insulator. Genetics. 2007;177:113-21 pubmed
    ..It seems likely that Fab-7 strengthens the relatively weak white promoter, which leads to the efficient enhancer-promoter interaction and insulator bypass...
  3. Berdichevets I, Shimshilashvili H, Gerasymenko I, Sindarovska Y, Sheludko Y, Goldenkova Pavlova I. Multiplex PCR assay for detection of recombinant genes encoding fatty acid desaturases fused with lichenase reporter protein in GM plants. Anal Bioanal Chem. 2010;397:2289-93 pubmed publisher
    ..Here, we report a multiplex polymerase chain reaction method for detection of desA and desC desaturase genes of cyanobacteria Synechocystis sp. PCC6803 and Synechococcus vulcanus, respectively, fused to licBM3 reporter in GM plants. ..
  4. Olovnikov I, Ryazansky S, Shpiz S, Lavrov S, Abramov Y, Vaury C, et al. De novo piRNA cluster formation in the Drosophila germ line triggered by transgenes containing a transcribed transposon fragment. Nucleic Acids Res. 2013;41:5757-68 pubmed publisher
    ..We show that transgene-derived hsp70 piRNAs stimulate in trans cleavage of cognate endogenous transcripts with subsequent processing of the non-homologous parts of these transcripts into piRNAs. ..
  5. Golovnin A, Biryukova I, Birukova I, Romanova O, Silicheva M, Parshikov A, et al. An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila. Development. 2003;130:3249-58 pubmed
    ..Genetic analysis shows that at least two proteins, Suppressor of Hairy wing and Modifier of MDG4, required for the activity of this insulator, are involved in the transcriptional regulation of Achaete-scute. ..
  6. Kyrchanova O, Toshchakov S, Parshikov A, Georgiev P. Study of the functional interaction between Mcp insulators from the Drosophila bithorax complex: effects of insulator pairing on enhancer-promoter communication. Mol Cell Biol. 2007;27:3035-43 pubmed
    ..These results indicate that the relative placement and orientation of insulator-like elements can determine proper enhancer-promoter communication. ..
  7. Melnikova L, Kostuchenko M, Silicheva M, Georgiev P. Drosophila gypsy insulator and yellow enhancers regulate activity of yellow promoter through the same regulatory element. Chromosoma. 2008;117:137-45 pubmed
    ..These finding suggest that proteins bound to the -100 to -69 sequence are essential for communication between the yellow promoter and upstream regulatory elements. ..
  8. Golovnin A, Melnikova L, Volkov I, Kostuchenko M, Galkin A, Georgiev P. 'Insulator bodies' are aggregates of proteins but not of insulators. EMBO Rep. 2008;9:440-5 pubmed publisher
    ..Hence, it is not the functional genomic insulators but rather aggregated proteins that make the so-called 'insulator bodies'. ..
  9. Kostyuchenko M, Savitskaya E, Koryagina E, Melnikova L, Karakozova M, Georgiev P. Zeste can facilitate long-range enhancer-promoter communication and insulator bypass in Drosophila melanogaster. Chromosoma. 2009;118:665-74 pubmed publisher
    ..Zeste is also required for insulator bypass by the eye enhancer. Taken together, these results show that Zeste can support specific long-range interactions between enhancers and promoters. ..

Scientific Experts

More Information

Publications13

  1. Silicheva M, Golovnin A, Pomerantseva E, Parshikov A, Georgiev P, Maksimenko O. Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding. Nucleic Acids Res. 2010;38:39-47 pubmed publisher
  2. Kuzmin D, Gogvadze E, Kholodenko R, Grzela D, Mityaev M, Vinogradova T, et al. Novel strong tissue specific promoter for gene expression in human germ cells. BMC Biotechnol. 2010;10:58 pubmed publisher
  3. Erokhin M, Davydova A, Kyrchanova O, Parshikov A, Georgiev P, Chetverina D. Insulators form gene loops by interacting with promoters in Drosophila. Development. 2011;138:4097-106 pubmed publisher
    ..Both insulators support basal activity of the yellow and white promoters in eyes. Thus, the ability of insulators to interact with promoters might play an important role in the regulation of basal gene transcription...
  4. Abramov Y, Shatskikh A, Maksimenko O, Bonaccorsi S, Gvozdev V, Lavrov S. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Genetics. 2016;202:93-106 pubmed publisher
    ..We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. ..