Experts and Doctors on gene expression regulation in St Petersburg, Russia


Locale: St Petersburg, Russia
Topic: gene expression regulation

Top Publications

  1. Khavinson V, Lin kova N, Polyakova V, Kvetnoy I, Benberin V, D yakonov M, et al. Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins. Bull Exp Biol Med. 2012;153:559-62 pubmed
    ..Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis. ..
  2. Nikolaeva S, Bachteeva V, Fock E, Herterich S, Lavrova E, Borodkina A, et al. Frog urinary bladder epithelial cells express TLR4 and respond to bacterial LPS by increase of iNOS expression and L-arginine uptake. Am J Physiol Regul Integr Comp Physiol. 2012;303:R1042-52 pubmed publisher
  3. Savvateeva Popova E, Popov A, Grossman A, Nikitina E, Medvedeva A, Peresleni A, et al. Pathogenic chaperone-like RNA induces congophilic aggregates and facilitates neurodegeneration in Drosophila. Cell Stress Chaperones. 2007;12:9-19 pubmed
    ..This novel model demonstrates that expression of a specific highly structured RNA alone is sufficient to trigger neurodegeneration, possibly through chaperone-like facilitation of protein misfolding and aggregation. ..
  4. Rybnikova E, Vataeva L, Tyulkova E, Gluschenko T, Otellin V, Pelto Huikko M, et al. Mild hypoxia preconditioning prevents impairment of passive avoidance learning and suppression of brain NGFI-A expression induced by severe hypoxia. Behav Brain Res. 2005;160:107-14 pubmed
    ..The preconditioning up-regulated severe hypoxia-suppressed neocortical and hippocampal expression of NGFI-A, suggesting a possible role for NGFI-A in the neuroprotective mechanisms activated by hypoxic preconditioning. ..
  5. Berstein L. Endocrinology of the wild and mutant BRCA1 gene and types of hormonal carcinogenesis. Future Oncol. 2008;4:23-39 pubmed publisher
  6. Enukashvily N, Ponomartsev N. Mammalian satellite DNA: a speaking dumb. Adv Protein Chem Struct Biol. 2013;90:31-65 pubmed publisher
    ..The current review summarizes recent data about satellite DNA transcription. The possible functions of the transcripts are discussed. ..
  7. Mogilenko D, Kudriavtsev I, Shavva V, Dizhe E, Vilenskaya E, Efremov A, et al. Peroxisome proliferator-activated receptor ? positively regulates complement C3 expression but inhibits tumor necrosis factor ?-mediated activation of C3 gene in mammalian hepatic-derived cells. J Biol Chem. 2013;288:1726-38 pubmed publisher
    ..These results suggest novel mechanism controlling C3 expression in hepatocytes during acute phase inflammation and demonstrate a crosstalk between PPAR? and TNF? in the regulation of complement system. ..
  8. Osechkina N, Ivanov M, Nazarov G, Batotsyrenova E, Lapina N, Babkin A, et al. Assessment of Expression of Genes Coding GABAA Receptors during Chronic and Acute Intoxication of Laboratory Rats with Ethanol. Bull Exp Biol Med. 2016;160:452-4 pubmed publisher
    ..In preliminarily alcoholized rats, acute intoxication with ethanol enhanced expression of genes Gabrb1 and Gabra5 by 1.7 and 8.7 times, respectively. There was neither acute nor chronic effect of ethanol on expression of gene Gabra3. ..
  9. Abramova M, Kukushkin A, Pospelova T, Svetlikova S, Pospelov V. [Role of the TCF phosphorylation state and the chromatin structure in the negative transcription regulation of the c-fos proto-oncogene in E1A + c-Ha-ras transformed cells]. Mol Biol (Mosk). 2002;36:66-75 pubmed
    ..The c-fos suppression in transformed REF was explained by formation of a transcriptionally inactive chromatin structure in the fos promoter region as a result of histone deacetylation, rather than by insufficient TCF phosphorylation. ..

