Experts and Doctors on homeodomain proteins in Porto, Portugal


Locale: Porto, Portugal
Topic: homeodomain proteins

Top Publications

  1. Rebelo S, Chen Z, Anderson D, Lima D. Involvement of DRG11 in the development of the primary afferent nociceptive system. Mol Cell Neurosci. 2006;33:236-46 pubmed
  2. Rebelo S, Reguenga C, Osório L, Pereira C, Lopes C, Lima D. DRG11 immunohistochemical expression during embryonic development in the mouse. Dev Dyn. 2007;236:2653-60 pubmed
    ..5 up to the same early post-natal ages in several cranial sensory ganglia and brain nuclei. These results suggest that DRG11 is required for the establishment of the first neuronal sensory relay along development. ..
  3. Barros R, Camilo V, Pereira B, Freund J, David L, Almeida R. Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation. Biochem Soc Trans. 2010;38:358-63 pubmed publisher
    ..In the present paper, we review the basic pathology of gastric IM as well as the current knowledge on molecular pathways involved in CDX2 regulation in the gastric context. ..
  4. Rocha S, Costa E, Rocha Pereira P, Ferreira F, Cleto E, Barbot J, et al. Erythrocyte membrane protein destabilization versus clinical outcome in 160 Portuguese Hereditary Spherocytosis patients. Br J Haematol. 2010;149:785-94 pubmed publisher
    ..Our data suggest that the quantification and the analysis of RBC membrane proteins may be helpful in predicting the clinical outcome of HS. ..
  5. Pereira B, Sousa S, Barros R, Carreto L, Oliveira P, Oliveira C, et al. CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic Acids Res. 2013;41:3986-99 pubmed publisher
  6. Regadas I, Matos M, Monteiro F, Gomez Skarmeta J, Lima D, Bessa J, et al. Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1). J Biol Chem. 2013;288:36285-301 pubmed publisher
    ..Concomitantly, we demonstrate that zebrafish Phox2b is required for the expression of drgx in the facial, glossopharyngeal, and vagal cranial ganglia. ..
  7. Bessa J, Gebelein B, Pichaud F, Casares F, Mann R. Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt. Genes Dev. 2002;16:2415-27 pubmed
    ..A key step in the transition from an immature proliferative state to a committed state in eye development is the repression of hth by the BMP-4 homolog Decapentaplegic (Dpp). ..
  8. Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, et al. Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. J Pathol. 2008;215:411-20 pubmed publisher
    ..In conclusion, we identified for the first time that the BMP pathway is active in intestinal metaplasia and that BMP2 and BMP4 regulate CDX2 expression and promote intestinal differentiation through the canonical signal transducers. ..
  9. Fonseca N, Vieira C, Holland P, Vieira J. Protein evolution of ANTP and PRD homeobox genes. BMC Evol Biol. 2008;8:200 pubmed publisher
    ..Our results help focus experimental studies onto investigating the biochemical functions of key homeodomain residues in different gene classes. ..

More Information


  1. Barros R, Mendes N, Howe J, Reis C, de Bolos C, Carneiro F, et al. Juvenile polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4. Histochem Cell Biol. 2009;131:765-72 pubmed publisher
    ..In conclusion, juvenile polyps have gastric transdifferentiation associated with downregulation of CDX2 and SMAD4, lending support to the role of the BMP/SMAD pathway in CDX2 regulation. ..
  2. Moutinho Pereira S, Debec A, Maiato H. Microtubule cytoskeleton remodeling by acentriolar microtubule-organizing centers at the entry and exit from mitosis in Drosophila somatic cells. Mol Biol Cell. 2009;20:2796-808 pubmed publisher
    ..Our data reveal a new form of cell cycle-regulated MTOCs that contribute for MT cytoskeleton remodeling during mitotic spindle assembly/disassembly in animal somatic cells, independently of centrioles. ..
  3. Barros R, Peleteiro B, Almeida R, Figueiredo C, Barros H, David L, et al. Relevance of high virulence Helicobacter pylori strains and futility of CDX2 expression for predicting intestinal metaplasia after eradication of infection. Scand J Gastroenterol. 2010;45:828-34 pubmed publisher
    ..pylori strains, IM is a point of difficult return in the gastric carcinogenic pathway. The appearance of CDX-expressing cells in non-metaplastic foci was not associated with the development of IM during the six-year follow-up. ..
  4. Camilo V, Barros R, Sousa S, Magalhães A, Lopes T, Mário Santos A, et al. Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells. Carcinogenesis. 2012;33:1985-92 pubmed publisher
    ..These results provide a novel link between H. pylori infection and the BMP pathway in the regulation of intestinal and gastric-specific genes that might be relevant for gastric IM. ..
  5. Barros R, Freund J, David L, Almeida R. Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends Mol Med. 2012;18:555-63 pubmed publisher
    ..Here, we review the pathophysiology of intestinal metaplasia in the context of the molecular network involved in its establishment and maintenance, with emphasis on CDX2 function and regulation...
  6. Mesquita P, Jonckheere N, Almeida R, Ducourouble M, Serpa J, Silva E, et al. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem. 2003;278:51549-56 pubmed