More Information


  1. Brigino E, Haraguchi S, Koutsonikolis A, Cianciolo G, Owens U, Good R, et al. Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. Proc Natl Acad Sci U S A. 1997;94:3178-82 pubmed
    ..These findings indicate that extracellular Nef may contribute to the immunopathogenesis of HIV infection by inducing IL-10. ..
  2. Khavinson V, Lin kova N, Dudkov A, Polyakova V, Kvetnoi I. Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. Bull Exp Biol Med. 2012;152:615-8 pubmed
    ..Peptide T-34 normalizes the synthesis of these proteins by regulating the expression of the corresponding genes...
  3. Mogilenko D, Kudriavtsev I, Trulioff A, Shavva V, Dizhe E, Missyul B, et al. Modified low density lipoprotein stimulates complement C3 expression and secretion via liver X receptor and Toll-like receptor 4 activation in human macrophages. J Biol Chem. 2012;287:5954-68 pubmed publisher
    ..These data provide a novel mechanism of C3 gene regulation in macrophages and suggest new aspects of cross-talk between mLDL, C3, C3a, and TLR4 during development of atherosclerotic lesions. ..
  4. Shteinikov V, Korosteleva A, Tikhonova T, Potapieva N, Tikhonov D. Ligands of histamine receptors modulate acid-sensing ion channels. Biochem Biophys Res Commun. 2017;490:1314-1318 pubmed publisher
    ..ASIC2a were virtually insensitive to the drugs tested. We conclude that ligands of histamine receptors should also be considered as ASIC modulators. ..
  5. Cheng F, Lienlaf M, Perez Villarroel P, Wang H, Lee C, Woan K, et al. Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Mol Immunol. 2014;60:44-53 pubmed publisher
    ..This dynamic interaction results in dynamic changes in the expression of IL-10 and might help to explain the intrinsic plasticity of the APC to determine T-cell activation versus T-cell tolerance. ..
  6. Shavva V, Mogilenko D, Dizhe E, Oleinikova G, Perevozchikov A, Orlov S. Hepatic nuclear factor 4? positively regulates complement C3 expression and does not interfere with TNF?-mediated stimulation of C3 expression in HepG2 cells. Gene. 2013;524:187-92 pubmed publisher
    ..These results suggest a novel mechanism of C3 regulation during acute phase response in HepG2 cells and display the mechanism of interaction of TNF?-induced pathways and HNF4? in transcriptional regulation of C3 gene. ..
  7. Abramova M, Zatulovskiy E, Svetlikova S, Kukushkin A, Pospelov V. e2f1 Gene is a new member of Wnt/beta-catenin/Tcf-regulated genes. Biochem Biophys Res Commun. 2010;391:142-6 pubmed publisher
    ..Thus we have firstly demonstrated that e2f1 belongs to genes regulated through Wnt/beta-catenin/Tcf pathway. ..
  8. Mokrousov I, Sapozhnikova N, Narvskaya O. Mycobacterium tuberculosis co-existence with humans: making an imprint on the macrophage P2X(7) receptor gene?. J Med Microbiol. 2008;57:581-4 pubmed publisher
  9. Samoilov M, Sitnik N, Rybnikova E, Gluschenko T, Tjulkova E. The expression pattern of pro- and antiapoptotic proteins bax and Bcl-2 in rat brain neurons in response to severe hypobaric hypoxia: the correcting effect of hypoxic preconditioning. Dokl Biol Sci. 2005;402:176-8 pubmed
  10. Kropotov A, Grudinkin P, Pleskach N, Gavrilov B, Tomilin N, Zhivotovsky B. Downregulation of peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks. FEBS Lett. 2004;572:75-9 pubmed
  11. Spirov A, Bowler T, Reinitz J. HOX Pro: a specialized database for clusters and networks of homeobox genes. Nucleic Acids Res. 2000;28:337-40 pubmed